Kinase terminal avian proteins. Medical search. Frequent questions

CRKL or v-crk sarcoma virus CT10 oncogene homolog (avian)-like is a protein kinase containing SH2 and SH3 (src homology) domains that activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion (1). (rockland.com)
KRAS - (Kirsten rat sarcoma viral oncogene homolog) - One of many RAS proteins. (wikilectures.eu)

This cascade causes following cytoskeletal adjustments and activation of RAS-MAPK (mitogen-activated protein kinase) signaling pathways (26, 28). (cahrr.org)
However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. (origene.com)
Stimulation of heterophils with each specific TLR agonist led to a differential increase in the phosphorylation of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase 1/2 (ERK 1/2) activation, but not the phosphorylation of c-Jun NH2-terminal kinase (JNK). (ox.ac.uk)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)
Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor (PDGFR) pathway and epidermal growth factor receptor (EGFR). (wikipedia.org)
Phosphorylated Y397 FAK can recruit another essential signaling protein, p85 PI3-kinase (phosphoinositide 3-kinase), development factor receptor destined protein Grb 7, phospholipase Cgamma(PLCgamma) and. (cahrr.org)
a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
We made RBD-HA, a fusion of the receptor-binding domain (RBD) of spike derived from SARS-CoV-2 as a vaccine target with HA derived from influenza A virus (IAV) as a carrier protein. (bvsalud.org)
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. (origene.com)
Our study also showed that there are no genetic differences in receptor specificity or the cleavability of the haemagglutinin proteins of these viruses regardless of whether they are of low or high pathogenicity in mink. (biomedcentral.com)
Alternative splicing of the avian trkB receptor generates an extracellular deletion (ED) isoform missing 11 amino acids from the neurotrophin-binding domain of the full-length (FL) receptor. (jneurosci.org)
The trk receptors, a family of receptor tyrosine kinases including trkA, trkB, and trkC, serve as the principal signal-transducing receptors for the neurotrophins ( Barbacid, 1994 ). (jneurosci.org)
Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. (ningbobio.com)
c-Fgr is a human non-receptor tyrosine kinase family member that was discovered by using a probe toward the v-Fgr portion of the cell-derived domain of Gardner-Rasheed feline sarcoma virus. (ningbobio.com)
Her2 (or ERBB2) (Human epidermal growth factor receptor 2) - tyrosin-kinase receptor protein, expressed on the breast cells controls the extent of growth. (wikilectures.eu)
ErbB4, also called Her4 (human epidermal growth factor receptor 4), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. (bio-techne.com)
Because ErbB3 contains a defective kinase domain, the kinase domain of ErbB2 is responsible for initiating the tyrosine phosphorylation signal through the heterodimeric receptor. (bio-techne.com)

v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk. (wikipedia.org)
Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase. (wikipedia.org)
It belongs to a family of Src family kinases and is similar to the v-Src (viral Src) gene of Rous sarcoma virus. (wikipedia.org)
The broad TLR expression profile in heterophils reflects their principal role as first line effector cells in avian host defense against bacterial, viral, fungal, and parasitic infections. (ox.ac.uk)
Interestingly, our previous studies revealed that the viral Np9 protein is an oncoprotein and potently activates a variety of pathways such as β-catenin, ERK, Akt and Notch1, and promotes the growth of human leukemia stem/progenitor cells [ 1 ]. (aging-us.com)
Given that we previously defined the viral np9 gene, which is aberrantly activated in human leukemia, as a potent oncogene [ 1 ], we next attempted to search for cellular homologs of the viral oncogene np9 in NCBI database by performing alignment using Np9 protein sequence. (aging-us.com)
It encodes a transctiption factor and its structure is highly similar to the viral protein. (wikilectures.eu)

Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. (avivasysbio.com)
It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. (avivasysbio.com)
Coupled with previous experimental data and genetic characterization here we tried to investigate the possible influence of different genes on the virulence of these H10 avian influenza viruses in mink. (biomedcentral.com)
As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)

