Knockout mouse mice mutant strains. Medical search. Frequent questions

The International Mouse Phenotyping Consortium project is systematically phenotyping knockout mice from the mutant ES cells produced by the International Mouse Knockout Consortium. (jax.org)
EUCOMM mice, and International Mouse Phenotyping Consortium (IMPC) mutant resources. (infrafrontier.eu)
We have also integrated global recommendations of the International Mouse Phenotyping Consortium (IMPC) , which identified important parameters that will collectively summarize the consequences of removing the function of a single gene in the context of the whole animal. (jax.org)
The KO-first allele design also forms the basis for generation of lacZ-tagged conditional alleles as part of the International Knockout Mouse Consortium (IKMC) effort organized by the International Mouse Phenotyping Consortium (IMPC). (cyagen.com)

We will determine whether this approach can induce ALS phenotypes in the wild type mice and/or modulate the disease phenotypes and pathology in the mutant ALS transgenic mice. (neurodegenerationresearch.eu)
Strains accurately and systematically curated and annotated, as they carry mutant alleles or transgenes and express phenotypes which precisely model particular cancer types, according to the original reports in the associated peer-reviewed publications. (infrafrontier.eu)
Alterations of their tumorigenic phenotypes including survival rate, tumor formation and tumor spectrum, were assessed in FVB/N-Trp53 em2Hwl /Korl and C57BL/6-Trp53 em1Hwl /Korl knockout (KO) mice over 16 weeks. (biomedcentral.com)
Most of these mice showed similar phenotypes as an effective result of the null alleles. (biomedcentral.com)
This study was therefore undertaken to compared the tumorigenic phenotypes of FVB/N-Trp53 em2Hwl /Korl and C57BL/6-Trp53 em1Hwl /Korl KO mice encompassing the TALEN-mediated Trp53 mutant gene (Fig. 1 ). (biomedcentral.com)
We found many unexpected phenotypes detected only because we screened for them, emphasizing the value of screening all mutants for a wide range of traits. (blogspot.com)
The finding that unexpected phenotypes will be uncovered if you screen for them brings to mind developmental biologist Lewis Wolpert's query after yet another experiment showed "no phenotype" in a knockout mouse, "But have you taken it to the opera? (blogspot.com)
Indeed, no matter how well-intentioned, they can't expose these mice to all possible environments, and so can't observe all possible phenotypes. (blogspot.com)
2013 The CRISPR/Cas9 technology was subsequently used in mice to observe loss-of-function phenotypes and to generate knock-out strains (Wang et al. (health-ground.com)
Perform quantitative and qualitative assessment of phenotypes for each mutant line using automated calling procedures and technical, statistical and scientific review. (jax.org)
To verify the biological role of novel identified GRA proteins, we constructed the NcGRA23 and NcGRA11 (a-e) knockout strains using the CRISPR/Cas9 system and analyzed the phenotypes of these mutants. (biomedcentral.com)

Access to over 1700 mouse strains carring mutations in genes that are implicated in causing more than 1300 distinct rare diseases. (infrafrontier.eu)
Mice harboring spontaneous mutations have long been a major source for animal models of human genetic disorders, particularly mendelian diseases. (jax.org)
After years of obscurity, strains of mice with mutations in particular genes are thrust to the fore of autism research. (the-scientist.com)
In 1996, researchers had made mice with mutations in TCF4 , which regulates the expression of other genes and plays a key role in immune cell development . (the-scientist.com)
2013 Mutations are inheritable due to mosaic targeting of the germline allowing rapid establishment of mutant strains. (health-ground.com)
Mutations in the gene were found in human hepatic cutaneous porphyria a disorder characterized by defects in iron metabolism in the liver skin photosensitivity and reduced erythrocytic heme production (Balwani and Desnick 2012 A point mutation in identified in the mutant zebrafish line was shown to recapitulate these features (Wang et al. (health-ground.com)
The 'knockout-first' (KO-first) allele overcomes the limitations of constitutively-expressed mutations, flexibly producing reporter knockouts, conditional knockouts, and null alleles through exposure to site-specific cyclization recombination (Cre) and flippase (FLP) recombinases - such as in crosses to FLP and cre mice. (cyagen.com)
The North American Conditional Mouse Mutagenesis project (NorCOMM) is a large-scale research initiative focused on developing and distributing a library of mouse embryonic stem (ES) cell lines carrying single conditional knockout mutations across the mouse genome. (tigm.org)
To understand the physiological significance of HS-induced RAGE oligomerization in vivo, we generated RAGE knock-in mice ( Ager AHA/AHA ) by introducing point mutations to specifically disrupt HS-RAGE interaction. (elifesciences.org)

