• He is known for his work on lectin structure and interactions, orientation and dynamics of cell surface carbohydrate receptors and protein folding, diabetes, antimalarials and anti-cancer agents based on curcumin, flavonoids, etc. (wikipedia.org)
  • Surolia has elucidated the role of glycosphingolipids as biological receptors through studies on lectin-glycolipid interactions using liposomes. (wikipedia.org)
  • This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. (unige.ch)
  • Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors. (unige.ch)
  • Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (unige.ch)
  • The most common and widely studied PRRs are toll-like receptors (TLRs) and C-type lectin receptors (CLRs) [8]. (fortunejournals.com)
  • Their response involves antigen capture, enhancing their MHC-II presentation receptors and production of chemokines and/or cytokines at the site of inflammation [9]. (fortunejournals.com)
  • Unger WWK and VAN KOOYK Y. 'Dressed for success' C-type lectin receptors for the delivery of glycovaccines to dendritic cells. (dc4u-technologies.nl)
  • In the Brown Group, we are interested in a superfamily of receptors called C-type lectin receptors (CLRs). (exeter.ac.uk)
  • We have previously shown that hemocyanins are internalized by APCs through receptor-mediated endocytosis with proteins that contain C-type lectin domains, such as mannose receptor (MR). However, the contribution of other innate immune receptors to the proinflammatory signaling pathway triggered by hemocyanins is unknown. (exeter.ac.uk)
  • Central in her work is the development of new glycan modified immune therapy for cancer and allergy, targeting glycan binding receptors on skin resident antigens presenting cells that induce or inhibit immunity. (immunologyamsterdam.org)
  • We investigate how binding of carbohydrates, altered due to tissue inflammation or wound healing processes, control modulation of immune cells through recognition/signaling of glycan binding receptors, such as C-type lectins and Siglecs. (immunologyamsterdam.org)
  • We investigate glycan binding receptors such as C-type lectins and Siglecs on innate myeloid, macrophages and DC for targeting purposes to guide glycosylated antigens binding and uptake that influence antigen presentation, T cell differentiation and immune cell signaling. (immunologyamsterdam.org)
  • The cancer nano-vaccines we develop use specific glycans that target receptors such as DC-SIGN and Langerin that stimulate anti-tumor immunity, in human skin models and in-vivo mouse tumor models. (immunologyamsterdam.org)
  • APCs exhibit many C-type lectin receptors (CLRs) that become phagocytic receptors.24 25 Some CLRs contain internalization motifs within their cytoplasmic domains which direct the uptake of ligands and subsequent sorting of CLRs and attached cargo into past due endosomes. (monossabios.com)
  • He discovered novel blood group and tumor antigen specific lectins and made original contribution towards elucidation of the energetics and mechanism of protein-sugar recognition. (wikipedia.org)
  • He delineated the molecular basis of carbohydrate recognition by legume lectins and demonstrated the novel C-H...O/N hydrogen bond in protein-sugar interactions. (wikipedia.org)
  • His studies showed that the monomers of legume lectins have the necessary structural features for carbohydrate recognition and that oligomerization imparts them with topology necessary for their biologic activities such as agglutination, mitogenesis, etc. (wikipedia.org)
  • We have previously demonstrated that the C-type lectin macrophage galactose-type lectin (MGL), expressed by human antigen presenting cells, can distinguish healthy tissue from CRC through its specific recognition of Tn antigen. (oncotarget.com)
  • Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins. (ucibio.pt)
  • Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen. (ucibio.pt)
  • 2019. The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose‐Type Lectin. (ucibio.pt)
  • Molecular Recognition of a Thomsen-Friedenreich Antigen Mimetic Targeting Human Galectin-3. (ucibio.pt)
  • Aarnoudse CA, Vallejo JJ, Saeland E and VAN KOOYK, Y. Recognition of tumor glycans by antigen-presenting cells. (dc4u-technologies.nl)
  • Geijtenbeek TBH, van Vliet SJ, Engering A, 't Hart BA and VAN KOOYK, Y. Self- and non-self recognition by C-type lectins on Dendritic Cells. (dc4u-technologies.nl)
  • ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. (bdbiosciences.com)
