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Inositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInositol PhosphatesInositolSugar PhosphatesCalciumPhosphatidylinositol 3-KinasesPhosphatidylinositolsCalcium ChannelsReceptors, Cytoplasmic and NuclearMAP Kinase Signaling SystemProtein-Serine-Threonine KinasesProtein KinasesPhosphatidylinositol PhosphatesType C PhospholipasesPhosphotransferases (Alcohol Group Acceptor)Phosphoric Monoester HydrolasesProtein Kinase CCalcium-Calmodulin-Dependent Protein KinasesCalcium SignalingProtein Kinase Inhibitorssrc-Family KinasesKineticsCyclic AMP-Dependent Protein KinasesSignal TransductionPhytic AcidPhosphorylationPhosphatidylinositol 4,5-Diphosphatep38 Mitogen-Activated Protein KinasesMitogen-Activated Protein Kinase 1Second Messenger SystemsProtein-Tyrosine KinasesCell Linep21-Activated KinasesMitogen-Activated Protein Kinase KinasesMitogen-Activated Protein Kinase 3JNK Mitogen-Activated Protein KinasesIsoenzymesCarbacholMolecular Sequence DataCytosolEnzyme ActivationDiglycerides1-Phosphatidylinositol 4-KinaseLithiumCells, CulturedMacrocyclic CompoundsProtein BindingInosine TriphosphateAmino Acid SequenceCreatine KinaseCyclin-Dependent KinasesCDC2 Protein KinaseThapsigarginMAP Kinase Kinase KinasesCell MembraneCasein Kinase IITransfectioneIF-2 KinaseCasein KinasesCyclic AMPPyruvate KinaseRibosomal Protein S6 KinasesEstrenesAdenosine TriphosphateThimerosalBoron CompoundsMutationPhosphotransferases (Phosphate Group Acceptor)Dose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesMAP Kinase Kinase 1Proto-Oncogene Proteins c-aktTetradecanoylphorbol AcetateReceptor Protein-Tyrosine KinasesRecombinant ProteinsProtein Structure, TertiaryThymidine KinaseMitogen-Activated Protein KinasesBinding SitesEnzyme InhibitorsSubstrate SpecificityDiacylglycerol KinaseFura-2Blotting, WesternPyrrolidinonesMAP Kinase Kinase 4Proto-Oncogene ProteinsAndrostadienesChromatography, High Pressure LiquidTime FactorsGlycogen Synthase Kinase 3rho-Associated KinasesPhosphoproteinsIonomycinProtein Kinase C-alphaModels, BiologicalCDC2-CDC28 KinasesRecombinant Fusion ProteinsCyclic GMP-Dependent Protein Kinases
ReceptorPhospholipasePhosphatidylinositol 3-kinaPhosphorylationPolyphosphateDiacylglycerolPIP2MetabolismBiosynthesisCalciumReceptorsTyrosine kinasesPathwayPhosphatesCytoplasmicEnzymeInhibitsTetrakisphosphatePhospholipidsEndoplasmicPI3KMembrane2020MediatesPolyphosphates2016HydroxylCyclicPhosphate groupIsoformInhibitorInhibitorsAdenosineBinds
Receptor17
  • An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca sensitivity. (rochester.edu)
  • Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis. (rochester.edu)
  • The release of Ca 2+ from intracellular stores through the inositol 1,4,5-trisphosphate receptor (InsP 3 R) occurs in both excitable and nonexcitable cells. (jneurosci.org)
  • DAG activates protein kinase C, and InsP3 mobilizes calcium from intracellular stores via the InsP3 receptor. (nih.gov)
  • Pyk2 overexpression in HEK293 results in attenuated basal and agonist-stimulated inositol phosphate formation in mGluR1 expressing cells and involves a mechanism whereby Pyk2 displaces Galphaq/11 from the receptor. (uwo.ca)
  • TLR-4, toll-like receptor-4. (cams.cn)
  • Fas receptor was activated by incubating NRVM with recombinant Fas ligand (rFasL, 50 ng/ml) and enhancing antibody (1 μg/ml), or by incubation of murine ventricular myocytes with the Fas-activating antibody Jo2 (10 μg/ml). (haifa.ac.il)
  • Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2a differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. (jefferson.edu)
  • Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179. (jefferson.edu)
  • Complement C3a receptor 1 is the receptor for complement factor C3a, a component of the alternative complement cascade. (guidetomalariapharmacology.org)
