ChronicMalignanciesHematopoieticMyelodysplastic syndromesReverted to anti-leukemicCellsAnti-leukemic activityProgenitorsLymphomasLineagePrognosisStem cellMutationsKinaseLymphomaCancersPolycythemiaMalignancyBlood and bone marrowGeneGenesChemotherapyBlastsNeoplasticTherapeutic targetsPathogenesisApoptosisMalignantNeoplasiaClonalLymphocytesAdult acuteTumor2022MyelofibrosisBonePatientsProliferationBiomarkersAggressivePrognosticDiseasesAssociated with causing acuteHairy cell leuTargetsTranscription factorHematopoiesisLocalizationAlterationsGeneticTypes of leukemia
Chronic25
- EVs were isolated from the serum of acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL) patients, and healthy volunteers. (nature.com)
- Here we provide an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemia). (atlasantibodies.com)
- Acute (AML) and chronic (CML) myeloid leukemia are cancers of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (atlasantibodies.com)
- In the setting of chronic leukemia, cutaneous involvement can indicate blast transformation. (medscape.com)
- Cutaneous infiltration by neoplastic lymphocytes may be seen in acute myeloid leukemia , acute lymphocytic leukemia , chronic myeloid leukemia , chronic lymphoid leukemia , hairy cell leukemia, prolymphocytic leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndromes . (medscape.com)
- This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
- Hairy cell leukemia (HCL) is certainly a chronic lymphoproliferative disorder seen as a somatic recently discovered somatic inhibition in hematopoiesis inside our murine choices aswell as in individuals with in HCL individuals we performed quantitative sequencing of the spot of ITD-1 p. (academicediting.org)
- Bone marrow fibrosis is also detected in the spent phase of chronic myelogenous leukemia and polycythemia vera. (medscape.com)
- Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
- Dasatinib (Sprycel): Indicated for the treatment of adult patients with chronic myeloid leukemia in chronic, accelerated, or myeloid or lymphoid blast phase who are resistant or intolerant to prior therapy including imatinib. (medscape.com)
- Previously, we have developed a p210-breakpoint derived penta-peptide vaccine for controlling minimal residual disease in Chronic Myeloid Leukemia (CML) patients treated with imatinib [ 7 ]. (hindawi.com)
- In previous research, the authors demonstrated that the methanol extract of Artemisia vulgaris (AVM) has the ability to inhibit chronic myeloid leukemia (CML) cell proliferation. (spandidos-publications.com)
- Chronic myeloid leukemia (CML) is a malignancy of the blood and bone marrow that affects children and adults. (spandidos-publications.com)
- The only currently approved BH3-mimetic, the selective BCL2 inhibitor venetoclax, is highly efficacious in chronic lymphocytic leukemia and has rapidly advanced to an approved standard of care in frontline and relapsed disease in combination with anti-CD20 monoclonal antibodies. (biomedcentral.com)
- Aberrant activation of lymphoid enhancer-binding factor-1 (LEF1) has been identified in several cancers, including chronic lymphocytic leukemia (CLL). (oncotarget.com)
- Chronic lymphocytic leukemia (CLL) is a B-cell hematological malignancy characterized by the clonal expansion and accumulation of morphologically mature B-lymphocytes in peripheral blood, bone marrow, and secondary lymphoid tissues. (oncotarget.com)
- Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
- to analyze TP53, NOTCH1 and SF3B1 mutations in chronic lymphocytic leukemia (CLL) patients, sufferers of Chornobyl NPP accident to clarify the possible relationship between ionizing radiation (IR) and CLL. (org.ua)
- Chronic lymphocytic leukemia in Hiroshima and Nagasaki, Japan. (org.ua)
- Radiation and the risk of chronic lymphocytic and other leukemias among chornobyl cleanup workers. (org.ua)
- Chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chernobyl NPP accident - with focus on immunoglobulin heavy chain gene analysis. (org.ua)
- In addition, the BCR-ABL fusion gene product, a constitutively activated tyrosine kinase which is crucial for the development of chronic myeloid leukemia (CML), is highly sensitive to bosutinib. (mdm2-receptor.com)
- Treatment protocols for chronic myelogenous leukemia are provided below for chronic phase, accelerated phase, and blast phase. (medscape.com)
- See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
- Many people with chronic lymphocytic leukemia do not have any symptoms when it is diagnosed. (bloodhealthadvice.com)
Malignancies8
- Leukemia and lymphoma are blood malignancies that affect people of all ages and result in approximately 23,000 deaths in the United States per year [ 1 ]. (nature.com)