  • During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. (gu.se)
  • At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
  • Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
  • These cells participate in pathogen recognition, apoptotic cell clearance, and antigen presentation ( 14 ). (frontiersin.org)
  • We explore how glycan- glycan binding receptor control the immune signature and regulate tumor growth or pathogen recognition and inflammation. (immunologyamsterdam.org)
  • The 15 members of the family are normally classified according to their struc- ture and number of carbohydrate recognition domains (CRDs). (fdocuments.net)
  • However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition. (lookformedical.com)
  • The complexity of the human bone marrow, with context to haematological malignancies, is more difficult to elucidate with the present strategies compared to the niche of solid tumors. (fortunejournals.com)
  • There can, however, be few similarities between the two, as the bone marrow is a common site of metastasis of solid tumors too [6]. (fortunejournals.com)
  • Relevant information has now been established on solid tumors and their micro-environments, which include immune, endothelial and mesenchymal cells. (fortunejournals.com)
  • Switchable targeting of solid tumors by BsCAR T cells. (yale.edu)
  • strong course="kwd-title" Keywords: Plasma membrane, Alkylating agencies, Leukocyte influx, Carbohydrate analogs, Dihydroxyacetone phosphate inhibitors Launch Alkylation of essential intracellular nucleophiles is certainly a non-specific, but effective antineoplastic technique in lots of hematological malignancies plus some solid tumors because of following perturbation of cell proliferation. (buyresearchchemicalss.net)
  • The carbohydrate specificity of either type of subunit appears to be the same, preferring α-linked N-acetylgalactosamine structures. (biotrend.com)
  • Carbohydrate xenoantigens and xenoantibody epitope-specificity, the removal of xenoantibodies by plasmapheresis, and antibody neutralization using soluble saccharides, were all explored. (gu.se)
  • Peptide vaccines possess immunological and financial advantages as cancers vaccines because CTL epitope peptides from tumor-associated antigens possess high antigen-specificity. (monossabios.com)
  • Along this line, nanoparticle (NP) delivery systems can enhance the immunogenicity of antigens by protecting them from degradation and increasing their uptake by antigen-presenting cells, as well as offering co-delivery with adjuvants. (univ-nantes.fr)
  • Singh, SK, Streng-Ouwehand I, Litjens M, Kalay H, Saeland E and VAN KOOYK Y. Tumour -associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses. (dc4u-technologies.nl)
  • The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells. (nih.gov)
  • Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. (ucibio.pt)
  • CD 69 antigen of human lymphocytes is a calcium-dependent carbohydrate-binding protein. (unige.ch)
  • Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. (unige.ch)
  • Maclura pomifera agglutinin or lectin (MPA/MPL) is tetrameric plant protein isolated from Osage orange. (biotrend.com)
  • Em492 antigen had a protein/carbohydrate ratio of 0.25, reacted with a series of lectins, and is related to the laminated layer-associated Em2(G11) antigen. (unibe.ch)
  • However, inclusion of protein antigens fromStreptococcus pneumoniaecombined with potent adjuvants and a suitable delivery system are expected to both extend protection to serotype strains not represented in the formulation and stimulate a broader immune response, thus more effective in young children, elderly, and immunocompromised populations. (univ-nantes.fr)
  • C-reactive protein (CRP, not shown) leads to classic pathway activation analogous to lectin pathway activation by MBL and ficolins. (medscape.com)
  • The protein encoded by this gene is an S-type lectin. (thermofisher.com)
  • The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight. (lookformedical.com)
  • Conjugated protein-carbohydrate compounds including mucins , mucoid, and amyloid glycoproteins . (lookformedical.com)
  • This lectin has a high affinity for tumor-associated T-antigen disaccharide (Gal beta 1,3GalNAc alpha) and many O-linked glycopeptide structures. (biotrend.com)
  • Lectin array technology is based on the lectin-glycan affinity ( 6 ), which is not suitable for glycoproteomic analysis. (frontiersin.org)
