Known sequence homology amino acid. Medical search. Frequent questions

A sequence comparison of piscivorin and other CRISP family proteins suggests that the Glu186 residue is the crucial site for the blocking of the calcium channels. (wikipedia.org)
Both rat and mouse B-myc proteins contain an identical and unique stretch of 14 carboxy terminal amino acid residues not found in other myc proteins. (mssm.edu)
The two proteins demonstrate 76 percent homology in their amino acid sequences. (quizlet.com)
Mature human CRISP-2 shares 86%, 73% and 71% amino acid sequence identity with the equine, mouse and rat proteins, respectively. (rndsystems.com)
Sequence alignment and analysis of orthologous proteins to human bactericidal/permeability-increasing protein (huBPI). (elifesciences.org)
A ) Sequence alignment of amino acid sequences of orthologous proteins. (elifesciences.org)
A ) Sequence alignment of amino acid sequences of orthologous proteins.Functional regions I-III are framed, and positively charged amino acids are shown in blue. (elifesciences.org)
B ) Sequence identities of investigated orthologous proteins without signal peptide in comparison to scorpionfish BPI (scoBPI) and human BPI (huBPI). (elifesciences.org)
To solve this dilemma, cells must use their own proteins as sources of amino acids in response to the nutritional downshift. (go.jp)
Sequence and structure comparisons revealed that human glyoxalase I should be assigned to a subfamily A, while S. aureus glyoxalase I represents a new subfamily B, which includes also proteins from other bacteria. (rcsb.org)
The specificity of the proteins is determined by the sequences outside the repeats themselves. (embl.de)
We chose proteins that include amino and carboxyl extensions as well as proteins that are made up entirely of WD-repeats. (embl.de)
Alignment of the amino acid sequence of aprotinin with the Kunitz domains of human proteins allowed the identification and design of a family of peptides, named Angiopeps. (aspetjournals.org)
They usually appear in multidomain proteins, together with catalytic domains, or other protein binding modules, such as Src homology 3 (SH3), phosphotyrosine binding (PTB) or pleckstrin homology (PH) domains. (lu.se)
These types of RNA help assemble protein building blocks (amino acids) into functioning proteins. (medlineplus.gov)
Our analysis has been the amino acid sequences in proteins differ from what is carried out using two different methods, which differ substantially expected from random sequences in a statistically significant from what is used in ref. 3, although the starting point is similar. (lu.se)
PROT data base (6) of functional proteins, this method yields model containing only two amino acid types, hydrophobic and clear evidence for nonrandomness. (lu.se)
To under- denoted the AB model, consists of chains of two kinds of stand the statistical distribution of hydrophobicity along proteins ``amino acids'' interacting with Lennard-Jones potentials. (lu.se)

Nucleic Acids Res. (rostlab.org)

The Human Genome Variation Society (HGVS) has established a sequence variant nomenclature , an international standard used to report variation in genomic, transcript and protein sequences. (ucsc.edu)
Furthermore, using sequence analysis of human genomic DNA, researchers concluded that the amino acids important for catalysis by COX-1 are conserved and are equally important for catalysis by COX-2. (medscape.com)

By using sequence alignment of herpesviruses homologs, we identified conserved amino acids in the putative pUL105 ATP binding site and in the putative pUL70 zinc finger pattern. (frontiersin.org)

Sequence alignment and analysis of orthologous Actinopterygii bactericidal/permeability-increasing protein (BPI). (elifesciences.org)
Here, we present results of a recent search of the protein sequence database for new DS domains using generalized profiles, a sensitive multiple alignment-based search technique. (embl-heidelberg.de)
The proposed alignment with the galactose oxidase sequence makes it possible to construct homology-based three-dimensional models for the most interesting examples, as illustrated by an accompanying paper on the C1 and C2 domains of factor V. (embl-heidelberg.de)
Areas covered include sequence databases, pairwise and multiple sequence alignment, homology searches in sequence databases and subcellular localization prediction. (lu.se)

The degree of similarity between sequences of amino acids. (wakehealth.edu)
The degree of similarity between sequences. (bvsalud.org)