- Effective immune surveillance of patients with hematologic malignancies such as leukemia is mediated by cellular and noncellular arms of the innate and adaptive immune system. (nature.com)
- [ 1 , 2 , 3 ] Owing to the variety of hematologic malignancies or proliferative disorders that may be associated with leukemia cutis, terms such as myeloid or lymphoid leukemia cutis have been used to further classify the leukemic cells. (medscape.com)
- Even though stem cell source for myeloid malignancies such as myeloproliferative neoplasms myelodysplastic syndromes and acute myeloid leukemia (AML) is definitely well established a link between aberrations in HSPCs and development of mature lymphoid malignancies has been less thoroughly investigated. (academicediting.org)
- Collectively these results claim that genomic and useful analyses of lymphoid malignancies may reveal unforeseen alterations in much less differentiated HSPC populations. (academicediting.org)
- Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment. (piedmontcancerinstitute.com)
- Venetoclax is active in other lymphoid malignancies including several B cell non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, with the highest intrinsic sensitivity observed in mantle cell lymphoma and Waldenstrom macroglobulinemia. (biomedcentral.com)
- The NCI group has published a recent update of one of their studies, with an additional 10 years of follow-up, and it continues to suggest a possible link between formaldehyde exposure and mortality due to lymphohematopoietic malignancies, particularly myeloid leukemia (Beane Freeman, Blair et al. (who.int)
Hematopoietic11
- The more aggressive forms of hematopoietic and lymphoid tissue diseases require treatment with chemotherapy, radiotherapy, immunotherapy and, in some cases, a bone marrow transplant. (atlasantibodies.com)
- Researchers undertook the clinical trial because relapse remains a leading cause of death after allogeneic hematopoietic cell transplantation for patients with high-risk leukemias. (fredhutch.org)
- The subtype of leukemia is determined by the hematopoietic lineage of neoplastic cells and the stage at which maturational arrest occurs. (medscape.com)
- Acute myeloid leukemia is a hematopoietic neoplasm of dismal prognosis that results from the accumulation of immature myeloid blasts in the bone marrow and the peripheral blood. (frontiersin.org)
- Akin to the normal hematopoietic system, leukemias are sustained by a small number of leukemia stem-like cells (LSC), which can be distinct from the normal hematopoietic stem cells (HSC) but also exhibit functional characteristics of self-renewal and (abnormal or hindered) differentiation, and are often quiescent ( 2 - 4 ). (frontiersin.org)
- Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
- This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
- 3 Detection of the MLL-AF4 fusion protein in CD34 + /CD19 − fetal hematopoietic stem or progenitor cells or in fetal cells before hematologic specification suggests that there is a window of opportunity during development for the MLL-AF4 fusion protein to immortalize hematopoietic stem and progenitor cells (HSPCs). (ashpublications.org)
- Uncovering a unique role for DNA methylation in hematopoietic and leukemic stem cells. (mdc-berlin.de)
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. (cusabio.com)
- Malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived hematopoietic progenitor cell results in a high circulating number of blasts, replacement of normal marrow by malignant cells, and the potential for leukemic infiltration of the central nervous system (CNS) and testes. (msdmanuals.com)
Myelodysplastic syndromes1
- WT1 is expressed 10 to 1,000 times higher in leukemic cells compared to normal CD34 blood stem cells, and the magnitude of expression correlates with the aggressiveness of acute myeloid leukemia, acute lymphoid leukemia and myelodysplastic syndromes. (fredhutch.org)
Reverted to anti-leukemic1
- Regularly, anergy of T cells or other immune cells can be regularly reverted to anti-leukemic functionality. (nature.com)
Cells54
- show that this approach can detect characteristic changes that affect blood cells as a result of malaria, spherocytosis, bacterial and viral infections, and leukemia. (elifesciences.org)
- The protein, called AML1, plays a critical role in the development of the blood system and in the production of platelets and immune cells. (mskcc.org)
- The existence of specific clusters of cells with stemness-like characteristics like differentiation, self-renewal, detoxification, and resistance to apoptosis in Leukemia makes them difficult to treat. (bvsalud.org)
