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Cell DifferentiationHLA AntigensAntigensAntigens, NeoplasmHLA-B AntigensAntigens, BacterialHLA-DR AntigensAntigens, SurfaceHLA-A AntigensLeukocytesHistocompatibility TestingAntigens, ViralLeukocyte RollingHistocompatibility Antigens Class ICells, CulturedHLA-DQ AntigensHLA-DRB1 ChainsAntigens, CDHLA-DQ beta-ChainsMolecular Sequence DataCell LineHLA-C AntigensAllelesHLA-G AntigensHistocompatibility Antigens Class IIT-LymphocytesHLA-A2 AntigenAntibodies, MonoclonalLeukocyte CountAmino Acid SequenceHLA-D AntigensFlow CytometryAntigens, DifferentiationEpitopesMice, Inbred C57BLAntigens, ProtozoanSignal TransductionAntigens, Polyomavirus TransformingBase SequenceRNA, MessengerGene Expression RegulationStem CellsHistocompatibility AntigensImmunohistochemistryReceptors, Antigen, T-CellLymphocyte ActivationChemotaxis, LeukocytePhenotypeTranscription FactorsAntigens, FungalCell DivisionGene Expression Regulation, DevelopmentalGenes, MHC Class IHLA-B52 AntigenHLA-DR Serological SubtypesT-Lymphocytes, CytotoxicCell ProliferationHaplotypesHLA-B44 AntigenTime FactorsAntigens, HelminthH-2 AntigensB-LymphocytesSex DifferentiationMice, TransgenicMice, Inbred BALB CCell LineageGenes, MHC Class IIEmbryonic Stem CellsFluorescent Antibody TechniqueHLA-DP beta-ChainsTumor Cells, CulturedIsoantibodiesCarcinoembryonic AntigenHistocompatibilityCell AdhesionReverse Transcriptase Polymerase Chain ReactionGene ExpressionMajor Histocompatibility ComplexHLA-DR3 AntigenEnzyme-Linked Immunosorbent AssayMonocytesMice, KnockoutGene FrequencyAntigens, Viral, TumorTransfectionHLA-DR2 AntigenHLA-B27 AntigenPeptidesAntigens, CD8Polymerase Chain ReactionTretinoinProliferating Cell Nuclear AntigenMembrane GlycoproteinsAntigens, CD45HLA-A24 AntigenImmunoglobulin GAntigens, CD15Recombinant ProteinsCD8-Positive T-Lymphocytes
White Cell Differentiation AntigensCluster of differentiatMoleculeMonoclonal antibodyReceptorCD36HistocompatibilityReceptorsHumanExtracellularProliferationMarkersAPCsMaturationClassificationMSCsMyeloid leukemiaPolymorphonuclearVitroSurfaceSubunitSubstancesImmunoglobulinsMolecularProteinsStagesLymphocytes1996PhagocyticCellsGeneticsPeripheral blood leukocytesInteractionComplementRecognitionFactorsGene expressionBonePotentialTypicallyAcute
White Cell Differentiation Antigens1
Cluster of differentiat3
  • The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. (wikipedia.org)
  • cluster of differentiation 257). (wikidoc.org)
  • In molecular biology , CD4 ( cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells , monocytes , macrophages , and dendritic cells . (wikidoc.org)
Molecule4
  • The CD designations were used to describe the recognized molecules, but had to be clarified by attaching the term antigen or molecule to the designation (e.g. (wikipedia.org)
  • Since leucocyte-endothelial cell interactions involve various adhesion receptors we have analysed the expression and distribution pattern of the neural cell adhesion molecule (NCAM), the intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1), the endothelial leucocyte adhesion molecule-1 (ELAM-1), and the cluster of differentiation antigen-44 (CD44) on flat preparations of normal and organ-cultured HCECs. (bmj.com)
  • The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikidoc.org)
  • All of the lines possess surface human leukocyte antigen (HLA) class I and intercellular adhesion molecule-1 (ICAM-1). (medscape.com)
Monoclonal antibody3
  • Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. (wikidata.org)
  • Alessio M, Ghigo D, Garbarino G, Geuna M, Malavasi F: Analysis of the human CD36 leucocyte differentiation antigen by means of the monoclonal antibody NL07. (exbio.cz)
  • [ 17 ] These cell lines express vimentin, cytokeratins 8 and 18, and mesothelial antigen recognized by HBME-1 monoclonal antibody. (medscape.com)
Receptor5
CD361
  • Won WJ, Bachmann MF, Kearney JF: CD36 Is Differentially Expressed on B Cell Subsets during Development and in Responses to Antigen. (exbio.cz)
Histocompatibility4
Receptors3
  • The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
  • Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
  • [4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
Human10
  • The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982. (wikipedia.org)
  • Since 1982 there have been nine Human Leukocyte Differentiation Antigen Workshops culminating in a conference. (wikipedia.org)
  • Human Cell Differentiation Molecules Council (successor to the HLDA Workshops). (wikipedia.org)
  • Bernard A, Boumsell L, Hill C. Joint report of the first international workshop on human leucocyte differentiation antigens by the investigators of the participating laboratories: T2 protocol. (bdbiosciences.com)
  • An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
