OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
TobramycinGentamicinsAminoglycosidesAnti-Bacterial AgentsAmikacinKanamycinPseudomonas aeruginosaNetilmicinPseudomonas InfectionsAzlocillinTicarcillinCarbenicillinMicrobial Sensitivity TestsCystic FibrosisSisomicinPiperacillinColistinMoxalactamCeftazidimeDrug Resistance, MicrobialAdministration, InhalationFosfomycinDrug IncompatibilityAztreonamConjunctivitis, BacterialPenicillinsDrug SynergismCefamandoleEnterobacteriaceaeProvidenciaEncyclopedias as TopicHearing Loss
AntibioticSulfateGentamicinDropsInfectionsTobradexInhalationSerumTOBIAntimicrobialConcentrationsIntravenouslyParenteralOphthalmic SuspensionAminoglycosidesVancomycinAntibioticsDexamethasone OphthalmicTroughPharmacokinetics2023Anti-pseudomonalNephrotoxic effectsInfectionFluorometholoneIntravenous administrationPeakDoseAeruginosaCysticAssayBacteriaEfficacyDiscomfortClinicallyPatientsSensitivityPreparationsDrugsOfloxacinSolutionSubsequent
Antibiotic20
  • Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius that is used to treat various types of bacterial infections, particularly Gram-negative infections. (wikipedia.org)
  • Tobramycin ophthalmic solution, USP 0.3% is a sterile topical ophthalmic antibiotic formulation prepared specifically for topical therapy of external ophthalmic infections. (nih.gov)
  • Tobramycin is a water-soluble aminoglycoside antibiotic active against a wide variety of gram-negative and gram-positive ophthalmic pathogens. (nih.gov)
  • Tobramycin ophthalmic solution, 0.3% is a topical antibiotic indicated in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. (nih.gov)
  • Ofloxacin is a fluoroquinolone antibiotic and Tobramycin is an aminoglycoside antibiotic. (medicinenet.com)
  • Tobramycin ( Tobrex ) is an aminoglycoside antibiotic eye drop used to treat external infections of the eye caused by bacteria. (medicinenet.com)
  • Tobramycin is an aminoglycoside antibiotic that is used for treatment of infections of susceptible strains of aerobic gram-negative bacteria that are resistant to less-toxic antibiotics. (medscape.com)
  • Tobramycin is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. (nih.gov)
  • Antibiotic eye drops (tobramycin) is an eye-affecting agent. (healthtap.com)
  • Antibiotic medication Moxifloxacin & Tobramycin Eye Drops works by preventing the infection-causing germs from growing. (zexuspharma.com)
  • Tobramycin is an antibiotic that kills bacteria by preventing the synthesis of essential proteins that bacteria require to perform vital functions. (zexuspharma.com)
  • Tobramycin and fluorometholone are aminoglycoside antibiotic, which means it belongs to a group of medications known as aminoglycoside antibiotics. (eyerisvisioncare.com)
  • Tobramycin eye drops belong to a drug class also categorized as an antibiotic. (grevispharma.com)
  • Tobramycin, an antibiotic, functions by blocking the production of crucial proteins vital for the growth, reproduction, and multiplication of bacteria, ultimately leading to their eradication. (grevispharma.com)
  • To compare ofloxacin solution with a combination of fortified antibiotic cefazolin sodium and tobramycin sulfate solutions in the treatment of bacterial keratitis. (jamanetwork.com)
  • Hypothesis/Objective: The present study will test the hypothesis that administering a validated local dose of tobramycin injection in combination with systemic perioperative intravenous (IV) antibiotic prophylaxis will reduce the rate of deep surgical site infection (SSI) 1 year after open fracture fixation surgery. (uky.edu)
  • Specific Aims: Aim 1: Determine if a validated local dose of tobramycin (2 mg/mL) injection in combination with systemic perioperative IV antibiotic prophylaxis (weight based cefazolin or clindamycin if penicillin-allergic) will reduce the rate of deep SSI 1 year after open fracture fixation surgery. (uky.edu)
  • Tobramycin is an aminoglycoside antibiotic that works by killing bacteria. (bayviewrx.com)
  • Tobramycin is an antibiotic. (fr.nf)
