• mice
  • Increased fatty acid (FA) synthesis enzymes and triglyceride deposition correlated with increased profibrotic factors were found in the kidney in diabetes in rats ( 4 ) and mice ( 5 ). (diabetesjournals.org)
  • The mice were sacrificed at 8 weeks post-STZ injection and kidney tissue harvested for analysis using metabolomics and proteomic approaches. (rti.org)
  • acute kidney
  • Our preliminary data suggest that Kim-1-mediated phagocytosis induces autophagy and cytoprotection in PTCs following acute kidney injury. (grantome.com)
  • This is in contrast to outcomes in ischemia/reperfusion induced acute kidney injury where meprin deficiency was previously shown to be protective. (rti.org)
  • urine
  • It has also been used to prevent methotrexate-induced kidney damage by alkalinalizing one's urine, hence speeding up methotrexate excretion by increasing its solubility in urine. (wikipedia.org)
  • functional
  • In this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. (harvard.edu)
  • Blood is filtered by millions of nephrons, the functional units that comprise the kidneys. (wikipedia.org)
  • organic
  • Exogenous cyclic 3',5'-AMP (cAMP) and substances known to increase the intracellular concentration of this nucleotide (isoproterenol, theophylline, noradrenaline, lactate) were shown to inhibit the transport of fluorescein (a weak organic acid) into the rat renal proximal tubules at 20 degrees C. Carbacholine decreasing intracellular cAMP concentration stimulated the transport. (semanticscholar.org)
  • metabolic
  • Further analysis will determine the kidney meprin targets and metabolic pathways which play a role in the progression of DN. (rti.org)
  • Many negatively charged metabolic waste products are eliminated from the body by the kidneys. (wikipedia.org)
  • function
  • The findings from this study will shed light on the role of Kim-1 in acute and chronic kidney injury, as well as highlight the potential therapeutic benefits of modulating Kim-1 function in kidney injury. (grantome.com)
  • Contraindications include: Hyperchloremic acidosis Hypokalemia (low blood potassium) Hyponatremia (low blood sodium) Adrenal insufficiency Impaired kidney function Hypersensitivity to acetazolamide or other sulfonamides. (wikipedia.org)
  • injury
  • Kidney injury continues to have unacceptably high morbidity and mortality with few therapeutic options. (grantome.com)
  • water
  • As a result, there is a change in the activity of the potassium ion (K+) channels that changes the transepithelial transport of solutes and water in the kidney. (wikipedia.org)
  • known
  • Of the four α- and three β-subunit isoforms known, α 1 (NaK-α 1 ) and β 1 (NaK-β 1 ) are predominantly expressed in kidney ( 11 ). (aacrjournals.org)