GPCRPathwaysTransmembraneProteinsRepertoireProteinPutativeNeuralTransductionSubunitsEstrogen receptorOrthologsPathwayAMPAAgonistAttention deficitSusceptibilityGenomeTissuesGlutamateExpressionInhibitionPolymorphismsRegulationActivationMutationSequenceFunctionHumanRoleDomainsFoundAnalysisResultsResearchCellFunctions
GPCR11
- This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). (wikipedia.org)
- The valuable source of large-scale genomic information initiated attempts to identify the origin(s) of G protein-coupled receptors (GPCR), count and categorize those genes, and follow their evolutionary history. (springer.com)
- Phylogenetic analyses revealed several kinds of evolutionary patterns that occurred during GPCR evolution including one-to-one orthologous relationships, species-specific gene expansion, and episodic duplication of the entire GPCR repertoire in certain species lineages. (springer.com)
- These data document the highly dynamic process of birth and death of GPCR genes since hundreds of millions of years. (springer.com)
- The chapter summarizes evolutionary processes working on GPCR genes and sheds light on their consequences at the levels of receptor structure and function. (springer.com)
- YOs) through binding a yet uncharacterized GPCR, which triggers a signalling cascade, leading to inhibition of the ecdysis sequence. (biomedcentral.com)
- An analysis of the Ciona repertoire of GPCRs from a comparative genomic perspective provides insight into the evolutionary origins of the GPCR signalling system in vertebrates. (biomedcentral.com)
- The Rhodopsin family accounts for ~68% of the Ciona GPCR repertoire wherein the LGR-like subfamily exhibits a lineage specific gene expansion of a group of receptors that possess a novel domain organisation hitherto unobserved in metazoan genomes. (biomedcentral.com)
- Our studies suggest that the ascidians contain the basic ancestral complement of vertebrate GPCR genes. (biomedcentral.com)
- This is evident at the subfamily level comparisons since Ciona GPCR sequences are significantly analogous to vertebrate GPCR subfamilies even while exhibiting Ciona specific genes. (biomedcentral.com)
- GPCR based signal transduction is ubiquitous in eukaryotic genomes and forms the basis of detection of diverse environmental cues such as odorant molecules, amines, peptides, lipids, nucleotides and photons. (biomedcentral.com)
Pathways3
- Kim JY, Haastert PV, Devreotes PN (1996) Social senses: G-protein-coupled receptor signaling pathways in Dictyostelium discoideum . (springer.com)
- We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)
- We demonstrated that myocilin is involved in myelination of the optic and sciatic nerves acting through different signaling pathways. (nih.gov)
Transmembrane3
- The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. (tcdb.org)
- Violin JD, Lefkowitz RJ (2007) Beta-arrestin-biased ligands at seven-transmembrane receptors. (springer.com)
- G protein-coupled receptors (GPCRs) constitute a large family of integral transmembrane receptor proteins that play a central role in signal transduction in eukaryotes. (biomedcentral.com)
Proteins6
- Sequence comparison does not support an evolutionary link between halobacterial retinal proteins including bacteriorhodopsin and eukaryotic G-protein-coupled receptors. (springer.com)
- We are particularly interested in genes encoding olfactomedin domain-containing proteins. (nih.gov)
- Some family members, such as latrophilins and gliomedin, are membrane-bound proteins containing the olfactomedin domain in the extracellular N-terminal region, while the intracellular C-terminal domain of these proteins is essential for the transduction of extracellular signals to the intracellular signaling pathway. (nih.gov)
- Several genes encoding olfactomedin domain-containing proteins are expressed in the eye. (nih.gov)
- G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides. (biomedcentral.com)
- The rationale of this organization may be related to important roles of these proteins as "exchange hubs" for the signaling proteins for their migration from the subcortical cytosol to the membrane. (frontiersin.org)
Repertoire2
- Genetic drift and selective forces have shaped the individual structure of a given receptor gene but also of the species-specific receptor repertoire - a process that is still ongoing. (springer.com)
- The thymic selection of the human T-cell receptor repertoire releases polyspecific receptors with the ability to recognize and respond to peptides from unrelated viruses. (elifesciences.org)
Protein15
- Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene. (wikipedia.org)
- In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. (wikipedia.org)