- To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
- 90% leukemic cells. (aacrjournals.org)
- After more than four decades of intensive research, the cellular origins of acute lymphocytic leukemia (ALL) have been well defined, and several distinct genetic mechanisms that lead to malignant transformation of these cells have been identified ( 1 - 4 ). (aacrjournals.org)
- A clot is formed when fibrin, a fibrous protein, forms a mesh that entraps blood cells, primarily platelets and red blood cells, to stop bleeding and seal a wound when there is vascular injury. (labtestsguide.com)
- CSCs were first identified in hematological cancer such as acute myeloid leukemia in the late '90s when scientists isolated a subpopulation of leukemia cells that expressed the surface marker CD34 but not CD38. (atlasantibodies.com)
- Leukemia and lymphoma are cancers that affect white blood cells. (cshlpress.com)
- SEATTLE - Feb. 27, 2013 - In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center for the first time have successfully infused large numbers of donor T-cells specific for a key anti-leukemic antigen to prolong survival in high-risk and relapsed leukemia patients after stem cell transplantation. (fredhutch.org)
- Reporting results of a pilot clinical trial in the Feb. 27 issue of the journal Science Translational Medicine , researchers describe the use of T-cells that were taken from a donor, programmed in the lab to recognize the Wilm's Tumor Antigen 1 (WT1) and kill leukemia cells, grown in large numbers, and then infused into patients to promote anti-leukemic activity. (fredhutch.org)
- The WT1 protein is overexpressed in leukemias and is in part responsible for why the cells have become leukemic. (fredhutch.org)
- The best results were achieved when some of the patients received T-cell clones that were exposed to interleukin 21 (IL-21) during the programming and growth process, based on the hypothesis that such exposure would create cells that could survive longer and produce greater anti-leukemic activity after transfer. (fredhutch.org)
- This is the first time patients have received an infusion of WT1 specific T-cells, and thus also the first demonstration that such cells can provide a therapeutic anti-leukemic effect, as has been suggested from earlier vaccine trials that induce less potent responses," said Philip Greenberg, M.D. , corresponding author and head of the Immunology Program at Fred Hutch. (fredhutch.org)
- Among the seven patients who received infused T-cells generated without the presence of IL-21, two showed direct evidence of anti-leukemic activity, including one patient with advanced progressive disease who had a temporary response. (fredhutch.org)
- However, because donor stem cells are not selected for specificity for leukemia antigens and commonly recognized proteins expressed by many other host tissues, substantial morbidity and mortality from GVHD can occur. (fredhutch.org)
- The scientists theorized that infusions of T-cells that target WT1 could potentially promote additional anti-leukemic activity without inducing GVHD. (fredhutch.org)
- Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells ONCOTARGET. (nottingham.ac.uk)
- Leukemia cutis is defined by migration of leukemic cells to the skin. (medscape.com)
- The pathophysiology underlying the specific migration of leukemic cells to the skin is not clear. (medscape.com)
- 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
- In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
- RUNX1-positive leukemia cells in preclinical models. (lu.se)
- We previously showed that constitutive overexpression of the oncogenic transcription factor Spi1/PU.1 leads to pre-leukemic cells that have a shortened S phase duration with an increased replication fork speed and increased mutability in the absence of DNA breaks. (oncotarget.com)
- Here, we demonstrate that the S phase checkpoint protein CHK1 is maintained in a low phosphorylation state in Spi1/PU.1-overexpressing cells and provide evidence that this is not due to negative control of its primary kinase ATR. (oncotarget.com)
- Mice sacrificed at 12 months of age acquired no overt phenotype beyond the B lineage despite apparent activation of mitogen-activated proteins kinase (MAPK) signaling in B lineage cells (Fig. 3 A to fig and D. S3 G and F. = 0.006) upsurge in spleen weight aswell as the quantity and size of GC B cells in = 0.02) in Cd19-cre on HSC self-renewal. (academicediting.org)
- One reason for this is that unlike adult myeloid cells subsets of normal adult B cells are characterized by the capacity to self-renew and differentiate as part of their normal function. (academicediting.org)
