Kinase repressor proteins. Medical search. Frequent questions

Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. (nih.gov)
Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)
Hatzis P, Kyrmizi I, Talianidis I. (2006) Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression. (forth.gr)

Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. (sigmaaldrich.com)
Alvocidib, a cyclin-dependent kinase 9 (CDK9) inhibitor and indirect transcriptional repressor of the anti-apoptotic factor MCL-1, has previously shown clinical activity in AML. (haematologica.org)
In this study, we investigated the effect of AKI603, a novel small molecule inhibitor of Aurora kinase A (AurA) to overcome resistance mediated by BCR-ABL-T315I mutation. (scite.ai)
Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent Inhibitor, Repressor of (p58 Repressor) (aa 1-761) Protein, tagged with His tag. (creative-biolabs.com)

Alterations in genes with potential clinical utility are observed in more than three quarters of the cases and included members of the PI3-kinase and homologous DNA repair pathways. (nih.gov)
At the end of rapid growth, a co-ordinated transient up-regulation of about 100 genes, including many for ribosomal proteins, was seen in the parent strain but not the Δ bldA mutant. (biomedcentral.com)
Transcripts or proteins from a further 147 genes classified as bldA -influenced were mostly expressed late in culture in the wild-type, though others were significantly transcribed during exponential growth. (biomedcentral.com)
Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. (avivasysbio.com)
It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. (avivasysbio.com)
Here, we report the transcriptional regulation of two genes, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD) and phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE), by IKAROS in T-ALL. (psu.edu)
To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
AhR heterodimerizes with AhR nuclear translocator (ARNT) before binding to dioxin response elements (DREs) in the upstream regulatory regions of AhR target genes, such as the cytochrome P450-dependent monooxygenase Cyp1a1, the AhR repressor (AhRR), and the IL-22 interleukin. (invivogen.com)
These thermosensors are part of a regulatory network, such as the production of heat shock proteins mediated by sigma factor 32 (RpoH) in Escherichia coli or the transcriptional repressor of heat-shock genes HrcA in Bacillus subtilis (Hecker et al. (springer.com)
Tissue-specific deletion of important autophagy genes (ATG) such as for example or has uncovered that autophagy has a cytoprotective function by degrading possibly dangerous aggregated proteins and broken organelles (2C9). (careersfromscience.org)
It binds to downstream elements inseveral vertebrate ribosomal protein genes, where it apparently acts positively to stimulatetranscription and can act either negatively or positively in the context of the immunoglobulin k 3enhancer and immunoglobulin heavy-chain E1 site as well as the P5 promoter of theadeno-associated virus. (careersfromscience.org)

Functional analysis demonstrates that IKAROS functions as a transcriptional repressor of both PIK3CD and PIKFYVE. (psu.edu)
2006) Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. (forth.gr)

The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis. (bvsalud.org)
ERF is an ETS domain transcriptional repressor regulated by Erk1/2 phosphorylation via nucleo-cytoplasmic shuttling. (ox.ac.uk)

Targeted inhibition of individual kinases of the MAPK signaling pathway using synthetic compounds represents a promising way to effective anti-cancer therapy. (mdpi.com)
Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes of targeted therapies and plays important role during development of drug resistance in cancers. (mdpi.com)

Glutamine-expanded Ataxin-1 causes disease by a gain-of-function mechanism given that mice lacking this protein do not reproduce SCA1 features. (bcm.edu)
Our analysis of SCA1 transgenic mice revealed that the mutant protein aggregates in the nuclei of cerebellar Purkinje cells and that these aggregates stain positively for ubiquitin, the proteasome, and some chaperones. (bcm.edu)
Most of the important insights regarding the specific function of AP-1 proteins have been established through the use of mice with either loss- or gain-of-function manipulations of various members of the bZIP protein family [ 13 ]. (biomedcentral.com)
By using a direct in vivo shRNA screen, we show that liver cancer cells that have mutations in the gene encoding the tumor suppressor protein p53 (Trp53 in mice and TP53 in humans) and that are driven by the oncoprotein NRAS become addicted to MYC stabilization via a mechanism mediated by aurora kinase A (AURKA). (scite.ai)
ETS2 repressor factor (ERF) insufficiency causes craniosynostosis (CRS4) in humans and mice. (ox.ac.uk)
Wild type, PI3Kγ knock-out (PI3Kγ -/- ) and PI3K kinase dead knock-in (PI3Kδ D910/A910 ) transgenic mice were exposed to cigarette smoke for 3 days and the expression levels of the co-repressor complex components HDAC-2, mSin3a, Mi-2α and Mi-2β and HDAC-2 activity in the lungs were assessed. (biomedcentral.com)
Both mSin3a and Mi-2α protein expression was reduced in smoke-exposed mice. (biomedcentral.com)
Budesonide alone protected mSin3a protein expression with no additional effect seen with abrogation of PI3Kγ/δ activity, however Mi-2α, but not Mi-2β, expression was protected in both PI3Kδ D910/A910 and PI3Kγ -/- budesonide-treated smoke-exposed mice. (biomedcentral.com)