The nucleotide sequence of piscivorin cDNA spans 1323 bp, containing an open reading frame of 240 codons. (wikipedia.org)
Previous studies indicate that the rat B-myc gene contains a single exon which shows 77% nucleotide homology to the second exon of the rat c-myc gene. (mssm.edu)
Nucleotide analysis of B-myc coding and non-coding sequences suggests that it may be a functional gene evolved by selective duplication of part of the second c-myc exon. (mssm.edu)
Nucleotide sequence homology between the three genes is >95% and each predicted protein contains three IG/IG-like domains, a transmembrane region and a TIR domain. (usda.gov)

A ) Sequence homology of amino acid sequences to huBPI without signal peptide. (elifesciences.org)
Exenatide is a synthetic version of exendin-4, a 39 amino acid peptide originally isolated from the venom of the Gila monster. (hindawi.com)
The heavy chain of HPlm consists of five repeating triple-disulfide-linked peptide regions, c. 80 amino acid residues in length, termed kringles (K), that are responsible for interactions of HPlg and HPlm with substrates, inhibitors and regulators of HPlg activation. (embl.de)
Gliadorphin is a 7 amino acid long peptide: Tyr-Pro-Gln-Pro-Gln-Pro-Phe which forms when the gastrointestinal system is compromised. (greenmedinfo.com)
Liraglutide is an acylated human Glucagon-Like Peptide-1 (GLP-1) receptor agonist with 97% amino acid sequence homology to endogenous human GLP-1(7-37). (empr.com)
This ATL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the Central region of human ATL3. (prosci-inc.com)
It is the only ESA that is peptide-based and its building blocks (amino acids) are arranged in a different order than erythropoietin (i.e., it has no sequence homology to endogenous erythropoietin). (takeda.com)

The Src homology 2 (SH2) domains are about 100 residues in length with an average of 28% pairwise residue identity (Pfam code PF00017). (lu.se)

The 152 amino acid protein consists of two similar domains with α + β topology. (rcsb.org)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
SH2 domains mediate intramolecular recognition and intermolecular protein-protein association almost invariably by binding to phosphorylated tyrosine (pY) residues in specific sequence contexts. (lu.se)

The mature form of the zymogen, human plasminogen (HPlg), contains 791 amino acids present in a single polypeptide chain. (embl.de)
Recombinant Human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains. (peprotech.com)
[ 3 ] It is also important to understand that the same polypeptide sequence can produce many different patterns of interresidue or intraresidue interactions. (medscape.com)

The amino acid sequence bears considerable homology to melittin. (enzolifesciences.com)
ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). (thermofisher.com)
Furthermore, on the amino acid sequence level, all three factors shared considerable homologies with corresponding host factors. (uni-wuerzburg.de)

The discoidin domain family revisited: new members from prokaryotes and a homology-based fold prediction. (embl-heidelberg.de)

Human and mouse TREM-1 share approximately 42% amino acid sequence homology (1-3). (rndsystems.com)
Human CRISP-2 also shares 71% amino acid sequence homology with human CRISP-3. (rndsystems.com)
The amino acid sequence mediating the bactericidal activity of human BPI (huBPI) is underlined. (elifesciences.org)
Human CCR9 has above 80% amino acid sequence homology with its mouse counterpart. (biolegend.com)
We examined the possibility that the C2 domain, amino acid residues 2173-2332, of factor VIII (fVIII) contains a binding site for von Willebrand factor (vWf) to clarify previous data showing that some monoclonal and human inhibitor antibodies with epitopes in C2 prevent fVIII-vWf binding. (embl-heidelberg.de)
This PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S372 of human PARP1. (avivasysbio.com)
In canine epidermolysis bullosa acquisita, the immunoglobulin G (IgG) autoantibodies also target the type VII collagen noncollagenous (NC1) domain, which shares greater than 80% homology in amino acid sequence with the human NC1 domain. (medscape.com)
Genogroup VIII, found in five of the six countries, had the highest degree of homology (up to 66% at the amino acid level) to human sapovirus strains. (lu.se)

and (iii) an intracellular signal-transductor of the Smad family (1530 bp cDNA, 318 amino acids) could be identified and completely characterized. (uni-wuerzburg.de)

however, it is devoid of enzymatic activity due to amino acid substitutions in the catalytic triad. (spandidos-publications.com)
Amino acid substitutions comprise the most common mutational event. (lu.se)

