Milk proteins with a nutritional role in the infant: α-lactalbumin and bioactive peptides. (ku.dk)
Lactalbumin is produced by precipitating whey proteins. (adpi.org)
A theoretical approach to possible biological functions of the milk-whey proteins, alpha-lactalbumin and beta-lactoglobulin. (ncsu.edu)
Considered a byproduct, the globe-like proteins contained in whey include lactalbumin, lactoferrin and immunoglobulins . (livestrong.com)
HAMLET (Human Alpha-lactalbumin Made Lethal to Tumour cells) is a compound of proteins and lipids (fats and fat-like substances) from breast milk. (lu.se)
Lysozyme2
The Zn2+ ion binds specifically in the "cleft" of alpha-lactalbumin (the region which forms the active site of the homologous protein lysozyme). (ox.ac.uk)
Fig. 1 Crystal structures of human -lactal- bumin (PDB file 1HML), lysozyme (2LZT) and ribonuclease A (7RSA) showing potentially long-lived internal water molecules, disul- fide bonds (yellow), and the Ca2+ ion (green) in -lactalbumin. (lu.se)
Oleic acid5
Complexes of the milk protein, α-lactalbumin, and the fatty acid, oleic acid, have previously been shown to be cytotoxic. (teagasc.ie)
Complexes of α-lactalbumin and five different fatty acids (vaccenic, linoleic, palmitoleic, stearic, and elaidic acid) were prepared and compared to those formed with oleic acid. (teagasc.ie)
The cytotoxic effect of complexes between α-lactalbumin and linoleic acid, vaccenic acid, or oleic acid was further investigated using flow cytometry and found to induce cell death resembling apoptosis on Jurkat cells. (teagasc.ie)
The cytotoxicity of all the variants is similar to that previously determined for α-lactalbumin/oleic acid complexes. (teagasc.ie)
LEthal to Tumour cells protein, or HAMLET for short, is a protein complex found at high levels in human breast milk made up of the protein alpha-lactalbumin and a fatty acid, oleic acid. (thenakedscientists.com)
Whey protein2
Lactalbumin, also known as "whey protein", is the albumin contained in milk and obtained from whey. (wikipedia.org)
Targeted small scientific studies suggest that certain types of lactalbumin (whey protein) may improve immune responsiveness and increase levels of glutathione systemically in animals and which apparently possess antiviral (against viruses), anti-apoptotic (impede cell death) and anti-tumor (against cancers or tumors) activities in humans, but larger and better studies are needed to confirm these attributions. (wikipedia.org)
Possesses1
Alpha-lactalbumin possesses a distinct zinc binding site. (ox.ac.uk)
Cytotoxic1
Practical applications: Cytotoxic complexes of α-lactalbumin and several different fatty acids could be produced. (teagasc.ie)
Amino acid1
1. A double lumen jejunal perfusion technique has been used in man to study the effect of peptide chain length on absorption of amino acid nitrogen from two partial enzymic hydrolysates of lactalbumin. (portlandpress.com)
Milk protein1
Our objective was to examine whether elevated α-lactalbumin (αlac) protein intake compared to elevated supra sustained milk protein (SSP) and sustained milk protein (SP) intake results into a difference in body weight and body composition over a 6-month energy-restriction intervention. (edu.au)
Calcium1
aminés, en calcium et en phosphore dans le plasma et le tube digestif chez les rats. (edpsciences.org)
Alpha11
The murine alpha-lactalbumin-encoding gene (m alpha La) was isolated and completely sequenced. (eurekamag.com)
It has been proposed that the binding of Zn2+ to alpha-lactalbumin switches the conformation to one akin to a state intermediate in the folding of the protein. (ox.ac.uk)
However, the high resolution x-ray crystal structure of human alpha-lactalbumin-Zn2+ complex at 1.7-A resolution (pH 7.6) does not reveal any significant change in conformation from the native state. (ox.ac.uk)
Rapid collapse and slow structural reorganisation during the refolding of bovine alpha-lactalbumin. (ox.ac.uk)
The refolding of bovine alpha-lactalbumin (BLA) from its chemically denatured state in 6 M GuHCl has been investigated by a variety of complementary biophysical approaches. (ox.ac.uk)
We can make the same complex with cows' milk alpha-lactalbumin. (thenakedscientists.com)
Multimeric alpha-lactalbumin killed all transformed, embryonic, and lymphoid cells tested but spared mature epithelial elements. (lu.se)
Finally, analysis of the mechanism by which multimeric alpha-lactalbumin induces apoptosis in transformed epithelial cells could lead to the design of antitumor agents. (lu.se)
The effects of alpha-lactalbumin and glycomacropeptide on the association of CaCo-2 cells by enteropathogenic Escherichia coli, Salmonella typhimurium and Shigella flexneri. (webmd.com)
Found1
Lactalbumin is found in the milk of many mammals. (wikipedia.org)
People2
This graph shows the total number of publications written about "Lactalbumin" by people in UAMS Profiles by year, and whether "Lactalbumin" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Lactalbumin" by people in Profiles over the past ten years. (uams.edu)
Made lethal to tumor cells2
15. Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells). (nih.gov)
Two proteins isolated from breast milk are showing promise as antibiotics: lactoferrin, which is also active against viruses and fungal infections as well as bacteria, and HAMLET - Human Alpha-lactalbumin Made Lethal to Tumor Cells, which is active against tumour cells. (dailymail.co.uk)
Casein3
