• Patients
  • OBJECTIVE: We describe 4 patients who presented with palpable purpura, arthralgia or arthritis, leukopenia, and antineutrophil cytoplasmic antigen (ANCA) positivity most likely as a result of a hypersensitivity reaction to cocaine-levamisole induced vasculopathy. (biomedsearch.com)
  • CONCLUSIONS: Cocaine-levamisole-related cutaneous vasculitis with leukopenia is a diagnosis of exclusion, but this diagnosis should be strongly considered in patients with a history of cocaine abuse who present with a tetrad of cutaneous manifestations consisting of palpable purpura or bullae with ear involvement, arthralgias, leukopenia, and positive ANCA in high titers and negative Antimyeloperoxidase, when other infectious or idiopathic vasculitic entities have been excluded. (biomedsearch.com)
  • It would therefore a priori be of advantage to identify patients at risk of severe leukopenia to allow for a personalized treatment approach. (aacrjournals.org)
  • A prediction model has been created to estimate the risk that patients will suffer from severe leukopenia. (aacrjournals.org)
  • Further studies on this are of interest to improve identification of patients at high risk of severe leukopenia after gemcitabine and carboplatin treatment. (aacrjournals.org)