• Alignment of topoisomerase II nucleotide sequences of Leishmania killicki , L. infantum , and L. major . (cdc.gov)
  • Leishmania species were identified by comparing sequences with those of the reference strains L. infantum MHOM/FR/78/LEM75, L. killicki MHOM/TN/80/LEM163, and L. major MHOM/MA/81/LEM265 ( 7 ). (cdc.gov)
  • It is a severe, often fatal, disease in dogs caused by a microscopic parasite called Leishmania infantum. (homehealth-uk.com)
  • The remaining supernatant nonadhered phages were submitted to positive selection against IgG from the blood serum of dogs that were infected with Leishmania infantum. (uam.es)
  • Visceral leishmaniasis (VL), caused by Leishmania infantum chagasi ( L.i. chagasi syn. (iastate.edu)
  • With this aim, partners from eight Mediterranean countries identified sites with documented Leishmania infantum transmission by six different vector species and performed multiannual trappings. (hacettepe.edu.tr)
  • Here, employing whole-genome databases, we report the composition, and structural features, of the PUF family in Leishmania infantum . (biomedcentral.com)
  • Additionally, the 10 genes of the L. infantum PUF family were cloned and used to express the Leishmania PUFs in bacteria as recombinant proteins. (biomedcentral.com)
  • Visceral leishmaniasis (VL), the most severe form of leishmaniases (usually fatal if untreated), is typically caused by Leishmania donovani and Leishmania infantum (syn. (biomedcentral.com)
  • Although several studies have investigated genetic diversity of Leishmania infantum in North Africa, genome-wide analyses are lacking. (hal.science)
  • Based on previous reports about the antileishmanial activity of dihydropyridine-CCBs, this work aimed to investigate whether the in vitro anti- Leishmania infantum and anti- Trypanosoma cruzi activities of this therapeutic class would be shared by other non-dihydropyridine-CCBs. (hindawi.com)
  • Leishmania infantum, an etiologic agent of zoonotic visceral leishmaniasis, is endemic in the foxhound population in the United States and Canada. (vt.edu)
  • Non-sand fly transmission of a North American isolate of Leishmania infantum in experimentally infected BALB/c mice," Journal of Parasitology, Vol. 91, No. 5, pp. 1113-1115. (vt.edu)
  • Visceral leishmaniasis (kala-azar, Dumdum fever) is typically caused by L. donovani or L. infantum (previously called L. chagasi in Latin America) and occurs in India, Africa (particularly the Sudan), Central Asia, the Mediterranean basin, South and Central America, and infrequently China. (msdmanuals.com)
  • The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast. (bvsalud.org)
  • Infection of Human Neutrophils With Leishmania infantum or Leishmania major Strains Triggers Activation and Differential Cytokines Release. (bvsalud.org)
  • Coinfección leishmania infantum, VIH e histoplasma capsulatum: manifestaciones dermatoló. (bvsalud.org)
  • La coinfección Leishmania/VIH es frecuente y por lo general son casos de leishmaniosis visceral (LV), sin embargo, Leishmania infantum, el agente etiológico, también puede causar formas cutáneas en pacientes VIH-positivos. (bvsalud.org)
  • En el caso estudiado concluimos que la presentación dérmica es causada por L. infantum, caracterizada por técnicas moleculares, eH. (bvsalud.org)
  • However, Leishmania infantum, the etiological agent, could also cause cutaneousforms in HIV-positive patients. (bvsalud.org)
  • instance, are the main reservoir of, and the most susceptible species, of Leishmania infantum and they can develop what is called canine leishmaniasis. (cdc.gov)
  • It is a human blood parasite responsible for visceral leishmaniasis or kala-azar, the most severe form of leishmaniasis. (wikipedia.org)
  • According to the World Health Organization, each year between 50,000 and 90,000 people become sick with visceral leishmaniasis (kala-azar), a form of the disease that attacks the internal organs and is fatal in more than 95 percent of cases left untreated. (sciencedaily.com)
  • Post-kala-azar dermal leishmaniasis follows the treatment of visceral leishmaniasis and has predominantly been described in Africa (about 2% of cases) and India (about 10% of cases). (medscape.com)
