• Asymptomatic plasma cell myeloma is a plasma cell neoplasm defined by the presence of serum monoclonal protein of 3.0 gm/dL or greater (by electrophoresis) and/or clonal plasma cells in the bone marrow of 10% or greater, without evidence of end-organ damage (hypercalcemia, renal insufficiency, anemia, lytic lesions of bone). (medscape.com)
  • Symptomatic plasma cell myeloma is a plasma cell neoplasm defined as the presence of end-organ damage (hypercalcemia, renal insufficiency, anemia, lytic lesions of bone) in a patient with a monoclonal protein (of any amount) and clonal plasma cells in the bone marrow (of any amount) or plasmacytoma. (medscape.com)
  • Hypercalcemia results from the increased osteoclastic activity, with resultant lytic bone lesions and pathologic fractures (see the image below). (medscape.com)
  • Common manifestations include lytic lesions in bones that cause pain and/or fractures, renal insufficiency, hypercalcemia, anemia, and recurrent infections. (merckmanuals.com)
  • Clinical investigation of MM requires the evaluation of bone marrow for plasma cell infiltration, and detection and quantification of monoclonal protein in the serum or urine, and evidence for end-organ damage (i.e., hypercalcemia, renal insufficiency, anemia, or bone lesions). (intechopen.com)
  • Concurrent use of gallium nitrate with other potentially nephrotoxic drugs (e.g., aminoglycosides, amphotericin B) may increase the risk for developing severe renal insufficiency in patients with cancer-related hypercalcemia. (nih.gov)
  • About 30% of patients with myeloma develop hypercalcemia associated with extensive osteolytic lesions and impaired glomerular filtration. (nih.gov)
  • Monoclonal immunoglobulin serum levels are lower than 30 g/l, the marrow contains less than 10% of monocloal plasma cells with no signs of organ affection (no hypercalcemia, renal insufficiency, anemia or osteolytic lesions). (muni.cz)
  • While MM presents with a variety of disease-related complications, the most common complications include the following: hypercalcemia, renal insufficiency, anemia, and bone lesions [ 2 , 3 ]. (thejh.org)
  • Relapse is indicated by any number of clinical signs, including hypercalcemia, renal insufficiency, anemia, new bone lesions or paraproteinemia. (scientiacme.org)
  • In either form of plasma cell myeloma, immune dysfunction, cytopenias and lytic bone lesions occur as a result of direct cellular interactions (cytokines, growth factors) and/or mass effect. (medscape.com)
  • Plasma cell myeloma presents with generalized marrow involvement, with or without lytic lesions of bone. (medscape.com)
  • Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
  • Symptomatic plasma cell myeloma is associated with CRAB: hypercalcaemia, renal insufficiency, anaemia and bone lesions. (microscopic-haematology.com)
  • These symptoms are referred to as CRAB (calcium [elevated], renal failure, anaemia and bone disease]. (janssenmedicalcloud.com)
  • Multiple myeloma accounts for one of the 'M's in the popular mnemonic for lucent bone lesions FEGNOMASHIC . (radiopaedia.org)
  • The prevalence production, lytic lesions and increased of leptomeningeal infiltration in breast can- plasma cells in the bone marrow [ 1 ]. (who.int)
  • The authors insufficiency, hypercalcaemia, anaemia and concluded that "the reasons underlying the recurrent infection [ 3,4 ]. (who.int)
  • Several reports have evaluated changes in renal function following RNU and demonstrated that the decline in renal function may render a substantial number of patients ineligible to receive adjuvant chemotherapy (AC) [ 10 - 15 ]. (hindawi.com)
  • It occurs with various levels of hypertension, albuminuria, gradual - slow decline in renal function. (mesogeios.gr)
  • Intravascular lithotripsy was used to prepare these severely calcified lesions for stenting. (medscape.com)
  • The pool included patients with the highest rates of comorbidities, such as diabetes and renal insufficiency, while 43.9% also had severely calcified lesions. (philips.com)