- Peptides derived from p190-breakpoint area are leukemia-specific antigens that may mediate an antitumor response toward p190+ leukemia cells. (hindawi.com)
- Thus, from an immunologic point of view, peptides derived from p190-breakpoint area are leukemia-specific antigens that may be employed as therapeutic vaccine with the purpose to induce a T cell response toward p190+ leukemia cells. (hindawi.com)
- 1 Mixed lineage leukemia (MLL) gene fusions are the molecular hallmark of infant acute lymphoblastic leukemia (ALL) and are present in tumor cells in up to 80% of patients. (ashpublications.org)
- Targeting of Mll-AF4 in early fetal HSPCs enhanced the lymphoid potential of primed multipotent cells but was insufficient by itself to induce leukemia. (ashpublications.org)
- Comparative transcriptomic analysis of tumor cells from diseased mice revealed the expression of several well-known MLL-rearranged leukemia-associated target genes, including Meis1 , Runx1 ( pMIRH-128a mice), HoxA9 , Flt3 ( pMIRH-130b mice), Cdk6 , and Bcl2 . (ashpublications.org)
- These cells may also be called leukemic cells. (piedmontcancerinstitute.com)
- These leukemic cells are not able to fight infection very well. (piedmontcancerinstitute.com)
- Also, as the number of leukemic cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. (piedmontcancerinstitute.com)
- Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
- In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
- Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
- Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells. (mdc-berlin.de)
- Effect of transcription-factor concentrations on leukemic stem cells. (mdc-berlin.de)
- The human CD19 antigen is a transmembrane protein expressed from pre-B cells until the terminal differentiation to plasma cells [ 42 ]. (biomedcentral.com)
- However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
- In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
- BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. (biomedcentral.com)
- The progressive accumulation of leukemic cells is mostly ascribed to extended cellular survival rather than excessive cellular proliferation [ 1 ]. (oncotarget.com)
- All cells need the amino acids asparagine and glutamine for protein synthesis and growth, and while normal healthy cells can obtain most through its own synthesis, cancer cells cannot produce enough to meet cellular demands and must therefore rely on circulating levels. (emadicancerlab.com)
- Recently, we have discovered that combination of Ven and PegC synergistically targets Gln metabolism and mTOR-eIF4E-driven ribosomal translational protein synthesis in AML cells. (emadicancerlab.com)
- As cells undergo oncogenesis, neoantigens are released and captured on major histocompatibility complex (MHC)/ human leukocyte antigen (HLA) of dendritic cells (DCs) that subsequently mature and migrate to central lymphoid organs. (encyclopedia.pub)
- These cells secrete immune inhibitory growth factors and cytokines, including vascular endothelial growth factor (VEGF), which is primarily produced by microglia, myeloid-derived suppressor cells (MDSCs) and tumour-associated macrophages (TAMs). (encyclopedia.pub)
- Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
- A study by Tang et al has determined that long-term TKI therapy may reduce the abundance of leukemic stem cells in select patients. (medscape.com)
- Many of the signs and symptoms of advanced CLL occur because the leukemia cells replace the bone marrow's normal blood-making cells. (bloodhealthadvice.com)
- Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
- Загальні відомості про лейкоз Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms. (msdmanuals.com)
Anti-leukemic activity1
- In addition, in a clinical study designed and conducted by Dr. Emadi, asparaginase led to complete plasma glutamine depletion in patients, which correlated to anti-leukemic activity in 40% of patients with relapsed or refractory acute myeloid leukemia (AML). (emadicancerlab.com)
Progenitors3
- Leukemia is a group of diseases characterized by altered growth and differentiation of lymphoid or myeloid progenitors of blood. (bvsalud.org)
- Targeted deletion of the Hoxa cluster affects B lymphopoiesis through depletion of early lymphoid progenitors. (nottingham.ac.uk)
- Further transplantation experiments demonstrated that lympho-myeloid progenitors (LMPPs) allowed the propagation of pMIRH-130b mixed B-cell/myeloid leukemia, whereas Lin-Sca1 +/− Il7 + Kit + blasts maintained pro-B-ALL disease of pMIRH-128a mice. (ashpublications.org)
Lymphomas1
