• carcinoma
  • Ross CW, Hanson CA, Schnitzer B: CD30 (Ki-1)-positive, anaplastic large cell lymphoma mimicking gastrointestinal carcinoma. (springer.com)
  • Even within lymph nodes, the involvement can be clearly sinusoidal and may mimic anaplastic carcinoma or melanoma in extremely rare cases. (clinicaladvisor.com)
  • It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. (wikipedia.org)
  • Anaplastic carcinoma is a general term for a malignant neoplasm arising from the uncontrolled proliferation of transformed cells of epithelial origin, or showing some epithelial characteristics, but that reveal no cytological or architectural features associated with more differentiated tumors, such as the glandular formation or special cellular junctions that are typical of adenocarcinoma and squamous cell carcinoma, respectively. (wikipedia.org)
  • Along with that, there has also been an up-regulation of mRNA levels in human breast cancer cells and testicular carcinoma tissues which reveals that NFE2L3 plays a role in inducing carcinogenesis. (wikipedia.org)
  • gene
  • It can be divided into two major subtypes, based on the presence or absence of a chromosome rearrangement involving the gene ALK , referred to as 'ALK+' or 'ALK‑' anaplastic largecell lymphoma, respectively. (b-s-h.org.uk)
  • Dr Nicole Prutsch and colleagues used a mouse model of anaplastic largecell lymphoma in which the Tyk2 gene was deleted in T cells. (b-s-h.org.uk)
  • As the mice developed lymphoma, those in which Tyk2 had been deleted survived significantly longer than those which had the normal Tyk2 gene. (b-s-h.org.uk)
  • In addition, human lymphoma cell lines in which the TYK2 gene was either deleted or switched off grew significantly slower than cell lines with a normal TYK2 gene. (b-s-h.org.uk)
  • Specifically, he showed that apoptosis, or programmed cell death, was the predominant mechanism through which imatinib eliminates leukemic cells, that leukemic animals could be cured using imatinib, and that resistance to imatinib could be mediated by gene amplification of BCR-ABL1. (wikipedia.org)
  • Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. (wikipedia.org)
  • The EML4-ALK fusion gene is responsible for approximately 3-5% of non-small-cell lung cancer(NSCLC). (wikipedia.org)
  • inhibitors
  • Prof Kenner says: "We look forward to TYK2 inhibitors, which are currently being developed for treating immunological diseases, being available, since we urgently need better treatments for rare lymphomas. (b-s-h.org.uk)
  • PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. (wikipedia.org)
  • lymph nodes
  • After the lymph nodes shrink again or the disease gets less bulky, we typically offer patients an autologous stem cell transplantation procedure and can salvage probably about 50 percent of relapsed patients. (lymphoma.org)
  • Drugs
  • RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. (clinicaltrials.gov)
  • Drugs which block TYK2 also reduced the survival and growth of human cell lines representing both ALK+ and ALK‑ anaplastic largecell lymphoma. (b-s-h.org.uk)
  • 1) In experimental models of testicular inflammation, mast cells were present in 10-fold greater numbers and showed signs of activation, and (2) Treatment with drugs which stabilize mast cell activation has proved beneficial in treating some types of male infertility. (wikipedia.org)
  • induces
  • Interleukin 33 (IL-33) induces IL-9 expression and secretion in T cells, which was confirmed by the results obtained in mice by using Human in vitrosystem. (wikipedia.org)
  • CHOP
  • Unfortunately for T-cell lymphomas, we do not have the supplemental biologic therapies, such as Rituxan, that are now the standard of care for the B-cell lymphomas, so CHOP alone given on a 21-day basis for six to eight cycles, is still the standard of care. (lymphoma.org)
  • tumours
  • Along with the placenta, the expression of this protein has also been observed in human choriocarcinoma cell lines which have been derived from trophoblastic tumours found in the placenta. (wikipedia.org)
  • type
  • The giant cell-rich type is characterized by several multinucleated elements, often provided with Reed-Sternberg-like features and prominent intrasinusoidal diffusion [ 1 , 5 , 15 , 16 ]. (hindawi.com)
  • Occasional examples are of null (neither T nor B) cell type. (wikipedia.org)
  • According to the FDA, the data so far suggest that this type of lymphoma occurs more frequently after implantation of textured-surface breast implants vs smooth-surface implants. (cancernetwork.com)
  • A special type of Reed-Sternberg cells (RSCs) is the lacunar histiocyte, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces (called lacunae) between them. (wikipedia.org)
  • Basigin interacts with the fourth C-type lectin domain in the receptor Endo180 to form a molecular epithelial-mesenchymal transition suppressor complex that if disrupted results in the induction of invasive prostate epithelial cell behavior associated with poor prostate cancer survival. (wikipedia.org)
  • apoptosis
  • It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. (wikipedia.org)
  • This cytokine stimulates cell proliferation and prevents apoptosis. (wikipedia.org)
  • abundant cytoplasm
  • The hallmark cells are of medium size and feature abundant cytoplasm (which may be clear, amphophilic or eosinophilic), kidney shaped nuclei, and a paranuclear eosinophilic region. (wikipedia.org)