HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. (wikipedia.org)
During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
Haplotypes1
HLA- DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative. (vdocuments.net)
Disease1
Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. (hindawi.com)
Alleles1
During the Ph.D. program in the Department of Transplantation Immunology and Immunogenetics, All India Institute of Medical Sciences, Dr. Raja developed DNA-based HLA typing method and studied the diversity of HLA in Asian Indians, and the association between HLA alleles and infectious diseases. (ucsf.edu)
Hepatitis3
The pathogenesis of polyarteritis nodosa is not clear, but, in some patients, it may be related to hepatitis B antigen-associated immune complex disease or other immune complexes. (medscape.com)
Serologic tests for hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) immunoglobulin M (IgM) are required for the diagnosis of acute hepatitis B virus (HBV). (medscape.com)
To evaluate the patient's level of infectivity, quantification of hepatitis (HBV) DNA is essential, and the presence of hepatitis B e antigen (HBeAg) should be determined. (medscape.com)
Diseases2
Single institutions or consortia of institutions are invited to participate in a cooperative research group to define the association between human leukocyte antigen (HLA) region genes or genetic markers and immune-mediated diseases, including risk and severity of disease, and organ, tissue, and cell transplantation outcomes. (nih.gov)
As the CLIA-approved Laboratory Director, Clinical Consultant and Technical Supervisor, Dr. Raja provides leadership to all areas of clinical Histocompatibility and Immunogenetics testing including stem cell transplantation, various solid organ transplantations (kidney, pancreas, liver, heart, lung), testing for HLA-associated diseases, and testing for transfusion services. (ucsf.edu)
T1DM2
Children who present with T1DM have a broad range of clinical features, ranging from extremely subtle symptoms to life-threatening diabetic ketoacidosis (DKA) (Merger, Leslie, & Boehm, 2013). (ukdiss.com)
From 1990-1994, the incidence of T1DM in children (ages 14 and younger) was reported to be 0.036% (36 per 100,000 per year) in Finland and Sardinia (highest incidence of T1DMM in the world) (Maahs, West, Lawrence et al. (inquiriesjournal.com)
Genetic1
Possibilities include immunologic responses to unknown antigens and genetic susceptibility, such as genetic predisposition to the development of defective suppressor T-lymphocyte function, production of autoantibodies (eg, antinuclear antibodies), and activation of the complement pathway. (medscape.com)
Recognition1
The published associations of specific polymorphisms in antigen recognition pathways, proinflammatory cytokines, anti-inflammatory cytokines, and effector molecules are reviewed. (biomedcentral.com)
Human3
HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. (wikipedia.org)
2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
Dr. Raja's current research is focused on understanding the KIR-HLA genomic differences in human populations and their relevance in therapeutic transplantations and disease association. (ucsf.edu)
Group1
The goal of this RFA is to establish a cooperative research group to conduct research and to generate high quality HLA-disease association data for public use that will be submitted to and maintained by dbMHC, the publically accessible database of MHC genetics housed and maintained by the National Center for Biomedical Information (NCBI) at the National Institutes of Health National Library of Medicine (NLM). (nih.gov)
Range1
a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)