- Since these tissues are all intimately connected through both the circulatory and the immune system, a disease affecting one system will often affect the other as well, making myeloproliferation (leukemias) and lymphoproliferation (lymphomas) closely related and often overlapping conditions. (atlasantibodies.com)
Lineage2
- Acute myeloid leukemia (AML) is a malignant disease that affects the myeloid lineage and progresses from normal to pre-leukemic and leukemic stages due to the accumulation of mutations over time. (oncotarget.com)
- Latest genomic analyses of leukemias of another lymphoid lineage T cell severe lymphoblastic leukemia (T-ALL) uncovered that a particular subset of T-ALL is normally highly similar on track and myeloid leukemic HSCs in gene appearance and mutational profile (25). (academicediting.org)
Prognosis4
- They were considered at high risk of death because they had already relapsed and/or had a poor prognosis due to unfavorable characteristics of their leukemia. (fredhutch.org)
- A diagnosis of leukemia cutis in the setting of acute leukemia generally portends a poor prognosis and strongly correlates with additional sites of extramedullary involvement. (medscape.com)
- Ph+ acute lymphoblastic leukemia (Ph+ ALL) is a high-risk acute leukemia with poor prognosis, in which the specific t(9;22)(q34;q11) translocation results in a chimeric bcr-abl (e1a2 breakpoint) and in a 190 KD protein (p190) with constitutive tyrosine kinase activity. (hindawi.com)
- Mutations in FMS-like tyrosine kinase 3 (FLT3), transmembrane ligand-activated receptor tyrosine kinase important for myeloid and lymphoid development, are one of the most common genetic alterations reported in AML are associated with a more aggressive disease and poor prognosis. (emadicancerlab.com)
Stem cell4
- It was recently reported that an oncofetal RNA binding protein, insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), maintains leukemic stem cell properties. (bvsalud.org)
- We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
- A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. (piedmontcancerinstitute.com)
- Treatment typically includes combination chemotherapy to achieve remission, intrathecal and systemic chemotherapy and/or corticosteroids for CNS prophylaxis, and sometimes cerebral irradiation for intracerebral leukemic infiltration, consolidation chemotherapy with or without stem cell transplantation, and maintenance chemotherapy for up to 3 years to avoid relapse. (msdmanuals.com)
Mutations3
- Class II mutations cause defects in myeloid cell differentiation. (medscape.com)
- Emergence of LSC is dependent on individual or combined genetic mutations that broadly determine the cellular affiliation of the leukemia, and permit or impose ectopic self-renewal and a restricted differentiation potential into what constitutes the proliferative bulk of the leukemia ( 5 , 6 ). (frontiersin.org)
- Although genomic alterations have been extensively characterized in AML [ 1 ], little is known about the determining events that favor the accumulation of mutations and the progression from the pre-leukemic to leukemic stage. (oncotarget.com)
Kinase5
- MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma. (cshlpress.com)
- Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
- q11) resulting in a chimeric bcr-abl (e1a2 breakpoint) fusion gene that encodes a 190 KD protein (p190) with constitutively active tyrosine kinase activity that can alter multiple signaling pathways, contributing to tumor growth and proliferation. (hindawi.com)
- Experimentalists are similarly afflicted: while trying to identify LMs, they are likely to spend a lot of resources, time and ACY-1215 kinase inhibitor effort carrying out experiments within the false motif candidates, which usually vastly outnumber the genuine ones in any set of proteins of interest (1). (insulin-receptor.info)
- The tyrosine kinase Src is a member of a family of related kinases known as the Src family kinases (SFKs) that share a common structural organization and function as key regulators of signal transduction pathways triggered by a wide variety of surface receptors, including receptor tyrosine kinases, integrins, G-protein-coupled receptors, and antigen receptors (Thomas and Brugge 1997). (mdm2-receptor.com)
Lymphoma8
- Examples of hematologic cancer include leukemia, lymphoma, and multiple myeloma. (atlasantibodies.com)
- Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. (cshlpress.com)
- In addition, the authors discuss state-of-the-art preclinical models of leukemia and lymphoma, existing and prospective therapeutic strategies, and how technologies such as next-generation sequencing have accelerated progress in the field. (cshlpress.com)
