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ProteinAntibodiesAutophagyCellsFunction

Protein4

• Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. (wikipedia.org)
• Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. (wikipedia.org)
• The protein encoded by this gene is a member of a family of membrane glycoproteins. (wikipedia.org)
• Online Mendelian Inheritance in Man (OMIM): Lysosome-associated membrane protein 2 - 309060 Konecki DS, Foetisch K, Zimmer KP, Schlotter M, Lichter-Konecki U (October 1995). (wikipedia.org)

Antibodies6

• Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis. (wikipedia.org)
• Find LAMP2 Antibodies with a specific Grade. (antibodies-online.com)
• Find LAMP2 Antibodies for a variety of species such as anti-Human LAMP2, anti-Mouse LAMP2, anti-Rat LAMP2. (antibodies-online.com)
• Find LAMP2 Antibodies validated for a specific application such as WB, ELISA, FACS, IHC. (antibodies-online.com)
• Find available monoclonal or polyclonal LAMP2 Antibodies. (antibodies-online.com)
• Find LAMP2 Antibodies with a specific conjugate such as Biotin, FITC, PE. (antibodies-online.com)

Autophagy2

• LAMP-2A is the receptor for chaperone-mediated autophagy. (wikipedia.org)
• Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). (nih.gov)

Cells7

• Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
• Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly metastatic cancer such as colon cancer and melanoma. (wikipedia.org)
• They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
• LAMP2, along with LAMP1, interact with E-selectin and galectins to mediate the adhesion of some cancer cells to the ECM. (wikipedia.org)
• It has also been shown that the down-regulation of LAMP2 could both reduce the resistance of breast cancer cells to the paclitaxel and could inhibit cell proliferation in multiple myeloma cells. (wikipedia.org)
• In a study of glial tumors, the cell membranes of glial and endothelial cells were found to contain LAMP1 and LAMP2, while YKL-40 (a different glycoprotein) was found in the cytoplasm. (wikipedia.org)
• Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). (nih.gov)

Function1

• It may also function in the protection, maintenance, and adhesion of the lysosome. (wikipedia.org)