  • In 1994, a joint effort by several investigators in the field led to a new nomenclature in which the term "galectins" was used to define lectins with an affinity for - galactosides and with sequence similarity in the carbohydrate-binding site [3]. (fdocuments.net)
  • Elevated cell-surface expression of truncated carbohydrate structures such as Tn antigen (GalNAcα-Ser/Thr) is frequently observed during tumor progression. (oncotarget.com)
  • In the current study we show that designer glycopeptides containing the Thomsen-Freidenreich (TF) antigen (β-Gal-[1→3]-α-GalNAc- O -serine) are immunogenic in vivo and generate TF-specific CTL capable of recognizing a variety of tumor cells in vitro including a MUC1-expressing tumor. (silverchair.com)
  • CD62E may also play a role in the metastasis of certain tumor cells. (bdbiosciences.com)
  • Recently, more and more evidence indicates that epithelial-to-mesenchymal transition (EMT) is an important mechanism taking place during tumor invasion and metastasis, but the molecular pathways underlying EMT have not been clearly established. (chksignal.com)
  • In cancers, tumor cell-derived exosomal circRNAs can act on target cells or organs through the transport of exosomes, and then participate in the regulation of tumor development and metastasis. (ijbs.com)
  • Galectins are a family of proteins that bind to carbohydrates on the surface of cells, regulating the amount of leukocytes through of apoptotic and non-apoptotic mechanisms being galectin-3 the most well studied of these lectins. (fapesp.br)
  • Bevilacqua MP, Stengelin S, Gimbrone MA Jr, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. (bdbiosciences.com)
  • Changes in glycan structures and the interactions of these structures with endogenous carbohydrate- binding proteins, known as lectins, are now considered to be potential biomarkers on cancer cells for monitoring tu- mor progression. (fdocuments.net)
  • Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. (lookformedical.com)
  • The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. (lookformedical.com)
  • Proteins that share the common characteristic of binding to carbohydrates . (lookformedical.com)
  • PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). (lookformedical.com)
  • These vesicles could be prepared in a variety of ways which might have an effect on the immunogenicity from the encapsulated antigens.20 Efficient delivery of antigens to immune cells could be facilitated by agents that bind selectively to molecular set ups on the top of targeted cells. (monossabios.com)
  • He showed the existence of co-operativity in lectin-multimeric sugar interactions. (wikipedia.org)
  • Les interactions sucres/protéines (enzymes, lectines) sont au cœur de la communication cellulaire tant extracellulaire (interactions cellule-cellule, cellule-matrice, hôte-pathogène) qu'intracellulaire (GlcNAcylation en tant que modification post-traductionnelle). (univ-nantes.fr)
  • Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
  • We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
  • It simply does not require specific antigen-antibody interactions for initiation. (medscape.com)
  • This β -sandwich fold is conserved in all galectins and includes a gly- cine, which stabilizes the galectin-carbohydrate interactions [4]. (fdocuments.net)
  • Evidence suggesting that the interactions between lectins and their ligands have a major role in the different steps of cancer progression has accumulated at a rapid pace and has gained the attention of several on- cologists. (fdocuments.net)
  • In accordance, attempts have been made to establish a link between the immune system and the tumor microenvironment, to comprehend tumor progression and achieve effective therapeutic approaches. (fortunejournals.com)
  • Endogenous lectins and glycans are critical signals in the resolution of cell death. (nature.com)
  • Furthermore, differential binding was observed also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA. (researchgate.net)
  • Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. (unige.ch)
  • The structure of Gal beta 1,3GalNAc alpha occurs on the surface of tumor cells as a mucin-associated antigenic marker, termed as T-antigen. (biotrend.com)
  • However, with regard to cellular immunity, a suppressive effect on concanavalin A- or crude parasite extract-induced splenocyte proliferation in these mice was observed upon addition of Em492 antigen, but trypan blue exclusion tests and transmission electron microscopy failed to reveal any cytotoxic effect in Em492 antigen-treated spleen cells. (unibe.ch)