  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. (drugbank.com)
  • If you are a Human Resources kinase, this response ought to be on a complex in your receptor. (familie-vos.de)
  • Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)
  • Lipid rafts are enriched in a number of signaling molecules including receptor tyrosine kinases, the Src family of nonreceptor tyrosine kinases, small G proteins, and adenylyl cyclases (ACs) and CBA-DAF complex can easily contact lipid rafts because of the absence of cytoplasmic website of DAF (Parton and Richards 2003). (biotechpatents.org)
  • Both stimulated Rac1 activation, reactive oxygen species (ROS) generation, and enhanced Rac1-dependent NADPH oxidase 1 (NOX1) activity, but independent of the activation of Toll-like receptor 3 (TLR-3). (biotechpatents.org)
  • IP3 diffuses through the cytoplasm to the ER and binds to the inositol 1,4,5-trisphosphate (Ins3P) receptor, releasing calcium from the endoplasmic reticulum into the cytoplasm. (smpdb.ca)
  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. (antibodies-online.cn)
Phospholipase10
  • Phospholipase C (PLC) is the focal point for two major signal transduction pathways: one initiated by G protein-coupled receptors and the other by tyrosine kinase receptors. (nih.gov)
  • Both effects of endothelin-1 were blocked by an antagonist of phospholipase C, suggesting that Ins(1,4,5) P 3 and/or diacylglycerol production was necessary. (biologists.com)
  • Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina. (neurotree.org)
  • Group I metabotropic glutamate receptors (mGluRs) are coupled via Galphaq/11 to the activation of phospholipase Cbeta, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. (uwo.ca)
  • Activation of mAChRs is relatively slow (milliseconds to seconds) and, depending on the subtypes present (M1-M5), they directly alter cellular homeostasis of phospholipase C, inositol trisphosphate, cAMP, and free calcium. (genome.jp)
  • Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. (wakehealth.edu)
  • Biosynthesis of IP metabolites begins with the synthesis of inositol 1,4,5-trisphosphate (InsP 3 , IP3), which is produced by phospholipid-specific phospholipase C (PLC). (molcells.org)
  • Furthermore, a strong positive genetic interaction occurs between Gap1 and phospholipase Cgamma (PLCgamma), an enzyme that generates inositol-1,4,5-trisphosphate, a precursor for IP4 and a second messenger for intracellular Ca2+ release. (sdbonline.org)
  • the Src family of tyrosine kinases, phospholipase C (PLC), and is mediated specifically from the IP3R isoform 3. (biotechpatents.org)
  • The Gαq/11 subunit activates phospholipase C (PLC) which cleaves the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) into the secondary messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). (smpdb.ca)
Phosphatidylinositol 3-kina4
  • Phosphatidylinositol 3-kinase is necessary for lens fiber cell differentiation and survival. (jefferson.edu)
  • Radcliff K, Tang TB, Lim J, Zhang Z, Abedin M, Demer LL, Tintut Y. Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways. (jefferson.edu)
  • a phosphatidylinositol 3-kinase (PI3K) to phosphorylate phosphatidylinositol 4,5-bisphosphate and produce phosphatidylinositol 3,4,5-trisphosphate, a major growth signal for activation of Akt kinase. (molcells.org)
  • Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. (drugbank.com)
Phosphorylation7
Polyphosphate2
  • Insights into the biological functions of IPs have come from genetic studies in yeast and by manipulating inositol polyphosphate multikinase (IPMK) expression in mammalian cells. (molcells.org)
  • The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. (enzyme-database.org)
Diacylglycerol5
  • The synthesis of PI involves CDP-activated 1,2-diacylglycerol condensation with myo-inositol. (hmdb.ca)
  • Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
  • Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)
  • Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. (drugbank.com)
  • Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol- 1,4,5-trisphosphate. (antibodies-online.cn)
PIP21
Metabolism1
  • This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. (wikipedia.org)
Biosynthesis2
  • Recently, we reported that functional wheat inositol penta kis phosphate kinase ( TaIPK1 ) is involved in PA biosynthesis, however, the functional roles of the IPK1 gene in wheat remains elusive. (frontiersin.org)
  • LPA biosynthesis proceeds through two major pathways: (1) the conversion of lysophospholipids (e.g. (smpdb.ca)
Calcium5
Receptors4
  • These organelles are defined by the expression of receptors for the second messenger Inositol 1,4,5-trisphosphate. (rochester.edu)
  • Although ventricular cardiomyocytes express inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ] receptors, it is unclear how these Ca 2+ channels contribute to the effects of Gq-coupled agonists. (biologists.com)
  • The endothelin-1-mediated spontaneous Ca 2+ transients were abolished by application of 2-aminoethoxydiphenyl borate (2-APB), an antagonist of Ins(1,4,5) P 3 receptors. (biologists.com)
  • We show here, that the proline-rich tyrosine kinase 2 (Pyk2) interacts with both mGluR1 and mGluR5 and is precipitated with both receptors from rat brain. (uwo.ca)
Tyrosine kinases3
  • Therefore, we tested the effect of the tyrosine kinases inhibitors, genistein (50 μmol/l) and herbimycin A (50 μg/ml), on the abovementioned Fas-mediated effects in cultured neonatal rat ventricular myocytes (NRVM) and in freshly isolated adult murine ventricular myocytes. (haifa.ac.il)
  • This prevention of apoptosis by tyrosine kinases blockade was accompanied by inhibition of hypoxia-induced increased Fas expression and decreased expression of the anti-apoptotic protein xIAP. (haifa.ac.il)
  • Two tyrosine kinases (Abl Fidarestat (SNK-860) and Fyn) are triggered by DAF clustering and both are required for CVB access into polarized epithelial cells (Coyne and Bergelson 2006). (biotechpatents.org)
Pathway1
  • Our data reveal that Pyk2 couples the activation mGluRs to the mitogen-activated protein kinase pathway even though it attenuates mGluR1-dependent G protein signaling. (uwo.ca)
Phosphates1
  • Inositol phosphates (IP) are a group of inositol metabolites that contain multiple phosphates. (molcells.org)
Cytoplasmic1
  • One known cause is the retention of excess cytoplasm around the midpiece due to an arrest in spermiogenesis and incomplete cytoplasmic extrusion [ 1 ]. (biomedcentral.com)
Enzyme5
  • The systematic name of this enzyme class is ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase. (wikipedia.org)
  • This enzyme is also called 1D-myo-inositol-tetrakisphosphate 5-kinase. (wikipedia.org)
  • This enzyme also phosphorylates Ins(1,3,4) P 3 on O-5 and O-6. (enzyme-database.org)
  • A cyclase enzyme (lyase) catalyzes the formation of the cyclic nucleotide from its nucleotide triphosphate precursor ( Figure 1 ). (pancreapedia.org)
  • The Gαi/o subunit inhibits the enzyme adenylyl cyclase (AC) which catalyzes the production of the important secondary messenger 3',5'-cyclic AMP (cAMP) from adenosine triphosphate (ATP). (smpdb.ca)
Inhibits1
Tetrakisphosphate1
  • An inositol-1,3,4,5-tetrakisphosphate (IP4)-sensitive extended PH domain is essential for Gap1 activity, while Ca2+-sensitive C2 domains and a glutamine-rich region contribute equally to full activity in vivo. (sdbonline.org)
Phospholipids1
  • Phosphatidylinositols are acidic (anionic) phospholipids that consist of a phosphatidic acid backbone, linked via the phosphate group to inositol (hexahydroxycyclohexane). (hmdb.ca)
Endoplasmic1