A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background. (taconic.com)
Transgenic mice carrying an Nrl-EGFP allele and homozygous for either knock-out of rhodopsin (Nrl-EGFP, Rho-/-) or heterozygous for knock-in of P23H mutant rhodopsin (Nrl-EGFP, RhoP23H/+) were used in this study. (ox.ac.uk)
Here, we identified in two different DYT1 mouse strains, heterozygous torsinA knockout mice (Tor1a+/-) and human ΔGAG mutant torsinA transgenic mice (hMT), the anatomical abnormalities in the cerebellum, during a critical age for synaptogenesis (postnatal day 14, P14). (foundationdystoniaresearch.org)

The phenotype of the L1 mutant mouse indicates that it is a potentially valuable model for the human CRASH syndrome. (jneurosci.org)
However, this is difficult to model in mice because loss of one TBK1 allele in mice does not cause an overt phenotype but a complete knockout of this gene causes embryonic lethality. (neurodegenerationresearch.eu)
We will inject the rAAV into several mouse strains including the normal wild type and mutant transgenic mice that develop ALS phenotype. (neurodegenerationresearch.eu)
Heterozygote knockout phenotype is expected to be similar to the wild-type phenotype. (mmrrc.org)
Many mouse knockout experiments have been reported to show "no phenotype", that is, have no effect on the mouse, but the authors suggest that other researchers didn't look hard enough. (blogspot.com)
targeting yielded red fluorescent erythrocytes in zebrafish embryos recapitulating the phenotype observed in the mutant. (health-ground.com)
RP11-175B12.2 2009 (Physique S1A-B Fig. 1A-C). As a control we used a gRNA efficiently targeting an irrelevant gene (Physique S1A-B). We observed that targeting led to the appearance of fluorescent erythrocytes in circulation at 30 hpf (Fig. 1D) mimicking the phenotype seen in mutant fish (Wang Pinaverium Bromide et al. (health-ground.com)
Effective high-throughput mouse phenotyping is therefore critically important to establish baseline genotype/phenotype understanding for functional analysis of the KOMP resource. (jax.org)
This antibody blocks RAGE signaling in vitro and in vivo, recapitulating the phenotype of Ager AHA/AHA mice. (elifesciences.org)

A loss-of-function mutation in the mouse delta-like3 (Dll3) gene has been generated following gene targeting, and results in severe axial skeletal defects. (ox.ac.uk)
Scientists around the world are working to generate a targeted knockout mutation for every gene in the mouse genome through the Knockout Mouse. (jax.org)
A homozygous mutation in the murine resulting in a C\terminal truncation from the protein leads to severe mixed immunodeficiency, SCID 17, and a kinase\inactive DNA\PKcs\mutated protein network marketing leads to Ku70/Ku80\ and p53\reliant embryonic lethality in mice 18. (exposed-skin-care.net)
Collectively, our data suggest that huRBCs reconstituted NSG mice infected with attenuated P . falciparum is a valuable tool to explore the role of C9 mutation in the growth and survival of parasite mutants and their response to the host's immune responses. (frontiersin.org)

2006. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. . (oregonstate.edu)
If successful, this experiment will establish a new mouse model for ALS and a new method that is faster than the conventional gene knockout approach for construction of mouse models for ALS and for studying mutant gene interactions in vivo. (neurodegenerationresearch.eu)
Dynamic in vivo quantification of rod photoreceptor degeneration using fluorescent reporter mouse models of retinitis pigmentosa. (ox.ac.uk)
Here we describe a novel technique for the in vivo visualisation of rod photoreceptors which permits semiquantitative assessment of outer retinal degeneration, and validate this approach in two mouse models of retinitis pigmentosa (RP). (ox.ac.uk)
A human blood chimeric mouse could serve to harmonize in vitro P. falciparum cultivation and in vivo studies carried out in rodent animal models. (frontiersin.org)
This unexpected finding suggests that by preserving the expression of RAGE protein (in a dominant-negative form), Ager AHA/AHA mouse might represent a cleaner genetic model to study physiological roles of RAGE in vivo compared to Ager −/− mice. (elifesciences.org)
This paper explores the role of heparan sulfate in the oligomerization of RAGE and the role of oligomerization in vivo function using mouse knockout models. (elifesciences.org)