A set of 34 genes clustered around the rifK gene encoding AHBA synthase were defined by sequencing all but 5 kilobases (kb) of a 95 kb contiguous region of DNA from A. mediterranei. (nih.gov)
The DNA sequence of the gene coding for the OXA-2 beta-lactamase has been completed. (bl.uk)
A specific DNA probe was designed to come entirely from within the coding sequence of the OXA-2 beta-lactamase gene. (bl.uk)
Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species. (bvsalud.org)

When digestive enzymes are insufficient to break gliadorphin down into 2-3 amino acid lengths and a compromised intestinal wall allows for the leakage of the entire 7 amino acid long fragment into the blood, glaidorphin can pass through to the brain through circumventricular organs and activate opioid receptors resulting in disrupted brain function. (greenmedinfo.com)

Although its basic precursors (3-amino-5-hydroxy benzoic acid AHBA, and acetic and propionic acids) had been established, and several biosynthetic intermediates had been identified, very little was known about the origin of AHBA nor had the PKS and the various genes and enzymes that modify the initial intermediate been characterized. (nih.gov)
The amino acid sequence homology of the rainbow trout il1rl1 genes are highly related to Atlantic and Coho salmon (~94%) but relatively low (22-26%) with avian and mammalian species. (usda.gov)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)

He localized the biologic activity to a fraction of lipid soluble acids that he termed "prostaglandin," hypothesizing that these substances originate in the prostate gland. (medscape.com)

For example, in an environment rich in amino acids, cells do not expend energy for making amino acid biosynthetic enzymes. (go.jp)
However, if the environment becomes depleted of amino acids (nutritional downshift), cells will be exposed to a lack of both the amino acid biosynthetic enzymes and the amino acids required to make these enzymes. (go.jp)
Once amino acid biosynthetic enzymes start to accumulate, the cell is able to produce its own amino acids, and a new growth phase begins. (go.jp)
Their distinct biosynthetic activity includes an endoperoxidase synthase reaction that oxygenates and cyclizes polyunsaturated fatty acid precursors (eg, arachidonic acid) to form prostaglandin G 2 (PGG2), and a peroxidase reaction that converts PGG2 to prostaglandin H 2 (PGH2), as shown below. (medscape.com)

For sequences with a typical fraction of hydrophobic residues, we impact on how permissive with respect to sequence specificity find that the nonrandomness can be interpreted as anticorrela- the protein folding process is-- only sequences with nonran- tions. (lu.se)
permissive with respect to sequence specificity the protein folding process is, we have carried out the same analysis for a Section 1: Introduction toy model (7, 8), for which unbiased samples of folding and Hydrophobicity is widely believed to play a central role in the nonfolding sequences can be obtained. (lu.se)

Sequence Homology, Amino Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)

Mapping of the 80R epitope showed it is located within the N-terminal 261-672 amino acids of S protein and is not glycosylation-dependent. (nih.gov)

We also constructed, by homology modeling, a theoretical structure of the pUL105 N-terminal domain which indicates that the mutated conserved amino acids in this domain could be involved in ATP hydrolysis. (frontiersin.org)

Both subfamilies have a similar protein chain fold but rather diverse sequences. (rcsb.org)
The non-WD-repeat amino terminal alpha helix of G beta does not inhibit folding because G beta does not fold even when this region is removed. (embl.de)
sequences that fold well are isolated. (lu.se)
wavelength corresponding to -helix structure, as one might have statistical analysis on the sequences that fold well indicates expected, but also at large wavelengths. (lu.se)

Mutational analysis of several of these amino acids both in pUL105 and pUL70, proved that they are crucial for viral replication. (frontiersin.org)
Sequence analysis of this clone confirmed the presence of one single coding exon. (mssm.edu)
Analysis of the rodent B-myc open reading frames revealed two in-frame amino acid duplications in mouse B-myc and a 96% conservation at the amino acid level. (mssm.edu)
New samples obtained twelve months later also showed a predominance of RNA and were used for metagenomic analysis by deep sequencing. (virology.ws)
Analysis of the RNA viral sequences revealed coding regions for a predicted RNA dependent RNA polymerase (RdRp), a hallmark of RNA viruses. (virology.ws)
Funk and co-investigators localized COX-1 to 9q32-q33.3 via somatic hybrid deoxyribonucleic acid (DNA) analysis. (medscape.com)
In this way, the analysis is more sensitive to teins in the SWISS-PROT data base, convincingly show that long-range correlations along the sequence. (lu.se)

