PneumoniaInfectionsMultidrug-resistant Klebsiella pneumoniaeAntibioticsBacteriaSpeciesVirulenceAntimicrobial resistanceIsolates of Klebsiella pneumoniaeSubspSerotypeStrainsGenusClinical isolatesEscherichia ColiCarbapenemsGenomicColiResistantGenesOxytocaCarl FriedlanderVaccineGenomeEdwin KlebsGeneticPathogen2016AntigensSearch
Pneumonia10
- Klebsiella [kleb−see−ell−uh] is a type of gram-negative bacteria that can cause different types of healthcare-associated infections, including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis. (cdc.gov)
- For example, Klebsiella must enter the respiratory (breathing) tract to cause pneumonia, or the blood to cause a bloodstream infection. (cdc.gov)
- Klebsiella pneumonia : epidemiology and genomics / Tara Palmore, Julie Segre, Henry Masur. (nih.gov)
- Klebsiella pneumonia, a rare and severe disease with dark brown or red currant-jelly sputum, lung abscess formation, and empyema, is most common among people with diabetes and people with an alcohol use disorder. (msdmanuals.com)
- Klebsiella pneumoniae ( K. pneumoniae ) causes a wide range of infections, including pneumonia, urinary tract infections, bacteremia and liver abscesses, and mainly infects immunocompromised people. (wreg.com)
- This rapid risk assessment evaluates the risk of transmission and further spread of OXA-48-producing Klebsiella pneumonia e ST392 from travellers having sought medical care in Gran Canaria to healthcare facilities in their country of origin in the EU/EEA. (europa.eu)
- Klebsiella pneumoniae is one of the pathogens on the WHO priority list and is a significant cause of hospital-acquired diseases such as pneumonia, bloodstream infections, and infections among ICU patients and newborns. (indiatimes.com)
- Jodhpur: Indian Institute of Technology - Jodhpur (IIT-J) is studying the mechanisms behind Klebsiella pneumoniae one of the pathogen which is identified by World Health Organisation (WHO) as a significant cause of hospital-acquired diseases such as pneumonia, bloodstream infections, and infections among ICU patients and newborns. (indiatimes.com)
- Carl Friedlander was the first scientist to describe Klebsiella pneumoniae in 1882 as an encapsulated bacillus after isolating the bacterium from the lungs of patients who had died from pneumonia (Ashurst and Dawson, 2022). (etsu.edu)
- Was Glasgow coma scale 3, PE, on life support 3 weeks, had klebsiella pneumonia and acinetobacter which they quarantined me for. (cancer.org)
Infections21
- The following is a discussion on the specific agents used in the antimicrobial therapy of Klebsiella infections. (medscape.com)
- Useful for most Klebsiella infections. (medscape.com)
- Effective for K pneumoniae meningitis and other Klebsiella infections. (medscape.com)
- Indicated for a variety of Klebsiella infections. (medscape.com)
- In healthcare settings, Klebsiella infections commonly occur among sick patients who are receiving treatment for other conditions. (cdc.gov)
- Patients whose care requires devices like ventilators (breathing machines) or intravenous (vein) catheters, and patients who are taking long courses of certain antibiotics are most at risk for Klebsiella infections. (cdc.gov)
- Healthy people usually do not get Klebsiella infections. (cdc.gov)
- Klebsiella infections that are not drug-resistant can be treated with antibiotics. (cdc.gov)
- Researchers are developing a promising alternative to antibiotic treatment for infections caused by Klebsiella pneumoniae bacteria resistant to carbapenem antibiotics. (nih.gov)
- Klebsiella bacteria cause about 10 percent of all hospital-acquired infections in the United States. (nih.gov)
- The majority of human Klebsiella infections are caused by K. pneumoniae, followed by K. oxytoca. (wikipedia.org)
- ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
- RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)
- Infections with Klebsiella , Enterobacter , and Serratia are often hospital-acquired and occur mainly in patients with diminished resistance. (msdmanuals.com)