  • In the present work , Tobramycin (TB), an aminoglycoside antibiotic that displays several undesirable side effects, has been encapsulated into cationic Eudragit®E100 (E100) NPs for the treatment of infections caused by Pseudomonas aeruginosa . (bvsalud.org)
Sulfate2
  • Stability of nafcillin sodium, oxacillin sodium, penicillin G potassium, penicillin G sodium and tobramycin sulfate in polyvinyl chloride drug reservoirs. (stabilis.org)
  • A Randomized Controlled Trial of Alternating Irrigation of Vancomycin HCl and Tobramycin Sulfate in Patients Undergoing Two-Stage Exchange Arthroplasty for Periprosthetic Joint Infection of Hip or Knee. (nyu.edu)
Gentamicin5
  • Bacterial susceptibility studies demonstrate that in some cases, microorganisms resistant to gentamicin retain susceptibility to tobramycin. (nih.gov)
  • A single case report describes development of a rash following inhaled tobramycin, in a patient who had developed a similar rash following a course of intravenous gentamicin and piperacillin-tazobactam [ 5 ]. (biomedcentral.com)
  • Tell your doctor if you are allergic to any aminoglycoside antibiotics (including gentamicin, streptomycin, tobramycin, others). (fr.nf)
  • Gentamicin and tobramycin have similar antimicrobial spectra against gram-negative bacilli, but tobramycin is more active against P. aeruginosa , and gentamicin is more active against Serratia marcescens . (msdmanuals.com)
  • Amikacin is frequently active against gentamicin - and tobramycin -resistant pathogens. (msdmanuals.com)
Drops20
  • Eye drops and ointments (tobramycin only, Tobrex, or combined with dexamethasone, sold as Tobradex) and nebulised formulations both have low systemic absorption. (wikipedia.org)
  • Tobrex eye drops are a 0.3% tobramycin sterile ophthalmic solution produced by Alcon Pharmaceuticals. (wikipedia.org)
  • Use tobramycin eye drops or ointment exactly as directed. (medlineplus.gov)
  • If you become pregnant while using tobramycin eye drops or eye ointment, call your doctor immediately. (medlineplus.gov)
  • Side effects associated with the use of tobramycin eye drops are mostly limited to the area(s) of application. (medicinenet.com)
  • Moxifloxacin 0.5%, Tobramycin 0.3% Eye Drops - Zeximox-T Eye Drops is an antibacterial eye drop that kills and prevents the growth of infection-causing bacteria. (zexuspharma.com)
  • How do the Moxifloxacin & Tobramycin Ophthalmic Drops Work? (zexuspharma.com)
  • Moxifloxacin & Tobramycin ophthalmic drops should be used in the dose and duration as advised by your doctor. (zexuspharma.com)
  • For how many days should I use moxifloxacin & tobramycin eye drops? (zexuspharma.com)
  • Does moxifloxacin & tobramycin eye drops cause blurry vision? (zexuspharma.com)
  • Moxifloxacin & Tobramycin eye drops might cause hazy vision and make things difficult for you. (zexuspharma.com)
  • Is it safe for pregnant women to use moxifloxacin and tobramycin eye drops? (zexuspharma.com)
  • Because moxifloxacin and tobramycin eye drops might have serious negative effects when used during pregnancy, pregnant women should see their doctor before using them. (zexuspharma.com)
  • How does moxifloxacin & tobramycin eye drops work? (zexuspharma.com)
  • Tobramycin and Dexamethasone eye drops for dogs and cats with bacterial eye infections. (californiapetpharmacy.com)
  • Tobramycin and Fluorometholone Eye Drops come with the brand name "Mahafluro - T" and are a combination of two medicines: Tobramycin and Fluorometholone Eye Drop which are used in the treatment of bacterial eye infections. (grevispharma.com)
  • Tobramycin and Fluorometholone Eye Drops serve as a remedy for bacterial eye infections. (grevispharma.com)
  • We have won many awards for our brilliant work and expertise in the manufacturing department thus we are considered as the best Tobramycin and Fluorometholone Eye Drops manufacturer and supplier in India. (grevispharma.com)
  • Now we are also offering our amazing business opportunities in Pan India with the help of our ophthalmic solutions and Tobramycin and Fluorometholone Eye Drops PCD Franchise. (grevispharma.com)
  • Use Tobramycin and Dexamethasone ophthalmic eye drops or ointment exactly as directed by your doctor. (fr.nf)
