• protein
  • These lymphomas show immunopositivity for ALK protein in 70% of cases. (wikipedia.org)
  • CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. (wikipedia.org)
  • The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. (wikipedia.org)
  • Along with the placenta, the expression of this protein has also been observed in human choriocarcinoma cell lines which have been derived from trophoblastic tumours found in the placenta. (wikipedia.org)
  • Multiple mechanisms are likely to be involved, but proteasome inhibition may prevent degradation of pro-apoptotic factors such as the p53 protein, permitting activation of programmed cell death in neoplastic cells dependent upon suppression of pro-apoptotic pathways. (wikipedia.org)
  • gene
  • Specifically, he showed that apoptosis, or programmed cell death, was the predominant mechanism through which imatinib eliminates leukemic cells, that leukemic animals could be cured using imatinib, and that resistance to imatinib could be mediated by gene amplification of BCR-ABL1. (wikipedia.org)
  • Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. (wikipedia.org)
  • The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2 and coding for the catalytic domain, is fused to the 5' portion of NPM from chromosome 5. (wikipedia.org)
  • The EML4-ALK fusion gene is responsible for approximately 3-5% of non-small-cell lung cancer(NSCLC). (wikipedia.org)
  • squamous cell carc
  • Anaplastic carcinoma is a general term for a malignant neoplasm arising from the uncontrolled proliferation of transformed cells of epithelial origin, or showing some epithelial characteristics, but that reveal no cytological or architectural features associated with more differentiated tumors, such as the glandular formation or special cellular junctions that are typical of adenocarcinoma and squamous cell carcinoma, respectively. (wikipedia.org)
  • carcinoma
  • Ross CW, Hanson CA, Schnitzer B: CD30 (Ki-1)-positive, anaplastic large cell lymphoma mimicking gastrointestinal carcinoma. (springer.com)
  • It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. (wikipedia.org)
  • Along with that, there has also been an up-regulation of mRNA levels in human breast cancer cells and testicular carcinoma tissues which reveals that NFE2L3 plays a role in inducing carcinogenesis. (wikipedia.org)
  • morphologic
  • Morphologic variants include the following types: Common (featuring a predominance of hallmark cells) Small-cell (featuring smaller cells with the same immunophenotype as the hallmark cells) Lymphohistiocytic Sarcomatoid Signet ring The hallmark cells (and variants) show immunopositivity for CD30 (also known as Ki-1). (wikipedia.org)
  • Agnarsson BA, Kadin ME: Ki-1 positive large cell lymphoma: A morphologic and immunologic study of 19 cases. (springer.com)
  • induces
  • Interleukin 33 (IL-33) induces IL-9 expression and secretion in T cells, which was confirmed by the results obtained in mice by using Human in vitrosystem. (wikipedia.org)
  • lymph nodes
  • After the lymph nodes shrink again or the disease gets less bulky, we typically offer patients an autologous stem cell transplantation procedure and can salvage probably about 50 percent of relapsed patients. (lymphoma.org)
  • CHOP
  • Unfortunately for T-cell lymphomas, we do not have the supplemental biologic therapies, such as Rituxan, that are now the standard of care for the B-cell lymphomas, so CHOP alone given on a 21-day basis for six to eight cycles, is still the standard of care. (lymphoma.org)
  • treatment
  • 1) In experimental models of testicular inflammation, mast cells were present in 10-fold greater numbers and showed signs of activation, and (2) Treatment with drugs which stabilize mast cell activation has proved beneficial in treating some types of male infertility. (wikipedia.org)
  • apoptosis
  • It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. (wikipedia.org)
  • This cytokine stimulates cell proliferation and prevents apoptosis. (wikipedia.org)
  • known
  • it has what is known as a jackhammer effect, which will cause it to expand the pocket and make it slightly larger than the original pocket that we made for that implant. (cancernetwork.com)
  • Interleukin 9, also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins. (wikipedia.org)
  • belongs
  • PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. (wikipedia.org)