• Reduction
  • Refluxing single-layer graphene oxide (SLGO) in solvents leads to size reduction and folding of individual sheets as well as loss of carboxylic group functionality, by up to 20%, indicating thermal instabilities of SLGO sheets dependent on their preparation methodology. (wikipedia.org)
  • It is apparent that conventional chemical treatment of carboxylic groups on SLGO generates morphological changes of individual sheets that leads to a reduction in chemical reactivity, which may potentially limit their use in composite synthesis. (wikipedia.org)
  • 4) Initial reduction of α,α'-dihalo ketones leads to metal enolate intermediates. (wikipedia.org)
  • alkyl
  • Addition of methoxy or methyl groups at the C5-C7 positions led to retention of anti-biofilm activity, in some cases dependent on the alkyl chain length at position C2. (ucc.ie)
  • protein
  • The information derived from this original pharmacophore has led to the synthesis of highly specific inhibitors against a number of protein kinases, including PKC, cyclin-dependent kinases, G-protein coupled receptor kinases, tyrosine kinase, and cytomegalovirus pUL97 protein. (wikipedia.org)
  • equivalents
  • however, the use of borane (BH3) or borane equivalents leads to the conversion of only 33% of the starting olefin to product after oxidation or protonolysis-the remaining olefin is incorporated into boron-containing byproducts. (wikipedia.org)
  • stress
  • Two types of oxidative stress, peroxidation and halogenation stress, are gaining increasing importance as biochemical windows to a better understanding of the pathogenesis of this disease. (austinpublishinggroup.com)
  • loss
  • In contrast, halogenation at either the C3 or C6 positions led to loss of activity, with one notable exception. (ucc.ie)
  • People combining with cortisol in the long term should avoid pheniramine as it may decrease levels of adrenaline (epinephrine) which may lead to loss of consciousness. (wikipedia.org)
  • Room
  • Room temperature treatment of SLGO with carbodiimides leads to the collapse of the individual sheets into star-like clusters that exhibited poor subsequent reactivity with amines (c. 3-5% conversion of the intermediate to the final amide). (wikipedia.org)