We have recently applied the NanoString digital platform to study expression of mouse odorant receptor genes, which form with 1,200 members the largest gene family in the mouse genome. (biomedcentral.com)
Gene-wise statistical analyses of gene expression data, for which the significance relative to a fold change threshold is important, give reproducible and reliable results on NanoString data of mouse odorant receptor genes. (biomedcentral.com)
Gene expression studies often seek to identify genes that are Differentially Expressed (DE) between RNA samples from two types of biological conditions, such as gene knockout mice compared to wild-type mice. (biomedcentral.com)
The first study on the mice came out in 2000, when researchers knew practically nothing about genes linked to autism. (the-scientist.com)
Two other genes, CHD8 and ANK2 , were also thrust to the forefront of autism research-and as with SCN2A , mice lacking these genes had been generated years before for unrelated studies . (the-scientist.com)
Searching for these mice can sometimes be tricky because the genes are christened with new names as time goes on. (the-scientist.com)
A paper in Cell reports preliminary results of an effort to systematically mutate each of the genes in a mouse genome, one at a time, to determine the function of every gene ("Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes," White et al. (blogspot.com)
Transfection of gRNAs and Cas9 mRNA or DNA into bacteria human or mouse cells was shown to efficiently inactivate target genes (Cho et al. (health-ground.com)
The global loss of some genes is usually embryonic lethal making them challenging to study in adults and there Pinaverium Bromide is a great need in the field to create tissue-specific knockouts. (health-ground.com)
In conditional knockout mice, a gene is inactivated in a specific tissue to study the function of individual genes and model human diseases. (cyagen.com)
The Cre-Lox recombination system enables the generation of tissue-specific or inducible knockouts with a high level of control over the spatial and temporal expression of genes. (cyagen.com)
The members of the International Knockout Mouse Consortium are working together to mutate all protein-coding genes in the mouse using a combination of gene trapping and gene targeting in C57BL/6 mouse embryonic stem (ES) cells. (tigm.org)

Introduction of several mouse strains with genetic immune deficiencies has greatly benefited the development of a small laboratory animal model ( 7 - 15 ) to study the asexual blood stage infection of P. falciparum . (frontiersin.org)

The knockout models are designed to be null alleles. (taconic.com)

Over 4700 lines generated from the International Knockout Mouse Consortium (IKMC) ES cell resources e.g. (infrafrontier.eu)
The Mouse Genome Informatics group is a founding member of the Gene Ontology Consortium . (tigm.org)

Nuclear receptor family knock-out and conditional mouse lines generated by PHENOMIN-ICS. (infrafrontier.eu)
Our TurboKnockout ® service can provide you with knockout and conditional knockout (flox) mouse models in as fast as 6-8 months. (cyagen.com)
For conditional knockouts, it may be possible for Cyagen to breed founders directly to your tissue-specific Cre mice or even develop the Cre strains necessary for your study. (cyagen.com)
Although conditional knockout (cKO) mouse models are used in similar applications to KO models, conditional models provide precise control of gene expression to yield greater experimental capabilities. (cyagen.com)
We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. (umassmed.edu)

In addition, gene identification in patients permits us to identify naturally occurring animal models or create new transgenic or knockout animal models with retinal degeneration due to defects in the gene homologs. (berkeley.edu)
In particular, we have the examined retinal degeneration in the naturally arising rd mouse strains (defects in the b-subunit of phosphodiesterase). (berkeley.edu)
These conditions include but are not limited to artery or vein occlusion in diabetic retinopathy, hypoxic retina in retinopathy of prematurity, aging in age-related macular degeneration, expression of mutant proteins in inherited retinal degeneration, traumatic injury leading to retinal detachment, and light sensitivity in the case of light-induced retinal degeneration. (molvis.org)

Another promising strategy for dominantly inherited retinal diseases involves directly targeting the mutant mRNA product using Talens, CRISPR , and siRNA constructs. (berkeley.edu)
A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing. (coremarketplace.org)

The extensive library of single-gene knockout strains generated through the KOMP program will become significantly more valuable with comprehensive assessments of the functional consequences of removing one gene. (jax.org)

However, this process is slow because of the low yield of double or triple transgenic mice and the multigenerational crosses that are necessary to bring different transgenic lines to the same genetic background. (neurodegenerationresearch.eu)

ii) ZmpC, only present in about 25% of pneumococcal strains, has a lower influence on virulence in mice. (biomedcentral.com)
In this study, we observed that the knockout of calcium-dependent protein kinase 3 (CDPK3) in the type II ME49 strain greatly attenuated virulence in mice and significantly reduced cyst formation. (nature.com)