- This project will investigate the suitability of combined bacteriophage and antibiotic approaches to reduce multidrug-resistant Klebsiella pneumoniae infections, particularly in humans. (bund.de)
- Klebsiella pneumoniae has been reported as one of the leading causes of nosocomial infections including urinary, respiratory and blood infections (Podschun and Ullmann, 1998). (scielo.br)
- Background: Data elucidating trends of community-onset extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae infections remain sparse in low prevalence areas. (aau.dk)
- Healthcare associated infections due to carbapenem-resistant Klebsiella pneumoniae (CRKP) are a major concern in Portuguese hospitals. (unl.pt)
- Hypervirulent Klebsiella pneumoniae isolates of capsular serotype K2 (hvKP-K2) that cause community-acquired invasive infections represent several unrelated clones, which all belong to phylogenetic group KpI. (microbiologyresearch.org)
- Klebsiella pneumoniae bacteria are normal gastrointestinal flora but, particularly in people with weakened immune systems and/or debilitating diseases, can also cause severe infections whose management has been complicated by increasing antimicrobial resistance over the last 20 years. (biomedcentral.com)
- Themanagement of severe neurologic infections due to multidrug-resistant (MDR) Klebsiella pneumoniae infection remains a challenge. (figshare.com)
Multidrug-resistant Klebsiella pneumoniae2
- Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. (microbiologyresearch.org)
- it has been evaluated as a potential treatment for multidrug-resistant isolates and as an antibiotic adjuvant for meropenem against hypervirulent multidrug-resistant Klebsiella pneumoniae isolates. (iisc.ac.in)
Antibiotics5
- Increasingly, Klebsiella bacteria have developed antimicrobial resistance, most recently to the class of antibiotics known as carbapenems . (cdc.gov)
- Some Klebsiella bacteria have become highly resistant to antibiotics. (cdc.gov)
- When bacteria such as Klebsiella pneumoniae produce an enzyme known as a carbapenemase (referred to as KPC-producing organisms), then the class of antibiotics called carbapenems will not work to kill the bacteria and treat the infection. (cdc.gov)
- Explaining the basis of the virulence of the bacteria, Dr Shankar Manoharan, Assistant Professor, Department of Bioscience and Bioengineering, IIT Jodhpur , said, "One of the ways in which Klebsiella pneumoniae escapes the body's immune system, and antibiotics is by producing an extremely sticky and viscous protective covering (hypermucoviscosity) around itself. (indiatimes.com)
- In this study, we will assess and characterize a Klebsiella bacteriocin that may work synergistically with antibiotics so that antibiotic dosage might be reduced. (etsu.edu)
Bacteria12
- Klebsiella bacteria are normally found in the human intestines (where they do not cause disease). (cdc.gov)
- To get a Klebsiella infection, a person must be exposed to the bacteria. (cdc.gov)
- In healthcare settings, Klebsiella bacteria can be spread through person-to-person contact (for example, from patient to patient via the contaminated hands of healthcare personnel, or other persons) or, less commonly, by contamination of the environment. (cdc.gov)
- Klebsiella species are examples of Enterobacterales, a normal part of the human gut bacteria, that can become carbapenem-resistant. (cdc.gov)
- Klebsiella bacteria. (nih.gov)
- Klebsiella is a genus of Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule. (wikipedia.org)
- similipneumoniae K. grimontii K. variicola Klebsiella bacteria tend to be rounder and thicker than other members of the family Enterobacteriaceae. (wikipedia.org)
- any of several rod-shaped, aerobic bacteria of the genus Klebsiella, certain species of which, as K. pneumoniae, are found in the respiratory, intestinal, and genitourinary tracts of humans and animals and are sometimes pathogenic. (infoplease.com)
- Klebsiella oxytoca (KO) is one of several Klebsiella bacteria. (healthline.com)
- Each type of infection is the result of Klebsiella bacteria getting into your body. (healthline.com)
