• presynaptic
  • For example, one study found that Group I mGluRs are located mostly on postsynaptic parts of cells, while groups II and III are mostly located on presynaptic elements, though they have been found on both pre- and postsynaptic membranes. (wikipedia.org)
  • 12 Capsaicin, by binding to the ligand-gated vanilloid-sensitive transient receptor potential channel, TRPV1, on presynaptic terminals, directly catalyzes Ca +2 entry and also effects a depolarization that activates presynaptic calcium channels, as well as releasing Ca +2 from intracellular reticuli whose membranes contain TRPV1 channels, 13 all of which result in the release of glutamate and SP from primary nociceptor terminals. (asahq.org)
  • genome
  • Normal cellular homologs of v-Raf and v-Mil were soon found in both the mouse and chicken genome (hence the name c-Raf for the normal cellular Raf gene), and it became clear that these too had a role in regulating growth and cell division. (wikipedia.org)
  • calcium
  • In comparison to calcium (Ca), the most abundant cation in the human body, Mg 2+ displays higher affinity for oxygen donor ligands, that is negatively charged carboxylates and phosphates or enolate moieties (WOLF, CITTADINI 2003). (docplayer.net)
  • Incubation of rat brain frontal cortical slices with 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1 H -3-benzazepine (SKF83959), a recently identified selective agonist of the PI-linked D 1 -like dopamine receptor, elicited transient time- and dose-dependent stimulations of cyclin-dependent kinase 5 (cdk5) and calcium/calmodulin-dependent protein kinase II (CaMK II) activities. (aspetjournals.org)
  • activation
  • Moreover, we found that cdk5 phosphorylates dopamine and cAMP-regulated phosphoprotein at Thr75, whereas CaMK II is responsible for the activation of cAMP response element-binding protein in response to SKF83959 stimulation. (aspetjournals.org)
  • gene
  • Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). (nih.gov)
  • Pseudogenes of this gene are found on chromosomes 10, 13, and 17. (nih.gov)
  • The first Raf gene, v-Raf was found in 1983. (wikipedia.org)
  • A year later, another transforming gene was found in the avian retrovirus MH2, named v-Mil - that turned out to be highly similar to v-Raf. (wikipedia.org)
  • One gene of particular interest is ras, which is found mutated at high frequency in a number of malignancies. (embl.de)
  • although
  • It should also not be confused with AMP-activated protein kinase - which, although a member of the protein kinase superfamily and a Ser/Thr kinase, may have opposite effects - nor be confused with cyclin-dependent kinases (Cdks), nor be confused with the acid dissociation constant pKa. (wikipedia.org)
  • domain
  • On its N-terminal segment, a Ras-binding domain (RBD) and a C-kinase homologous domain 1 (C1 domain) are found next to each other. (wikipedia.org)
  • Historically, this autoinhibitory block was labelled as the CR1 region ("Conserved Region 1"), the hinge region being named CR2, and the kinase domain CR3. (wikipedia.org)
  • cells
  • All cells function to maintain the resting condition adenylate metabolite concentrations as best as possible in the face of increasing ATP demand. (hindawi.com)
  • Not surprisingly considering its relevance for cellular metabolism, Akt/PKB is often found hyperactive in cancer cells. (frontiersin.org)
  • We found virus type-specific (HTLV1 vs. HTLV3), expression-specific (Tax1 vs. Tax3) and cell-type-specific (T lymphocytes vs. kidney epithelial cells) changes in the metabolite profiles. (pubmedcentralcanada.ca)