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  • gynecomastia
  • The pathologic causes of gynecomastia are diverse and may include Klinefelter syndrome, certain cancers, endocrine disorders, metabolic dysfunction, various medications, or may occur due to a natural decline in testosterone production. (wikipedia.org)
  • Medications such as aromatase inhibitors have been found to be effective in rare cases of gynecomastia from disorders such as aromatase excess syndrome or Peutz-Jeghers syndrome, but surgical removal of the excess tissue is usually required. (wikipedia.org)
  • A small proportion of male gynecomastia cases may be seen with rare inherited disorders such as spinal and bulbar muscular atrophy and the very rare aromatase excess syndrome. (wikipedia.org)
  • Osteoporosis
  • For example, guys with Klinefelter syndrome may be more likely to get some types of cancer and other diseases, like type 2 diabetes and osteoporosis, a condition where the bones become weaker later in life. (kidshealth.org)
  • Osteoporosis (weakening of the bones) is common complication of Klinefelter syndrome. (sharedjourney.com)
  • Klinefelter syndrome can lead to weak bones ( osteoporosis ), varicose veins, and autoimmune diseases (when the immune system acts against the body), such as lupus or rheumatoid arthritis. (hormone.org)
  • Klinefelter syndrome is associated with an increased risk for breast cancer, a rare tumor called extragonadal germ cell tumor, lung disease, varicose veins and osteoporosis. (genome.gov)
  • hormone
  • Klinefelter HF Jr, Reifenstein EC Jr, Albright F. Syndrome characterized by gynecomastia aspermatogenesis without a-Leydigism and increased excretion of follicle-stimulating hormone. (medscape.com)
  • Throughout their development, the syndrome prevents their bodies from producing enough of the male sex hormone testosterone. (sharedjourney.com)
  • under the supervision of Fuller Albright he described a group of nine men with "gynecomastia, aspermatogenesis without aleydigism, and increased excretion of follicle-stimulating hormone", the first description of what would be called the Klinefelter syndrome. (wikipedia.org)
  • The title, "A Syndrome Characterized by Gynecomastia, Aspermatogenesis without Aleydigism, and Increased Excretion of Follicle-Stimulating Hormone," was so long that the syndrome came to be known by my name, though it was really just another of Dr. Albright's diseases. (wikipedia.org)
  • male
  • See our section on Klinefelter treatment, under Male Infertility: Drugs and Treatment, for more information. (sharedjourney.com)
  • A small proportion of male gynecomastia cases may be seen with rare inherited disorders such as spinal and bulbar muscular atrophy and the very rare aromatase excess syndrome. (wikipedia.org)
  • Disorders
  • Men who have Klinefelter syndrome also have an increased risk for autoimmune disorders such as lupus, rheumatoid arthritis and Sjogren's syndrome. (genome.gov)
  • Medications such as aromatase inhibitors have been found to be effective in rare cases of gynecomastia from disorders such as aromatase excess syndrome or Peutz-Jeghers syndrome, but surgical removal of the excess tissue is usually required. (wikipedia.org)
  • facial
  • The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue. (drugs.com)
  • findings
  • Klinefelter described his findings as follows: I first worked under Dr. Howard Means, measuring oxygen consumption of adrenal gland slices in the Warburg apparatus, but I was so unsuccessful at it, breaking most of the apparatus, that in September, I asked Dr. Means if I might work with Dr. Fuller Albright, since I primarily wanted to learn some clinical endocrinology. (wikipedia.org)
  • often
  • Since high-school life often revolves around schoolwork and sports, guys with Klinefelter may feel like they don't fit in or lack self-confidence. (kidshealth.org)
  • Often, men don't even know they have Klinefelter until they run into problems trying to have a child. (webmd.com)
  • Males with XYY syndrome are fertile and are not often aware that they have an abnormality. (wikipedia.org)
  • humans
  • If the findings can be safely transferred into humans, it might eventually be possible for men with Klinefelter syndrome (XXY) or Double Y syndrome (XYY) that are infertile to have children through assisted reproduction using this technique. (eurekalert.org)
  • In humans, a single transverse palmar crease is a single crease that extends across the palm of the hand, formed by the fusion of the two palmar creases (known in palmistry as the "heart line" and the "head line") and is found in people with Down Syndrome. (wikipedia.org)
  • Huntington's
  • Human genetic diseases attributable to changes in a single gene include sickle cell anemia, cystic fibrosis, Huntington's disease and fragile X syndrome, e. (reference.com)
  • Examples of this type of disorder are Huntington's disease, neurofibromatosis type 1, neurofibromatosis type 2, Marfan syndrome, hereditary nonpolyposis colorectal cancer, hereditary multiple exostoses (a highly penetrant autosomal dominant disorder), Tuberous sclerosis, Von Willebrand disease, and acute intermittent porphyria. (wikipedia.org)
  • Diseases
  • AML, MDS, or myeloproliferative disorder (MPD) with a high incidence of secondary diseases and a six-month survival rate are associated with a polysomy 8 syndrome. (wikipedia.org)
  • people
  • If left untreated people with Kallmann syndrome will have poorly defined secondary sexual characteristics, show signs of hypogonadism, almost invariably be infertile and be at increased risk of developing osteoporosis. (wikipedia.org)
  • total
  • Kallmann syndrome has an additional symptom of a total lack of sense of smell or a reduced sense of sense of smell which distinguishes it from other forms of hypogonadotropic hypogonadism. (wikipedia.org)