  • Joshi MD, Unger WJ, Storm G, van Kooyk Y, Mastrobattista E. Targeting tumor antigens to dendritic cells using particulate carriers. (dc4u-technologies.nl)
  • Glycan modificatio of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cells. (dc4u-technologies.nl)
  • Saeland E, van Vliet SJ, Bäckström M, van den Berg VC, Geijtenbeek TB, Meijer GA, VAN KOOYK Y. The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma. (dc4u-technologies.nl)
  • van Vliet SJ, Gringhuis SI, Geijtenbeek TB and VAN KOOYK, Y. Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45. (dc4u-technologies.nl)
  • Regulatory T cells (Treg) from CD4+ CD25+, actively suppress the immune response against self antigens, alloantigens and tumor antigens, promoting tolerance antigen-specific suppression of activation and expansion of effectors cells, and the transcription factor Foxp3 marker as well characterization of this lineage. (fapesp.br)
  • Activated endothelial cells upregulate surface CD62E expression in response to various activators including inflammatory cytokines such as Interleukin-1 and Tumor Necrosis Factor. (bdbiosciences.com)
  • CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al. (nih.gov)
  • Many malignant cells (such as those found in breast and stomach cancer) develop a tumor marker called the Thomsen-Friedenreich (T) antigen. (dadamo.com)
  • This antigen is suppressed in normal healthy cells, much like a rock is covered over by water at high tide. (dadamo.com)
  • Healthy cells do not normally express the T or Tn antigen, which are 'encrypted' or covered up by polysaccharides much the same way that a rock is covered by water at high tide. (dadamo.com)
  • In malignant or pre-malignant cells, the ability to synthesize the polysaccharides which normally cover the T antigen is often lost, which causes T to be 'expressed' or uncovered, much like a falling tide will often uncover previously hidden rocks at a low tide. (dadamo.com)
  • In this example, the T and Tn antigens are the stumps found in cancer, while the well-groomed yard has bushes, shrubs, and flowers, that correspond to the ABO markers and other antigens found on healthy cells. (dadamo.com)
  • One of the functions of these T and Tn antigens is to promote cancer cell adhesion----the ability for the cancer cell to stick to other cells including healthy cells. (dadamo.com)
  • How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)
  • Although lectins were already known because of their ability to agglutinate red blood cells, 3 the involvement of lectins and glycans in PCD had not been elucidated. (nature.com)
  • TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells from Mammals. (exeter.ac.uk)
  • Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses toward type 1 T helper (Th1) polarization. (exeter.ac.uk)
  • Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells. (yale.edu)
  • Professional antigen-presenting cells such as dendritic cells (DC) and Langerhans cells (LC) have also the capability to induce long-term cellular immunity. (immunologyamsterdam.org)
  • Since appearance and cloning options for AZ-960 tumor-associated antigens have already been reported cancers vaccines that creates effective cell immunity could AZ-960 be appealing healing applicants but Th2 cells are unwanted for make use of in cancers immunotherapy. (monossabios.com)
  • Nevertheless cancer vaccines experienced limited efficiency in clinical replies because of the capability of cancers cells to "get away" from cancers immunity and a minimal performance of antigen-specific CTL induction because of immunogenic-free artificial peptides. (monossabios.com)
  • On the other hand carbohydrate-decorated particles such as for example carbohydrate-coated liposomes with encapsulated antigens may be more desirable as antigen delivery automobiles to antigen-presenting cells. (monossabios.com)
  • Furthermore OMLs with an encased antigen can induce antigen-specific CTLs from peripheral bloodstream mononuclear cells extracted from sufferers. (monossabios.com)
  • NK cells are themselves adaptive: remembering their encounters and mounting pattern-sensitive (antigen-aware) secondary responses. (ishinobu.com)
  • Common mushrooms contain antigen-binding lectins which bind only to abnormal cells & then activate the body's defenses. (simplyplantbasedkitchen.com)
  • These lectins then become internalized into the cancer cell and interfere with the body's ability to replicate thus preventing spread of cancer without toxic effects on normal cells. (simplyplantbasedkitchen.com)