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3 PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3 This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
- The hemolytic Group A Streptococcus (GAS) possesses the Shr protein which as noted above, participates in iron acquisition by obtaining heme from host hemoglobin and delivering it to the adjacent receptor on the surface, Shp. (tcdb.org)
- Schioth HB, Fredriksson R (2005) The GRAFS classification system of G-protein coupled receptors in comparative perspective. (springer.com)
- Nordstrom KJ, Sallman Almen M, Edstam M et al (2011) Independent HHsearch, Needleman-Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families. (springer.com)
- The protein encoded by this gene may be involved in cell adhesion during neurodegeneration. (hindlish.com)
- The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function. (elifesciences.org)
- Polymorphisms in the gene coding for the adhesion G-protein coupled receptor LPHN3 are a risk factor for attention-deficit/hyperactivity disorder (ADHD). (hal.science)
- BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (novusbio.com)
- Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene . (wikidoc.org)
- This gene encodes MC 3 , a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. (wikidoc.org)
- The receptor is a G-protein coupled receptor , which activates the G protein G s . [2] . (wikidoc.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human G Protein Coupled Estrogen Receptor 1 (GPER) in serum, plasma, tissue homogenates and other biological fluids. (allelisakits.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human G Protein Coupled Estrogen Receptor 1 (GPER) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (allelisakits.com)
Putative4
- Three GPCRs clustered with recently identified putative CHH receptors (CHHRs), and differential expression over the molt cycle suggests that they are associated with ecdysteroidogenesis regulation. (biomedcentral.com)
- Two putative Corazonin receptors showed much higher expression in the YOs compared with all other GPCRs, suggesting an important role in molt regulation. (biomedcentral.com)
- Three putative CHH receptors were identified and could include an MIH receptor whose activation negatively regulates molting. (biomedcentral.com)
- We have identified 169 gene products in the Ciona genome that code for putative GPCRs. (biomedcentral.com)
Neural1
- Dr Bibha Choudhary, Manipal Inst Regenerative Med, discussed loss of type-II TGF-β receptor in neural crest stem cells leading to cardiovascular malformation and aneurysm. (ifcbiol.com)
Transduction2
- Latrophilins may function in both cell adhesion and signal transduction. (wikipedia.org)
- Journal of Receptor and Signal Transduction Research. (wikipedia.org)
Subunits2
- Nogo-A receptor (NgR1) and subunits of ionotropic glutamate AMPA receptor (GluR1-GluR4) were among the most interesting Olfm1 -interacting partners. (nih.gov)
- Microfluorimetric experiments using a variety of modulators of the P2X selleckchem subunits revealed the presence of different functional P2X receptors in the axodendritic fibres. (peptidescost.com)
Estrogen receptor2
- Taken together this suggests that an estrogen receptor agonist might be an effective autism therapy in this sub-group. (epiphanyasd.com)
- If not you would either need an estrogen receptor agonist that is cleverly developed to be brain specific, or take the much easier route of delivering an existing agonist direct to the brain, which may also be possible. (epiphanyasd.com)
Orthologs1
- Orthologs of receptors that were found to be involved in molt regulation in insects were also identified, including LGR3 and Corazonin receptor, the latter of which was expressed at much higher level than all other receptors, suggesting a key role in YO regulation. (biomedcentral.com)
Pathway1
- We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)
AMPA1
- 2018). Deletion of in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. (tcdb.org)
Agonist1
- The use of the synthetic agonist alpha,beta-meATP and the antagonist Ip(5)I revealed the activation of functional P2X1 and P2X3 receptors. (peptidescost.com)
Attention deficit1
- A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD). (wikipedia.org)
Susceptibility1
- Dr M Muenke, NIH, Bethesda, USA, demonstrated that a minimal critical region of ~327 kb within the latrophilin 3 gene was involved in susceptibility to the disease and that a variant confers protection against the disorder. (ifcbiol.com)
Genome1
- The genome of the protochordate Ciona intestinalis has a compact size with an ancestral complement of many diversified gene families of vertebrates and is a good model system for studying protochordate to vertebrate diversification. (biomedcentral.com)
