Lesion cell transplantation. Medical search. Frequent questions

Thereafter, the patient received autologous peripheral blood stem cell transplantation with high-dose chemotherapy (combination of ifosphamide, carboplatin and etoposide) as pretreatment. (karger.com)
High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (merckmanuals.com)

Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
Multiple myeloma (MM) is an incurable plasma cell malignancy of the bone marrow. (snmjournals.org)
Multiple myeloma (MM) is an incurable malignancy characterized by clonal proliferation of plasma cells in the bone marrow microenvironment. (snmjournals.org)
There is no end organ damage in MGUS or in a more progressed condition called smoldering MM. Accordingly, MGUS and smoldering MM are usually not treated, but there are investigational chemoprevention trials attempting to halt the progression to symptomatic MM. In smoldering MM, bone marrow biopsy shows a 10%-60% diffuse infiltration of plasma cells, and the infiltration is less than 10% in MGUS. (snmjournals.org)
The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (merckmanuals.com)
blood transfusion), spinal cord, lung cancer (oncology), respiratory cancer, radiology Background Multiple myeloma is a malignant proliferation of plasma cells mostly affecting the bone marrow and commonly presents with anaemia, hypercalcaemia, renal dysfunction, bone and skeletal involvement. (2011globalhealth.org)
We generated mice expressing ABCA1 in macrophages and mice with selected inactivation of ABCA1 in macrophages by bone marrow transplantation in ABCA1-deficient ( ABC1 -/- ) and wild-type (WT) mice. (jci.org)
The cells can be obtained from lipoaspirates or bone marrow aspirates. (educell.si)
Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
Some of these diseases develop mainly after bone marrow transplantation. (bvsalud.org)
An increased risk for the development of malignant neoplasias in individuals with Fanconi Anemia has been reported, and this is progressive after bone marrow transplantation. (bvsalud.org)

Although multiple myeloma patients younger than 66 years of age have an aggressive presentation, this did not translate into an inferior overall survival, particularly in those undergoing autologous hematopoietic stem cell transplantation. (scielo.br)
Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)
High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)

The classic imaging finding in MM is one or more focal osteolytic lesions seen on radiographs ( Fig. 1 ) or CT, but there is also a systemic bone loss leading to diffuse osteopenia or osteoporosis ( 7 , 8 ). (snmjournals.org)
Lateral skull (left) and humeral shaft (right) radiographs of the patient demonstrate multiple focal osteolytic lesions (some with arrows) that will never heal even if patient remains in complete remission for many years. (snmjournals.org)

p = 0.001) and higher in those who received autologous hematopoietic stem cell transplantation. (scielo.br)
Multivariable analysis revealed that creatinine ≥2 mg/dl, extramedullary disease, ≤very good partial remission and non-autologous hematopoietic stem cell transplantation are independent risk factors for shorter survival. (scielo.br)
Hematopoietic stem cell transplantation (HSCT) has been shown to be effective. (medscape.com)

To develop a functional motor assessment in HD patients, that sensitively capture improvements in motor function that manifest post-transplantation. (bmj.com)
RESULTS: We showed functional recovery up to 6 months post-transplantation in rats transplanted with our cells, whether freshly prepared or cryopreserved. (ca.gov)
Histologic analysis at the end point of the study (6 months post-transplantation) showed robust long-term survival of donor-derived tyrosine hydroxylase (TH)(+) dopaminergic neurons in rats transplanted with day 14 dopaminergic neurons. (ca.gov)
Collaboration between dermatologists and transplant physicians should be encouraged to ensure frequent, full body skin examinations by dermatologists, preferably in specialty clinics for high risk patients, both pre-and post- transplantation. (newswise.com)
At 8 weeks post-transplantation, engrafted dopaminergic neurons expressed tyrosine hydroxylase. (biomedcentral.com)

The Registry of the International Society for Heart and Lung Transplantation (ISHLT) monitors and reports statistics on clinical lung transplantation. (medscape.com)
In 2010, over a 12-month period, more than 3500 new lung transplant procedures were reported to the International Society of Heart and Lung Transplantation (ISHLT) Registry [ 1 ]. (ersjournals.com)