- Each chapter provides in-depth analysis of a particular aspect of leukemia and/or lymphoma, contributing to a comprehensive review on current biological and clinical understandings of leukemia and lymphoma. (cshlpress.com)
- Some antecedents are specific to a leukemia subtype, such as the association of acute T-cell leukemia-lymphoma (ATL) with human T-lymphotropic virus type I (HTLV-1). (medscape.com)
- Leukemia and Lymphoma. (elsevierpure.com)
- Leukemia, lymphoma and multiple myeloma, 1950-1987. (org.ua)
- Leukemia, lymphoma, and multiple myeloma after pelvix radiotherapy for benign disease. (org.ua)
Cancers1
- Solid as well as blood cancers are associated with overexpression of HOX proteins in the nucleus, which is traditionally a difficult area of the cell to target with conventional drugs. (nottingham.ac.uk)
Polycythemia1
- The long-term risks of polycythemia vera (PV) include leukemic and fibrotic transformation, which occur in fewer than 5% and 10% of patients, respectively, at 10 years. (medscape.com)
Malignancy4
- AML is an aggressive malignancy of the non-lymphoid lineages of the blood. (frontiersin.org)
- Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy that relies on highly heterogeneous cytogenetic alterations. (mdpi.com)
- pMIRH-130b mice presented with a mixed B-cell/myeloid malignancy, whereas pMIRH-128a mice developed pro-B-cell ALL. (ashpublications.org)
- BCL2 family proteins (BCL2, BCL-X L , MCL1, etc.) sequester BH3-only proteins and prevent apoptosis, and these anti-apoptotic properties are frequently upregulated in malignancy, making them an attractive therapeutic target [ 3 ]. (biomedcentral.com)
Blood and bone marrow1
- also called acute lymphocytic leukemia) is a cancer of the blood and bone marrow. (piedmontcancerinstitute.com)
Gene7
- Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene. (wikipedia.org)
- 2003). "A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein" (PDF). (wikipedia.org)
- Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
- [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
- For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
- Malouf et al also identified several candidate target genes that may mediate the leukemic activity of miR-128 (including the nuclear orphan receptor NR2F6 gene), miR-130b, or both (including the sphingomyelin synthase 1 [ SGMS1 ] gene). (ashpublications.org)
- A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. (mdc-berlin.de)
Genes4
- According to the study, investigators identified the methyltransferase enzyme that controls the activity of the normal AML1 protein - also called RUNX1 - demonstrating its ability to regulate the function of transcription factors, proteins that control cell fate by turning genes on or off. (mskcc.org)
- We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. (aacrjournals.org)
- In addition, the expression of stemness genes/proteins is also used to identify CSCs. (atlasantibodies.com)
- Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
Chemotherapy2
- The relapse rate remains high after chemotherapy for adult patients with acute lymphoblastic leukemia (ALL). (biomedcentral.com)
- Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
Blasts2
- Leukemic blasts with prominent granules, often resembling multiple Auer rods, are a characteristic feature of Acute Myeloid Leukemia (AML). (labtestsguide.com)
- Auer rods are needle-like inclusions within the cytoplasm of the leukemic blasts and are considered a hallmark of AML. (labtestsguide.com)
Neoplastic1
- Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, the dermis, or the subcutis, resulting in clinically identifiable cutaneous lesions. (medscape.com)
Therapeutic targets1
- We discuss the value of lncRNAs as putative diagnostic, prognostic and therapeutic targets in myeloid leukemias and indicate novel directions in this exciting research field. (frontiersin.org)
Pathogenesis1
- The pathogenesis of leukemia is well-characterized in the two-hit hypothesis of acute myeloid leukemia. (medscape.com)
Apoptosis2
- In brief, apoptosis is triggered when "pro-death/damage sensing" BH3-only proteins activate the downstream effector molecules BAX and BAK, which dimerize on the mitochondrial outer membrane surface and permeabilize it, triggering the release of cytochrome C, caspase activation and committing the cell to programmed death. (biomedcentral.com)
- Released from the inhibitory action of BCL2 and related proteins, these pro-apoptotic BH3-only proteins are then able to activate BAX and BAK and initiate apoptosis (Fig. 1 ). (biomedcentral.com)
Malignant1
- In this issue of Blood , Malouf et al characterize 2 microRNAs (miRNAs) that are effectors of malignant transformation by the MLL-AF4 fusion protein. (ashpublications.org)
Neoplasia1
- We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
