• EGF-receptor and Notch signaling are antagonistic: EGF-receptor signaling leads to down-regulation of the Notch-like receptor LIN-12 , while LIN-12 signaling induces negative regulators of EGF-receptor signaling such as MAP kinase phosphatase LIP-1 and the tyrosine kinase ARK-1. (wormbook.org)
  • Its receptor tyrosine kinase, c-Met , is expressed in the cochlear epithelium and melanocyte-derived intermediate cells in the stria vascularis. (jneurosci.org)
  • Compared to HL60 cells, the tyrosine phosphorylation level in K562 cells was markedly increased, suggesting that the increase in tyrosine phosphorylation is due to BCR ABL tyrosine kinase activity, which was confirmed by the expression of BCR ABL shown only in K562 cells. (rafinhibitors.com)
  • Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
  • The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. (iiab.me)
  • It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
  • HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (iiab.me)
  • HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. (iiab.me)
  • Finally, the Tumor Necrosis Factor Receptor Family include immune checkpoint molecules such as CD27, tumor markers such as CD30, and co-stimulatory molecules such as CD40. (pharna.com)
  • This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
  • In the present study, we performed a comparative study of the ubiquitous CMV promoter and three neuron-specific promoters, chicken Ca2+/calmodulin-dependent kinase (cCaMKII), chicken Nestin (cNestin), and human synapsin I. We explored the possibility of manipulating gene expression in chicken embryonic brain cells using in ovo electroporation with the selected promoters. (biomedcentral.com)
  • MELK-8a is a maternal embryonic leucine zipper kinase (MELK) inhibitor. (csnpharm.cn)
  • Several of the identified genes, for example, RYR1 , ALLC , PTPRN2 , LRRC3B , PAX2 and VTRNA2-1 , are genes previously linked to either pesticide exposure or lung-related diseases. (bmj.com)
  • Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)
  • Altering the positive limb core molecular clock transcription factor, CLOCK, or CLOCK-output genes, accelerates visual senescence, induces a systemic immune response, and shortens lifespan. (bvsalud.org)
  • The anchor cell induces nearby epidermal precursor cells to generate vulval cells via an epidermal growth factor (EGF) signaling pathway. (wormbook.org)
  • Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the MAP kinase and JNK family. (wikipedia.org)
  • This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. (wikipedia.org)
  • Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. (wikipedia.org)
  • The anterior intermediate mesoderm, which expresses LIM homeobox 1 ( Lhx1 ) and paired box gene 2 ( Pax2 ), develops into the ureteric bud lineage, which forms the ureteric epithelium through branching and growth. (j-organoid.org)
  • Cytokines are a family of cell signaling proteins that include Chemokines, Interleukins, Tumor Necrosis Factors (TNFs), Transforming Growth Factors (TGFs), Inter ferons, and Colony Stimulating Factors (CSFs). (pharna.com)
  • see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. elegans ), and WNT (see Wnt signaling ), as well as the functions of the SynMuv and mediator proteins (see Transcriptional regulation ). (wormbook.org)
  • Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. (cusabio.com)
  • This factor promotes the growth and branching of the ureteric bud. (j-organoid.org)
  • Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
  • Type I Cytokine Receptors include interleukin receptors, colony stimulating factor receptors, and hormone receptors whereas Type II Cytokine Receptors include inter feron receptors and cytokine receptors that bind to interleukin-10 family. (pharna.com)
  • A family history of pancreatic cancer is an essential risk factor [ 20 ], and germline BRCA2 mutations comprise the highest proportion of known reasons for inherited pancreatic cancer [ 21 ]. (biomedcentral.com)
  • Meanwhile, the ureteric bud secretes Wnt-9b and fibroblast growth factor 9 (FGF9), which differentiate the metanephric mesenchyme into pretubular aggregates. (j-organoid.org)
  • Introduction Type 1 diabetes (T1D) is a paradigmatic example of autoimmune disease stemming from a complex interaction between genetic Olcegepant hydrochloride and environmental factors [1]. (healthweblognews.info)
  • MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (wikipedia.org)
  • The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced apoptosis. (wikipedia.org)
  • these include the LIM domain protein LIN-11 , the Pax2/5/8 protein EGL-38 , the zinc finger protein LIN-29 , and the Nkx6.1/6.2 protein COG-1. (wormbook.org)
  • lacks kinase domain), and erbB-4. (iiab.me)
  • The interstitial stroma, another subcompartment of the metanephric nephron, is characterized by the expression of the transcription factor forkhead box D1 ( Foxd1 ). (j-organoid.org)
  • In characterizing the molecular differentiation of developing peripheral auditory structures, we discovered that hepatocyte growth factor ( Hgf ) is expressed in the future stria vascularis of the cochlear epithelium. (jneurosci.org)