Infections11
  • Tobramycin, in its injectable form, is also indicated for various severe or life-threatening infections caused by susceptible strains: sepsis, meningitis, lower respiratory tract infections, intra-abdominal infections, skin infections, bone infections, and skin structure infections, complicated and recurrent urinary tract infections. (wikipedia.org)
  • Ophthalmic tobramycin is used to treat eye infections. (medlineplus.gov)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of tobramycin and other antibacterial drugs, tobramycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Ofloxacin and Tobramycin are antibiotics used to treat bacterial infections of the eyes. (medicinenet.com)
  • Tobramycin treats only bacterial eye infections and does not work for other types of eye infections. (medicinenet.com)
  • This solution is a combination Moxifloxacin & Tobramycin medicine that is used to treat eye infections. (zexuspharma.com)
  • Fluorometholone 0.1% with Tobramycin 0.3% Ophthalmic Suspension - Flurokick-T Eye Drop is used to treat or prevent infections in the eyes. (eyerisvisioncare.com)
  • Tobramycin is a drug that is used to treat infections. (eyerisvisioncare.com)
  • Furthermore, it is frequently used to treat severe infections caused by tobramycin sensitive micro-organisms in hospitalised patients [3]. (betasciencepress-publishing.com)
  • Tobramycin and Dexamethasone ophthalmic is used to treat bacterial infections or inflammation of the eyes. (fr.nf)
  • Do not use Tobramycin and Dexamethasone ophthalmic for mycobacterial infections of the eye. (fr.nf)
Tobradex2
  • Has the patient ever had an allergic reaction to tobramycin, Tobradex, or another aminoglycoside medication? (pushhealth.com)
  • Tobradex ophthalmic contains a combination of tobramycin and dexamethasone. (fr.nf)
Inhalation8
  • In a study published in the journal Chest, the researchers randomly assigned 167 patients to receive nebulized tobramycin inhalation solution (TIS) and 172 patients to receive placebo. (medscape.com)
  • Delivery of tobramycin by inhalation to the lungs of patients with cystic fibrosis (CF) who are infected with Pseudomonas aeruginosa has been proven to be effective and safe. (biomedcentral.com)
  • We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age. (biomedcentral.com)
  • Hypersensitivity reaction should be considered in patients who develop recurrent eosinophilia and deterioration of pulmonary function following the use of tobramycin by inhalation or by intravenous administration. (biomedcentral.com)
  • Tobramycin inhalation powder for P. aeruginosa infection in cystic fibrosis: The EVOLVE trial. (medicalletter.org)
  • Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: The EAGER trial. (medicalletter.org)
  • With the introduction of the TOBI® Podhaler™ (dry powder inhaler with tobramycin), pulmonary administraion of tobramycin is likely to become even more popular in the treatment of CF and non-CF bronchiectasis patients colonised with Psa, since dry powder inhalation is much more user-friendly [4]. (betasciencepress-publishing.com)
  • A 4-way crossover study was conducted in 12 volunteers with tobramycin and salbutamol intravenously and via inhalation. (chdr.nl)
Serum6
  • For these reasons parenteral tobramycin needs to be carefully dosed by body weight, and its serum concentration monitored. (wikipedia.org)
  • Tobramycin should be used with caution in premature and neonatal infants because of their renal immaturity and the resulting prolongation of serum half-life of the drug. (nih.gov)
  • Peak serum concentrations of tobramycin occur between 30 and 90 minutes after intramuscular administration. (nih.gov)
  • Inhaled tobramycin was not associated with detectable ototoxic or nephrotoxic effects or with accumulation of the drug in serum. (nih.gov)
  • The most frequently used method to quantify tobramycin in serum or plasma is with an immunoassay method. (betasciencepress-publishing.com)