Tissues3
- We focus our attention on the genes that are expressed in RGCs and eye angle tissues. (nih.gov)
- Olfactomedin 1 (Olfm1) and the closely related genes Olfactomedin 2 (Olfm2) and Olfactomedin 3 (Olfm3) show overlapping expression patterns demonstrating preferential expression in the developing and adult neuronal tissues. (nih.gov)
- Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)
Glutamate1
- Phylogenetic analysis classified 49 as class A (Rhodopsin-like receptor), 35 as class B (Secretin receptor), and 9 as class C (metabotropic glutamate). (biomedcentral.com)
Expression4
- Our molecular assessment revealed that AGEs activate the RAGE-NF-κB signaling, which then recruits the NF-κB subunit p65 to the RAGE promoter and consequently enhances RAGE transcription, thereby forming a positive feedback loop between the NF-κB signaling and RAGE expression. (bvsalud.org)
- We will also look at how e strogen receptor expression may help explain why more males have autism. (epiphanyasd.com)
- Here, we find that persistent mtDNA stress is not associated with basally activated NF-κB signalling or interferon gene expression typical of an acute antiviral response. (regenerativemedicine.net)
- Distribution and functional expression of P2X receptors were analyzed in mouse cerebellum axodendritic fibres, using different experimental approaches such as RT-PCR, western blot, immunochemistry, microfluorimetric experiments and exocytotic studies. (peptidescost.com)
Inhibition1
- Increased NF-κB signaling ultimately upregulated Caveolin-1, promoting LDL transcytosis, and inhibition of RAGE suppressed AGE-induced LDL transcytosis. (bvsalud.org)
Polymorphisms1
- Studies performed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) , found that two specific polymorphisms in the MC3R gene may be associated with pediatric obesity and greater body mass because of greater energy intake. (wikidoc.org)
Regulation3
- In the first lecture Dr S Galande, NCCS, discussed the third dimension of gene regulation by a global chromatin organizer and transcription factor, SATB1. (ifcbiol.com)
- In this session Dr R Tuli, NBRI, gave a lucid overview of nucleosomal organization, histone modifications and regulation of gene activity. (ifcbiol.com)
- Mice deficient for this gene have increased fat mass despite decreased food intake suggesting a role for this gene product in the regulation of energy homeostasis. (wikidoc.org)
Activation1
- Activation of functional P2X4 receptors is observed when stimulated in the presence of ivermectin. (peptidescost.com)
Mutation1
- Mutation in the TENM3/ODZ3 gene in humans has been associated with the eye condition, microphthalmia. (wikipedia.org)
Sequence1
- These processes have left footprints in the genomic sequence that can be detected by bioinformatic methods and may help to interpret receptor function in the light of a given species in its environment. (springer.com)
Function2
- FLRT family members may function in cell adhesion and / or receptor signalling. (hindlish.com)
- This requires parallel studies on genes that are important for the function of the retina, the optic nerve and aqueous humor outflow system in the normal eye. (nih.gov)
Human2
- Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
- It also denotes the human gene encoding the receptor. (wikidoc.org)
Role1
- It's not that genes don't matter at all, but it turns out that your microbes have this very important role in shaping you and the food that you eat. (pullquote.com)
Domains1
- HoloNEAT1 also provided heme to apoNEAT2 by a fast and reversible process, the first transfer observed between isolated NEAT domains of the same receptor. (tcdb.org)
Found1
- Myocilin (MYOC) was the first gene in which identified mutations were found to cause glaucoma. (nih.gov)
Analysis1
- Immunochemistry analysis of tissular and cellular location of P2X1-4,7 receptors confirmed their presence and unequal distribution between somas and axodendritic prolongations. (peptidescost.com)
Results2
- RESULTS: RNA sequencing data were available for 279 patients, of which 74 (26.5%) were hormone receptor (HR)-negative, thus triple-negative breast cancer (TNBC). (bvsalud.org)
- Our results show that drugs targeting dopamine receptors appear to elicit similar effects on locomotion in zebrafish larvae and mammals. (hal.science)
Research1
- Another main area of our research is the identification of new genes involved in glaucoma. (nih.gov)
Cell1
- Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. (hindlish.com)
Functions1
- Toll-like receptors (TLRs) control immune functions. (tcdb.org)