Large lesion size (≥109 mm(2)) and the existence of subchondral cysts were significant predictors of unsatisfactory clinical outcomes in group A (P = .04 and .03, respectively). (researchgate.net)
Clinical features of lung transplantation-related pathology can range from an absence of symptoms to signs and symptoms of respiratory distress and/or infection and are not detailed in this article. (medscape.com)
Conclusion Understanding the optimal parameters for efficient grafting and being able to sensitively monitor any improvement in function, due to graft integration, is critical to our development of cell replacement therapies and will help us move this treatment to clinical application. (bmj.com)
There is a clear need to improve the clinical management of vascular lesions of the head and neck. (cancernetwork.com)
Unfortunately, if we are to improve care, what is most needed is an improvement in the clinical recognition of these lesions rather than in the names by which they are designated. (cancernetwork.com)
The late Dr. Louis T. Byars suggested that, from a practical standpoint, it might be easier to allow people to continue to call all vascular lesions 'hemangiomas' and instead concentrate efforts on clarifying the clinical differences among the multiple varieties. (cancernetwork.com)
Both of these lesions are cutaneous and intradermal, although quite different in clinical prognosis. (cancernetwork.com)
The aim of our study was to define the immunological profile of stable vitiligo lesions undergoing MKTP and correlate them with clinical outcomes. (umassmed.edu)
However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
Typically, the clinical presentation of clear cell acanthoma is a solitary nodule in the lower extremities. (medscape.com)
Patients were followed for up to 6 months using clinical assessment of achromic lesions. (cun.es)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
The Stem Cells Portal provides coverage of the latest research, clinical applications, policies, and developments in the stem cell and regenerative medicine fields. (stemcellsportal.com)
The clinical data and computed tomographic findings of 64 patients with solitary supratentorial brain lesions were presented to two panels of six experienced clinicians. (jamanetwork.com)
Although systematic gait analyses have been widely used in the clinical setting as important indices to evaluate the severity of PD, the extent of gait changes after unilateral 6-OHDA-induced lesions in rats remains to be explored. (biomedcentral.com)
The clinical oral findings described in the literature include periodontal changes, such as gingivitis and aggressive periodontitis, recurrent aphthous ulcers and traumatic lesions. (bvsalud.org)