  • Price J, Zaidi AK, Bohensky J, Srinivas V, Shapiro IM, Ali H. Akt-1 mediates survival of chondrocytes from endoplasmic reticulum-induced stress. (jefferson.edu)
PI3K2
  • Toualbi-Abed K, Daniel F, G?ller MC, Legrand A, Mauriz JL, Mauviel A, Bernuau D. Jun D cooperates with p65 to activate the proximal kappaB site of the cyclin D1 promoter: role of PI3K/PDK-1. (jefferson.edu)
  • cooling work PI3K and changes car, the HSV-1 activator serves needed by the MRN blood( MRE11A: RAD50: NBN) and RBBP8( CtIP) considered with BRCA1: BARD1, and coupled by EXO1 or DNA2 in subunit with DNA enzymes BLM, WRN and BRIP1( BACH1)( Sartori et al. (familie-vos.de)
Membrane4
  • Incubation of electrically-paced ventricular myocytes with a membrane-permeant Ins(1,4,5) P 3 ester provoked the occurrence of spontaneous diastolic Ca 2+ transients with the same characteristics and sensitivity to 2-APB as the events stimulated by endothelin-1. (biologists.com)
  • Glucose-induced activation of DAG/PKC signaling in microsomes was not associated with a change in the translocation of Glut-4 transporters from microsomes to the plasma membrane, a biological response that is known to be stimulated by agonists, e.g., phorbol esters, which increase DAG/PKC signaling in plasma membranes, as well as in microsomes. (jci.org)
  • PLCs are activated by external stimuli such as growth factors to cleave phosphatidylinositol 4,5-bisphosphate and produce IP3, which is then released from the cell membrane into the cytosol. (molcells.org)
  • 6 thus of 5 s consultation mTORC1 promoter host( neural society correlation( early federal isoform( disassemble your nucleotides with other K-dependent a membrane text all 3 type diaphragm localization system released a glazing catalyzing desmosomes widely directly. (familie-vos.de)
20203
  • 2020 May 1511 (1):2444. (rochester.edu)
  • Science China Life Sciences (2020) 63 (1): 18. (biologists.com)
  • Wnt5a Plays Controversial Roles in Cancer Progression[J].Chinese Medical Sciences Journal, 2020, 35(4): 357-365. (cams.cn)
Mediates1
Polyphosphates1
20161
  • Front Biosci (Landmark Ed). 2016 Jan 1;21(1):70-88. (smpdb.ca)
Hydroxyl2
  • In most organisms, the stereochemical form of this inositol is myo-D-inositol (with one axial hydroxyl in position 2 with the remainder equatorial), although other forms can be found in certain plant phosphatidylinositols. (hmdb.ca)
  • Cyclic nucleotides form when the phosphate group of the molecule of nucleotide triphosphate (ATP or GTP) is attacked by the 3' hydroxyl group of the ribose, forming a cyclic 3',5'-phosphate ester with release of pyrophosphate. (pancreapedia.org)
Cyclic2
  • The two well-established cyclic nucleotides are adenosine-3',5'-cyclic monophosphate (cyclic AMP) and guanine-3',5'-cyclic monophosphate (cyclic GMP). (pancreapedia.org)
  • The non-canonical cyclic nucleotides include the purines inosine-3',5'-cyclic monophosphate (cyclic IMP), xanthosine-3',5'-cyclic monophosphate (cyclic XMP) and the pyrimidines cytidine-3',5'-cyclic monophosphate (cyclic cCMP), uridine-3',5'-cyclic monophosphate (cyclic UMP), and thymidine-3',5'-cyclic monophosphate (cTMP) (145). (pancreapedia.org)
Phosphate group1
  • The inositol group that is part of every phosphatidylinositol lipid is covalently linked to the phosphate group that acts as a bridge to the lipid tail. (hmdb.ca)
Isoform1
  • Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. (drugbank.com)
Inhibitor1
  • Many studies have proposed multi-objective molecular generation methods and demonstrated their superiority using the public benchmark dataset for kinase inhibitor generation tasks. (bvsalud.org)
Inhibitors1
  • Radioiodine -refractory, progressive thyroid cancers may respond to targeted chemotherapies, such as tyrosine kinase inhibitors. (mhmedical.com)
Adenosine1
  • This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
Binds1