  • This may not be justified if lesions are non-functional, which is often the case early in the clinical course when spot T4 and calcium determinations are in the reference interval. (vin.com)
  • Some of these patients have been reported to have increased renal tubular calcium resorption. (nih.gov)
  • The objective of this study was to detail renal cystic and solid lesions and identify any association with clinical characteristics. (elsevierpure.com)
  • Measurements: Renal cystic and solid lesions by contrast-enhanced computed tomographic images. (elsevierpure.com)
  • The Orphan Drug Designation has been granted for CMC-001 for use as a targeted contrast agent for diagnostic MRI for detection and localization of focal liver lesions in patients where gadolinium-based contrast agents are contraindicated or cannot be administered. (salesandmarketingnetwork.com)
  • Magnus Corfitzen, Chairman of CMC Contrast AB "The diagnostic benefits of enhanced MRI liver imaging in detecting and localizing focal liver lesions are well established. (salesandmarketingnetwork.com)
  • Today's discussion is on focal liver lesions. (medscape.com)
  • What do we do with these focal liver lesions? (medscape.com)
  • Intravascular lithotripsy proved highly effective, safe, and user friendly as an adjunct to stenting for severely calcified coronary lesions at 30 days of follow-up in the pivotal Disrupt CAD III study aimed at gaining U.S. regulatory approval. (medscape.com)
  • In so doing, the intravascular lithotripsy device developed by Shockwave Medical successfully addressed one of the banes of contemporary interventional cardiology: heavily calcified coronary lesions. (medscape.com)
  • Severely calcified coronary lesions complicate percutaneous coronary intervention. (medscape.com)
  • The prevalence of coronary culprit lesions on angiography was 24%, and 21% of patients underwent revascularization. (eso-stroke.org)
  • 5 Compared to a control cohort of age- and sex-matched non-ST-segment-elevation myocardial infarction (NSTEMI) patients without stroke, the prevalence of coronary culprit lesions was lower in stroke patients. (eso-stroke.org)
  • 5 Nonetheless, coronary culprit lesions were identified in 24% of stroke patients with elevated troponin, thus demonstrating that elevated troponin should not be ignored in acute stroke patients. (eso-stroke.org)
  • This study explored the relationship of the atherogenic index of plasma (AIP) to coronary artery lesions in the T2DM population of different sexes. (biomedcentral.com)
  • In male T2DM patients, AIP may serve as a reliable marker for coronary artery lesions. (biomedcentral.com)
  • There is no doubt that coronary artery lesions directly affect the occurrence and development of CAD. (biomedcentral.com)
  • Therefore, to better reduce the incidence and mortality of CAD in T2DM patients, it is necessary to determine a method that can judge the degree of coronary artery lesions. (biomedcentral.com)
  • However, it is unclear whether AIP can reflect coronary artery lesions in T2DM patients. (biomedcentral.com)
  • This research explored the association of AIP with coronary artery lesions in T2DM patients and attempted to provide new ideas to better predict the risk of CAD in patients with T2DM for early intervention and treatment. (biomedcentral.com)
  • Therefore, in this large single-center cohort of patients, we sought to reveal the prevalence of CKD before and after RNU and to develop a nomogram to predict ineligibility for AC, which would help to accurately predict postoperative renal function and thus provide more optimal and personalized risk-based therapy options. (hindawi.com)
  • Objective -To determine whether amlodipine besylate decreases systemic arterial blood pressure (BP) and reduces the prevalence of complications in cats with induced hypertensive renal insufficiency. (avma.org)
  • Both uremia and uremic syndrome have been used interchangeably to denote a very high plasma urea concentration that is the result of renal failure. (wikipedia.org)
  • Large lesions are often cystic. (vin.com)