  • Tobramycin therapy is optimised by drug monitoring but the compound lacks a chromophore group and it is, therefore, very challenging to determine its concentration in serum or plasma by standard high-performance liquid chromatography (HPLC) with UV detection. (betasciencepress-publishing.com)
TOBI1
  • Tobramycin administered by the TOBI Podhaler for persons with cystic fibrosis: a review. (medicalletter.org)
Antimicrobial3
  • Tobramycin is an aminoglycoside antimicrobial drug frequently used in anti-pseudomonal therapy in cystic fibrosis and non-cystic fibrosis bronchiectasis patients. (betasciencepress-publishing.com)
  • Tobramycin is an aminoglycoside antimicrobial drug and is the cornerstone in anti-Pseudomonas aeruginosa (Psa) therapy in Cystic Fibrosis (CF) and non-CF bronchiectasis patients [1,2]. (betasciencepress-publishing.com)
  • Binary Medical Nanofluids by Combination of Polymeric Eudragit Nanoparticles for Vehiculization of Tobramycin and Resveratrol: Antimicrobial, Hemotoxicity and Protein Corona Studies. (bvsalud.org)
Concentrations6
  • Other diuretics can also increase the risk for side effects because they raise tobramycin concentrations in the body fluids. (wikipedia.org)
  • The aerosol administration allows high concentrations of tobramycin to be delivered to the site of infection with limited systemic absorption. (biomedcentral.com)
  • However, immunoassays lack sensitivity to evaluate the lower concentrations of tobramycin for pharmacokinetic studies of for instance inhaled tobramycin. (betasciencepress-publishing.com)
  • However, a disadvantage of immunoassays for tobramycin is the limit of detection of 0.2 mg/L. Immunoassay methods are suitable to measure trough and peak concentrations of intravenously administered tobramycin, but they lack the sensitivity to evaluate lower concentrations of tobramycin for pharmacokinetic studies of, for instance, inhaled (dry powder) tobramycin. (betasciencepress-publishing.com)
  • This high variability of EBC drug concentrations seems to preclude EBC as a matrix for pharmacokinetic analysis of tobramycin and salbutamol. (chdr.nl)
  • This strategy provides the ability to tailor drug release kinetics from the BVF composite based on modifications of the inorganic substrate and/or the polymeric component, allowing extended tobramycin release at bactericidal concentrations. (cdc.gov)
Intravenously2
  • Like all aminoglycosides, tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given intravenously or by injection into a muscle. (wikipedia.org)
  • Also, he developed similar signs and symptoms when he was administered tobramycin intravenously on one occasion at 5 1/2 years. (biomedcentral.com)
Parenteral2
  • Tobramycin Injection, USP is a clear and colorless sterile aqueous solution for parenteral administration. (nih.gov)
  • Furthermore, a patient with end-stage renal disease who was treated for sepsis with parenteral tobramycin and vancomycin developed persistent fever, eosinophilia and rash. (biomedcentral.com)
Ophthalmic Suspension1
Aminoglycosides2
  • Like other aminoglycosides, a major side effect for tobramycin is ototoxicity or a loss of equilibrioception, or both in genetically susceptible individuals. (wikipedia.org)
  • Patients treated with Tobramycin Injection, USP and other aminoglycosides should be under close clinical observation, because these drugs have an inherent potential for causing ototoxicity and nephrotoxicity. (nih.gov)
Vancomycin4
  • Although temporal sequence had suggested vancomycin as the probable cause [ 10 ], the possible contribution of tobramycin could not be totally excluded. (biomedcentral.com)
  • This formulation is a combination of Vancomycin 200 mg, Tobramycin 125 mg, and Betamethasone 0.5 mg capsules, used for nasal irrigation/nebulizer. (bayviewrx.com)
  • Bayview Pharmacy is proud to offer a unique compounded formulation of Vancomycin 200 mg/Tobramycin 125 mg/Betamethasone 0.5 mg Capsules for Nasal Irrigation/Nebulizer. (bayviewrx.com)
  • Vancomycin 200 mg/Tobramycin 125 mg/Betamethasone 0.5 mg Capsules are used to treat a variety of respiratory diseases, including Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Bronchiectasis, Asthma, and Allergic Rhinitis. (bayviewrx.com)