  • Visceral leishmaniasis (VL), commonly known as kala-azar, from the Hindu vernacular, is a human systemic disease caused by parasitic protozoan species of the genus Leishmania . (plos.org)
  • Results using oral Miltefosine are promising against Indian kala-azar (Leishmania donovani) but disappointing against South American leishmaniasis. (unboundmedicine.com)
  • VANESSA YARDLEY: This video will describe the procedures used when looking for Leishmania amastigotes in tissue samples with a patient with suspected visceral leishmaniasis or post kala-azar dermal leishmaniasis. (futurelearn.com)
  • But when people develop the disease, the most common forms are visceral leishmaniasis (also known as kala-azar), and then people would develop fever, they would lose weight, they would have an enlargement of the spleen and the liver. (cdc.gov)
  • Point mutations discriminating Leishmania species are outlined on a gray background. (cdc.gov)
  • Polymerase chain reaction (PCR) was used to identify the Leishmania species, which was found to be L. major. (who.int)
  • Leishmania donovani is a species of intracellular parasites belonging to the genus Leishmania, a group of haemoflagellate kinetoplastids that cause the disease leishmaniasis. (wikipedia.org)
  • It was Ross who resolved the conflict of priority in the discovery and correctly identified the species as member of the novel genus Leishmania. (wikipedia.org)
  • Leishmaniases constitute a vast variety of diseases ranging from cutaneous manifestations to visceral dissemination that are caused by different species of the genus Leishmania . (biomedcentral.com)
  • Although the Leishmania species differ clinically and biologically, their characteristics overlap and each clinical syndrome can be produced by multiple species of Leishmania . (medscape.com)
  • After recovery or successful treatment, cutaneous leishmaniasis induces immunity to reinfection by the species of Leishmania that caused the disease. (medscape.com)
  • Both New World and Old World species cause localized cutaneous leishmaniasis. (medscape.com)
  • Amastigotes multiply in infected cells and affect different tissues, depending in part on the Leishmania species (4). (plos.org)
  • In South America it is important to distinguish Leishmania species that cause only cutaneous disease from the mucocutaneous species. (uab.edu)
  • Fendiline demonstrated depolarization of mitochondrial membrane potential, with increased reactive oxygen species production in amlodipine and fendiline treated Leishmania , but without plasma membrane disruption. (hindawi.com)
  • Leishmaniasis is a neglected infectious disease caused by several different species of protozoan parasites of the genus Leishmania . (hindawi.com)
  • Additionally, the in vitro antiparasitic activity of eight clinically used dihydropyridines (azelnidipine, amlodipine, cilnidipine, lercanidipine, nicardipine, nifedipine, nimodipine, and nitrendipine) was demonstrated against a panel of Leishmania species and Trypanosoma cruzi [ 6 , 7 ]. (hindawi.com)
  • For this, the in vitro activity of four non-dihydropyridine agents (amrinone, fendiline, mibefradil, and lidoflazine) was tested against different Leishmania species and their cytotoxicity to mammalian cells was evaluated. (hindawi.com)
  • The causative Leishmania species is an important prognostic factor in immunocompetent patients. (unboundmedicine.com)
  • Leishmaniasis is a very serious group of diseases, and are caused by more than 20 species of protozoan parasites belonging to the genus of Leishmania . (databasefootball.com)
  • More than 20 well-recognized Leishmania species are known to infect humans and cause visceral (VL), cutaneous (CL) and mucocutaneous (ML) forms of the disease. (degruyter.com)
  • Cama said that the CDC's analysis showed that nearly all people who contracted leishmaniasis and did not travel internationally were infected by the same species of Leishmania. (keloland.com)
  • The infecting Leishmania species was identified in 198 patients. (lu.se)
  • Leishmaniasis is caused by species of Leishmania . (msdmanuals.com)
  • Treatment of visceral leishmaniasis is with liposomal amphotericin B or miltefosine , depending on the infecting Leishmania species and the geographic area of acquisition. (msdmanuals.com)