  • Background: The presence of a few renal cysts is considered of little relevance in healthy adults, although acquired renal cystic disease occurs in advanced kidney failure. (elsevierpure.com)
  • To determine this, we must begin by taking a detailed history and physical examination, understanding which medications a patient is taking, and then beginning to say whether [the lesion] is solid or cystic. (medscape.com)
  • Plasma cell lesions are the neoplastic (clonal) proliferation of plasma cells involving single bones (plasmacytoma) or multiple bones (multiple myeloma). (medscape.com)
  • Preoperative eGFR (OR = 0.991), absence of hydronephrosis (OR = 0.881), tumor located in renal pelvis (OR = 1.164), and smaller tumor size (OR = 0.969) could predict ineligibility for reduced-dose AC. (hindawi.com)
  • Older age, lower preoperative eGFR, smaller tumor size, tumor located in renal pelvis, and absence of hydronephrosis or multifocality were predictors of postoperative renal insufficiency. (hindawi.com)
  • This is critical because cats with a marginal glomerular filtration due to renal disease are reliant on the augmented cardiac output of the thyrotoxic state to maintain their urea and creatinine concentrations within normal limits. (vin.com)
  • Renal function was assessed via determination of glomerular filtration rate, measurement of serum creatinine and BUN concentrations, and determination of urine protein-to-creatinine ratio (UP/C). Serum aldosterone concentration and plasma renin activity were measured on day 75. (avma.org)
  • Glomerular filtration rate was significantly lower in groups RK and W, compared with group C. Histologic indices of renal injury and UP/C were significantly higher in group W, compared with groups C and RK. (avma.org)
  • Diabetes is serious due to its complications, namely: cardiovascular ailments, cerebral vascular accidents, renal insufficiency, blindness, sexual impotence and gangrene of the feet leading to amputation. (who.int)
  • The pathogenesis includes colonization of the small intestine, followed by the formation of AE lesions and a subsequent net secretory state. (medscape.com)
  • The pathogenesis of this lesion had not been determined, and the observation has been disputed. (mssm.edu)
  • The aim of this study was to investigate the longterm outcomes and factors that predict outcomes in patients with TA with renal artery stenosis. (jrheum.org)
  • Therefore, outcomes in patients with TA-associated renal artery stenosis have not been evaluated independent of revascularization procedures. (jrheum.org)
  • Of the 62 TA patients with renal artery involvement, 11 (17.7%) underwent renal artery revascularization. (jrheum.org)
  • Control (C) group cats had 2 intact kidneys, remnant kidney (RK) group cats underwent unilateral partial renal infarction and contralateral nephrectomy, and remnant-wrap (W) group cats underwent unilateral partial renal infarction and partial abtation and wrapping of the contralateral kidney. (avma.org)
  • She underwent craniotomy and excision of these lesions. (surgicalneurologyint.com)
  • 4 Further conditions frequently associated with elevated troponin include atrial fibrillation, heart failure, pulmonary embolism, sepsis, and renal insufficiency. (eso-stroke.org)
  • The necrotic lesion on his back suggested disseminated infection, but its polygon shape was inconsistent with sepsis. (hawaii.edu)
  • Computed tomography scan demonstrates a destructive lesion with an associated soft-tissue mass. (medscape.com)
  • Renal artery involvement was based on computed tomography and/or angiography findings. (jrheum.org)
  • To report the decline of renal function after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC) patients and to develop a nomogram to predict ineligibility for cisplatin-based adjuvant chemotherapy (AC). (hindawi.com)
  • The ability to predict which patients would develop renal insufficiency following RNU would be extremely useful. (hindawi.com)
  • Renal insufficiency [5/15 (33.3%) vs 3/47 (6.4%), p = 0.016] and bilateral involvement [12/15 (80.0%) vs 23/47 (48.9%), p = 0.041] were significantly more frequent in patients with poor than good outcomes. (jrheum.org)