- The gram-negative bacteria Klebsiella , Enterobacter , and Serratia are closely related normal intestinal flora that rarely cause disease in normal hosts. (msdmanuals.com)
- Knowing that other genes and mechanisms could play a part in the virulence of Klebsiella pneumoniae, the researchers continue to study variations (mutants) of the P34 strain of the bacteria to understand the correlation between the mucous formation and the genes present or absent. (indiatimes.com)
Species8
- Klebsiella species are found everywhere in nature. (wikipedia.org)
- The species of Klebsiella are all gram-negative and usually non-motile. (wikipedia.org)
- Klebsiella species are known to also infect a variety of other animals, both as normal flora and opportunistic pathogens. (wikipedia.org)
- Klebsiella species have also been implicated in the pathogenesis of ankylosing spondylitis and other spondyloarthropathies. (wikipedia.org)
- Here we report an analysis of 3,482 genome sequences representing 15 Klebsiella species sampled over a 17-month period from a wide range of clinical, community, animal and environmental settings in and around the Italian city of Pavia. (utu.fi)
- Klebsiella pneumoniae is the type species for the Klebsiella genus and is the bacterium of interest for this project. (etsu.edu)
- This potential bacteriocin demonstrates efficacy towards Citrobacter , Enterobacter , and Klebsiella species and could offer an alternative treatment option for the highly drug resistant Enterobacteriaceae family. (etsu.edu)
- Identification of the Klebsiella species and phylogroups was performed by combining the PCR and RFLP techniques. (refaad.com)
Virulence2
- 2004. Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. (mgc.ac.cn)
- Due to its high virulence and antibiotic resistance, the management and treatment of Klebsiella pneumoniae have challenged the medical and scientific community worldwide. (indiatimes.com)
Antimicrobial resistance1
- We characterize the antimicrobial resistance and the genetic relationship among five Klebsiella pneumoniae multidrug-resistant isolated from canine and one isolated from a horse in a Veterinary Teaching Hospital in Brazil. (refaad.com)
Isolates of Klebsiella pneumoniae1
- In this study, the discriminatory power of pulsed field gel electrophoresis (PFGE) and random amplified polymorphic DNA (RAPD) methods for subtyping of 54 clinical isolates of Klebsiella pneumoniae were compared. (scielo.br)
Subsp4
Serotype1
- The structure of the capsular polysaccharide isolated from Klebsiella serotype K69 has been investigated by a combination of chemical and spectroscopic methods. (eurekamag.com)
Strains2
- wzi gene sequencing, a rapid method for determination of capsular type for Klebsiella strains. (microbiologyresearch.org)
- The emergence of carbapenem-resistant Klebsiella pneumoniae strains is threatening antimicrobial treatment. (biomedcentral.com)
Genus3
- The members of the genus Klebsiella are a part of the human and animal's normal flora in the nose, mouth and intestines. (wikipedia.org)
- Members of the genus Klebsiella typically express two types of antigens on their cell surfaces. (wikipedia.org)
- The genus, Klebsiella , named after the microbiologist Edwin Klebs, are characterized as rod-shaped, Gram-negative γ-proteobacteria that can live in water, soil, and plants and are pathogenic to humans and animals. (mgc.ac.cn)
Clinical isolates2
- Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping. (microbiologyresearch.org)
- Development of a rapid identification method for Klebsiella pneumoniae phylogenetic groups and analysis of 420 clinical isolates. (microbiologyresearch.org)
Escherichia Coli2
- Prevalence of Extended Spectrum Beta Lactamase producing Escherichia coli and Klebsiella spp. (nepjol.info)
- Escherichia coli and Klebsiella spp. (nepjol.info)
Carbapenems1
- Healthcare-associated Klebsiella pneumoniae clones that are non-susceptible to carbapenems can spread rapidly, representing a high public health burden. (utu.fi)
Genomic2
Coli5
- A total of 402 E. coli and Klebsiella spp. (nepjol.info)
- Prevalence of ESBL among E. coli and Klebsiella spp. (nepjol.info)
- Among the E. coli , 16.1% (58/360) and only 4.8% (2/42) of Klebsiella spp. (nepjol.info)