Background: The ideal treatment for osteochondral lesions of the talus (OLTs) is still controversial, especially in older patients. (researchgate.net)
These correlations were not observed in group B. Conclusion: Injection of MSCs with marrow stimulation treatment was encouraging in patients older than 50 years compared with patients treated with marrow stimulation treatment alone, especially when the lesion size was larger than 109 mm(2) or a subchondral cyst existed. (researchgate.net)
Patients with monoclonal gammopathy of unknown significance, smoldering MM, plasma cell leukemia and amyloidosis were excluded. (scielo.br)
Methods A retrospective case series analysis was performed with 403 patients (420 eyes) who underwent extensive fascial resection combined with autologous limbal stem cell sharing transplantation in the Department of Ophthalmology, Second People's Hospital of Yunnan Province from January 2017 to June 2018. (researchsquare.com)
Does Transplantation Induce Aging In Patients? (medicaldaily.com)
Introduction Cell transplantation is becoming a viable therapy for patients with Huntington's disease (HD). (bmj.com)
Studies from patients with HD will help us to monitor the impact of the cell transplantation therapy through the development of a sensitive motor assessment. (bmj.com)
Further investigation confirmed that each of the two patients had undergone transplantation of a single lung from the same donor before disease onset. (cdc.gov)
Currently, the biggest remaining problem is that many patients with vascular lesions are left untreated because their physicians are not aware of the exact prognosis or the methods of management most suitable for that individual patient. (cancernetwork.com)
the burden was typically greatest among patients with more than 5% affected BSA, darker skin types, and lesions on the face or hands. (umassmed.edu)
In recent years, with a combination of autologous stem-cell transplantation and modern chemotherapy, the 10-y survival of patients presenting at an age less than 60 y is approximately 30% ( 1 , 2 ). (snmjournals.org)
I. Determine the response rate (complete and partial) in patients with relapsed or refractory Burkitt's, mantle cell or diffuse large cell non-Hodgkin's lymphoma treated with FR901228 (depsipeptide). (knowcancer.com)
In 15 to 20% of patients, plasma cells secrete only Bence Jones protein. (merckmanuals.com)
Fields et al reviewed 500 patients with Merkel cell carcinoma in a single-institution study. (medscape.com)
Investigations On admission the patients blood count was normal: haemoglobin 138 g/L, white cell count 5.14109/L with a normal differential and platelets 256109/L. Chemistry was normal with no evidence of renal failure or hypercalcaemia. (2011globalhealth.org)
Summary Over the last 25 years, lung transplantation has developed into a well-established treatment option for selected patients with very advanced lung disease. (ersjournals.com)
Lung transplantation should be viewed as a potential treatment option for highly selected patients with very advanced chronic lung disease who continue to progress despite maximal medical therapy. (ersjournals.com)
The role of autoimmunity in the pathogenesis is supported by many autoimmune features of oral lichen planus, including its chronicity, onset in adults, predilection for females, association with other autoimmune diseases, occasional tissue-type associations, depressed immune-suppressor activity in patients with oral lichen planus, and the presence of autocytotoxic T-cell clones in lichen planus lesions. (medscape.com)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
In the prospective Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3 comparison of autologous HSCT with 12 successive monthly intravenous pulses of cyclophosphamide in 156 patients with early diffuse cutaneous systemic sclerosis, HCST was associated with higher treatment-related mortality than in the first year after treatment. (medscape.com)
Implantable ventricular assist devices are being used to treat some patients who previously would have needed heart transplantation and patients for whom transplantation is contraindicated. (msdmanuals.com)
These devices are usually used to assist the left ventricle as interim (bridge-to-transplantation) or long-term (destination) treatment in patients who are not candidates for transplantation. (msdmanuals.com)
Transplant recipients have a 60-100-fold increased risk of squamous cell carcinoma (SCC), the second most common skin cancer in the United States, compared to patients with normal immune systems. (newswise.com)
The risk of basal cell carcinoma (BCC), the most common skin cancer, is increased about 10-fold while the risk for melanoma is 3.5 times that of immune competent patients. (newswise.com)
Invasive aspergillosis (IA) is a life-threatening infection that affects an increasing number of patients undergoing chemotherapy or allo-transplantation, and recent studies have shown that genetic factors contribute to disease susceptibility. (bvsalud.org)
Adult stem cells are the gold standard for patients! (stemcellresearchfacts.org)
The results obtained in the Lund transplantation program have provided proof-of-principle that human fetal midbrain dopamine neurons can survive and function for many years (more than a decade) after transplantation to the striatum in patients with advanced Parkinson´s disease ( publications 4 below ). (lu.se)
The brains from four of the grafted patients in the Lund program, who died 13-24 years after transplantation, have come to autopsy. (lu.se)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)

The therapeutic decision was an autologeous bone transplantation with a ventral plate osteosynthesis and a decompressive irradiation to the dorsal spine (10 × 3 GY) followed by glucocorticoid and vinblastine based chemotherapy: 10 mg/weeks for 6 weeks. (scirp.org)
The patient went on to have chemotherapy and autologous stem cell transplantation with a good outcome. (2011globalhealth.org)

