• catalytic
  • PKA is also commonly known as cAMP-dependent protein kinase, because it has traditionally been thought to be activated through release of the catalytic subunits when levels of the second messenger cAMP rise in response to a variety of signals. (wikipedia.org)
  • presynaptic
  • For example, one study found that Group I mGluRs are located mostly on postsynaptic parts of cells, while groups II and III are mostly located on presynaptic elements, though they have been found on both pre- and postsynaptic membranes. (wikipedia.org)
  • 12 Capsaicin, by binding to the ligand-gated vanilloid-sensitive transient receptor potential channel, TRPV1, on presynaptic terminals, directly catalyzes Ca +2 entry and also effects a depolarization that activates presynaptic calcium channels, as well as releasing Ca +2 from intracellular reticuli whose membranes contain TRPV1 channels, 13 all of which result in the release of glutamate and SP from primary nociceptor terminals. (asahq.org)
  • inhibitor
  • Pretreatment with Triton X-100, a detergent that damages the endocardial endothelium (EE), or with 1H-(1,2,4)oxadiazolo-(4,3-a)quinoxalin-1-one (ODQ), a specific inhibitor of soluble guanylate cyclase, or with the cGMP-activated protein kinase (PKG) inhibitor KT5328, abolished ANG II-mediated inotropism. (biologists.org)
  • Our study on the detergent-reconstituted enzyme shows that chlorophyllide a and phytol, the products of chlorophyll a hydrolysis, affect the activity, but their effects are antagonistic: chlorophyllide a activates chlorophyllase while phytol acts as the inhibitor. (docplayer.net)
  • genome
  • Normal cellular homologs of v-Raf and v-Mil were soon found in both the mouse and chicken genome (hence the name c-Raf for the normal cellular Raf gene), and it became clear that these too had a role in regulating growth and cell division. (wikipedia.org)
  • genes
  • out of 540 different protein kinase genes that make up for human kinome, only one other protein kinase, Casein kinase 2, is known to exist in a physiological tetrameric complex. (wikipedia.org)
  • In the in vivo study, we found that the levels of mrna of two chlorophyllases involved in chlorophyll catabolism in Arabidopsis thaliana, products of the AtCLH1 and AtCLH2 genes, dramatically increase upon illumination with white light. (docplayer.net)
  • calcium
  • Incubation of rat brain frontal cortical slices with 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1 H -3-benzazepine (SKF83959), a recently identified selective agonist of the PI-linked D 1 -like dopamine receptor, elicited transient time- and dose-dependent stimulations of cyclin-dependent kinase 5 (cdk5) and calcium/calmodulin-dependent protein kinase II (CaMK II) activities. (aspetjournals.org)
  • gene
  • Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). (nih.gov)
  • Pseudogenes of this gene are found on chromosomes 10, 13, and 17. (nih.gov)
  • The first Raf gene, v-Raf was found in 1983. (wikipedia.org)
  • A year later, another transforming gene was found in the avian retrovirus MH2, named v-Mil - that turned out to be highly similar to v-Raf. (wikipedia.org)
  • One gene of particular interest is ras, which is found mutated at high frequency in a number of malignancies. (embl.de)
  • activation
  • Moreover, we found that cdk5 phosphorylates dopamine and cAMP-regulated phosphoprotein at Thr75, whereas CaMK II is responsible for the activation of cAMP response element-binding protein in response to SKF83959 stimulation. (aspetjournals.org)
  • domain
  • On its N-terminal segment, a Ras-binding domain (RBD) and a C-kinase homologous domain 1 (C1 domain) are found next to each other. (wikipedia.org)
  • Historically, this autoinhibitory block was labelled as the CR1 region ("Conserved Region 1"), the hinge region being named CR2, and the kinase domain CR3. (wikipedia.org)
  • cells
  • All cells function to maintain the resting condition adenylate metabolite concentrations as best as possible in the face of increasing ATP demand. (hindawi.com)
  • Not surprisingly considering its relevance for cellular metabolism, Akt/PKB is often found hyperactive in cancer cells. (frontiersin.org)
  • We found virus type-specific (HTLV1 vs. HTLV3), expression-specific (Tax1 vs. Tax3) and cell-type-specific (T lymphocytes vs. kidney epithelial cells) changes in the metabolite profiles. (pubmedcentralcanada.ca)