  • Alternatives include amphotericin B deoxycholate and pentavalent antimony compounds ( sodium stibogluconate or meglumine antimoniate) if disease was acquired in areas where Leishmania species are likely to be susceptible. (msdmanuals.com)
  • A variety of topical and systemic treatments are available for cutaneous leishmaniasis depending on the causative species and clinical manifestations. (msdmanuals.com)
  • Human infection is caused by 20 Leishmania species that are morphologically indistinguishable but can be differentiated by laboratory analysis. (msdmanuals.com)
  • Animal reservoirs vary with the Leishmania species and geographic location and include dogs, other canines, rodents, and other animals. (msdmanuals.com)
  • Mucosal leishmaniasis (espundia) is caused mainly by L. braziliensis but occasionally by other Leishmania species. (msdmanuals.com)
  • There are molecular techniques that confirmthe diagnosis and characterize Leishmania species. (bvsalud.org)
  • It should be emphasized the importance of the differentialdiagnosis in order to apply the right treatment and also the uncommon clinicalmanifestation that is not associated to this Leishmania species. (bvsalud.org)
  • The leishmaniases are a group of diseases caused by protozoan parasites from more than 20 Leishmania species. (who.int)
  • And the parasite is called Leishmania and there are 20 Leishmania species that can cause disease in humans and we say that they are pathogenic to humans. (cdc.gov)
  • And depending on the Leishmania species and the host immune response, people will develop one clinical form or the other. (cdc.gov)
  • Cutaneous leishmaniasis (CL) is a widespread and resurging vector-borne disease caused by a protozoan parasite belonging to genus Leishmania ( 1 ). (cdc.gov)
  • Since the number of organisms per infected LC remained consistently low, the prime task of LC may not be the promotion of parasite spreading but the presentation of L. major antigen to T cells and, thus, the regulation of the cellular immunity during cutaneous leishmaniasis. (uni-wuerzburg.de)
  • Leishmaniasis is a disease caused by a single-celled parasite of the genus Leishmania. (citylab.bg)
  • Sera from individuals suffering from leishmaniasis have been shown to strongly react against conserved proteins from the parasite, such as ribosomal, histones and heat-shock proteins. (parasite-journal.org)
  • Once thought to be a danger largely reserved for travelers, a flesh-eating parasite known as Leishmania Mexicana is now likely spreading locally through some sand flies native to the southern U.S., a new Centers for Disease Control and Prevention analysis has concluded. (epibiodev.blog)
  • Hospitals have some options for drugs to use in trying to treat patients suffering from this disease caused by the parasite, which doctors call cutaneous leishmaniasis, though experts acknowledge there is "low certainty" about their effectiveness. (epibiodev.blog)
  • Leishmaniasis is a disease caused by an intracellular protozoan parasite (genus Leishmania ) transmitted by the bite of a female phlebotomine sandfly. (medscape.com)
  • A new study suggests that transmission of a protozoan parasite from insects may also cause leishmaniasis-like symptoms in people. (sciencedaily.com)
  • The parasite, however, does not respond to treatment with standard leishmaniasis drugs. (sciencedaily.com)
  • Leishmaniasis is a vector-borne tropical/subtropical disease caused by an intracellular parasite transmitted to humans by sand fly bite. (intechopen.com)
  • The human parasite Leishmania is the causative agent of leishmaniasis. (unil.ch)
  • Leishmania parasites possess an exceptional oxidant and chemical defense mechanism, involving a very unique small molecular weight thiol, trypanothione (T[SH] 2 ), that helps the parasite to manage its survival inside the host macrophage. (frontiersin.org)
  • The causative agent of CL, a protozoan parasite, Leishmania major has a digenetic lifecycle and lives in two hosts, sandfly and human, in the form of flagellated promastigotes and non-flagellated amastigotes, respectively. (frontiersin.org)