AIM OF THE STUDY: The aim is to study the effect of EP and Echinacea purpurea (L.) Moench extracts(EE) on avian influenza virus (AIV) immunity, and further explore the potential mechanism of immune regulation. (bvsalud.org)
MATERIALS AND METHODS: Broilers were fed with feed additives containing 2% EP or 0.5% EE, and vaccinated against avian influenza. (bvsalud.org)
In poly I:C stimulated mink lung cells the NS1 protein of influenza A virus showing high pathogenicity in mink down regulated the type I interferon promoter activity to a greater extent than the NS1 protein of the virus showing low pathogenicity in mink. (biomedcentral.com)
The outbreak of severe respiratory disease in mink ( Mustela vison) in 1984 was linked to an avian influenza virus of subtype H10N4. (biomedcentral.com)
Avian influenza (H5N1) is rare in humans in developed countries. (medscape.com)
Unless advised by the CDC or regional health departments, clinicians do not routinely need to test for avian influenza. (medscape.com)
Countries where avian influenza has been reported. (medscape.com)
Type I interferon antagonistic properties of influenza B virus polymerase proteins. (uni-muenster.de)
Evaluating the impact of environmental temperature on global highly pathogenic avian influenza (HPAI) H5N1 outbreaks in domestic poultry. (flugenome.org)
The emergence and unfold of extremely pathogenic avian influenza (HPAI) A virus subtype H5N1 in Asia, Europe and Africa has had an enormously socioeconomic influence and presents an vital risk to human well being due to its environment friendly animal-to-human transmission. (flugenome.org)
Genetic range and phylogenetic evaluation of extremely pathogenic avian influenza ( HPAI ) H5N1 viruses circulating in Bangladesh from 2007-2011. (flugenome.org)
Extremely pathogenic avian influenza (HPAI) H5N1 virus has been endemic in Bangladesh since its first isolation in February 2007. (flugenome.org)
Pre-exposing Canada Geese (Branta canadensis) to a low-pathogenic H1N1 avian influenza virus protects them in opposition to H5N1 HPAI virus problem. (flugenome.org)
In earlier research we examined the function of Canada Geese (Branta canadensis) within the epidemiology of Eurasian extremely pathogenic avian influenza (HPAI) H5N1. (flugenome.org)
To develop on this and higher perceive how pre-exposure to heterosubtypic low-pathogenic avian influenza (LPAI) viruses may affect the result of H5N1 HPAI an infection, we pre-exposed naïve juvenile Canada Geese to completely different North American wild-bird-origin LPAI viruses. (flugenome.org)
Enhanced infectivity of H5N1 extremely pathogenic avian influenza ( HPAI ) virus in pig ex vivo respiratory tract organ cultures following adaptation by in vitro passage. (flugenome.org)

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. (wikipedia.org)
Proto-oncogene changes to oncogene mainly by somatic point mutations, gene amplifications, or chromosomal translocations that bring proto-oncogene under control of differentially expressed protein. (wikilectures.eu)

Description: FES (Feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. (glucagon-receptor.com)
c-Src phosphorylates specific tyrosine residues in other tyrosine kinases. (wikipedia.org)

Blood antibody titer, jejunal sIgA content, tight junction protein, gene and protein expression of TLR4-MAPK signaling pathway were also detected. (bvsalud.org)

ed complications, at the end of the WNV and identify possible avian car- global smallpox vaccination cam- riers. (cdc.gov)
This study tests sampled migratory and local wild birds to detect WNV and identify possible avian carriers. (cdc.gov)

This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. (wikipedia.org)
The results demonstrate the differential involvement of TLR-induced signals in the stimulation of transduction pathways that regulate the oxygen-dependent and -independent antimicrobial defense mechanisms of avian heterophils. (ox.ac.uk)

RNA species obtained from clonal lines of avian sarcoma and from avian leukosis virus. (wikidata.org)
The BIC gene is activated by promoter insertion at a retroviral integration site on chromosome 21q21 in B cell lymphomas induced by avian leukosis virus. (biomedcentral.com)

The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells. (wikipedia.org)
Y861 and Y925 (19, 26), also to phosphorylation of FAK binding proteins after that, such as for example paxillin and Cas (27). (cahrr.org)

ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)

Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. (origene.com)
Recombinant full length human CRKL was expressed by baculovirus in Sf9 insect cells using an N-Terminal his epitope. (rockland.com)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (bio-techne.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (bio-techne.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (bio-techne.com)

Infection of ATI or ATII alveolar epithelial cells of the distal lung has been Roflumilast N-oxide detected in fatal cases of avian (H5N1) and 2009 pandemic (pH1N1) IAV, RSV, and SARS-CoV (Johnson et al. (cancercurehere.com)

Characterization of a 105,000 molecular weight gag-related phosphoprotein from cells transformed by the defective avian sarcoma virus PRCII. (wikidata.org)
Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus. (wikidata.org)

Two peptide fragments, corresponding to the amino acid residues 106-126 (PrP[Ac-106-126-NH2]) and 106-114 (PrP[Ac-106-114-NH2]) of the human prion protein have been synthesised in the acetylated and amide form at their N- and C-termini, respectively. (cnr.it)
It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues. (lookformedical.com)
Expression and Purification of Human Bcl-2 Residues 1-218 of the Bcl-2 gene (UniProt entry "type":"entrez-protein","attrs":"text":"P10415″,"term_id":"231632″P10415) were optimized for expression in (GeneArt, Life Technologies) and cloned into a pET28a vector with an N-terminal His6-MBP solubility tag with a TEV cleavage site to remove the tag. (immune-source.com)

FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. (glucagon-receptor.com)
The Kinase site offers Y576/577 tyrosines very important to catalytic activity of FAK. (cahrr.org)
Ribonucleic acid in protozoa having regulatory and catalytic roles as well as involvement in protein synthesis. (lookformedical.com)

FAK N-terminal site The function from the N-terminal, homologous to FERM site was from the binding of integrins, via their subunits(22). (cahrr.org)

from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin. (lookformedical.com)
Np17 is located on chromosome 8, consists of 7 exons, and encodes a 16.8kDa nuclear protein with149 amino-acid residue. (aging-us.com)
The human c-Fgr gene encodes a 529 amino acid protein. (ningbobio.com)

A putative cytadhesin-related protein (PvpA) undergoing variation in its manifestation was identified in the avian pathogen gene was cloned, expressed in and and 49% homology was found having a stretch of 205 amino acids of the cytadherence accessory protein HMW3 of strains, ranging from 48 to 55 kDa and caused by several types of deletions occurring in the PvpA C-terminal end and within the two directly repeated sequences. (careersfromscience.org)
Interestingly, assessment of the known cytadhesin acccessory molecules from (P30) and (P32) with the analogous molecules in (MGC1, MGC2, and GapA) exposed the presence in all of a proline-rich C-terminal region containing repeated coding sequences, as well as amino acid sequence homology (4, 5, 8, 10, 12, 31). (careersfromscience.org)

Genetic structure, transforming sequence, and gene product of avian sarcoma virus UR1. (wikidata.org)
The best yields were attained with an N-terminal affinity tag made up of a polyhistidine sequence and either the maltose binding proteins (MBP) Goat polyclonal to IgG (H+L)(Biotin) or the chaperone protein AB1010 cell signaling Result in AB1010 cell signaling Aspect (TF). (immune-source.com)

Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)

The unique property of some avian H10 viruses, particularly the ability to cause severe disease in mink without prior adaptation, enabled our study. (biomedcentral.com)
The ON mapping showed a close genomic relationship between the mink isolate (A/Mink/Sweden/3900/84) and the concomitant avian H10N4 viruses from fowl (A/fowl/Hampshire/378/85) and mallard (A/mallard/Gloucestershire/374/85) respectively, and a weaker genomic relationship with the H10 prototype [ 7 ] virus (A/chicken/Germany/N/49) [ 4 ]. (biomedcentral.com)
V) in HA protein of some clade 2.2 Bangladeshi viruses together with the human isolates , suggesting there was antigenic drift in clade 2.2. (flugenome.org)

High CDK7 mRNA and protein levels were identified to be associated with poor prognosis in NSCLC. (biomedcentral.com)
URG4/URGCP protein and mRNA expression were significantly upregulated in HCC cell lines. (biomedcentral.com)
In this study, at the mRNA and/or protein level, the expression patterns were similar for renal FXYD12 and NKA in the two medakas. (ijbs.com)

Relationships of FAK and additional proteins proven by group are demonstrated in Italics. (cahrr.org)
CAPN3 provides some exclusive domains including its NH2-terminal domains I which has 20C30 additional proteins not within - and m-calpains and two exclusive insertion sequences' of 62 and 77 proteins on the COOH-terminal parts of domains II (known as Is normally1) and domains III (known as IS2). (exposed-skin-care.net)

Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. (wikipedia.org)
Given the versatility inherent in this intrinsically disordered region, its multisite phosphorylations, and its divergence within the family, the unique domain likely functions as a central signaling hub overseeing much of the enzymatic activities and unique functions of Src family kinases. (wikipedia.org)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
Hsp70 chaperones are one family of chaperone proteins. (elifesciences.org)
Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility and adhesion. (ningbobio.com)
Src-family ki-nases contain an amino-terminal cell membrane anchor followed by an SH3 domain and an SH2 domain, which are involved in modular association and activation, respectively. (ningbobio.com)
Src-family kinases, which are normally maintained in an inactive state and can be activated transiently during cellular events such as mitosis. (ningbobio.com)
Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization and membrane trafficking. (ningbobio.com)
Moreover, the FXYD protein family was found to be a regulator of NKA. (ijbs.com)

Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. (avivasysbio.com)

The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. (biomedcentral.com)

Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
This protein has no ligand binding domain of its own and therefore cannot bind growth factors. (origene.com)
Proteins which bind to DNA. (lookformedical.com)
Proteins that specifically bind to TELOMERES. (lookformedical.com)
The presence of the interdomain linker makes it more difficult for unfolded proteins to bind. (elifesciences.org)