- Among total 30 ESBL isolates selected by systematic random sampling, 3 isolates (all three E. coli ) showed presence of TEM and 3 other isolates (two E. coli and one Klebsiella spp. (nepjol.info)
- In this study, we have isolated the plasmids from a possible Klebsiella bacteriocin and transformed them into E. coli to characterize the plasmid. (etsu.edu)
Resistant6
- Antibody-mediated killing of carbapenem-resistant ST258 Klebsiella pneumoniae by human neutrophils. (nih.gov)
- Klebsiella pneumoniae is a leading cause of antibiotic-resistant-associated deaths in the world. (nih.gov)
- Klebsiella pneumoniae (K. pneumoniae) is the leading pathogen globally underlying cases of neonatal sepsis and is frequently resistant to antibiotic treatment regimens recommended by the World Health Organization ( WHO ), including first-line therapy with ampicillin and gentamicin , second-line therapy with amikacin and ceftazidime , and meropenem . (bvsalud.org)
- News, via the Washington Post 's hard-working health reporter Brian Vastag: After 6 months with no cases, carbapenem-resistant Klebsiella has surfaced again at the Clinical Center of the National Institutes of Health, and has killed a boy from Minnesota who came to the specialty hospital after a bone-marrow transplant meant to address an immune deficiency. (marynmckenna.com)
- One of the things that broke while I was gone was a new paper in Science Translational Medicine describing the ferocious impact on a hospital at the National Institutes of Health of the arrival of carbapenem-resistant Klebsiella pneumoniae , known for short as KPC or CRKP. (marynmckenna.com)
- Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258. (microbiologyresearch.org)
Genes3
- Here, we report the identification of the D-galactan II-synthesizing genes by screening a transposon mutant library of an acapsulated Klebsiella pneumoniae O1 strain with bacteriophage. (frontiersin.org)
- It has been known that the capsule and mucous-like protections in Klebsiella pneumoniae are driven by the rmpA, rmpA2, rmpC, and rmpD genes. (indiatimes.com)
- Highlighting the future trajectory of their work, Dr Manoharan said, "We are currently studying these mutants and disrupted genes to explain the potentially new mechanisms behind this unusual sticky and viscous covering of Klebsiella pneumoniae P34. (indiatimes.com)
Oxytoca3
- What Is Klebsiella Oxytoca? (healthline.com)
- 2012. Complete genome sequence of Klebsiella oxytoca KCTC 1686, used in production of 2,3-butanediol. (mgc.ac.cn)
- 2012. Complete genome sequence of Klebsiella oxytoca E718, a New Delhi metallo-β-lactamase-1-producing nosocomial strain. (mgc.ac.cn)
Carl Friedlander1
- Carl Friedlander described Klebsiella bacillus which is why it was termed Friedlander bacillus for many years. (wikipedia.org)
Vaccine2
- However, currently, no Klebsiella vaccine has been licensed for use in the US. (wikipedia.org)
- Global, regional, and national estimates of the impact of a maternal Klebsiella pneumoniae vaccine: A Bayesian modeling analysis. (bvsalud.org)
Genome2
Edwin Klebs1
- Klebsiella is named after German-Swiss microbiologist Edwin Klebs (1834-1913). (wikipedia.org)
Genetic3
- In addition, available Klebsiella bacteriophages from the consortium will be sequenced to provide detailed information on the genetic basis of the phages. (bund.de)
- Although the composition of the O1 antigen of Klebsiella was resolved more than two decades, the genetic locus involved in the biosynthesis of D-galactan II and the role of D-galactan II in bacterial pathogenesis remain unclear. (frontiersin.org)
- Genetic Diversity of Klebsiella spp. (wikipedia.org)
Pathogen1
- Klebsiella pneumoniae is a major human pathogen responsible for high morbidity and mortality rates. (pacb.com)
20161
- 2016. Klebsiella pneumoniae: Going on the Offense with a Strong Defense. (mgc.ac.cn)
Antigens1
- The increased faecal recovery of klebsiella in the first two weeks was predominantly in HLA-B27 positive patients or patients possessing antigens which cross-react with B27, namely, HLA-B7 CREG. (bmj.com)