• sequence
  • Usually, the new sequence is also given a marker gene, a gene that normal mice don't have and that confers resistance to a certain toxic agent (e.g., neomycin) or that produces an observable change (e.g. colour or fluorescence). (wikipedia.org)
  • research
  • In developing the NIH KOMP plan, this working group considered the current state of the field and recommendations from members of mouse research community made during a second workshop in March 2005. (genome.gov)
  • The University of California, Davis (UC Davis) and Children's Hospital Oakland Research Institute (CHORI) in Oakland, Calif., will collaborate to preserve, protect and make available knockout mice and related products available to the research community. (genome.gov)
  • To collect information generated by the KOMP , track progress of the knockout mutant production pipelines, and make the data readily available to all members of the KOMP research network to support, coordinate, and synergize their individual research programs. (genome.gov)
  • To serve as the central public interface for the KOMP , with links to all groups funded by the KOMP research network, as well as link to other efforts generating knockout mice, such as the European and North American Conditional Mouse Mutagenesis programs (EUCOMM and NORCOMM). (genome.gov)
  • The SAP Knockout mouse was generated in 2001 by Michael J. Czar and Pamela Schwartzberg of the National Human Genome Research Institute, NIH. (taconic.com)
  • several
  • The SAP-deficient mouse model recapitulates several features of XLP: hyperproliferative T cell response following infections, impaired NK and CD8 cell cytotoxicity, defective humoral immune responses, abnormal germinal center formation, reduction in IgG+ memory B cell numbers, and the absence of NKT and other innate T cells. (taconic.com)
  • specifically
  • In the present study, we therefore compared blood pressure variability in knockout mice that lack specifically the gene for endothelial nitric oxide synthase with their respective wild-type controls. (ahajournals.org)
  • First, with the use of knockout mice in which the eNOS isoform was specifically mutated, 14 15 we investigated whether NO that is generated by the endothelial isoform of NO synthase is involved in the blood pressure-buffering effect of NO. Second, with the use of power spectral analysis, we determined the frequency range in which endothelium-derived NO can buffer blood pressure variability in mice. (ahajournals.org)
  • cell
  • Artificial DNA sequences typically are introduced into mouse ES cells using a retrovirus or other viral vector, and the modified ES cells are then grown in cell cultures . (britannica.com)
  • For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis. (wikipedia.org)
  • blood
  • One day after carotid artery cannulation, blood pressure was recorded in these conscious mice. (ahajournals.org)
  • In addition, endothelial nitric oxide is most effective in buffering blood pressure oscillations at frequencies that range from 0.05 to 0.40 s −1 (Hz) in conscious mice. (ahajournals.org)