• Since then, a variety of nitroxide spin labels have enjoyed widespread use for the study of macromolecular structure and dynamics because of their stability and simple EPR signal. (wikipedia.org)
  • As shown in Figure 1, we offer two new nitroxide spin labels, TEMPO Azide (1) and TEMPO-TEG Azide (2), compatible with Click Chemistry for site directed spin labelling (SDSL). (glenresearch.com)
  • Site-directed spin labeling (SDSL) is a technique for investigating the structure and local dynamics of proteins using electron spin resonance. (wikipedia.org)
  • The theory of SDSL is based on the specific reaction of spin labels with amino acids. (wikipedia.org)
  • Site-directed spin labeling (SDSL) was pioneered in the laboratory of Dr. W.L. Hubbell. (wikipedia.org)
  • In SDSL, sites for attachment of spin labels are introduced into recombinantly expressed proteins by site-directed mutagenesis. (wikipedia.org)
  • Electron Paramagnetic Resonance (EPR) spectroscopy is a sensitive technique for the characterization of materials and has been used to determine the molecular environment of spin labels 1,2 , including the location, orientation and motion of spin labels within biomolecules. (glenresearch.com)
  • Consequently, spin labels localized within biomolecules can act as bioorthogonal chemical reporters for studying the structure and dynamics of biomolecules using EPR spectroscopy. (glenresearch.com)
  • Spin labels can be easily incorporated into biomolecules by covalent attachment using Click Chemistry. (glenresearch.com)
  • A major assumption in arterial spin labeling (ASL) MRI perfusion quantification is the time course of the signal on arrival in the capillary network. (ox.ac.uk)
  • Spin labels are a unique molecular reporter, in that they are paramagnetic (contain an unpaired electron). (wikipedia.org)
  • Recently, the spin label 2,2,6,6- tetramethylpiperidine 1-oxyl (TEMPO) has been used to determine RNA structure using paramagnetic relaxation enhancement (PRE). (glenresearch.com)
  • Here, we solved this problem and present the molecular design of a dual label (DL) compound comprising a highly fluorescent dye together with an EPR spin probe, which also renders the fluorescence lifetime to be concentration sensitive. (fu-berlin.de)
  • Because spin labels are exquisitely sensitive to motion, this has profound effects on its EPR spectrum. (wikipedia.org)
  • The aim of my main research is to develop and validate MRI pulse sequences and post-processing tools for assessment of perfusion-related parameters using gd-based contrast agents (Dynamic Susceptibility Contrast MRI - DSC-MRI) and non-invasive methods (Arterial Spin Labelling - ASL and Intra Voxel Incoherent Motion - IVIM). (lu.se)
  • Spin labelling is a chemical technique that enables the integration of a molecule containing an unpaired electron into another framework for study. (bridge12.com)
  • The Assembly of a Multisubunit Photosynthetic Membrane Protein Complex: A Site-Specific Spin Labeling EPR Spectroscopic Study of the PsaC Subunit in Photosystem I". Biochemistry. (wikipedia.org)
  • In this study ASL data acquired whilst the label was still within larger arteries was used to compare models of label dispersion. (ox.ac.uk)
  • The wide variety of alkyne modifications already available from Glen Research offers a diverse set of options for site-specific conjugation of spin labels to oligonucleotides. (glenresearch.com)
  • Once incorporated into the protein, a spin label's motions are dictated by its local environment. (wikipedia.org)
  • By signing up to the SPIN Weekly newsletter you agree to receive electronic communications from SPIN that may sometimes include advertisements or sponsored content. (spin.com)
  • Functional groups contained within the spin label determine their specificity. (wikipedia.org)
  • Copies of this report have been sent to employee and management representatives at Superior Label Systems, Inc. and the OSHA Regional Office. (cdc.gov)
  • These two avenues came together in the development of arterial spin labeling (ASL) MRI techniques to measure regional cerebral blood flow. (nih.gov)
  • Optimal design of pulsed arterial spin labeling MRI experiments. (ox.ac.uk)
  • Quantitative measurement of cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI requires the acquisition of multiple inversion times (TIs) and the application of an appropriate kinetic model. (ox.ac.uk)
  • Here, optimal sampling schedule (OSS) design techniques, based on the Fisher Information approach, are applied in order to derive an optimal sampling scheme for pulsed arterial spin labeling (PASL) experiments. (ox.ac.uk)
  • Additionally, a concept that includes spin-labeled proteins and examination using modern pulsed EPR is introduced, which allows for a precise mapping of light-induced conformational changes. (frontiersin.org)
  • Data Labeling and Annotation (DL&A) play pivotal roles in unlocking these capabilities, facilitating accurate model training and bolstering the precision of AI applications in healthcare. (e-spincorp.com)
  • In summary, data labeling and annotation are foundational processes in AI for healthcare, playing crucial roles in accurate model training and bolstering the precision of AI applications. (e-spincorp.com)
  • The Assembly of a Multisubunit Photosynthetic Membrane Protein Complex: A Site-Specific Spin Labeling EPR Spectroscopic Study of the PsaC Subunit in Photosystem I". Biochemistry. (wikipedia.org)
  • Includes label insert and fold out insert. (discogs.com)
  • Data labeling enables the identification of specific structures or anomalies. (e-spincorp.com)
  • Spin City Now that these entrepreneurs have put a modern twist on the music industry, independent labels can stay in the game. (entrepreneur.com)
  • Since 2002, the founders of INgrooves , a digital media distribution and publishing company in San Francisco, have been bringing independent music labels up to speed by focusing on distribution through modern channels like online stores, video games and ringtones, and offering marketing, promotion and sync licensing services in the digital world. (entrepreneur.com)
  • E-SPIN Group is a leading provider of enterprise ICT solutions and value-added services. (e-spincorp.com)
  • 19. Inclusion complexes of cyclodextrins with nitroxide-based spin probes in aqueous solutions. (nih.gov)