Introduction To observe the short-term and long-term effects of extensive fascial resection combined with autologous limbal stem cell sharing transplantation for pterygium. (researchsquare.com)
Discussion and conclusion Extensive fascial resection combined with autologous limbal stem cell sharing transplantation for the treatment of pterygium, the patient's appearance satisfaction is higher, and the recurrence probability is lower than the average recurrence rate of limbal stem cell transplantation. (researchsquare.com)
Pterygium excision combined with autologous conjunctival flap transposition, pterygium excision combined with amniotic membrane transplantation, pterygium excision combined with autologous limbal stem cell transplantation and so on [12] . (researchsquare.com)
Non-myeloablative autologous hemopoietic stem-cell transplantation (HSCT) shows some promise in treating scleroderma. (mountsinai.org)
Achievement of a complete response on 18 F-FDG PET before stem-cell transplantation correlates with a superior outcome. (snmjournals.org)
Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
BACKGROUND AIMS: We have previously reported a Good Manufacturing Practice (GMP)-compatible process for generating authentic dopaminergic neurons in defined media from human pluripotent stem cells and determined the time point at which dopaminergic precursors/neurons (day 14 after neuronal stem cell [NSC] stage) can be frozen, shipped and thawed without compromising their viability and ability to mature in vitro. (ca.gov)
A review on stem cell therapy for neuropathic pain. (iasp-pain.org)
Stem cell transplantation is one of the attractive therapeutic platforms for the treatment of a variety of diseases such as neuropathic pain. (iasp-pain.org)
Here, the authors review the therapeutic effects of stem cell transplantation of different origin and species in different models of neuropathic pain disorders. (iasp-pain.org)
In conclusion, this review suggests that stem cell therapy can be a novel approach for the treatment of neuropathic pain. (iasp-pain.org)
Dr. Abutalib is Assistant Director in the Stem Cell Transplant & Cell Therapy Program at Cancer Treatment Centers of America in Chicago. (ascopost.com)
These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
The researchers showed that human pluripotent stem cell (hPSC)-derived neural stem cells engineered with reduced expression of a gene called SOX9 differentiate preferentially into spinal motor neurons. (genengnews.com)
This approach alters the grafts' response in the injury environment and confers enhanced neuronal differentiation capacity, survival, and integration, as well as reduced glial scar formation to provide a more effective stem cell therapy for severe traumatic SCI. (genengnews.com)
Stem Cell Rev Rep. 2018 Jun;14(3):346-369. (educell.si)
Allison is using her dramatic story of recovery to spread the word about adult stem cell therapy. (stemcellresearchfacts.org)
She wants to bring awareness about adult stem cell therapy to others suffering from debilitating diseases and conditions. (stemcellresearchfacts.org)
Allison and her friend and fellow adult stem cell recipient Stacey Crain started Instagram and Facebook pages called Stem Cell Thriver. (stemcellresearchfacts.org)
And when they visited Northwestern University for their checkups, they spent time meeting with and talking to other adult stem cell recipients to show them what their life could look like five or six years down the road. (stemcellresearchfacts.org)
Stem cell therapy has been such a huge miracle in my life. (stemcellresearchfacts.org)

As with all tumors, whether benign or malignant, identification of the cell or cell layer of origin is of the utmost importance. (medscape.com)
Liver tumors (also known as hepatic tumors) are abnormal growth of liver cells on or in the liver. (wikipedia.org)
Several distinct types of tumors can develop in the liver because the liver is made up of various cell types. (wikipedia.org)
As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)
Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)
One of the most common benign epithelial tumors is seborrheic keratosis /senile keratosis, which is a hereditary lesion that appears in persons aged more than 30 years. (medscape.com)
Risk of localized tumors was stable over time after transplantation, but higher with azathioprine maintenance therapy (IRR=1.35, 95%CI 1.03-1.77). (cdc.gov)
Some localized melanomas may result from azathioprine, which acts synergistically with ultraviolet radiation, while T-cell depleting induction therapies may promote late stage tumors. (cdc.gov)

In order to distinguish between KA and SCC, further histologic studies can be used, including proliferating-cell nuclear antigen immunostaining. (medscape.com)
[ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
In contrast, cells within an SCC that stain positive with proliferating-cell nuclear antigen immunostaining are more diffusely distributed. (medscape.com)

