• Cases of malignant lymphomas and leukemias were not described in gibbons until the 1960s, when several cases of haematopoietic neoplasia were reported in a single colony of white-handed gibbons housed at the SEATO research facility in Bangkok, Thailand. (wikipedia.org)
  • Hence, in our initial attempts to develop cell lines from patients with T -cell neoplasias, we chose clinical subpopulations which represent a more mature form of disease, namely, the cutaneous T -cell lymphomas and leukemias and E-rosette positive T -cell ALL (Gupta and Good 1980). (science-connections.com)
  • Gibbon-ape leukemia virus (GaLV) is an oncogenic, type C retrovirus that has been isolated from primate neoplasms, including the white-handed gibbon and woolly monkey. (wikipedia.org)
  • Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). (lookformedical.com)
  • Virologist initially suggested that GaLV was related to murine leukaemia virus (MLV) detected in Southeast Asian rodents. (wikipedia.org)
  • For viral replication to occur within the host, simian sarcoma-associated virus (SSAV) must also be present. (wikipedia.org)
  • Simian sarcoma (SSV): a defective GALV recombinant, derived from a single isolate of fibrosarcoma in a Woolly Monkey that was exposed to a GALV-infected captive gibbon. (wikipedia.org)
  • These include cross-species transmission of the retrovirus present within a species of East Asian rodent or bat, and the inoculation or blood transfusion of a MbRV-related virus into captured gibbons populations housed at medical research institutions. (wikipedia.org)
  • In 1971, phylogenetic analysis of the Leukemia-inducing retrovirus, lead to the identification of GaLV-SEATO, published within De Paoli et al. (wikipedia.org)
  • A novel retrovirus, human T -celllymphomaleukemia virus (HTLV), has been isolated from the fresh and cultured cells of two of these patients. (science-connections.com)
  • Subsequent characterization of this virus has shown that it is not significantly related to any known animal retrovirus, is not an endogenous (genetically transmitted) virus of man, and so far has been associated only with fresh or cultured T -cells from patients with T -cell neoplasia. (science-connections.com)
  • McERV, detected within Mus caroli, and Mus dunni endogenous virus (MDEV) isolated from the earth-coloured mouse (Lieber et al. (wikipedia.org)
  • 1971). Following this discovery, five other strains of GaLV was identified from animals whose associated neoplastic syndromes were exclusively recorded in captive gibbon populations, which include: GaLV-SF: identified from a gibbon lymphosarcoma in San Francisco and within captured gibbons populations at the University of California San Francisco Medical Center and the University of California. (wikipedia.org)
  • External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
  • Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
  • 1975). Although the Epstein-Barr virus (EBV), a DNA virus of the herpes group, is implicated in some aspect of Burkitt's lymphoma, a B-cell disease (De- The 1980), the etiology of all the T -cell neoplasias is, as of yet, obscure. (science-connections.com)
  • The virus was identified as the etiological agent of hematopoietic neoplasms, leukemias, and immune deficiencies within gibbons in 1971, during the epidemic of the late 1960s and early 1970s. (wikipedia.org)
  • Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. (lookformedical.com)
  • GaLV is transmitted horizontally by contact with excretory products of infected gibbons. (wikipedia.org)
  • The discovery of a contagious oncogenic gammaretrovirus in sub-human primates stimulated a great deal of research into the pathogenesis of GaLV and its origins including the virus' intermediate host, which is currently disputed. (wikipedia.org)
  • Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)