Oral hairy leukoplakia (OHL) is a disease of the mucosa first described in 1984. (medscape.com)
HIV-negative people can have oral hairy leukoplakia, especially individuals with organ transplants and other immunocompromised disease. (medscape.com)
The pathogenesis of hairy leukoplakia is clearly complex, potentially requiring a convergence of factors including EBV co-infection, productive EBV replication, EBV genetic evolution, expression of specific EBV "latent" genes, and immune escape. (medscape.com)
In addition, a marked decrease or an absence of Langerhans cells occurs in hairy leukoplakia biopsy tissues. (medscape.com)
Oral hairy leukoplakia (OHL) is associated with HIV infection and/or immunosuppression. (medscape.com)
[ 9 ] The risk of developing oral hairy leukoplakia doubles with each 300-unit decrease in CD4 count. (medscape.com)
Oral hairy leukoplakia also is associated with Behçet syndrome and ulcerative colitis. (medscape.com)
Smoking more than a pack of cigarettes a day is positively correlated with the development of oral hairy leukoplakia in HIV-positive men. (medscape.com)
No increase in oral hairy leukoplakia was observed when controlled for number of oral sex partners. (medscape.com)
Oral hairy leukoplakia may not be the traditional lesion reported in only HIV-positive individuals and other immunosuppressed individuals. (medscape.com)
Increased reports of oral hairy leukoplakia are now published in other populations. (medscape.com)
The authors concluded that oral hairy leukoplakia diagnosis should not be limited to HIV-positive individuals or those with immunosuppression. (medscape.com)
An oral and maxillary pathology archive spanning 1994-2020 was investigated looking for cases of oral hairy leukoplakia in immunocompetent individuals. (medscape.com)
The etiology of oral hairy leukoplakia in this group of patients was not clearly understood. (medscape.com)
These authors concluded that oral hairy leukoplakia should not be considered pathognomonic for HIV infection and should be included in the differential diagnosis of other keratotic lesions, especially in elderly individuals. (medscape.com)
Oral hairy leukoplakia (OHL) is an EBV-associated condition of the oral mucosa, which is often painless. (nih.gov)
Hairy leukoplakia is a white patch on the side of the tongue with a corrugated or hairy appearance. (wikidoc.org)
Hairy leukoplakia is seen in severe defects of immunity , particularly in HIV infection. (wikidoc.org)
Oral hairy leukoplakia is not associated with any malignant potential. (wikidoc.org)
However, hyperplastic candidiasis lesions are adherent and do not wipe off, making this disease especially difficult to distinguish from hairy leukoplakia. (medscape.com)
Resolution of the lesion with antifungal therapy suggests candidiasis over hairy leukoplakia. (medscape.com)
However, hairy leukoplakia lesions are commonly also infected with Candida, further confusing the clinical diagnosis. (medscape.com)
These lesions are typically not shaggy like hairy leukoplakia, and they may occur anywhere in the oral cavity. (medscape.com)
Lesions that clinically and histologically mimicked oral hairy leukoplakia (OHL) but were not associated with EBV were recently characterized as pseudo-hairy leukoplakia. (medscape.com)
Oral hairy leukoplakia in an HIV-seronegative heart transplant patient. (medscape.com)
Absence of Langerhans cells in oral hairy leukoplakia, an AIDS-associated lesion. (medscape.com)
Miziara ID, Weber R. Oral candidosis and oral hairy leukoplakia as predictors of HAART failure in Brazilian HIV-infected patients. (medscape.com)
Fewer cases of oral hairy leukoplakia have been reported in non-HIV patients. (medscape.com)
The incidence of oral hairy leukoplakia is similar to that in the United States and thereby reflects the prevalence of HIV. (medscape.com)
[ 9 ] However, a study from Spain reported only 1 case of hairy leukoplakia in 500 renal transplant recipients studied. (medscape.com)
In patients with HIV, the median CD4 count when oral hairy leukoplakia is first detected is 468/µL. (medscape.com)
Maclary from Donaldson's Dairy2
They know about Hairy Maclary from Donaldson's Dairy, the scruffy, naughty, good-hearted wee black dog whose adventures form the centre of the story. (scotsman.com)
Hairy Maclary from Donaldson's Dairy is everybody's favourite dog. (theatreview.org.nz)
Diagnosis4