Transplantation of neural progenitor cells (NPC) is a promising therapeutic strategy for replacing neurons lost after spinal cord injury, but significant challenges remain regarding neuronal integration and functional connectivity. (jneurosci.org)
A mixed population of neuronal and glial restricted precursors (NRP/GRP) derived from the embryonic spinal cord of alkaline phosphatase (AP) transgenic rats were grafted acutely into a DC lesion at C1. (jneurosci.org)
These findings provide the first evidence for the ability of NPC to form a neuronal relay by extending active axons across the injured spinal cord to the intended target establishing a critical step for neural repair with stem cells. (jneurosci.org)
An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
When transplanted into a rat model of spinal cord injury (SCI) these neural stem cells generated mature neuronal subtypes, were able to integrate and grow axons that projected over long distances and connected with the recipient's neurons. (genengnews.com)
In response to lesion healing, the scar can prevent inflammation from spreading and causing further damage," the researchers pointed out, but this barrier-like structure also prevents neuronal regeneration. (genengnews.com)
About 650 publications in the fields of neuroanatomy, neuronal regeneration, cell transplantation and repair in the central nervous system. (lu.se)
Intracerebral grafting of neuronal cell suspensions II. (lu.se)

Phototherapy using longer-wavelength ultraviolet A (UVA) light (ie, UVA1, 340-400 nm) has proved beneficial for cutaneous lesions in scleroderma. (medscape.com)

Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration? (educell.si)

METHODS: In this study, we evaluated the efficacy of freshly prepared and cryopreserved dopaminergic neurons in the 6-hydroxydopamine-lesioned rat PD model. (ca.gov)
Consistent with the behavioral analysis, no or few TH(+) neurons were detected in animals receiving day 10 cells, although human cells were present in the graft. (ca.gov)
Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new therapeutic opportunities to replace degenerated neurons and repair damaged circuits. (lu.se)
Conclusions: The data support the long-term therapeutic potential of ESC-derived human striatal progenitor grafts for the replacement of degenerated striatal neurons in HD and suggest that EE can effectively accelerate the maturation and promote the integration of human striatal cells. (lu.se)
Spinal neurons around the scar cannot be restored due to the low intrinsic regenerative ability of undamaged neurons and the lack of neural stem cells in the adult spinal cord. (genengnews.com)
Transplantation of human NSCs (hNSCs) derived from human pluripotent stem cells at the SCI sites has been considered a promising therapeutic strategy to compensate for the loss of spinal neurons, and could feasibly enable their connectivity with host neurons, leading to spinal cord recovery. (genengnews.com)
BDA labeling from the motor cortex revealed a dense corticospinal tract (CST) bundle in all groups except chronically treated PTEN-KO mice, indicating a potential long-term toxic effect of PTEN-KO to neurons in the motor cortex which was corroborated by a loss of ß-tubulin III labeling above the lesion within spinal cords after PTEN-KO. (bvsalud.org)
Scientists in Lund have pioneered the use of fetal dopamine neurons for transplantation in Parkinson´s Disease. (lu.se)
Current efforts in the Lund PD transplantation program are focused on the use of dopamine neurons derived from pluripotent stem cells, using a protocol that has been devloped here in Lund ( publications 9 below ). (lu.se)

Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
Over the last few decades, lung transplantation has become an accepted modality of treatment for many end-stage lung diseases. (medscape.com)
Thus, a comprehensive understanding of lung transplantation-related pathology is necessary for both tertiary care pathologists dealing with highly specialized lung transplantation teams and a much larger spectrum of healthcare providers who may be involved in the care of lung transplant recipients or candidates for lung transplantation. (medscape.com)
The etiology of lung transplantation-related pathology is almost always immune-mediated. (medscape.com)
A quick intraoperative gross examination of the lung allograft may reveal previously unrecognized lesions, the nature of which could be addressed with frozen section analysis. (medscape.com)
The cut surface shows the characteristic findings of the disease for which lung transplantation was indicated. (medscape.com)
The CT scan identified dense consolidation in the middle lobe of the donor lung, which evolved into a cavitary lesion during the subsequent week ( Figure ). (cdc.gov)
days later, the fever had persisted, and human embryonic lung fi broblast cell multiple liver and lung abscesses in a she was given amoxicillin-clavulanate monolayers (Sterilin, Felthan, UK) in- 7-year-old girl with acute lymphoblas- and local wound care. (cdc.gov)
A chest CT scan revealed a tumoral process measuring 25 mm at the lower lobe of the left lung evoking a Langerhans cell histiocytosis ( Figure 3 ). (scirp.org)
Furthermore, a meticulous approach to post-transplant management in the immediate post-operative period, in the early and long-term has contributed to continually improving long-term survival after lung transplantation. (ersjournals.com)
To outline recent advances made in improving the success of lung transplantation as a therapy for very advanced lung disease. (ersjournals.com)
To discuss where the major developments in lung transplantation may come over the next 5-10 years. (ersjournals.com)
Lung Transplantation is by no means a cure and should be thought of as another modality of treatment. (ersjournals.com)
Life after lung transplantation necessitates use of a large number of medications on a daily basis, frequent hospital visits and the risk of a large list of potential adverse effects due to use of powerful immunosuppression. (ersjournals.com)
Lung transplantation should generally be considered when a patient's risk of mortality from their lung disease is greater than 50% within the next 2 years. (ersjournals.com)