  • Direct transmission of Leishmania parasite has been reported through contaminated needles (for example, exchange of needles among drug users), also through blood transfusion and organ transplant. (cdc.gov)
  • He gave the popular name "Leishman-Donovan bodies", and subsequently the valid binomial Leishmania donovani, thereby equally crediting the two rivals. (wikipedia.org)
  • Leishmania donovani is a unicellular eukaryote having a well-defined nucleus and other cell organelles including a kinetoplast and a flagellum. (wikipedia.org)
  • The in vivo oral efficacy of amlodipine and lacidipine has been shown in the treatment of Leishmania (L.) donovani infected mice [ 5 ]. (hindawi.com)
  • The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterization of Leishmania donovani clinical isolates. (cambridge.org)
  • For each patient (146 total), we collected epidemiologic data (geographic origin, traveling history, especially to other leishmaniasis-endemic areas) and clinical data (number and size of lesions and clinical forms). (cdc.gov)
  • Lupoid cutaneous leishmaniasis is prevalent in endemic area of leishmaniasis, particularly in the Middle East and Afghanistan [6]. (who.int)
  • This genetic information adds credence to this idea that leishmaniasis is occurring here in the United States, it's endemic here in the United States, at least in Texas and maybe southern border states," Dr. Mary Kamb, of the CDC's Division of Parasitic Diseases and Malaria, said in an interview with CBS News. (epibiodev.blog)
  • This chapter reviews the global perspective of Leishmaniasis with increasing recognition of emerging "Atypical forms" and new surge of disease across the world mainly due to increasing conflicts in endemic areas leading to forced migration among other causes. (intechopen.com)
  • Epidemiological surveillance reveals that more than 350 million people in 98 countries are at potential risk of infection, which makes Leishmaniasis one of the six endemic diseases considered as high priorities worldwide [1]. (databasefootball.com)
  • Efficacy and safety of liposomal amphotericin B (Am-Bisome) for visceral leishmaniasis in endemic developing countries. (ajtmh.org)
  • Leishmaniasis represents a serious public health problem in Brazil and abroad, being endemic in 88 countries and the second most important disease caused by protozoan with medical relevance, exceeded only by malaria. (bvsalud.org)
  • Leishmaniasis is an endemic parasitic disease in 98 countries of egions ted e ar ic the world, and has a wide spectrum of clinical manifestations, s her ic viscer her r affecting over 12 million people globally. (who.int)
  • Existing systemic treatments for New World cutaneous leishmaniasis (CL) caused by Leishmania (vianna) braziliensis are unsatisfactory. (unboundmedicine.com)
  • AU - Brown,M, AU - Noursadeghi,M, AU - Boyle,J, AU - Davidson,R N, PY - 2005/7/21/pubmed PY - 2005/10/26/medline PY - 2005/7/21/entrez SP - 203 EP - 5 JF - The British journal of dermatology JO - Br J Dermatol VL - 153 IS - 1 N2 - Existing systemic treatments for New World cutaneous leishmaniasis (CL) caused by Leishmania (vianna) braziliensis are unsatisfactory. (unboundmedicine.com)
  • A cohort of 44 ECL patients infected by Leishmania braziliensis was established to evaluate the response to Sb5 and to compare immunologic responses in ECL patients with CL and healthy subjects. (fiocruz.br)
  • In this paper, we investigate whether there is any relationship between the recognition of some conserved proteins from Leishmania braziliensis by individuals suffering from cutaneous (CL) and mucocutaneous (MCL) leishmaniasis, and the recognition of the human homologues of these antigens found in sufferers from autoimmune diseases. (parasite-journal.org)
  • Dans ce travail, nous avons cherché s'il existe une relation entre la reconnaissance de certaines protéines conservées de Leishmania braziliensis par les personnes malades de leishmaniose cutanée (CL) et mucocutanée (MCL), et la réponse générée contre les mêmes antigènes humains durant les pathologies autoimmunitaires. (parasite-journal.org)
  • Disseminated leishmaniasis due to Leishmania braziliensis . (uab.edu)
  • Uncommonly, L. braziliensis spreads widely in the skin causing disseminated cutaneous leishmaniasis. (msdmanuals.com)