Antibiotics6
  • Tobramycin is contraindicated in people with hypersensitivity against aminoglycoside antibiotics. (wikipedia.org)
  • Combining tobramycin with betalactam antibiotics can be desirable because of their synergistic effects. (wikipedia.org)
  • Tobramycin is in a class of medications called antibiotics. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to tobramycin, other antibiotics, or any other drugs. (medlineplus.gov)
  • Ofloxacin and Tobramycin are different types of antibiotics. (medicinenet.com)
  • Patients under care at any one of 28 participating clinical centers who had an eye with suspected bacterial keratitis were randomly allocated in a double-masked manner to treatment with 0.3% ofloxacin solution or a combination of the fortified antibiotics (1.5% tobramycin and 10.0% cefazolin solutions). (jamanetwork.com)
Dexamethasone Ophthalmic8
  • What is Tobramycin and Dexamethasone ophthalmic? (fr.nf)
  • Do not use Tobramycin and Dexamethasone ophthalmic if you have a viral or fungal infection in the eye, such as herpes, vaccinia, or varicella. (fr.nf)
  • This may cause an allergic reaction to Tobramycin and Dexamethasone ophthalmic. (fr.nf)
  • It is not known whether Tobramycin and Dexamethasone ophthalmic will be harmful to an unborn baby. (fr.nf)
  • Do not use Tobramycin and Dexamethasone ophthalmic without first talking to your doctor if you are pregnant. (fr.nf)
  • How should I use Tobramycin and Dexamethasone ophthalmic? (fr.nf)
  • Long-term treatment with steroids (such as in Tobramycin and Dexamethasone ophthalmic) may cause glaucoma, nerve damage in the eye, or cataract formation. (fr.nf)
  • Store Tobramycin and Dexamethasone ophthalmic at room temperature away from moisture and heat. (fr.nf)
Trough1
Pharmacokinetics2
  • An institution's tobramycin pharmacokinetics (PK) database was reviewed to evaluate the efficacy and safety of empiric tobramycin dosing and monitoring strategies used in pediatric patients with cystic fibrosis (CF). The relationship between patient age and tobramycin dosing needed to achieve the area under the curve (AUC) goal was investigated. (allenpress.com)
  • Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: an exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis. (chdr.nl)
20231
  • 2023. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109093/11.0/tobramycin. (unboundmedicine.com)
Anti-pseudomonal1
  • Tobramycin has demonstrated anti-pseudomonal effects, but previous studies have been small, results have been inconclusive, and there are safety concerns with the currently approved method of intravenous injection. (medscape.com)
Nephrotoxic effects1
  • Methoxyflurane, when used as an inhalational anesthetic, can aggravate the nephrotoxic effects of injected tobramycin. (wikipedia.org)
Infection4
Fluorometholone1
  • Fluorometholone 0.1% with Tobramycin 0.3% Ophthalmic Drop may do affect your eye if you take it without the doctor's prescription. (eyerisvisioncare.com)
Intravenous administration2
  • Eosinophilia has been reported to be associated with intravenous administration of tobramycin, including a patient treated for Gram-negative bacteremia [ 8 ], and among nine of 88 patients who received tobramycin in combination with cefamandole for peritonitis [ 9 ]. (biomedcentral.com)
  • Salbutamol and tobramycin were largely undetectable in EBC after intravenous administration and were detectable after inhaled administration in all subjects in 50.8% and 51.5% of EBC samples, respectively. (chdr.nl)
Peak1
  • Peak levels are used to adjust the tobramycin dose per administration and should be within the reference range to be considered therapeutic. (medscape.com)
Dose3
  • Reproduction studies in 3 types of animals at doses up to 33 times the normal human systemic dose have revealed no evidence of impaired fertility or harm to the fetus due to tobramycin. (nih.gov)
  • No standard reference range exists for a tobramycin level when administered as a single-daily dose. (medscape.com)