The Wellcome Trust funded the acquisition of a limited number of gene knockout mouse strains and associated phenotypic data from Deltagen Inc. and Lexicon Pharmaceuticals. (infrafrontier.eu)

In contrast, no change in pyramidal or granule cell number is detected in the hippocampus of Fgf2 −/− mice. (jneurosci.org)

genetic background is controlled, but results will differ in other strains of mice), they've used a standard protocol for constructing the alleles they introduce, and the lines they produce are readily available to other researchers. (blogspot.com)
Knockout-first alleles can also be readily modified in cells using dual recombination-mediated cassette exchange. (cyagen.com)

After CHD8 topped the list of autism candidates in 2014, at least five teams rushed to create and characterize their own mutant strains. (the-scientist.com)
We proceeded to functionally characterize NcGRA23 and NcGRA11 (a-e) by gene knockout. (biomedcentral.com)
The Jackson Laboratory , offers a fully integrated suite of services to provide efficient and cost-effective solutions to cryopreserve, expand, breed and characterize your mice following recovery from the TIGM library. (tigm.org)

Additionally, intestinal inflammation with characteristics resembling both UC and CD has been shown to occur in immunodeficient mice that are reconstituted with a subset of CD4 + T cells 1 . (inotivco.com)
Read S, and Powrie F. Induction of Inflammatory Bowel Disease in Immunodeficient Mice by Depletion of Regulatory T Cells. (inotivco.com)
Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum . (frontiersin.org)
huRBC-reconstituted immunodeficient mice received infectious challenge with attenuated P. falciparum C9 parasite mutants (C9-M), complemented (C9-C), and wild type (NF54) progenitors to study the role of immune effectors in the clearance of the parasite from mouse circulation. (frontiersin.org)

They allow to visualize and concomitantly manipulate genetically defined cells in mice with single-cell resolution. (infrafrontier.eu)
MTB integrates data on the frequency, incidence, genetics, and pathology of neoplastic disorders, emphasizing data on tumors that develop characteristically in different genetically defined strains of mice. (tigm.org)

Using two mutant murine strains (the slow Wallerian degeneration mouse and a knockout for the chemokine receptors CCR2) we have found that prevention of macrophage accumulation in ganglia significantly inhibits the conditioning lesion response, suggesting that these macrophages play an important role in the response of neurons to injury. (case.edu)

In the motor, somatosensory, and visual cortex, many pyramidal neurons in layer V exhibited undulating apical dendrites that did not reach layer I. The hippocampus of L1 mutant mice was smaller than normal, with fewer pyramidal and granule cells. (jneurosci.org)

Using NcGRA17-BirA* fusion protein as bait, we have identified some known GRAs and verified localization of 11 novel GRA proteins by gene endogenous tagging or overexpression in the Nc1 strain. (biomedcentral.com)
The detection and evaluation of concentration of influenza virus proteins in biological samples is critical in a broad range of medical and biological investigations regarding the concern over potential outbreaks of virulent influenza strains in animals and humans. (omicsonline.org)

Eliminating α2δ4 in mice abolishes rod synaptogenesis and synaptic transmission to rod ON-bipolar cells, and disrupts postsynaptic mGluR6 clustering. (nih.gov)
For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. (taconic.com)
The cells are inserted into the embryonic mouse and its viability, fertility and the effect of the knockout "on a broad range of traits" are then assessed. (blogspot.com)
To TNFRSF10C elucidate the hereditary connections between DNA\PKcs as well as the XRCC4 paralogues (XRCC4, XLF, PAXX) in individual cells, we utilized knockout individual HAP1 cell lines 23. (exposed-skin-care.net)
In addition, the soma of the pyramidal cells in the frontal and parietal cortices are smaller in Fgf2 knock-out mice. (jneurosci.org)
The KO-first strategy has implications for functional genomics and proteomics across many model systems, including mouse, rat, and human pluripotent stem cells - serving as a functional genomics platform enabling systematic, genome-scale programs for proteomic mapping. (cyagen.com)
This NSG mouse, depleted with γ-chain of the IL-2 receptor, has been shown to better tolerate a variety of human transplanted cells ( 17 - 24 ). (frontiersin.org)
The reduction in the residual innate immune effectors (mainly cells of monocytes and macrophages lineage) and co-administration of huRBCs supplied with decomplemented human serum through an intravenous route led to the development of a reproducible humanized mouse. (frontiersin.org)
However, analysis of mice lacking the glucocorticoid receptor gene had revealed that adrenal chromaffin cells develop mostly normally in these mice. (silverchair.com)
Second, we are developing humanized mouse models of vitiligo, where we transfer human T cells, or both T cells and skin, from vitiligo patients to immunosuppressed mice that permit the growth of human tissues. (umassmed.edu)
The benefit of this approach is that we can study the key cells that participate in vitiligo directly from patients, without variables that may change them, including their transfer into mice. (umassmed.edu)
Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. (umassmed.edu)
We sought to identify PKA phosphorylation sites in PLIN5 and assess their functional relevance in cultured cells and the livers of mice. (uci.edu)