Clonal1
- The roles of clonal hematopoiesis, RNA-binding proteins, and alterations in metabolism and cell signaling (e.g. (cshlpress.com)
Lymphocytes2
- Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (piedmontcancerinstitute.com)
- The leukemia is often found when their doctor orders blood tests for some unrelated health problem or during a routine check-up and they are found to have a high number of lymphocytes. (bloodhealthadvice.com)
Adult acute5
- This summary is about adult acute lymphoblastic leukemia. (piedmontcancerinstitute.com)
- Adult Acute Myeloid Leukemia Treatment. (piedmontcancerinstitute.com)
- These and other symptoms may be caused by adult acute lymphoblastic leukemia or by other conditions. (piedmontcancerinstitute.com)
- L-asparaginase is a well-established treatment for pediatric and adult acute lymphoblastic leukemia. (emadicancerlab.com)
- ALL accounts for about 20% of adult acute leukemias. (msdmanuals.com)
Tumor2
- EVs were characterized by transmission electron microscopy and fluorescence nanoparticle tracking analysis, and EV surface protein profiles were analyzed by multiplex bead-based flow cytometry to identify tumor- or immune system-related EVs of AML, ALL, CLL, and healthy samples. (nature.com)
- Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
20221
- The American Cancer Society estimates that in the United States in 2022 there will be over 6600 new cases of acute lymphoblastic leukemia (ALL) and almost 1600 deaths will have occurred. (msdmanuals.com)
Myelofibrosis1
- Peripheral smear of a patient with agnogenic myeloid metaplasia (myelofibrosis) shows leukoerythroblastosis. (medscape.com)
Bone1
- All types of leukemia result from the abnormal development of leukocytes in the bone marrow. (medscape.com)
Patients4
- We hope to utilize these new findings to help develop and ultimately test new treatment strategies for patients with either myeloid or lymphoid types of acute leukemia. (mskcc.org)
- Leukemia cutis has been described in patients with myeloid and lymphoid types of leukemias. (medscape.com)
- Treatment responses of patients with acute myeloid leukemia (AML) are known to be heterogeneous, posing challenges for risk scoring and treatment stratification. (nature.com)
- In general, phosphorus-32 ( 32 P) therapy should be reserved for patients older than 80 years or patients with comorbid conditions in whom life expectancy is less than 5-10 years and the convenience of 32 P dosing outweighs the substantial risks of developing acute leukemia 5-15 years after 32 P administration. (medscape.com)
Proliferation1
- Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
Biomarkers1
- Aiming to provide proof-of-concept evidence and methodology for the potential role of serum-derived EVs as biomarkers in leukemic versus healthy samples in this study, we hope to pave the way for future detection of promising biomarkers for imminent disease progression and the identification of potential targets to be used in a therapeutic strategy. (nature.com)
Aggressive2
- Philadelphia positive acute lymphoblastic leukemia (Ph+ ALL) is a high-risk, aggressive form of acute leukemia, affecting primarily adults and the elderly. (hindawi.com)
- its aggressive leukemic phase. (bvsalud.org)
Prognostic1
- Accurate diagnosis has tremendous prognostic significance and may establish a diagnosis in cases in which leukemia cutis is the harbinger of a systemic leukemic process. (medscape.com)
Diseases1
- Acute lymphocytic leukemia (ALL), for example, is the most common childhood cancer, but these diseases can occur in individuals of all ages. (cshlpress.com)
Associated with causing acute1
Hairy cell leu1
- Hairy Cell Leukemia Treatment. (piedmontcancerinstitute.com)
Targets1
- Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
Transcription factor1
- The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
Hematopoiesis1
- Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia. (mdc-berlin.de)
Localization1
- Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic" (PDF). (wikipedia.org)
Alterations1
- Genetic alterations predisposing to leukemia may be congenital or acquired. (medscape.com)
Genetic3
- Similarly, some genetic or chromosomal abnormalities are found in specific leukemia subtypes. (medscape.com)
- People with Down syndrome and certain other genetic conditions get leukemia more frequently. (bloodhealthadvice.com)
- Similar to acute myeloid leukemia, acute lymphoblastic leukemia is caused by a series of acquired genetic aberrations. (msdmanuals.com)
Types of leukemia1
- Exposure to high doses of ionizing radiation has been associated with the development of all types of leukemia except CLL. (bloodhealthadvice.com)