  • The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. (lu.se)
  • Background: Leishmania tropica is a causative agent of cutaneous leishmanaisis in the Middle East, North Africa and parts of southeastern Europe. (huji.ac.il)
  • In several protozoans, the status of this mechanism remains elusive, such as in Leishmania , the causative agent of the disease leishmaniasis in humans and a wide array of vertebrate animals. (mdpi.com)
  • Leishmaniasis is a vector-borne disease caused by an obligate intracellular protozoa of genus Leishmania and is transmitted by the bite of a female phlebotomine sand fly ( Figure 1 ). (intechopen.com)
  • Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. (degruyter.com)
  • It is a chronic condition that typically follows acute cutaneous leishmaniasis infection. (who.int)
  • While this phenomenon already caused geographical expansion of several arthropod-borne diseases, it is likely to affect also temporal parameters of seasonally transmitted diseases such as leishmaniasis, a protozoan infection spread by the bite of phlebotomine sand flies. (hacettepe.edu.tr)
  • Active cutaneous leishmaniasis lesion with likely secondary infection in a soldier. (medscape.com)
  • As veterans of infection, Leishmania guyanensis parasites have been plaguing humankind for centuries, provoking a deleterious hyper-inflammatory immune response, destroying host tissue and forming the ulcerating lesions, which typify most forms of the disease. (unil.ch)
  • Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis. (unil.ch)
  • Classified as a neglected tropical disease (NTD), leishmaniasis is an infection spread by phlebotomine sand flies. (webmd.com)
  • This infection is typically more common in rural areas, so be sure to take precautions as needed if you spend a lot of time outdoors in areas where leishmaniasis occurs. (webmd.com)
  • Leishmaniasis is a reportable condition in Texas, and the DSHS encourages doctors to consider the infection if a patient has consistent symptoms and has not recently traveled overseas. (keloland.com)
  • It presents situation about Leishmaniasis and leishmania/HIV co-infection in Europe and also brings epidemiological features. (bvsalud.org)
  • by ELISA was positive and an aspirate from the lesion showed a large number of Leishmania amastigotes. (huji.ac.il)
  • Leishmania amastigotes reside within monocytes and macrophages of the tissue. (futurelearn.com)
  • Leishmania amastigotes are oval or round organisms around 2 by 4 micrometres with delicate cell margins. (futurelearn.com)
  • To report the results, use a grading system that indicates the number of Leishmania amastigotes in a specific set of microscopic view fields. (futurelearn.com)
  • This involves microscope examination of biopsy material in order to identify Leishmania amastigotes (LDUs) in the sample. (futurelearn.com)
  • En el 2012 es internado en el Instituto de Medicina Tropical (IMT) con fiebre, anemia, hepato-esplenomegalia, frotis de médula ósea y rk39 negativos para Leishmania, recibe tratamiento con Anfotericina B. En el 2013 presenta síndrome febril prolongado y en médula ósea se encuentran amastigotes de Leishmania sp. (bvsalud.org)
  • En el 2014 presenta úlceras en el rostro en las que se observan es porosmicóticos de H. capsulatum y amastigotes de Leishmania sp. (bvsalud.org)
  • Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. (medlineplus.gov)
  • Leishmaniasis is a parasitic disease found in parts of the tropics, subtropics, and southern Europe. (sciencedaily.com)
  • After malaria, leishmaniasis stands as the most important protozoan parasitic disease in the world, with 350 million people at risk on 5 continents in 98 countries and steadfastly listed in the top 10 most debilitating infectious diseases in the world (according to DALY units). (unil.ch)
  • Historically, it was considered that cutaneous leishmaniasis, or any type of leishmaniasis, is linked to international travel," said Vita Cama, a microbiologist working in the CDC's Division of Parasitic Diseases and Malaria. (keloland.com)
  • Celine Gossner] Leishmaniasis is a parasitic disease, and it's found in parts of Asia, Africa, Central and South America, Middle East, and also Southern Europe. (cdc.gov)