Based upon histological findings and in situ hybridisation showing numerous EBV-infected epithelial cells, a diagnosis of oral hairy leucoplakia was made. (nih.gov)
A blood smear showed 10% hairy cells, and a bone marrow biopsy confirmed a diagnosis of hairy cell leukemia and interstitial infiltration of CD20-positive, monoclonal antibody DBA.44-positive, and tartrate-resistant acid phosphatase-positive cells. (cdc.gov)
Bone marrow aspiration and biopsy showed hemophagocytosis and interstitial infiltration of CD20-positive, monoclonal antibody DBA.44-positive, CD 103-positive, CD25-positive, CD11c-positive, and CD123-positive cells, leading to a diagnosis of hairy cell leukemia. (cdc.gov)
This work presents a clinical diagnosis case of black hairy tongue, during a search campaign for oral cancer, in Jaibaras district of Sobral - CE, Brazil, in an alcoholic and inveterate smoker male 72 year-old edentulous patient. (bvsalud.org)
Complete remission3
A patient was considered to have a complete remission if they had no hairy leukemia cells visible in their bone marrow and blood (using a microscope), normal blood cell counts , and no swelling in their spleen at the end of the treatment. (cancer.gov)
For many types of leukemia, including hairy cell, "it makes the complete remission [last] a lot longer if you can eliminate minimal residual disease," Dr. Kreitman explained. (cancer.gov)
Two years later, the patient showed complete remission of hairy cell leukemia and melioidosis. (cdc.gov)
Tongue2
In "hairy" tongue , keratin (a normal body protein that is in hair, skin, and nails) accumulates on the normal projections on the top of the tongue (papillae) and gives it a hairy appearance. (msdmanuals.com)
Hairy tongue may develop when food debris is trapped in the papillae when people do not clean their mouth adequately. (msdmanuals.com)
Vetch13
Hairy vetch, Vicia villosa (Roth), is a cover crop that does not exhibit a typical domestication syndrome. (frontiersin.org)
Breeding efforts aim to reduce pod dehiscence in hairy vetch. (frontiersin.org)
Genotypes of hairy vetch exhibited wide variation in pod dehiscence, from completely indehiscent to completely dehiscent ratings. (frontiersin.org)
Breeding efforts are underway to reduce or eliminate PD in hairy vetch. (frontiersin.org)
documented 15% to 46% PD in one Argentinian landrace evaluated at one location over two years, but no studies have evaluated PD of hairy vetch among diverse germplasm or growing conditions. (frontiersin.org)
Hairy vetch is a winter annual legume that offers a number of potential benefits to row-crop or livestock producers when used as a winter cover crop. (farmprogress.com)
In addition to protecting land from erosion, hairy vetch can provide spring pasture for livestock. (farmprogress.com)
The most common use of hairy vetch is as a green manure crop to be turned under a nitrogen source just prior to planting a summer row crop such as corn, cotton or grain sorghum, or an annual forage crop such as pearl millet or a sorghum-sudan hybrid. (farmprogress.com)
About 3.5 percent of the dry matter of hairy vetch is nitrogen, so a substantial amount of nitrogen is available in forage and roots when turned under prior to planting a summer crop. (farmprogress.com)
It has long been known that hairy vetch can help conserve soil and water resources and also serve as an inexpensive source of nitrogen in conservation-tillage systems. (farmprogress.com)
Unfortunately, common hairy vetch does not flower until late spring, after many Southern farmers have had to turn under or kill a cover crop in preparation for spring crops. (farmprogress.com)
This is an early flowering variety that can more nearly maximize the potential of hairy vetch in the South. (farmprogress.com)
Extensive testing for forage yield, maturity, canopy height, composition and diseases of hairy vetch lines was conducted throughout Alabama and in Americus, Ga. AU EarlyCover was shown to be an excellent cover crop because of its early growth. (farmprogress.com)
Search1
Browse 1,204,100+ hairy stock photos and images available, or search for hairy chest or hairy man to find more great stock photos and pictures. (istockphoto.com)
Chest1
Whether you have a hairy chest, a hairy back, or only a patch of fuzz in the center of your chest, you're sexy. (askmen.com)
Species1
Monoplex aquatilis (Aquatile Hairy Triton) is a species of snails in the family Cymatiidae . (eol.org)
Bikers4
