• chronic leukemia
  • Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the "stemness" of chronic leukemia cancer (CLL) cells -- their ability to self-renew and resist terminal differentiation and senescence. (eurekalert.org)
  • rats
  • Contents of scvalene, sterols and their derivatives were studied in lymphoid tissues as well as in liver and kidney tissues of normal rats and the animals with Shvetz experimental leukosis. (msk.ru)
  • Amount of cholesterol and of its precursor scvalene was distinctly decreased simultaneously with an increase in total content of nonsaponified substances in thymus, spleen, bone marrow and liver tissue of rats with experimental leukosis. (msk.ru)
  • Palamarchuk V.I., Trikash I.O., Antonenko L.V., Content of squalene and sterols in tissues of the hemopoietic system in normal rats and in experimental leukemia, Voprosy meditsinskoi khimii, 1983, vol: 29(3), 64-67. (msk.ru)
  • Amount of cholesterol was distinctly decreased but content of scvalene, lanosterol, 7-dehydrocholesterol and 7-beta-hydroxycholesterol--increased in erythrocyte membranes of rats with Shvetz experimental leukosis. (msk.ru)
  • Palamarchuk V.I., Trikash I.O., Alterations in composition of sterols and in properties of erythrocyte membranes in rats with Shvetz experimental leukemia and after UV irradiation, Voprosy meditsinskoi khimii, 1983, vol: 29(3), 67-70. (msk.ru)
  • vivo
  • Projects in Group A use a broad spectrum of physiologically relevant in vitro and in vivo experimental systems to investigate cellular and molecular mechanisms of leukemogenesis. (uni-ulm.de)
  • Journal of Exper
  • The study , led by Dr. Caius Radu, an associate professor of molecular and medical pharmacology at UCLA, and Dr. David Nathanson, an assistant professor of molecular and medical pharmacology, was published in the Journal of Experimental Medicine. (pressreleasepoint.com)
  • By the next year, Dr. Friend had published her work in the Journal of Experimental Medicine, under the careful editing of Peyton Rous. (mssm.edu)
  • The Journal of Experimental Medicine. (wikipedia.org)
  • Biology
  • In 1966, Dr. Friend left Sloan-Kettering to become the first Director of the Center for Experimental Cell Biology and a Professor at the still developing Mount Sinai School of Medicine. (mssm.edu)
  • Old was also a member of the American Association for Cancer Research, New York Academy of Sciences, Reticuloendothelial Society, Society of Experimental Biology and Medicine, American Association for the Advancement of Science, American Association of Immunologists, National Academy of Sciences, the Academy of Cancer Immunology, and the American Academy of Arts and Sciences. (wikipedia.org)
  • gene
  • Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19) is the protein product of the PML gene. (wikipedia.org)
  • Recognition
  • Discovered the first linkage between the major histocompatibility complex (MHC) and disease-mouse leukemia-opening the way for the recognition of the importance of the MHC in the immune response (1964). (wikipedia.org)
  • found
  • Also, Dr. Jacob Furth announced that he had studied Dr. Friend's pathologic material and that leukemia truly had been found to result from the new virus, which quickly became known as the Friend leukemia virus. (mssm.edu)
  • breast
  • Written simply and clearly so that the experiments can be easily reproduced, the book presents Huggins's experiments in the induction of breast cancer and leukemia in rodents. (uchicago.edu)