Cellular studies of NTD and CTD oligomerization interface mutants demonstrate the importance of each interface in matrix assembly. (uci.edu)
The RAGE mutant demonstrated normal ligand-binding but impaired capacity of HS-binding and oligomerization. (elifesciences.org)
Remarkably, Ager AHA/AHA mice phenocopied Ager −/− mice in two different pathophysiological processes, namely bone remodeling and neutrophil-mediated liver injury, which demonstrates that HS-induced RAGE oligomerization is essential for RAGE signaling. (elifesciences.org)
The authors report that knock-in mice, with RAGE is mutated at sites responsible for heparan sulfate binding and oligomerization, phenocopy RAGE knockout mice. (elifesciences.org)

These defects, which consist of highly disorganised vertebrae and costal defects, are similar to those associated with the Dll3-dependent pudgy mutant in mouse and with spondylocostal dysplasia (MIM 277300) in humans. (ox.ac.uk)
Although animal models of IBD are not perfect analogs of the human disease, mouse models have characteristics that closely resemble both UC and CD in humans. (inotivco.com)

Inducible and/or tissue-specific gene expression - knockout, over-expression, etc. (cyagen.com)

Finally, we have performed RNA-seq analysis of neutrophils and lungs and found that while Ager −/− mice had a broad alteration of transcriptome in both tissues compared to wild-type mice, the changes of transcriptome in Ager AHA/AHA mice were much more restricted. (elifesciences.org)

The European Mutant Mouse Archive - EMMA comprises over 8700 mutant lines that are cryopreserved as frozen sperm and/or embryos. (infrafrontier.eu)
Mutant lines are invaluable to analyze gene function in both embryos and adults. (health-ground.com)

At 15 to 25 weeks of age, the homozygote variants of these mice were found to be dramatically susceptible to the development of multiple tumor types, and malignant lymphoma and sarcomas were frequently observed in the thymus and major visceral organs of these animals [ 9 ]. (biomedcentral.com)

The Genome of C57BL/6J "Eve", the Mother of the Laboratory Mouse Genome Reference Strain. (jax.org)
Furthermore, numerous solid tumors were also observed in various regions of the surface skin of FVB/N-Trp53 em2Hwl /Korl KO mice, but were not detected in C57BL/6-Trp53 em1Hwl /Korl KO mice. (biomedcentral.com)
Our results indicate that the spectrum and incidence of tumors induced by the TALEN-mediated Trp53 mutant gene is greater in FVB/N-Trp53 em2Hwl /Korl KO mice than C57BL/6-Trp53 em1Hwl /Korl KO mice over 16 weeks. (biomedcentral.com)
The first Trp53 KO mice were generated by the recombination of intron 4 and exon 5 in C57BL/6 mice using embryonic stem cell (ESC) targeting techniques. (biomedcentral.com)
Similar tumors were also observed in KO mice having the exon 2 or exon 2-6 deletion in C57BL/6 mice. (biomedcentral.com)

Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. (colorado.edu)
Our phenotypic analysis of Dll3(neo)/Dll3(neo) mutants shows that the developmental origins of the skeletal defects lie in delayed and irregular somite formation, which results in the perturbation of anteroposterior somite polarity. (ox.ac.uk)

A major part of the repository consists of strains donated to EMMA by individual researchers , but EMMA also archives and distributes strains originated by large-scale projects . (infrafrontier.eu)

The MMRRC was established by the National Institutes of Health (NIH) to provide a centralized resource for the production, distribution, and characterization of mutant mice. (coremarketplace.org)
Broad phenotypic characterization of emerging mouse models will add important value and greatly enhance their utility to the scientific community. (jax.org)

Mouse lines expressing Cre and Dre recombinases in various tissues and organs generated by PHENOMIN-ICS. (infrafrontier.eu)
By breeding floxed mice with tissue-specific Cre-expressing mice (Cre deleter strain), it is possible to specifically delete the floxed region and inactivate the gene in desired tissues, while the target gene remains functional in all other tissues. (cyagen.com)
Further, the presence of mutant parasites in deep-seated tissues suggests the escape of parasites from the host's immune responses and thus extended the survival of the parasite. (frontiersin.org)

