For instance, patients with significant poisoning by short-acting barbiturates recover quickly (within 24-48h) in a setting devoid of complications, as opposed to those poisoned with longer-acting agents, such as phenobarbital, which requires more aggressive interventions such as ventilatory support and admission to the ICU. (medscape.com)
Barbiturates were once commonly used to treat epilepsy, but the central nervous system depressants (CNS) carry the risk for chemical dependence and addiction. (serenityatsummit.com)
Mysoline2
Of these medications, Mysoline is a powerful barbiturate that for many years was used to treat the disorder. (serenityatsummit.com)
If you do have to use a barbiturate such as Mysoline, it helps to become familiar with the signs of addiction and what can be done should you develop a chemical dependency. (serenityatsummit.com)
Anticonvulsants2
Despite the decline in barbiturate use, cases of acute poisoning with severe toxicity are still noted at staggering rates in developing countries, where resource limitations and the affordability of barbiturates lend to their increased use as anticonvulsants. (medscape.com)
PENTOBARBITAL (pen toe BAR bi tal) is a short-acting barbiturate with anticonvulsant and sedative-hypnotic properties. (nembutalhome.com)
Sedative-hypnotic1
Barbiturates are the earliest class of sedative-hypnotic agents to be developed and were first used in medicine in the early 1900s and remained widely prescribed prior to the development of the less toxic hypnosedative drug class known as benzodiazepines. (medscape.com)
Medications2
A number of medications similar to PHB were developed, including primidone. (medscape.com)
Dosage is based on your medical condition, blood levels of primidone, use of other medications to treat seizures, and response to treatment. (blinkhealth.com)
Benzodiazepines3
Although barbiturates have largely been replaced, both medically and recreationally, by benzodiazepines, barbiturate toxicity still occurs. (medscape.com)
Benzodiazepines have largely replaced barbiturates both medically and recreationally due to their wider therapeutic window, lower drug tolerance, and lower propensity for abuse. (medscape.com)
While clinically barbiturate use has been largely replaced by benzodiazepines and propofol, there are two distinct scenarios in which their use may still be warranted: status epilepticus and elevated intracranial pressure (ICP). (medscape.com)
Medication4
Primidone, sold under various brand names, is a barbiturate medication that is used to treat partial and generalized seizures and essential tremors. (wikipedia.org)
Today, barbiturates are commonly used in geriatric suicide involving medication overdose. (medscape.com)
Read the Medication Guide provided by your pharmacist before you start using primidone and each time you get a refill. (blinkhealth.com)
If you are changing from a different anticonvulsant to primidone, your doctor may direct you to continue your old medication and slowly lower the dose as you begin taking primidone. (blinkhealth.com)
Seizures2
In the United States, primidone is approved for adjunctive (in combination with other drugs) and monotherapy (by itself) use in generalized tonic-clonic seizures, simple partial seizures, complex partial seizures, and myoclonic seizures. (wikipedia.org)
Withdrawal from primidone can be severe and include seizures and (rarely) death. (blinkhealth.com)
Alcohol1
Clinicians need to be aware not only of the effects of barbiturates alone, but of compound drugs that include barbiturates and barbiturates taken together with alcohol or other synergistic sedatives (see Presentation ). (medscape.com)
Drugs1
Barbiturates once enjoyed a central place in the world of recreational drugs at the beginning of the 20th century and were used for a wide range of conditions until their liability for abuse led to an extensive number of barbiturate poisoning cases in the 1950s and 1960s. (medscape.com)
Class1
Toxicity within the barbiturate drug class varies depending on the onset and duration of the agent. (medscape.com)
Effects2
Also known by street names such as, "reds", "downers", "barbs", "yellow jackets", "blue heavens", and "nenbies", barbiturates' owe their various effects to a combination of a pyrimidinetrione ring structure and the overall size and structure of the C-5 position substituents. (medscape.com)
Barbiturates were used for a variety of ailments throughout the beginning of the 20th century, but their adverse effects caused them to be replaced by other treatment options. (serenityatsummit.com)
Long1
Withdrawal is more likely if you have used primidone for a long time or in high doses. (blinkhealth.com)
Years1
Dupuytren's contracture, a disease of the fasciae in the palm and fingers that permanently bends the fingers (usually the little and ring fingers) toward the palm, was first noted to be highly prevalent in epileptic people in 1941 by a Dr. Lund, 14 years before primidone was on the market. (wikipedia.org)
Drug1
For patient education resources, see Poisoning - First Aid and Emergency Center , Barbiturate Abuse , Drug Overdose , Drug Dependence and Abuse , and Substance Abuse . (medscape.com)
Treatment2
In 1965, Monroe and Wise reported using primidone along with a phenothiazine derivative antipsychotic and chlordiazepoxide in treatment-resistant psychosis. (wikipedia.org)
In March 1993, S.G. Hayes of the University of Southern California School of Medicine reported that 9 out of 27 people (33%) with either treatment-resistant depression or treatment-resistant bipolar disorder had a permanent positive response to primidone. (wikipedia.org)
Medical1
Primidone was approved for medical use in the United States in 1954. (wikipedia.org)