Quantitative PCR analysis revealed ∼50% reduction in the expression of key lactogenesis mammary genes including whey acid protein, α-lactalbumin, and β-casein. (nih.gov)
The ability of noncovalently immobilized nisin to withstand exchange by the milk proteins bovine serum albumin, β-lactoglobulin, α-lactalbumin, and β-casein on surfaces that had been silanized with dichlorodiethylsilane to exhibit high and low. (oregonstate.edu)
The IgA antibodies were measured in serum against gluten, gliadin, lactoglobulin, lactalbumin, casein and ovalbumin in patients with MS and controls using ELISA technique. (greenmedinfo.com)
Milk6
Lactalbumin is found in the milk of many mammals. (wikipedia.org)
α-lactalbumin is a known immunomodulator present in human milk. (wyethnutritionsc.org)
In milk and egg, being allergic to only α-lactalbumin, β-lactoglobulin, or ovalbumin may indicate that you'll be able to tolerate baked forms of milk and eggs but not raw forms. (thermofisher.com)
18. Divergent Anticancer Activity of Free and Formulated Camel Milk α-Lactalbumin. (nih.gov)
To achieve these aims, we first fitted a mixed Bayesian multitrait genomic model to infer the genomic correlations among 6 milk nitrogen fractions [4 caseins (CN), namely κ-, β-, α S1 -, and α S2 -CN, and 2 whey proteins, namely β-lactoglobulin (β-LG) and α-lactalbumin (α-LA)], in a population of 989 Italian Brown Swiss cows. (nih.gov)
This gene encodes alpha-lactalbumin, a principal protein of milk. (nih.gov)
Bovine4
11. Molten globule of bovine alpha-lactalbumin at neutral pH induced by heat, trifluoroethanol, and oleic acid: a comparative analysis by circular dichroism spectroscopy and limited proteolysis. (nih.gov)
17. Comparative study on heat stability of camel and bovine apo and holo alpha-lactalbumin. (nih.gov)
19. [Structure and Anti-Tumor Activity of Bovine α-Lactalbumin after Binding Linoleic Acid]. (nih.gov)
The dendrimer was found to be superior to the imidazoquinoline monomer in inducing high titers of high-affinity antibodies to bovine α-lactalbumin. (ku.edu)
HAMLET4
Native α-lactalbumin (Protein Data Bank ID: 1B9O) undergoes a depletion of calcium and binds to oleic acids to form HAMLET. (medscape.com)
While partial unfolding of α-lactalbumin is an essential feature of HAMLET formation, the structure of the HAMLET complex is not fully understood. (medscape.com)
12. No need to be HAMLET or BAMLET to interact with histones: binding of monomeric alpha-lactalbumin to histones and basic poly-amino acids. (nih.gov)
A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. (nih.gov)
Protein2
Alpha-lactalbumin and beta-lactoglobulin form the major protein constituents of whey. (justia.com)
natural source of lactalbumin and immunoglobulinsnnProtein Powder is a highly efficient, advanced protein enhancement product. (fairwaymarket.com)
Apoptosis in tumor1
7. Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. (nih.gov)
Proteins1
Elizabeth is sensitized to α-lactalbumin proteins. (thermofisher.com)
Lactoglobulin2
Because on an industrial scale a complete separation of alpha-lactalbumin and beta-lactoglobulin is difficult, the implication is that cost effective alpha-lactalbumin preparations will contain beta-lactoglobulin as well. (justia.com)
So obviously any contamination of the alpha-lactalbumin preparation with beta-lactoglobulin, will dramatically lower the Trp/LNAA ratio of the final product. (justia.com)
Hydrolysates1
As mentioned, alpha-lactalbumin as well as its hydrolysates have gained popularity as a safe option to enhance plasma tryptophan levels. (justia.com)
LACTOSE SYNTHASE1
Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. (nih.gov)
Tumor1
9. Heat-treatment method for producing fatty acid-bound alpha-lactalbumin that induces tumor cell death. (nih.gov)
Molten2
Probing subtle differences in the hydrogen exchange behavior of variants of the human alpha-lactalbumin molten globule using mass spectrometry. (ox.ac.uk)
The hydrogen-exchange behavior of the low-pH molten globule of human alpha-lactalbumin, containing all four disulfides, has been examined and compared with that of a single disulfide variant, [28-111] alpha-lactalbumin, and of a series of proline variants of [28-111] alpha-lactalbumin. (ox.ac.uk)
Binds1
As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. (nih.gov)
Tryptophan3
Alpha-lactalbumin and tryptophan have been tested for various measures of overnight recovery, sleep quality and quantity, morning wakefulness and cognitive performance. (milkspecialties.com)
Alpha-lactalbumin preparations are readily available and have a relatively high tryptophan concentration. (justia.com)
However, the use of alpha-lactalbumin as a starting point for tryptophan-rich preparations, comes with disadvantages in terms of maximal Trp/LNAA ratios and costs. (justia.com)
Human2
[ 33 ] The crystal structure of human α-lactalbumin [ 34 ] reveals a large α-helical domain with three major α-helices and two short 3 10 -helices. (medscape.com)
14. Gastric digestion of α-lactalbumin in adult human subjects using capsule endoscopy and nasogastric tube sampling. (nih.gov)
Activity1
[ 9 , 26 ] However, native α-lactalbumin was shown to lack tumoricidal activity and no post-translational modifications explaining the new activity were found. (medscape.com)
Complex1
1. Structure and stability analysis of cytotoxic complex of camel α-lactalbumin and unsaturated fatty acids produced at high temperature. (nih.gov)