  • Most reported cases are associated with old world strains of leishmaniasis and Leishmania tropica is responsible for the majority of such cases [3]. (who.int)
  • A one year old male Pekingese dog from Maale Adumim, a focus of L. tropica human cutaneous leishmaniasis near Jerusalem, was presented by its owner with a large proliferative red mucocutaneous lesion on the lip between the mouth and nose. (huji.ac.il)
  • This study was supported by the Deutsche Forschungsgemeinschaft (DFG) as part of a German-Israeli-Palestinian cooperative project on the Emergence of Cutaneous Leishmaniasis in the Middle East: 'An investigation of Leishmania tropica in the Palestinian Authority and Israel' (SCHO 448/8-1). (huji.ac.il)
  • Local treatment modalities including topical paromomycin, cryotherapy, localized controlled heat, carbon dioxide laser therapy, or intralesional meglumine antimoniate can be effective against Leishmania major or Leishmania tropica. (unboundmedicine.com)
  • Early cutaneous leishmaniasis (ECL) is characterized by a nonulcerated papular lesion and illness duration less than 30 days. (fiocruz.br)
  • Classic Leishmania major lesion from a case in Iraq shows a volcanic appearance with rolled edges. (medscape.com)
  • A biopsy of the lesion was suggestive of the presence of Leishmania organisms. (huji.ac.il)
  • Leishmaniasis recidivans may occur years after a localized cutaneous lesion has healed, commonly presenting on the face (see the following image). (medscape.com)
  • Cutaneous leishmaniasis (CL) is, by far, the most prevalent form of the disease with symptoms ranging from a single self-healing lesion to chronic metastatic leishmaniasis (ML). In an increasingly immunocompromised population, complicated CL is becoming a more likely outcome, characterised by an allergic hyper-reactivity and resulting in severely inflamed, destructive lesions that are often refractory to current treatment. (unil.ch)
  • Symptoms and signs of mucosal leishmaniasis typically develop months to years after the appearance of the skin lesion. (msdmanuals.com)
  • Promastigotes of Leishmania were isolated from culture on NNN media of the aspirate as well as from a biopsy. (uab.edu)
  • In the research, larvae were infected with Leishmania (Viannia) panamensis promastigotes and the immunological response of the larvae was followed by using analytical techniques like electrophoresis and chromatography. (databasefootball.com)
  • Optimization of the experimental hamster model for cutaneous leishmaniasis by intradermal injection of Leishmania promastigotes at the dorsal skin. (jove.com)
  • Leishmania promastigotes are transmitted by sand flies ( Phlebotomus , Lutzomyia ) to vertebrate hosts. (msdmanuals.com)
  • Thus, we considered of interest to analyze whether Leishmania PUF proteins result antigenic during visceral leishmaniasis (VL). (biomedcentral.com)
  • Although, several Fe/S cluster proteins and their roles have been identified in Leishmania, some of the components of how T[SH] 2 is involved in the regulation of Fe/S proteins remains to be explored. (frontiersin.org)
  • Enzymatic and Molecular Characterization of Anti- Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4A Mus . (bvsalud.org)
  • WHO considers Leishmaniasis as one of the "Neglected Tropical Diseases" that continues to be prevalent despite international, national, and local efforts towards its control and elimination over the last decade. (intechopen.com)
  • The leishmaniases are a group of diseases caused by Leishmania spp. (bvsalud.org)
  • This clinical syndrome should be distinguished from DCL or diffuse cutaneous leishmaniasis, which has been well described throughout central/south America and the Caribbean, but is usually due to L. amazonensis or L. mexicana . (uab.edu)
  • This study aimed to show the trend in leishmaniasis incidence from 1983 to 2012 and to describe the epidemiological characteristics in 2012. (who.int)
  • In a retrospective cross-sectional study, data were extracted from th%e national leishmaniasis surveillance system for the 3 clinical types--cutaneous (zoonotic and anthroponotic) and visceral (zoonotic). (who.int)