  • In the present review, we provide evidence for how the interaction of dietary lectins with enterocytes and lymphocytes may facilitate the translocation of both dietary and gut-derived pathogenic antigens to peripheral tissues, which in turn causes persistent peripheral antigenic stimulation. (cambridge.org)
  • She studies these questions in in-vivo mouse tumor models such as pancreatic cancer, lung and melanoma in patient derived tissues and human in-vitro models such as skin model, tumor tissues and complex 3D culture models to identify cellular communication at omics level in the context of tissue alterations. (immunologyamsterdam.org)
  • Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation. (dc4u-technologies.nl)
  • DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations. (dc4u-technologies.nl)
  • Intracellular lectins and glycan-modifying enzymes mediate autophagy and control host immunity and inflammation. (nature.com)
  • Her other line of research is aimed to discover of glycan imposed regulatory immune imprinting by inflamed tissue and tumor microenvironment. (immunologyamsterdam.org)
  • New glycan immune regulatory programs will be studied in CRISPR-Cas9 generated glycan modified tumor/stromal mouse and human models, and glyco-code modifying therapies will be developed to revert suppression into tumor specific immunity. (immunologyamsterdam.org)
  • EndoBI-1-released N-glycans were quantified by a phenol-sulphuric total carbohydrate assay and the resultant N-glycan structures monitored by nano-LC-Chip-Q-TOF MS. The kinetic parameters and structural characterization of glycans released suggest EndoBI-1 can facilitate large-scale release of complex, bioactive glycans from a variety of glycoprotein substrates. (omicsdi.org)
  • We employed the monoclonal antibody (MAb) E492/G1, previously shown to be directed against a carbohydrate-rich, immunomodulatory fraction of Echinococcus granulosus, to characterize potentially related components in E. multilocularis. (unibe.ch)
  • Anti-idiotypic antibody mimicking a T-antigen-specific lectin inhibits human epithelial tumor cell proliferation. (conicet.gov.ar)
  • Not surprisingly, blood type A individuals have the least aggressive antibody immune response against the T and probably Tn antigens. (dadamo.com)
  • So the hypothesis goes that because of the lower level of antibody against T and Tn antigens or stumps, and because of this tendency for the immune system of A's to be a bit confused or disinclined to attack Tn antigens, blood type A is at an immunologic disadvantage in attacking any cell bearing these T and Tn antigenic markers. (dadamo.com)
  • Oligomannose-coated liposomes (OML) can remove set up tumors in mouse cancers models. (monossabios.com)
  • Liposomes have already been broadly exploited as antigen delivery systems for dealing with a number of illnesses. (monossabios.com)
  • Compared with traditional histological biopsy, the liquid biopsy technique developed in recent years to detect circulating tumor markers in body fluids has attracted increasing attention in early diagnosis of tumors and detection of therapeutic effects. (ijbs.com)
  • Tumors express embryonic carbohydrate antigens called tumor-associated carbohydrate antigens (TACA). (silverchair.com)
  • TACA-containing glycopeptides are appealing cytotoxic T cell (CTL)-based vaccines to prevent or treat cancer because the same sugar moieties are expressed in a variety of tumors, rendering a vaccination strategy applicable in a large population. (silverchair.com)
  • Because of these encouraging results, we applied the same antigenic strategy to TACA-containing glycopeptides because induction of a degenerate T cell response against this class of tumor antigens may be of great advantage in cancer immunotherapy ( 10 - 12 ). (silverchair.com)
  • Saeland E. and VAN KOOYK Y. Highly glycosylated tumor antigens: interaction with the immune system. (dc4u-technologies.nl)
  • In fact, the T and Tn antigens, and blood type A antigens are actually immunologically considered to be quite similar because of their shared terminal sugar (N-acetylgalactosamine), and so might be readily confused by the immune system of blood type A individuals. (dadamo.com)
  • It has been estimated that in about 90% of all cancers and some leukemias, T and Tn antigens are expressed and uncovered. (dadamo.com)