Often presenting as solitary lesions, they have a predilection for the face. (medscape.com)
Solitary extramedullary plasmacytoma (SEP) describes solid plasma cell tumours of soft-tissue origin as opposed to solitary plasmacytoma of bone. (2011globalhealth.org)
Heimans JJ , De Visser M , Polman CH , Nauta J , Kamphorst W , Troost D. Accuracy and Interobserver Variation in the Interpretation of Computed Tomography in Solitary Brain Lesions. (jamanetwork.com)

Histologically, the fully formed domelike lesion reveals a mass of proliferating squamous epithelial cells, which created the central core of keratin. (medscape.com)
KA lesions can easily be mistaken for squamous cell carcinoma (SCC). (medscape.com)
buffered char- scribed in a 73-year-old woman with squamous cell evocating carcinoma. (cdc.gov)
Guidelines for the management of squamous cell carcinoma in organ transplant recipients. (newswise.com)
Papillary atrophy, macroglossia, melanic pigmentation and squamous cell carcinoma are the most common oral manifestations on the tongue. (bvsalud.org)
Squamous cell carcinoma. (bvsalud.org)

The loose connective tissue under the epithelium contains a large number of fibroblasts and abundant capillaries, which indicates that the pterygium epithelial cells have a strong ability to proliferate and migrate. (researchsquare.com)
MM has 3 components: diffuse marrow infiltration, focal bone lesions, and soft-tissue (extramedullary) disease. (snmjournals.org)
The researchers reported on their developments in Advanced Science , in a paper titled, " Transplanting Human Neural Stem Cells with ≈50% Reduction of SOX9 Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury ," in which they concluded, "Our findings represent a new paradigm in generating genetically modified hNSCs for the treatment of SCI. (genengnews.com)
The obtained cell suspension can be used directly as an intra-articular or intra-tissue injection. (educell.si)
Cell suspension can also be used in combination with biocompatible scaffold for tissue regeneration and reconstruction . (educell.si)
Bowel lesions that are exudative or cause significant tissue edema, leading to obstruction. (cdc.gov)

Nine days after transplantation, the patient's laboratory results revealed an elevated white blood cell count and acute anemia, which prompted imaging studies. (cdc.gov)

In this study, we used the Catwalk system to investigate changes in gait parameters in adult rats with unilateral 6-OHDA-induced lesions and the rescue effect of dopaminergic neuron transplantation on gait function. (biomedcentral.com)

Atypical or persistent rash with coalescing or necrotic lesions, or both, some which have required extensive surgical debridement or amputation of an affected extremity. (cdc.gov)

We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)

Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
Mastocytosis is a diverse group of disorders characterised by the expansion and accumulation of mast cells in one or more organ systems. (dermnetnz.org)
Overview of Plasma Cell Disorders Plasma cell disorders are a diverse group of disorders of unknown etiology characterized by Disproportionate proliferation of a single clone of B cells Presence of a structurally and electrophoretically. (merckmanuals.com)
Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)

Rats in 2 of 4 groups with SCI received basic treatments (scar ablation followed by transplantation of lamina propria of olfactory mucosa and cultured olfactory ensheathing cells into the lesion cavity) 6 weeks after SCI. (nih.gov)
Lesions leading to stricture and scar formation resulting in significant morbidity such as urethral and bowel strictures, phimosis, and facial scarring. (cdc.gov)