  • The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
  • We examined the relationships of human leukocyte antigen (HLA) and related polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic Whites) from the San Francisco Bay area. (aacrjournals.org)
  • Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. (karger.com)
  • However, in the absence of human leukocyte antigen (HLA)-compatible donors, no other curative treatment options are available, and therefore, new treatment strategies, such as gene therapy, should be explored. (biomedcentral.com)
  • Human Cell Differentiation Molecules is an organisation which runs HLDA (Human Leucocyte Differentiation Antigens) Workshops and names and characterises CD molecules. (hcdm.org)
Extracellular1
  • Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)
Proliferation3
  • The differentiation, proliferation, prognosis, and safety of MSCs for in vivo therapy remain controversial. (molvis.org)
  • It has been also shown to play an important role in the proliferation and differentiation of B cells. (wikidoc.org)
  • the regulation of the proliferation, differentiation and activity of leukocytes (Dale et. (referat.ru)
Markers4
  • While CD molecules are very useful in defining leukocytes, they are not merely markers on the cell surface. (wikipedia.org)
  • 2007. Leukocyte and Stromal Cell Molecules:The CD Markers . (biolegend.com)
  • The HUCMSCs derived multiple donors were performed comprehensively analysis and potent assays including expressions of surface markers, viability, growth curve, karyotype analysis, tumorigenicity, differentiation potentials, and immune regulation capability. (researchsquare.com)
  • Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. (biomedcentral.com)
APCs2
  • Several cells are known to initiate the process of plasma cell differentiation and are known collectively as antigen presenting cells (APCs) (Waller & Renwick, 1994). (referat.ru)
  • Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
Maturation2
  • After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)
  • The neutrophil maturation and differentiation pathway termed myelopoiesis takes approximately 12 days. (medscape.com)
Classification1
  • This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells). (wikipedia.org)
MSCs5
  • Adipose-derived MSCs, in particular, pose an attractive option for cell-based therapy due to their relatively decreased morbidity during isolation and potential for expansion and differentiation [ 12 ]. (hindawi.com)
  • Multipotential differentiation of MSCs into adipogenic, osteogenic, and chondrogenic cell lineages. (hindawi.com)
  • Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
  • and (iii) MSCs maintains the differentiation potentials of adipocytes, osteoblasts, and chondroblasts in vitro [14]. (researchsquare.com)
  • In spite of tissue origin, many other elements such as culture method and further modulations also influence the heterogeneity of MSCs, leading to differential gene expression profiles, growth phenotype, and differentiation potentials [15-17]. (researchsquare.com)
Myeloid leukemia1
Polymorphonuclear1
  • Histological examination of gingivitis or periodontitis lesions reveals that the polymorphonuclear leukocyte (PMN) appears to play a key role in the maintenance of the periodontal health (3). (bvsalud.org)
Vitro1
  • In vitro differentiation of GS-2 iPSCs into hematopoietic stem and progenitor cells was done using Op9 feeder layers and specified media. (biomedcentral.com)
Surface10
  • Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. (wikidata.org)
  • Immunophenotyping relies on detecting specific antigenic determinants on the surface of WBCs by antigen-specific monoclonal antibodies that have been labeled with a fluorescent dye or fluorochrome, such as phycoerythrin (PE) or fluorescein isothiocyanate (FITC). (cdc.gov)
  • The alpha subunit is the CD11C ANTIGEN, a surface antigen expressed on some myeloid cells. (bvsalud.org)
  • The HUCMSCs derived multiple donors kept a high consistency in surface marker expressions, viability, growth curve, tumorigenicity in nude mic, but had robust heterogeneities in differentiation potentials and immune regulations. (researchsquare.com)
  • LymphokinesThe antigen on the surface of the APC triggers TH-cells to produce hormone-like lymphokines (Lessof, 1993). (referat.ru)
  • The mission of HCDM is to characterise the structure, function and distribution of leucocyte surface molecules and other molecules of the immune system. (hcdm.org)
  • Novel surface antigens expressed on dividing cells but absent from non-dividing cells. (nordicmubio.com)
  • T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikidoc.org)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • the differentiation is based on the percentage of body surface area of skin detachment. (medscape.com)