  • SIGNIFICANCE STATEMENT We found the roles of hepatocyte growth factor (HGF) signaling in stria vascularis development for the first time and that lack of HGF signaling in the inner ear leads to profound hearing loss in the mouse. (jneurosci.org)
  • demonstrated that ectopic expression of Pax2 in the ventral optic nerve cup prevents choroidal fissure closure [ 14 ]. (biomedcentral.com)
  • Promoters are a key factor determining the expression dynamics of transgenes, and various promoters are being studied in neuronal cells. (biomedcentral.com)
  • While several genetic susceptibility loci have been pinpointed, the environmental factors at play remain boldly elusive. (healthweblognews.info)
  • On day E10.5 of murine development, the metanephric mesenchyme secretes glial cell line-derived neurotrophic factor (GDNF). (j-organoid.org)
  • Specifically, mice fed on an HFD for 2, 4, and 8 wk showed time-dependent renal injury, the significant decrease in renal Pax2 and Ampk at both mRNA and protein levels, and a significant increase in renal sEH at mRNA, protein, and molecular levels. (nih.gov)
  • Also, administration of an sEH inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea, significantly attenuated the HFD-caused renal injury, decreased renal sEH consistently at mRNA and protein levels, modified the renal levels of sEH-mediated epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids (DHETs) as expected, and increased renal Pax2 and Ampk at mRNA and/or protein levels. (nih.gov)
  • Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the MAP kinase and JNK family. (wikipedia.org)
  • Multiple-labelling immunocytochemical studies indicated that these cells did not express either of the preprotachykinin peptides, and that they generally lacked protein kinase Cγ, which is expressed by a subset of the excitatory interneurons in this region. (biomedcentral.com)
  • Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
  • As a proof of concept, we investigated the effect of individual activation of each human transcription factor (n=1,634) on the expression of the cellular prion protein PrP C . We identified 24 upregulators and 12 downregulators of PrP C expression. (biorxiv.org)
  • PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. (csnpharm.cn)
  • H 89 2HCl is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM. (csnpharm.com)
  • Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
  • In addition, COUP-TF activates transcription through protein-protein interaction with DNA-bound factor, such as with HNF-4 in the HNF-1a gene promoter. (guidetopharmacology.org)
  • At P7 Zeb1 can be co-expressed using the proliferation marker Ki67 and two markers of Abscisic Acid GNP identification Siah2 and Meis1/2 and it is greatly low in cyclin-dependent kinase inhibitory protein p27Kip1/Cdkn1b (known as p27 thereafter)-positive postmitotic CGNs in the internal EGL. (tam-receptor.com)
  • 4. Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors. (nih.gov)
  • PKR-IN-1 is a potent human R-type pyruvate kinase (PKR) inhibitor and also shows potency for mutant PKR including R510Q PKR, R532W PKR, T384W PKR etc. (csnpharm.cn)
  • TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) with IC50s of 0.50 μM. (csnpharm.com)
  • PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively. (csnpharm.com)
  • Ellagic acid is a potent and cell permeable casein kinase 2 (CK2) inhibitor with Ki of 20 nM, acts as a potent antioxidant and anti-mutagenic. (csnpharm.com)
  • CK1-IN-1 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively[1]. (csnpharm.com)
  • BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. (csnpharm.com)
  • SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. (csnpharm.com)
  • For all sufficiently studied stem or progenitor cells, melatonin's signaling pathways leading to expression of respective morphogenetic factors are discussed. (nih.gov)
  • These proteins are transcription factors that control developmental pathways. (lookformedical.com)
  • It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
  • HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (iiab.me)
  • HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. (iiab.me)
  • MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (wikipedia.org)
  • Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. (wikipedia.org)
  • 6. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. (nih.gov)
  • Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). (nih.gov)
  • Regulation of follicular development and differentiation by intra-ovarian factors and endocrine hormones. (docslib.org)
  • Finally, the sexual differentiation of many structures passes from an indifferent stage, in which male and female differences are not readily apparent, to a male or female pathway, depending on the presence of specific promoting or inhibiting factors acting on the structure. (clinicalgate.com)
  • Second, goosecoid was identified as a central player in a regulatory sub-circuit controlling mouth formation, while tbx2/3 emerged as a critical factor for differentiation of the dorsal ectoderm . (echinobase.org)
