• LMNA
  • Mutations associated with FPL have been reported in LMNA (lamin A/C), PPARG (PPARĪ³), AKT2 (AKT serine/threonine kinase 2), PLIN1 (perilipin-1), and CIDEC (cell-death-inducing DFFA-like effector B). Six types (1-6) have been described. (wikipedia.org)
  • Type 2 (Dunnigan Variety, FPL2) is the most common form and is due to mutations in the LMNA gene. (wikipedia.org)
  • This review summarizes the clinical characteristics of this disease, the underlying mutation in the lamin A (LMNA) gene that results in this phenotype and the recent advances in treatment strategies. (spotidoc.com)
  • FPLD results from mutations in LMNA gene, which is the gene that encodes nuclear lamins A and C. Familial partial lipodystrophy Hegele, RA (December 2000). (wikipedia.org)
  • hypertension
  • FPLD recapitulates the main metabolic attributes of the insulin resistance syndrome, including central obesity, hyperinsulinemia, glucose intolerance and diabetes usually type 2, dyslipidemia, hypertension, and early endpoints of atherosclerosis. (wikipedia.org)