PIK3CD encodes the protein p110δ subunit of phosphoinositide 3-kinase (PI3K). (psu.edu)
Cigarette smoke exposure induced glucocorticoid insensitivity and alters co-repressor activity and expression which is prevented by blockade of PI3K signaling with glucocorticoid treatment. (biomedcentral.com)

Since Myc is the common downstream protein of both BCR-ABL and AurA, we proposed the combinational effect of AKI603 and imatinib could be caused by inhibition of Myc. (scite.ai)

ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene. (wikipedia.org)
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (nih.gov)
Based on recent data, a new view is emerging that vertebrate Dachshund(Dach) proteins are components of Six1/6 transcription factor-dependent signaling cascades. (biologists.com)
The c-Jun dimerization protein 2, JDP2 is an AP-1 repressor protein that potently inhibits AP-1 transcription. (biomedcentral.com)
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. (academicinfluence.com)
Due to the inherent diversity in the underlying mechanisms, protein-based thermosensors affect different cellular processes such as transcription, translation, protein stability, signal transduction as well as proteolytic processes. (springer.com)
The key co-repressor complex components HDAC-2, Mi-2α/β and mSin3a are all critical to the regulation of gene transcription. (biomedcentral.com)
Gene transcription is tightly regulated by a highly complex and dynamic set of processes central to which is the recruitment of co-repressors to promoter bound sequence specific transcription factors [ 1 - 3 ]. (biomedcentral.com)

In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. (hmdb.ca)
Autophagy is a vesicular trafficking pathway that regulates the degradation of aggregated protein and damaged organelles. (careersfromscience.org)
Furthermore to ULK1, the course III phosphatidylinositol 3-kinase Vps34 is necessary for the forming of autophagosomes during pathway initiation. (careersfromscience.org)

We report that chick Dach1 interacts with the Smad complex and the corepressor mouse Sin3a, thereby acting as a repressor of BMP-mediated transcriptional control. (biologists.com)
This led us to propose that wild-type Ataxin-1 might take on a conformation that resists clearance or interacts strongly with other proteins and that such conformation is favored by the expanded polyglutamine tract. (bcm.edu)

What pathways are this gene/protein implicaed in? (cancerindex.org)
In addition, the sterol regulatory element-binding protein SREBP (Sre) was used for the regulation of lipid metabolic pathways to promote lycopene overproduction in P. pastoris for the first time. (bvsalud.org)
Protein complexes, which are formed as a result of these interactions, consist of two or more components that associate along specific pathways - protein association pathways. (lu.se)

The coronavirus genome encodes a spike protein, an envelope protein, a membrane protein, and a nucleoprotein. (creative-biolabs.com)

Protein transport between the nuclear and the cytoplasmic compartment is a key factor for cell viability and proliferation. (massgeneral.org)

This protein is the full-length p52 subunit and partial p100 subunit. (abcam.com)

It thus appears that YY1 is a bifunctional protein, capable of functioning asan activator in some transcriptional control elements and a repressor in others. (careersfromscience.org)

Inhibitors of anti-apoptotic BCL-2 family proteins in combination with chemotherapy and hypomethylating agents (HMAs) are promising therapeutic approaches in acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS). (haematologica.org)

This model predicts that most proteins that interact with wild-type Ataxin-1 should interact with the mutant protein and that modifications of Ataxin-1 that might alter its conformation are critical to pathogenesis. (bcm.edu)
Changes in temperature are typically sensed as a result of conformation changes of protein structure as well as misfolded proteins. (springer.com)
de Marcos-Lousa C, P Sideris D, Tokatlidis K. (2006) Translocation of mitochondrial inner-membrane proteins: conformation matters. (forth.gr)
HDACs function by deacetylating of key components of the transcriptional machinery including the core histone proteins resulting in their in re-association with the DNA, thus presenting a transcriptionally closed conformation [ 1 , 16 ]. (biomedcentral.com)

Different dimer combinations act as transcriptional activators or repressors, respectively. (abcam.com)

IKAROS, encoded by the IKZF1 gene, is a DNA-binding protein that functions as a tumor suppressor in T cell acute lymphoblastic leukemia (T-ALL). (psu.edu)

Protein-based thermosensors are a very diverse group including transcriptional regulators, sensor kinases, chaperones or proteases (reviewed in Klinkert and Narberhaus 2009 ). (springer.com)

Earlier studies suggested that extracellular Mg(2+) signalled through the presumed sensor histidine kinase, CsrS. (lu.se)