Open in another window Shape 1 Focal Adhesion Kinase Besifloxacin HCl can be overexpressed in tumor examples. (cahrr.org)
Open up in another window Shape 2 Focal Adhesion Kinase (FAK) framework. (cahrr.org)
Vertebrate paxillin, a cytoskeletal focal adhesion protein. (embl.de)
Zyxin is a low-abundance adhesion plaque protein which has been shown to interact with CRP. (embl.de)

Therefore, FAK-Src signaling complicated activates a great many other signaling proteins, involved with success, motility and metastatic, intrusive phenotype in tumor cells. (cahrr.org)
It has been shown that, due to its α -tocopheryl moiety, the agent activates protein phosphatase-2A that, in turn, inhibits protein kinase C (PKC). (nature.com)

This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)
FAK gets the N-terminal, Kinase site as well as the C-terminal domains. (cahrr.org)
LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. (embl.de)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)

Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)

Binding of CAPN3 to titin, a huge myofibrillar proteins that acts as a scaffold for sarcomeric. (exposed-skin-care.net)

c-Src should not be confused with CSK (C-terminal Src kinase), an enzyme that phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity. (wikipedia.org)

The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. (wikipedia.org)

The C-terminal site of FAK offers Y861 and Y925 tyrosines. (cahrr.org)

Tyrosine-specific protein kinase activity associated with p105 of avian sarcoma virus PRCII. (wikidata.org)
Grapevine fanleaf virus RNA1-encoded proteins 1A and 1BHel suppress RNA silencing. (harvard.edu)
Src is the human homolog of the v-Src gene of the rous sarcoma virus, also designated avian sarcoma virus or ASV. (ningbobio.com)
c-jun - This gene is the putative transforming gene of avian sarcoma virus 17. (wikilectures.eu)

The N-terminal site offers Y-397-Y-autophosphorylation site. (cahrr.org)
The N-terminal site (1C415 a.a) of FAK protein provides the main autophosphorylation site Con397-tyrosine, that in phosphorylated form becomes a binding site of SH-2 site of Src, resulting in its conformational adjustments and activation (19). (cahrr.org)

While it is possible that this protein could display some level of activity, the functionality of this protein has not been explicitly measured or validated. (novusbio.com)
Furthermore, overexpressing URG4/URGCP increased - whereas knockdown of URG4/URGCP decreased - VEGFC expression, NF-κB transcriptional activity, the levels of phosphorylated (but not total) IκB kinase (IKK) and IκB-α, and expression of TNFα, IL-6, IL-8 and MYC in HCC cells. (biomedcentral.com)

It includes an SH2 domain, an SH3 domain and a tyrosine kinase domain. (wikipedia.org)
The dimerization of c-Src is mediated by the interaction of the myristoylated N-terminal region of one partner and the kinase domain of another partner. (wikipedia.org)
The crystal structure from the N-terminal domain of avian FAK, including FERM domain offers been Besifloxacin HCl recently referred to (23). (cahrr.org)

The human being FAK (also called PTK2, protein tyrosine kinase 2) gene continues to be mapped to chromosome 8 (15, 16). (cahrr.org)
A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)

is usually multifactorial, involving the coordinate action of main adhesin molecules (P1 and P30) and several high-molecular-weight accessory membrane proteins that act in concert with cytoskeletal elements to facilitate the lateral movement and concentration of the adhesin buy Kaempferol-3-rutinoside molecules in the attachment organelle (4, 9, 15, 16, 29, 32, 38, 39). (careersfromscience.org)

The type II alveolar (ATII) cells produce pulmonary Rabbit polyclonal to PAI-3 surfactant that is required to prevent alveolar collapse and proteins that participate in innate defense of the lung (Mason, 2006). (cancercurehere.com)

Saccharomyces cerevisiae (Baker's yeast) rho-type GTPase activating protein RGA1/DBM1. (embl.de)

Anatomy16

Organisms10

Chemicals and Drugs167

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes44

Disciplines and Occupations1

Information Science3

Oncogene homolog2

Mitogen-activa4

Receptor15

Viral7

Genes6

Influenza16

Proto-oncogene2

Tyrosine kinases2

Signaling pathway1

Identify possible avian2

Pathways2

Leukosis virus2

Phosphorylation2

Cytoplasmic1

Recombinant5

H5N11

Characterization2

Residues3

Catalytic3

Homologous1

Encodes3

Homology2

Sequence2

Transcript1

Viruses3

MRNA3

Additional proteins2

Family9

Activator2

Polymerase1

Bind6

Adhesion4

Activates2

Domains6

Amino-acid protein1

Myofibrillar1

Regulation1

Regulator1

Tyrosines1

Virus4

Autophosphorylation2

Activity2

Domain3

Chromosome2

Cytoskeletal1

Defense1

GTPase1