Researchers at the University of Hong Kong (HKUMed) LKS Faculty of Medicine, and at City University of Hong Kong (CityU) have generated human neural stem cells (hNSCs) that exhibit what they claim is "powerful therapeutic potential" for the treatment of spinal cord injury. (genengnews.com)
A research team from HKUMed has generated human neural stem cells with powerful therapeutic potential for the treatment of spinal cord injury that paves the way for new therapeutic opportunities. (genengnews.com)

Although MM can arise de novo, it usually progresses in a stepwise fashion from MGUS or smoldering MM. If marrow infiltration with plasma cells exceeds 60%, or if end organ damage is present, the patient is diagnosed with active MM ( 1 , 2 ). (snmjournals.org)

Most transplantation therapies adopt the use of a cocktail of growth factors embedded in the extracellular matrix to enhance the viability and neurogenic potency of grafted hNSCs in SCI rodent models. (genengnews.com)

The melanocyte-keratinocyte transplantation procedure (MKTP) treats stable and recalcitrant vitiligo. (umassmed.edu)
Stable focal osteolytic bone lesions of skull and right humerus in a patient with MM in complete remission for 5 y. (snmjournals.org)
Our results demonstrate that transplantation of autologous melanocytes cultured on AM is a new, simple, and effective treatment for stable vitiligo. (cun.es)
Pigment cell transplantation offers an alternative for the treatment of segmental vitiligo or stable non-segmental lesions. (medscape.com)

They are caused by either abnormal growth of neoplastic cells or in response to liver injury, known as regenerative nodules. (wikipedia.org)
20. Liver imaging at screening showing any lesions (except benign lesions, i.e., hemangiomas). (who.int)

We examined the survival, maturation, self-organization and integration of the graft as well as its impact on lesion-dependent motor alterations up to 6 months post-graft. (lu.se)

To determine the extent to which cell transplantation can alleviate a range of cognitive deficits in rodent models of HD, and to identify the optimal parameters for successful alleviation of deficits. (bmj.com)

that many people around the globe have been helped by adult stem cells! (stemcellresearchfacts.org)

This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)

Common manifestations include lytic lesions in bones that cause pain and/or fractures, renal insufficiency, hypercalcemia, anemia, and recurrent infections. (merckmanuals.com)
Common manifestations include lytic lesions in bones that cause. (merckmanuals.com)

Renal transplantation in lupus nephritis. (unican.es)

KOH dissolves keratin found in cellular material and freeing fungal hyphae and yeast cells. (slideshare.net)
To date, few treatment strategies applying cellular transplantation to the chronically injured spinal cord have yielded significant functional improvement in animal experiments. (nih.gov)

In fact, clear cell acanthoma possesses a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus, and discoid lupus erythematosus and might be a localized form of inflammatory eruption rather than a neoplasm. (medscape.com)
Less common causes include vascular and inflammatory lesions and haematological malignancies. (2011globalhealth.org)
UVA1 inhibits the inflammatory process and can soften former sclerotic skin lesions. (medscape.com)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

Spinal cord injury (SCI) is characterized by cell death and loss of connectivity with permanent functional deficits. (jneurosci.org)
MRI of the spine showed a spinal cord compression due to bone and epidural tumoral lesions of the posterior wall of the D1 to D5 thoracic vertebras ( Figure 1 ). (scirp.org)
Final diagnosis was therefore Langerhans cell histiocytosis of the dorsal spine complicated by spinal cord compression. (scirp.org)

On the other hand, clear cell acanthoma is a rare, benign epithelial cutaneous tumor. (medscape.com)
This presence of melanin provides pigmentation to the benign tumor, and this occurrence has been termed pigmented clear cell acanthoma. (medscape.com)

Surgical indications or arterial embolization for FNH include if the FNH lesion is large, symptomatic, or there is uncertainty surrounding the correct diagnosis. (wikipedia.org)
The hallmark radiographic lesion of symptomatic MM is a well-demarcated, focal osteolytic bone lesion. (snmjournals.org)

EE selectively increased cell differentiation into MSN phenotype and promoted host-to-graft connectivity. (lu.se)