Therefore, COX - also known as prostaglandin-endoperoxide synthase (PTGS), fatty acid COX, prostaglandin H (PGH) synthase, and EC 1.14.99.1 - is implicated in the production of fever, inflammation, and pain. (medscape.com)

Functional regions I-III are framed, and positively charged amino acids are shown in blue. (elifesciences.org)

Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. (peprotech.com)
Based on the amino acid sequence homology and biological activity in macrophages, Shimamoto et al ( 15 ) identified that HLP was identical to MSP ( 15 ). (spandidos-publications.com)

They display significant amino acid sequence homology. (wikipedia.org)

Direct sequencing of viral communities from the environment, known as viral metagenomics, is one approach being taken to discover archaeal viruses. (virology.ws)
One assembled sequence of 5,662 nucleotides, believed to be a complete viral genome, encodes a single open reading frame containing a RdRp and a putative capsid protein similar to that of the positive-strand RNA containing nodaviruses, tetraviruses, and birnaviruses. (virology.ws)
Another viral sequence encoded a protein with 70% amino acid homology to the predicted RdRp. (virology.ws)

In Escherichia coli , amino acid starvation leads to the accumulation of an unusual molecule, polyphosphate (polyP), a linear polymer of many hundreds of orthophosphate residues. (go.jp)

Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is called F5/8 type C, FA58C, or C1/C2- like domain. (embl-heidelberg.de)
In the Dictyostelium discoideum (Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. (embl-heidelberg.de)

The amino acid residues important in these kringle/ligand binding interactions have been proposed by structural determinations, and their relative importance quantified by site-directed mutagenesis experimentation. (embl.de)

Homology-based searches recognize HVO_1799 as a geranylgeranyl reductase. (duke.edu)

Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. (rndsystems.com)
The sequences are from a novel virus which does not belong to any known virus family. (virology.ws)
A sequence homology search identified the protein as a member of the structural family Glyoxalase I. We have shown that the enzyme possesses glyoxalase I activity in the presence of Zn 2+ , Mg 2+ , Ni 2+ , and Co 2+ , in this order of preference. (rcsb.org)
So far, no three-dimensional structure of a known example of this extracellular module has been determined, limiting the usefulness of identifying a new sequence as member of this family. (embl-heidelberg.de)
Two decades later, the prostaglandins were deduced to be a family of related compounds that contain 20-carbon polyunsaturated fatty acids with a cyclopentane ring, as depicted below. (medscape.com)

Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)

The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)

ments of the amino acids along the protein chains. (lu.se)

It encodes the inactive pre-pro-HGF, a single chain of 728 amino acids (83 kDa), which includes a signal sequence ( 1 - 31 ), a heavy α chain (69 kDa), and a light β chain (34 kDa). (spandidos-publications.com)

Confirmation that the OXA-2 beta-lactamase is a serine enzyme has come from the DNA sequence and the interaction with mechanism based inactivators. (bl.uk)

Samples were obtained from 28 different sites and extracted nucleic acids were treated with DNAase (to remove DNA genomes) and then reverse transcriptase (to copy RNA to DNA). (virology.ws)

This graph shows the total number of publications written about "Sequence Homology, Amino Acid" by people in this website by year, and whether "Sequence Homology, Amino Acid" was a major or minor topic of these publications. (wakehealth.edu)
Exenatide shows 53% sequence homology with native GLP-1, while still binding effectively to GLP-1 receptor on pancreatic β cells for its insulinotropic effects. (hindawi.com)

D ) Number of basic amino acids in regions I-III as shown for oyster BPI (osBPI), scorpionfish BPI (scoBPI), huBPI and murine BPI (muBPI). (elifesciences.org)
B ) Number of basic amino acids in regions I-III of Actinopterygii BPI. (elifesciences.org)

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