  • Bilateral lesions and renal functional impairment at presentation, but not implementation of revascularization procedures, were significant factors for outcomes in TA patients with renal artery involvement. (jrheum.org)
  • Patients were excluded from the analysis if imaging evaluation of renal artery involvement was not available. (jrheum.org)
  • No, patients with primary APS may also develop membranous glomerulonephritis, a disease of minor lesions. (mesogeios.gr)
  • Approximately 25% of patients with primary APS show renal involvement as well. (mesogeios.gr)
  • This is pointed out nicely in the recent review, [ 2 ] that if patients have mild to moderate renal insufficiency, it is perhaps best to avoid contrast agent for CT and to defer to the MRI. (medscape.com)
  • A liver MRI scan is a specialized radiology procedure used to examine the liver to identify certain conditions or diseases which can be malignant cancerous or benign lesions. (salesandmarketingnetwork.com)
  • Renal involvement may occur due to APS nephropathy with a major feauture of small vessel thrombosis in the glomerulus (Kidney filter). (mesogeios.gr)
  • If it's not a solid lesion for which you're concerned about HCC, more often than not these are discovered to be what we call "incidentalomas"-that is, a suspect benign lesion. (medscape.com)
  • The cer is about 2%-5% and as high as 26% in most common complications include renal small-cell lung carcinoma [ 5 ]. (who.int)
  • Once identified, the first question to ask is whether the lesion raises concerns about a diagnosis of hepatocellular carcinoma (HCC). (medscape.com)
  • The lesion may be compact, containing a core of tightly packed venous loops, or it may be diffuse, with anomalous vessels dispersed among normal brain parenchyma. (medscape.com)
  • In retrospect, it was believed that the necrotic lesion on his back was probably due to pressure necrosis resulting from something (in the back of the pick-up truck) pressing upon his flank while he was unconscious. (hawaii.edu)
  • Further, it should be considered that stenotic lesions in TA may be resolved after treatment with immunosuppressants, even without vascular intervention 12 , 13 , 14 . (jrheum.org)
  • 0.001) and bilateral renal artery involvement (HR 5.053, 95% CI 1.179-21.661, p = 0.029) were significant risk factors for poor outcomes at followup, but performance of revascularization procedure was not (HR 0.663, 95% CI 0.176-2.498, p = 0.543). (jrheum.org)
  • The rheumatologist along with the hematologist monitor it while the nephrologist is involved only in the case of renal involvement. (mesogeios.gr)
  • Is there a renal involvement in the APS? (mesogeios.gr)
  • How frequent is the renal involvement in APS? (mesogeios.gr)
  • 1: Marcantoni C, Emmanuele C, Scolari F. Renal involvement in primary antiphospholipid syndrome. (mesogeios.gr)
  • 5: Sciascia S, Cuadrado MJ, Khamashta M, Roccatello D. Renal involvement in antiphospholipid syndrome. (mesogeios.gr)
  • 6: Pons-Estel GJ, Cervera R. Renal involvement in antiphospholipid syndrome. (mesogeios.gr)
  • The presence of a single lesion showing clinical features of lichenoid keratosis should raise the concern of a melanoma undergoing regression [ 2, 3 ]. (karger.com)
  • Revascularization procedures, including balloon angioplasty with or without stenting, are often used for the treatment of steno-occlusive lesions 6 , 7 , 8 . (jrheum.org)
  • Mild diminution of renal function was also seen. (mssm.edu)
  • Lip biopsy specimens showed an unusual cellular infiltrate similar to his kidney lesions. (bmj.com)
  • If the cervical mass is large, ultrasound the lesion with the highest frequency transducer you have. (vin.com)
  • The need for dental treatment and other soft tissue lesions were also investigated. (bvsalud.org)
  • However, the present limited ability to predict tumor stage and grade accurately before surgery makes it difficult to select proper candidates for neoadjuvant therapy, while the loss of renal unit would limit the use of cisplatin-based chemotherapy in adjuvant therapy [ 10 , 11 ]. (hindawi.com)