It's a Hairy Bikers mini globe barbecue! (menkind.co.uk)
No problem, this Hairy Bikers Mini BBQ is all you need! (menkind.co.uk)
Officially licensed Hairy Bikers merchandise, this mini BBQ has their stamp of approval. (menkind.co.uk)
So, order this Hairy Bikers Mini BBQ now! (menkind.co.uk)
Texture2
Showcasing a monochromatic look, the hat is outfitted with a reinforced stitched brim and features a soft hairy texture that is inviting to touch. (highsnobiety.com)
Hairy cell leukemia is an uncommon cancer of the blood in which the body produces a large number of abnormal B lymphocytes (a type of white blood cell). (cancer.gov)
Hairy-tailed Moles are uncommon in the state, and therefore Deemed in Need of Management by both TWRA and Tennessee Department or Environment and Conservation. (tn.gov)
Cell37
Hairy cell leukemia is so named because the cancerous blood cells (purple) appear "hairy" when viewed with a microscope. (cancer.gov)
In a small study, the combination of two targeted therapies led to long-lasting remission s for the majority of patients with hairy cell leukemia that had come back after previous treatments. (cancer.gov)
The drugs, vemurafenib (Zelboraf) and rituximab (Rituxan) , are already used separately to treat hairy cell leukemia. (cancer.gov)
Hairy cell leukemia occurs when abnormal, hairy-looking white blood cells build up in the bone marrow , spleen , and bloodstream. (cancer.gov)
If hairy cell leukemia comes back after or doesn't respond to initial treatment with chemotherapy, patients have several treatment options. (cancer.gov)
The new study involved 30 people with hairy cell leukemia that had come back after or had not responded to previous treatment. (cancer.gov)
This study is a "proof of principle" that adding rituximab to another therapy for hairy cell leukemia often makes the treatment more effective, said Robert Kreitman, M.D., of NCI's Center for Cancer Research , who was not involved in the study. (cancer.gov)
Dr. Kreitman has seen that trend in his own studies involving patients with hairy cell leukemia, including an ongoing clinical trial of rituximab in combination with moxetumomab pasudotox-tdfk (Lumoxiti) (see box). (cancer.gov)
The Italian research team is planning a follow-up trial that will compare vemurafenib plus rituximab with chemotherapy for people who are newly diagnosed with hairy cell leukemia, said lead investigator Enrico Tiacci, M.D., of the University and Hospital of Perugia, Italy. (cancer.gov)
Researchers are also exploring similar drug combinations as treatments for hairy cell leukemia, Dr. Kreitman noted. (cancer.gov)
About a decade ago, Dr. Tiacci and his colleagues began to explore the genetic underpinnings of hairy cell leukemia. (cancer.gov)
They discovered that almost all people with hairy cell leukemia have a mutant form of the BRAF protein in their cancer cells. (cancer.gov)
That finding led to studies of vemurafenib , which blocks the activity of mutant BRAF, as a potential treatment for hairy cell leukemia. (cancer.gov)
Similarly, treating hairy cell leukemia with rituximab-a drug that binds to a protein called CD20 on white blood cells-doesn't typically eliminate all of the cancer. (cancer.gov)
What is Hairy Cell Leukemia-Variant (HCL-V)? (healthline.com)
Hairy cell leukemia-variant is an extremely rare and unique type of leukemia (cancer) that was once grouped with another type but is now considered a separate condition. (healthline.com)
One rare form of leukemia is hairy cell leukemia (HCL) , named for the hair-like filaments found on affected white blood cells. (healthline.com)
Hairy cell leukemia-variant (HCL-V) was once thought to be a form of HCL but is now viewed as a distinct condition. (healthline.com)
What causes hairy cell leukemia-variant? (healthline.com)
What are the symptoms of hairy cell leukemia-variant? (healthline.com)
How do doctors diagnose hairy cell leukemia-variant? (healthline.com)
How is hairy cell leukemia-variant treated? (healthline.com)
What is the survival rate of hairy cell leukemia-variant? (healthline.com)
Randomized Phase II Trial of Rituximab with Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia (NCI-10-C-0025). (cancer.gov)
Hairy cell leukemia is usually treated with a chemotherapy drug called cladribine when signs or symptoms of the disease develop, such as low blood cell counts, recurrent infections, or a swollen spleen. (cancer.gov)