Subunit1
Substances1
  • Antigens are foreign substances that evoke an immune response. (medscape.com)
Immunoglobulins1
  • Antibodies are immunoglobulins, modified blood proteins with a specific action against antigens. (referat.ru)
Molecular1
  • Molecular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)
Proteins2
  • Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)
  • 1994). This sequence involves more than thirty proteins (Mollnes & Harboe, 1996) and has the function of the destruction and removal of invading micro-organisms and subcellular debris and to promote clearance of antigen-antibody complexes (Dale et. (referat.ru)
Stages1
Lymphocytes2
19961
  • Antigens are foreign molecules that initiate an immune response, they have inherent immunogenicity (Tortora & Grabowski, 1996). (referat.ru)
Phagocytic1
  • This complex has several functions: for instance, to immobilise an antigen therefore preventing attack upon host cells, to block active toxic regions of particular bacteria, and to allow phagocytic attack. (referat.ru)
Cells18
  • This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. (scielo.br)
  • They have a higher odontogenic differentiation capacity compared to other cell groups due to their content of specific progenitor cells. (scielo.br)
  • Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
  • VSV infection triggered rapid differentiation of blood monocytes into immature dendritic cells as well as their apoptosis, which depended on caspase 3/7 activation. (karger.com)
  • Monocyte differentiation required infectious VSV, but loss of CD14+ cells was also associated with the presence of a cytokine/chemokine milieu produced in response to VSV infection. (karger.com)
  • Interestingly, the number of CD80 + pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens. (hindawi.com)
  • DC are professional antigen-presenting cells with the unique capacity to polarize the differentiation of T cells, thereby regulating the balance between inflammation and tolerance [ 12 ]. (hindawi.com)
  • It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. (biogenex.com)
  • CD20 is lost upon terminal differentiation into plasma cells. (biogenex.com)
  • Memory cellsOnce the antigens have been destroyed the plasma cells disappear leaving a few as memory cells which enable a swift response upon second exposure to the antigen (Trounce, 1997). (referat.ru)
  • In vivo differentiation to cells from all three germlines was tested using a teratoma assay. (biomedcentral.com)
  • Differentiation capacity into cells from all three germ layers was confirmed using the teratoma assay. (biomedcentral.com)
  • Herein, we report a potential leukocyte differentiation antigen gene VSTM1 ( V-set and transmembrane domain-containing 1 ) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. (biomedcentral.com)
  • VSTM1 ( V-set and transmembrane domain-containing 1 ) encodes a potential leukocyte differentiation antigen that is highly expressed in myeloid cells, but silenced in multiple leukemia cell lines [ 1 ]. (biomedcentral.com)
  • The focus of this review is to highlight the role of statins in modulating the function and differentiation of various blood cells. (archivesofmedicalscience.com)
  • cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
  • Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
  • Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)
Genetics1
  • genetics of a complex differentiation process. (lu.se)
Peripheral blood leukocytes1
  • SIGLEC5 is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. (fishersci.com)
Interaction1
  • The interaction of antibody with specific antigen results in the formation of the antibody-antigen complex. (referat.ru)
Complement1
  • The role of complement & antibody-antigen complexesAntibodies have two distinct functions: to recognise and combine with an antigen, and to activate a defence mechanism for example by activating the complement sequence (Dale et. (referat.ru)
Recognition1
  • In the example of CD4 & CD8, these molecules are critical in antigen recognition. (wikipedia.org)
Factors1
Gene expression1
Bone1
  • Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. (lookformedical.com)
Potential1
  • Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia. (biomedcentral.com)
Typically1
  • Typically, the pleural fluid has less than 1000 leukocytes per microliter, few erythrocytes, elevated protein levels, and normal lactate dehydrogenase levels. (medscape.com)
Acute1
  • Acute simple transfu- tance of providing antigen-matched blood sions are usually used to treat sequestration for chronic transfusion patients, such as crisis, aplastic crisis, blood loss and in pre- those with thalassaemia and SCA, in order operative preparation. (who.int)