The number of focal bone lesions correlates inversely with outcome. (snmjournals.org)

A surgical biopsy showed an infiltrate of eosinophilic cells with oval, grooved and convoluted nucleus, associated with eosinophils, lymphocytes and plasma cells ( Figure 2 ). (scirp.org)
It consists of Langerhans cells with oval, grooved and convoluted nucleus and slightly eosinophilic cytoplasm, associated with eosinophils, lymphocytes and plasma cells (H & E × 400). (scirp.org)
Most T cells in the epithelium and adjacent to the damaged basal keratinocytes are activated CD8 + lymphocytes. (medscape.com)
Activated CD8 + T cells (and possibly keratinocytes) may release cytokines that attract additional lymphocytes into the developing lesion. (medscape.com)

Comorbidities, including recent organ transplantation, increase the risk for infection. (cdc.gov)

Because of the possibility of a transplant-associated infection with Legionella , the hospital notified the Organ Procurement and Transplantation Network (OPTN) and initiated an investigation by OPTN's ad hoc Disease Transmission Advisory Committee (DTAC). (cdc.gov)

Due to the increased susceptibility to the development of cancer in this specific population, it is important for the dentist to know the common oral manifestations and potentially cancerous lesions, in order to make an early diagnosis in individuals with Fanconi Anemia. (bvsalud.org)

The dense subepithelial mononuclear infiltrate in oral lichen planus is composed of T cells and macrophages, and there are increased numbers of intraepithelial T cells. (medscape.com)

Subsequent studies have shown that the transplants can provide sustained improvement over long time, up to 24 years after transplantation ( publications 6 below ). (lu.se)

Korpershoek JV, Rikkers M, Wallis FSA, Dijkstra K, Te Raa M, de Knijff P, Saris DBF , Vonk LA. Mitochondrial Transport from Mesenchymal Stromal Cells to Chondrocytes Increases DNA Content and Proteoglycan Deposition In Vitro in 3D Cultures. (mayo.edu)
Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)

Current data suggest that oral lichen planus (OLP) is a T-cell-mediated autoimmune disease in which autocytotoxic CD8 + T cells trigger the apoptosis of oral epithelial cells. (medscape.com)

After receiving bilateral striatal lesions, a subset will be grafted with foetal ganglionic eminence. (bmj.com)
Results: Human striatal progenitors survived up to 6 months after transplantation and showed morphological and neurochemical features typical of human MSNs. (lu.se)

The basal surface of the cells break through the basement membrane and infiltrates and grows into the matrix. (researchsquare.com)
Clear cell acanthoma usually stains positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. (medscape.com)
Drug release assays showed that Met exhibited sustained release after encapsulation by the macrophage cell membrane. (bvsalud.org)

PTEN-KO mice had significantly more ß-tubulin III labeled axons within the lesion when treatment was delivered acutely, but not chronically post-SCI. (bvsalud.org)

Anatomy20

Organisms11

Diseases53

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment96

Psychiatry and Psychology2

Phenomena and Processes27

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Information Science5

Named Groups6

Health Care31

Geographicals1

Autologous peripheral blood stem cell transplant2

Bone marrow15

Multiple myeloma4

Osteolytic lesions2

Hematopoietic stem cell trans3

Post-transplantation5

Heart and Lung Transplantation2

Clinical20

Patients32

Chemotherapy2

Stem cell23

Tumors8

Proliferating-cell nu3

Neuronal8

Cutaneous lesions1

Mesenchymal stem2

Neurons9

Lung15

Solitary3

Squamous6

Tissue6

Patient's1

Rats with unilateral1

Necrotic1

Therapy1

Disorders4

Scar2

Neural2

Marrow1

Therapies1

Stable4

Liver2

Survival1

Alleviate1

Adult1

Allogeneic1

Lytic2

Renal1

Cellular2

Inflammatory4

Spinal3

Benign2

Symptomatic2

Differentiation1

Outcome1

Lymphocytes4

Comorbidities1

Organ Procurement1

Manifestations1

Intraepithelial1

Transplants1

Stromal Cells3

Epithelial cells1

Striatal2

Membrane3

Acutely1