Therefore, doctors are interested in finding new treatments or new combinations of existing treatments for patients with hairy cell leukemia who have relapsed or not responded to previous therapies. (cancer.gov)
Moreover, rituximab has been used successfully to treat some patients with hairy cell leukemia who have relapsed or not responded to previous chemotherapy. (cancer.gov)
Dr. Kreitman is currently directing a randomized clinical trial of rituximab with cladribine in newly diagnosed (untreated) patients and patients who have had only one prior course of cladribine, but no prospective trial has yet evaluated rituximab with pentostatin in patients with hairy cell leukemia. (cancer.gov)
NCI researchers think that combining bendamustine and rituximab may prove effective in treating patients with multiply relapsed or refractory hairy cell leukemia. (cancer.gov)
In this trial, patients with hairy cell leukemia who have not responded to initial chemotherapy followed by second-line treatment with rituximab, or who have relapsed following two courses of chemotherapy, will be randomly assigned to receive rituximab combined with either pentostatin or bendamustine. (cancer.gov)
Most of the calls we get at NCI are from multiply relapsed hairy cell patients," said Dr. Kreitman. (cancer.gov)
Treating Multiply Relapsed or Refractory Hairy Cell Leukemia was originally published by the National Cancer Institute. (cancer.gov)
We report 2 cases of melioidosis and hairy cell leukemia in travelers returning from Thailand. (cdc.gov)
Treatment for hairy cell leukemia with cladribine was initiated after 10 weeks of antimicrobial drug treatment. (cdc.gov)
Thus, he did not require any treatment for hairy cell leukemia. (cdc.gov)
Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Cladribine1
Although the hairy cells that remain after cladribine or pentostatin treatment are essentially always CD20 positive, only a minority of patients respond to rituximab therapy alone. (cancer.gov)
Abnormal1
These abnormal cells appear "hairy" when viewed under a microscope and give the disease its name. (cancer.gov)
Mole2
Of the 3 moles that are found in the state, the Hairy-tailed mole is the smallest. (tn.gov)
The Hairy-tailed Mole, like other moles, tunnel deeper in the ground during the winter where it's better insulated from cold weather. (tn.gov)
Forage1
In general, do not graze areas where most of the forage is hairy or warty caltrop. (tamu.edu)
Chests2
In contrast to the mild popularity of hairless chests in American films in the 1950s, such as Marlon Brando 's in A Streetcar Named Desire , European productions showed masculine chests in all of their hairy glory. (askmen.com)
These hairy chests have inspired its nickname of "Hoff crab," in homage to David Hasselhoff of Baywatch fame. (nationalgeographic.com)
Populations1
University of Adelaide researcher Michael Swinbourne has studied southern hairy-nosed wombat populations and estimates their numbers have increased up to three times over the past 30 years. (abc.net.au)
Stages1
Each stage has three mushrooms to collect, and it's these that hold the real challenge in Hairy Tales - merely completing the stages, at least until the latter part of world 2, is easy. (eurogamer.net)
blood containing classic hairy cells - medium size center. (bvsalud.org)
Maturity1
The fruit of hairy caltrop is beaked, and at maturity it breaks up into eight to 12 one-seeded nutlets. (tamu.edu)
Title3
Hairy may refer to: people or animals covered in hairs or fur plants covered in trichomes insects covered in setae people nicknamed "the Hairy" Hairy (gene) Hairies, a fictional people Haerye, a Korean text Hary (disambiguation) This disambiguation page lists articles associated with the title Hairy. (wikipedia.org)
Hairy Tales is more than just a great name - and, as a debut title, suggests a bright future for Arges Systems. (eurogamer.net)
Instead of gunning for the title of "most hairy", how about being the "most creative" this November? (cdc.gov)
Find2
You can find the complete instructions for creating Hairy Monster Pots on the Young Gardeners Web page . (educationworld.com)
He is very hairy and I don't find the feel of his body hair very pleasant. (metrotimes.com)
Leads1
The "Hairy Monster Pots" art project leads to student writing fun. (educationworld.com)
Cases1
The first proven cases of cattle losses to hairy caltrop in the Trans-Pecos region of Texas were documented in 1944. (tamu.edu)