  • As a general rule, well-differentiated cancers usually have a preponderance of T antigens and less of the Tn antigens. (dadamo.com)
  • Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. (unige.ch)
  • Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69. (unige.ch)
  • Introduction Galectins, formerly known as S-type lectins, rep- resent a family of evolutionarily conserved ani- mal lectins that are widely distributed from lower invertebrates to higher vertebrates. (fdocuments.net)
  • By eliminating dietary elements, particularly lectins, which adversely influence both enterocyte and lymphocyte structure and function, it is proposed that the peripheral antigenic stimulus (both pathogenic and dietary) will be reduced and thereby result in a diminution of disease symptoms in certain patients with RA. (cambridge.org)
  • Furthermore usage of the hepatitis B primary particle where tumor-antigen epitopes are established has consistently been proven to induce solid CTL replies without the usage of an adjuvant. (monossabios.com)
  • He has published more than 150 scientific articles in the fields of carbohydrate biochemistry, glycobiology, allo- and xeno-transplantation, and regeneratvie medicine. (gu.se)
  • Actually, several in vitro and in vivo tests have demonstrated the effectiveness of plasma membrane alkylating real estate agents that focus on carbohydrate moieties [17C21]. (buyresearchchemicalss.net)
  • Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (unige.ch)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • An excess of nitrates in the body is linked to the development of many different types of cancer, including stomach, colorectal and brain tumors. (marnieclark.com)
  • Using a cohort of 386 colon cancer patients we demonstrate that high MGL binding to stage III tumors is associated with poor disease-free survival, independent of microsatellite instability or adjuvant chemotherapy. (oncotarget.com)
  • As a general rule, an orderly expression of T antigens on a cancer cell usually indicates a cancer with a relatively favorable outlook. (dadamo.com)
  • However, a prevalence of Tn antigens (Note: Tn Antigen is actually a precursor to T antigen or a less well developed T antigen) on a cancer cell usually denotes a highly aggressive, metastatic cancer irrespective of organ or type of cancer. (dadamo.com)
  • The difference between the yards is largely because a cancer cell is unable to completely assemble a normal, healthy cell membrane structure like a blood type ABO antigen. (dadamo.com)
  • However, as a cancer cell becomes poorly differentiated, Tn antigen expression predominates. (dadamo.com)
  • The current progress in pharmaceutical nanotechnology field has been exploited in the design of tumor-targeting nanoscale and microscale carriers being able to deliver radionuclides in a selective manner to improve the outcome of cancer diagnosis and treatment. (chksignal.com)
  • At present, the detection of a specific circRNA in fluid exosomes of cancer patients provides new ideas and research methods for liquid biopsy of tumors [ 9 ]. (ijbs.com)
  • Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. (bdbiosciences.com)
  • Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. (bdbiosciences.com)
  • The adhesion between endothelial CD62E molecules and a carbohydrate ligand on neutrophils is inhibited by the mAb 68-5H11. (bdbiosciences.com)
  • We investigate how the glyco-code of the tumor-stromal network affects immune regulation. (immunologyamsterdam.org)
  • T antigen only becomes 'unsuppressed' as a cell moves towards malignancy, much like the covered rock in our example becomes uncovered as the tide moves out. (dadamo.com)
  • It is even more rare to find a Tn antigen on a healthy cell. (dadamo.com)
  • The emergence of functional studies on animal lectins during the 1990s has provided the appropriate framework to better understand their roles in cell death. (nature.com)
  • This will come as no real surprise as cell surface area carbohydrates get excited about multitudes of essential physiological processes. (buyresearchchemicalss.net)
  • Based on A antigen expression, a hypothesis explaining why blood group A2 kidneys could be successfully transplanted to O recipients was postulated. (gu.se)
  • The Thomsen-Friedenreich (T) antigen and Tn antigen show some structural similarity to the A antigen (even though it is derived from the M blood type antigen). (dadamo.com)
  • These results have high potential for immunotherapy against a broad range of tumors. (silverchair.com)