  • Zeb1 gain- or loss-of-function regulates CGN differentiation neurite expansion and GZ leave Provided the Zeb1 manifestation profile we reasoned Abscisic Acid that transcription element might regulate GNP differentiation. (tam-receptor.com)
  • Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK. (nih.gov)
  • However, PAX2, the mediator for CMA, has not been reported in HFD-caused renal injury. (nih.gov)
  • Here we report that HFD-caused renal injury involved the inactivation of Pax2 and Ampk, and the activation of soluble epoxide hydrolase (sEH), in a murine model. (nih.gov)
  • Furthermore, palmitic acid (PA) treatment caused significant increase in Mcp-1, and decrease in both Pax2 and Ampk in murine renal mesangial cells (mRMCs) time- and dose-dependently. (nih.gov)
  • Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. (nih.gov)
  • The following product was used in this experiment: PAX2 (Renal Cell and Ovarian Carcinoma Marker) Monoclonal Antibody (rPAX2/8506) from Thermo Fisher Scientific, catalog # 5076-MSM2-P1ABX. (thermofisher.com)
  • Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with PAX2 Recombinant Mouse Monoclonal Antibody (rPAX2/8506) at 2 µg/mL. (thermofisher.com)
  • PAX2/Renal Coloboma Syndrome Expresses Extreme Intrafamilial Phenotypic Variability. (beds.ac.uk)
  • Identification of of a PAX2 mutation from maternal mosaicism causes recurrent renal disorder in siblings. (beds.ac.uk)
  • Renal cell carcinoma (RCC) is a comprehensive concept, which includes a variety of tumor entities with independent driving factors, histological patterns and clinical prognosis. (biomedcentral.com)
  • PAX2 and CAKUT Phenotypes: Report on Two New Variants and a Review of Mutations from the Leiden Open Variation Database. (beds.ac.uk)
  • 3. Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. (nih.gov)
  • 16. Gene regulation by homeobox transcription factor Prox1 in murine hepatoblasts. (nih.gov)
  • The anterior intermediate mesoderm, which expresses LIM homeobox 1 ( Lhx1 ) and paired box gene 2 ( Pax2 ), develops into the ureteric bud lineage, which forms the ureteric epithelium through branching and growth. (j-organoid.org)
  • CK2/PIM1-IN-1 is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders[1]. (csnpharm.com)
  • On day E10.5 of murine development, the metanephric mesenchyme secretes glial cell line-derived neurotrophic factor (GDNF). (j-organoid.org)
  • Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. (lookformedical.com)
  • DOI: http://dx.doi.org/10.7554/eLife.12717.001 and mRNA was 28-fold greater than another most abundant transcription element (Shape 1a). (tam-receptor.com)
  • Phenotypic spectrum and genetics of PAX2-related disorder in the Chinese cohort. (beds.ac.uk)
  • Although phenotypic sex is genetically determined, genetic sex can be overridden by environmental factors, thus leading to a discordance between the two. (clinicalgate.com)
  • RNA removal and reverse-transcription polymerase string response Total RNA was extracted with RNAprep genuine Cell/Bacteria Package (TIANGEN Beijing China) relating to manufacturer's teaching. (morainetownshipdems.org)
  • The metanephros originates from the intermediate mesoderm, which expresses odd-skipped related transcription factor 1 ( Osr1 ). (j-organoid.org)
  • PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. (nih.gov)
  • Stem cell-specific differences in melatonin and Wnt receptors, and contributions of transcription factors and noncoding RNAs are outlined, as well as possibilities and the medical importance of re-programming for transdifferentiation. (nih.gov)
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • EGFP + cells in the GRP-EGFP mouse did not express Pax2, and their axons contained the vesicular glutamate transporter 2 (VGLUT2), indicating that they are excitatory interneurons. (biomedcentral.com)
  • This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. (wikipedia.org)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)
  • The iPSC was generated from MEF of E13.5 129/C57 F1 mice embryos by transducing MEF with Yamanaka factors. (morainetownshipdems.org)
  • Production of lentiviral vectors carrying tri-fusion reporter gene and establishment of iPS-TF line The lentivirus vectors were produced by cotransfecting 293T cells with three plasmids including reporter gene-carrying plasmid with fluc-mRFP-ttk fusion gene packaging system ps PAX2 and envelop plasmid pMD2G detailed protocol see Ref. 16. (morainetownshipdems.org)
  • A combination is represented by These cells of white matter interneuron or oligodendrocyte precursors as these cells also express Pax2? (tam-receptor.com)
  • COUP-TFII stimulates the transcriptional activity of the rat cholesterol 7a-hydroxylase (CYP7A) promoter by binding to the nucleotide sequence located between 74 and 54 (relative to the transcription start site), which contains a direct repeat of two hormone response element half-sites separated by 4 nucleotides. (guidetopharmacology.org)
  • Lung cancer risk factors, including smoking and exposure to environmental carcinogens, have been linked to chronic inflammation. (biomedcentral.com)