With the aim of discovering consequences of bldA mutation that are not obvious to the naked eye, we set out to analyse the RNA and protein extracted from a series of liquid cultures of isogenic bldA + and bldA deleted strains. (biomedcentral.com)
In collaboration with Harry Orr's group (University of Minnesota), we determined that the mutation responsible for SCA1 is an expansion of a CAG trinucleotide repeat encoding glutamine in the protein Ataxin-1. (bcm.edu)

Both the mSin3a and Mi-2/NuRD co-repressor complexes are large multi-component complexes in which not all of the components and their functions have been identified [ 2 , 6 ]. (biomedcentral.com)
The impact of oxidative stress on key components of the co-repressor complexes have only just started to be explored, with the very recent publication highlighting the impact of oxidative stress driven protein kinase-CK2 activation on co-repressor activity and HDAC2 function [ 20 ]. (biomedcentral.com)

mTORC1 suppresses autophagy and in parallel promotes cell development via the activation of eIF4E and ribosomal S6 proteins kinase (S6K) (15). (careersfromscience.org)

Nutrient restriction represents among the major ways that autophagy is turned on, and in this framework, the recycling of mobile components supplies the cell using a way to obtain ATP and proteins to maintain regular homeostatic procedures (1). (careersfromscience.org)

NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. (abcam.com)
NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. (hmdb.ca)

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
In TE7 cells, these TGF-β1-induced changes were reversed by 100 ng/mL of bone morphogenetic protein 7 (BMP7), another member of the TGF-β1 superfamily. (aacrjournals.org)
HT29-Lucia™ AhR cells are engineered from the human HT-29 colon adenocarcinoma cell line for the study of the aryl hydrocarbon receptor (AhR) genomic signaling induction (see details), by monitoring the activity of the Lucia luciferase reporter protein. (invivogen.com)

Inactive AhR resides in the cytoplasm within a Hsp90:XAP2:p23:Src protein complex. (invivogen.com)

but this includes many previously unknown effects at a variety of different levels, including post-translational changes in proteins and global cellular physiology. (biomedcentral.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Frequencies of synonymous and non-synonymous substitutions allow studying selection of cancer somatic mutations in protein-coding regions [ 11 ]. (biomedcentral.com)

Recent reports demonstrate that the expression of protein kinase C alpha (PKCα) in triple-negative breast cancer (TNBC) correlates with decreased survival outcomes. (oncotarget.com)
This study shows that the expression of both myeloid zinc finger 1 (MZF-1) and Ets-like protein-1 (Elk-1) correlates with PKCα expression in TNBC. (oncotarget.com)
The restoration of glucocorticoid function coincided with the protection of both HDAC activity and mSin3a and Mi-2α protein expression. (biomedcentral.com)

There was a statistically significant but weak positive global correlation between transcript and corresponding protein levels. (biomedcentral.com)

This suggested to us that the nuclear inclusions are probably protective by sequestering the glutamine-expanded protein and reducing its native interactions. (bcm.edu)

Hb, Kr, and Kni are zinc-finger gap proteins that act primarily as repressors in specific embryonic domains. (sdbonline.org)
AP-1 proteins are primarily considered to be oncogenic. (biomedcentral.com)

Recognizing the importance of protein interactions for mediating SCA1 pathogenesis, and given that SCA1 shares clinical and pathological features with several other inherited ataxias, we proposed that understanding the interactions of Ataxin-1 as they relate to the interactions of proteins implicated in other ataxias might provide better insight about molecular mechanisms leading to Purkinje cell degeneration and ataxia. (bcm.edu)

EMT was mediated via canonical TGF-β1 signaling with concomitant up-regulation of SMAD-interacting protein 1. (aacrjournals.org)

In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. (sigmaaldrich.com)
53BP1 (p53-binding protein 1) facilitates ATM-dependent DSB repair but is largely dispensable for ATM activation or checkpoint arrest. (birmingham.ac.uk)
We found that 14-3-3 proteins interact with Ataxin-1 in a S776-dependent manner and that 14-3-3 augments levels of Ataxin-1 when phosphorylated at S776 by Akt kinase. (bcm.edu)
The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. (avivasysbio.com)

Temperature has a direct effect on fundamental biological systems, including enzyme activity and correct folding of proteins. (springer.com)

ERF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)

Anatomy8

Organisms10

Chemicals and Drugs145

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes67

Information Science3

Mitogen-activa4

Inhibitor4

Genes11

Functions as a transcriptional2

Phosphorylation2

MAPK2

Mice8

PI3K2

Inhibition1

Transcription8

Pathway3

Interacts2

Pathways3

Encodes1

Factor1

Subunit1

Transcriptional control1

Inhibitors1

Conformation4

Activators1

Tumor1

Chaperones1

Extracellular1

Mutation2

Complexes2

Ribosomal1

Homeostatic1

P1052

Cells3

Complex1

Cellular1

Mutations2

Expression3

Transcript1

Nuclear1

Primarily2

Molecular1

Regulation1

Dependent4

Activity1

MeSH1