  • The portion of inhaled tobramycin available for systemic absorption includes approximately 10% of the total dose that is delivered to the lungs, and some that gets to the oropharynx and eventually swallowed [ 1 ]. (biomedcentral.com)
Aeruginosa4
  • Clinically, tobramycin is frequently used to eliminate Pseudomonas aeruginosa in cystic fibrosis patients. (wikipedia.org)
  • Nebulized tobramycin significantly reduced the density of Pseudomonas aeruginosa in sputum and improved quality of life for adults with bronchiectasis in a study with more than 300 individuals. (medscape.com)
  • The proportion of patients with P. aeruginosa isolates for which the minimal inhibitory concentration of tobramycin was 8 microg per milliliter or higher increased from 25 percent at week 0 to 32 percent at week 24 in the tobramycin group, as compared with a decrease from 20 percent at week 0 to 17 percent at week 24 in the placebo group. (nih.gov)
  • In a 24-week study of patients with cystic fibrosis, intermittent administration of inhaled tobramycin was well tolerated and improved pulmonary function, decreased the density of P. aeruginosa in sputum, and decreased the risk of hospitalization. (nih.gov)
Cystic1
Assay1
Bacteria2
  • Tobramycin has a narrow spectrum of activity and is active against Gram-positive Staphylococcus aureus and various Gram-negative bacteria. (wikipedia.org)
  • Tobramycin kills susceptible bacteria by blocking bacterial protein synthesis. (medicinenet.com)
Efficacy1
  • The efficacy of ofloxacin solution in treating bacterial keratitis is equivalent to that of the fortified cefazolin and tobramycin solutions. (jamanetwork.com)
Discomfort1
  • Side effects of Ocuflox that are different from Tobramycin include eye discomfort, redness, dryness, feeling as if something is in your eye, and sensitivity to light . (medicinenet.com)
Clinically1
  • Despite its wide use, tobramycin has rarely been linked to instances of clinically apparent liver injury. (nih.gov)
Patients7
  • Tobramycin ophthalmic solution, 0.3% is contraindicated in patients with known hypersensitivity to any of its components. (nih.gov)
  • A total of 520 patients (mean age, 21 years) were randomly assigned to receive either 300 mg of inhaled tobramycin or placebo twice daily for four weeks, followed by four weeks with no study drug. (nih.gov)
  • The patients in the tobramycin group were 26 percent (95 percent confidence interval, 2 to 43 percent) less likely to be hospitalized than those in the placebo group. (nih.gov)
  • In rare patients, systemic absorption of inhaled tobramycin may be significant enough to produce toxic effects, such as renal and vestibular toxicities. (biomedcentral.com)
  • There is poor systemic absorption of aerosolized tobramycin into the lungs among patients with CF, and its absorption from alveolar space into the pulmonary circulation is rate-limited [ 2 ]. (biomedcentral.com)
  • Retrospective chart review was performed for patients who received tobramycin during a CF exacerbation from 2009 to 2019 who received PK monitoring by pediatric pharmacists. (allenpress.com)
  • Desired AUC was achieved by 43.5% of pediatric patients with CF using tobramycin 10 mg/kg every 24 hours. (allenpress.com)
Sensitivity2
Preparations1
  • Development of acute bronchospasm has been associated with use of intravenous preparations of tobramycin for aerosol administration. (biomedcentral.com)
Drugs1
Ofloxacin2
Solution3
  • Ophthalmic tobramycin comes as as a solution (liquid) to instill in the eyes and as an eye ointment to apply to the eyes. (medlineplus.gov)
  • Tobramycin ophthalmic solution, USP 0.3% has a pH range between 7.0 and 8.0 and an osmolality of 260-320 mOsm/kg. (nih.gov)
  • Because of the potential for adverse reactions in nursing infants from tobramycin ophthalmic solution, 0.3%, a decision should be made whether to discontinue nursing the infant or discontinue the drug, taking into account the importance of the drug to the mother. (nih.gov)
Subsequent1
  • Subsequent tobramycin doses are either increased or decreased to attain levels within this range. (medscape.com)