• phenotype
  • Laser microdissection expression profiling of marginal edges of colorectal tumours reveals evidence of increased lactate metabolism in the aggressive phenotype. (abcam.com)
  • catalyses
  • As its name indicates, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) catalyses the conversion of glyceraldehyde 3-phosphate to D-glycerate 1,3-bisphosphate. (wikipedia.org)
  • poorer
  • It also catalyzes the dehydrogenation of 2-Hydroxybutyrate , but it is a much poorer substrate than lactate. (wikipedia.org)
  • catalyzes
  • Glyceraldehyde 3-phosphate dehydrogenase (abbreviated as GAPDH or less commonly as G3PDH) (EC 1.2.1.12) is an enzyme of ~37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. (wikipedia.org)
  • glycolysis
  • It converts pyruvate, the final product of glycolysis , to lactate when oxygen is absent or in short supply, and it performs the reverse reaction during the Cori cycle in the liver . (wikipedia.org)
  • aerobic
  • Pyruvic acid supplies energy to cells through the citric acid cycle (also known as the Krebs cycle) when oxygen is present (aerobic respiration), and alternatively ferments to produce lactate when oxygen is lacking (fermentation). (wikipedia.org)
  • oxygen
  • If insufficient oxygen is available, the acid is broken down anaerobically, creating lactate in animals and ethanol in plants and microorganisms (and carp). (wikipedia.org)
  • heart
  • Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases. (ebi.ac.uk)