• type
  • It is considered a slow-growing type of leukemia that occurs more commonly in older men. (unm.edu)
  • A genetic mutation referred to as the BRAF V600E mutation is thought to be an involved the excessive replication of hairy cell leukemia, as it is a common mutation in this type of cancer. (unm.edu)
  • cell
  • The targeted agent, Zelboraf┬« (vemurafenib), which is approved for the treatment of melanoma, provided high anti-cancer activity among patients with hairy-cell leukemia that had stopped responding to prior therapies. (unm.edu)
  • Researchers from Italy and the United States conducted clinical trials to evaluate Zelboraf among patients with hairy cell leukemia that had stopped responding to prior standard therapy. (unm.edu)
  • TWEAK also increased monocyte chemoattractant protein-1 secretion in human acute monocytic leukemia cell line cells, an effect blocked with an HMGB1 small interfering RNA. (ahajournals.org)