To analyse the importance in virulence of three of these metalloproteinases, intranasal challenge of MF1 outbred mice was carried out using a range of infecting doses of wild type and knock-out pneumococcal mutant strains, in order to compare mice survival. (biomedcentral.com)
Mice vaccinated with ME49Δ cdpk3 were efficiently protected against the tachyzoites of a variety of wild-type strains, including type I RH, type II ME49, Chinese 1 WH3 and Chinese 1 WH6, as well as the cysts of wild-type strains ME49 and WH6. (nature.com)
Re-expression of PLIN5 S155A in the liver of Plin5 liver-specific null mice reduced lipolysis compared with wild-type PLIN5 re-expression, but was not associated with other changes in hepatic lipid metabolism. (uci.edu)

To solve these problems, we propose a rAAV-intrathecal gene delivery approach for construction of transgenic mouse models for ALS. (neurodegenerationresearch.eu)
EMMA has manually curated the information of several archived mouse strains reported to constitute specific disease models. (infrafrontier.eu)
Cerebellar synaptogenesis is compromised in mouse models of DYT1 dystonia. (foundationdystoniaresearch.org)
The Jackson Laboratory maintains and distributes chromosome-aberration stocks that provide mouse models for Down syndrome, as well as the study of. (jax.org)
This resource provides mouse models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial. (jax.org)
More recently, models of mouse IBD have been developed using naturally occurring mutant mouse strains (e.g. (inotivco.com)
Boismenu R, and Chen Y. Insights from mouse models of colitis. (inotivco.com)
These "knockouts" are often fatal-which can squash interest in studying them as models for medical conditions. (the-scientist.com)
In conventional knockout models, one or more critical exons of the target gene are replaced with a drug-selection cassette. (cyagen.com)

Hence, DNA\PKcs is normally redundant with ATM in mice 21 functionally, 22. (exposed-skin-care.net)

International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data. (jax.org)
KATIE CAREY FOR SPECTRUM N early 20 years ago, a new strain of mice debuted in a California laboratory. (the-scientist.com)
Maher tracked down the mice in the literature and found them at The Jackson Laboratory in Bar Harbor, Maine. (the-scientist.com)
The Mouse Genome Informatics (MGI) Database at the Jackson Laboratory provides integrated access to data on the genetics, genomics and biology of the laboratory mouse. (tigm.org)

2003. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. . (oregonstate.edu)

However, the conventional transgenic technologies of gene overexpression and knockout are slow and expensive, thus becoming a bottleneck constraining new model development. (neurodegenerationresearch.eu)

Maintaining experimental mouse colonies is a lot like juggling. (jax.org)

Strains are related to SARS-CoV-2 and other Coronaviridae viral infections via their human orthologues. (infrafrontier.eu)
Manipulation of UPR markers has been made possible by the use of knockout mice, pharmacological agents, and viral vector-mediated augmentation of gene expression. (molvis.org)
The immunosensor was successfully applied in the detection and quantification of PB1-F2 in infected mouse lungs and cell lines, providing temporal expression profiles of PB1-F2 during viral infection. (omicsonline.org)

Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia. (coremarketplace.org)

Thus, the development of an effective toxoplasmosis vaccine is critical for limiting the infection of various Toxoplasma strains. (nature.com)
EMMA strains that could be used for Coronaviridae infection research. (infrafrontier.eu)
Therefore, humanized mice capable of harboring the human malaria infection are urgently needed to understand the parasite biology. (frontiersin.org)

Overall, the Mutant Mouse Resource and Research Centers are vital resources for researchers and students interested in using mice as model organisms to study a wide range of biological processes. (coremarketplace.org)

This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. (biomedcentral.com)
The benefit of this system is the powerful tools available to study diseases in mice. (umassmed.edu)

Of note, these alterations were rescued and in part over-compensated in the adult age in both mouse strains, suggesting that torsinA dysfunction can induce an altered maturation of cerebellar synaptic contacts. (foundationdystoniaresearch.org)
Synaptic transmission and long-term potentiation are demonstrably impaired in mice 6 months of age. (mmrrc.org)
This mutant mouse exhibits plaque and tangle pathology associated with synaptic dysfunction, traits similar to those observed in Alzheimer's disease patients. (mmrrc.org)

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