  • The incidences of cutaneous and zoonotic visceral leishmaniasis have decreased in recent years, which coincides with national leishmaniasis control efforts. (who.int)
  • In some districts t cases of and zoonot leishmaniasis Ther repor leishmaniasis in ot of clinical features of the disease (zoonotic and anthroponotic cu- taneous leishmaniasis and zoonotic and anthroponotic visceral x es, leishmaniasis) are predominantly found within the World Health a Organization (WHO) Eastern Mediterranean Region (EMR). (who.int)
  • The patient, who had not previously undergone any treatment for cutaneous leishmaniasis, was treated with systemic meglumine antimoniate (Glucantime, Aventis, France) 20 mg/kg per day intramuscularly for 20 days. (who.int)
  • This patient had also not been treated for leishmaniasis before and was treated similarly with systemic meglumine antimoniate (Glucantime, Aventis, France) 20 mg/kg per day intramuscularly for 20 days. (who.int)
  • During the last several decades, researchers have described rare cases of patients co-infected with both Leishmania and other groups of protozoan parasites that usually infect insects, including Crithidia . (sciencedaily.com)
  • Patients who sought treatment at Hajout hospital in Hajout, Algeria (a community of ≈51,000 persons), from January 2010 through April 2013 with cutaneous lesions consistent with leishmaniasis, underwent clinical examination. (cdc.gov)
  • Whilst there is no specific cure for Leishmaniasis, early diagnosis is important so that your Vet can start treatment before the symptoms worsen. (homehealth-uk.com)
  • Many patients who initially respond to treatment remain at risk of their leishmaniasis relapsing. (epibiodev.blog)
  • The 63-year old patient initially sought treatment for the symptoms of visceral leishmaniasis, including weight loss, fever, anemia, and an enlarged liver and spleen. (sciencedaily.com)
  • However, after eight months of standard leishmaniasis treatment, the patient's symptoms had not improved. (sciencedaily.com)
  • Also, accurate diagnosis is relevant for monitoring success in the chemotherapeutic treatment of leishmaniases. (biomedcentral.com)
  • Many therapeutic agents are being used in Leishmania treatment, but the only effective treatment is achieved with current pentavalent antimonials. (intechopen.com)
  • The authors are all members of the Leishmaniasis East Africa Platform and are currently engaged in the clinical development of paromomycin for treatment of visceral leishmaniasis. (plos.org)
  • For New World leishmaniasis, parenteral antimonials represent the first-line treatment in all forms except those caused by Leishmania guyanensis in which pentamidine is preferable. (unboundmedicine.com)
  • Therapy of leishmaniasis ranges from local treatment of cutaneous lesions to systemic often toxic, therapy for disseminated CL, ML and VL. (degruyter.com)
  • Relapses after treatment are more frequent than in visceral leishmaniasis. (karger.com)
  • HIV patients infected by Leishmania have frequently visceral involvement, and responses to treatment are poor. (karger.com)
  • Do the diminishing efficacy and increasing toxicity of sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar, India, justify its continued use as a first-line drug? (ajtmh.org)
  • Treatment of visceral leishmaniasis in Kenya by aminosidine alone or combined with sodium stibogluconate. (ajtmh.org)
  • In this report we describe 2 cases of lupoid leishmaniasis that were not diagnosed for several years and caused large scars on the face. (who.int)
  • He had been infected with cutaneous leishmaniasis in Afghanistan 10 years before but some red infiltrative nodules appeared at the margin of the remaining scars 2 years before referring to our centre (Figure 1). (who.int)
  • The clinical spectrum of leishmaniasis ranges from a self-resolving cutaneous ulcer to a mutilating mucocutaneous disease and even to a lethal systemic illness. (medscape.com)
  • All these challenges related to environment, disease, and vector pose major implications on WHO's leishmaniasis control and elimination plan. (intechopen.com)
  • We dub this process "hyperpathogenism" and have exposed its importance as major clinical consideration in metastatic leishmaniasis. (unil.ch)