• mice
  • ADAM17 hypomorphic mice, specific ADAM17 inhibitor-treated WT mice, or mice with inducible KO of ADAM17 in proximal tubule (Slc34a1-Cre) were significantly protected against these effects. (jci.org)
  • Increased fatty acid (FA) synthesis enzymes and triglyceride deposition correlated with increased profibrotic factors were found in the kidney in diabetes in rats ( 4 ) and mice ( 5 ). (diabetesjournals.org)
  • The mice were sacrificed at 8 weeks post-STZ injection and kidney tissue harvested for analysis using metabolomics and proteomic approaches. (rti.org)
  • Taken together, the data suggest that presence of meprin β partially protects mice from the tubular kidney injury associated with diabetes. (rti.org)
  • urine
  • In vivo, in acute kidney injury (AKI) and chronic kidney disease (CKD, fibrosis) patients, soluble AREG is indeed highly upregulated in human urine, and both ADAM17 and AREG expression show strong positive correlation with fibrosis markers in related kidney biopsies. (jci.org)
  • It has also been used to prevent methotrexate-induced kidney damage by alkalinalizing one's urine, hence speeding up methotrexate excretion by increasing its solubility in urine. (wikipedia.org)
  • Mitochondrial
  • Mitochondrial reactive oxygen species (ROS) cause kidney damage in diabetes. (diabetesjournals.org)
  • In conclusion, the mitochondrial ETC is neither the target nor the site of ROS production in kidney tubule mitochondria in short-term diabetes. (diabetesjournals.org)
  • Mitochondrial fatty acid oxidation is the source of the increased net ROS production, and the site of electron leakage is located proximal to coenzyme Q at the electron transfer flavoprotein that shuttles electrons from acyl-CoA dehydrogenases to coenzyme Q. (diabetesjournals.org)
  • functional
  • In this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. (harvard.edu)
  • Blood is filtered by millions of nephrons, the functional units that comprise the kidneys. (wikipedia.org)
  • organic
  • Exogenous cyclic 3',5'-AMP (cAMP) and substances known to increase the intracellular concentration of this nucleotide (isoproterenol, theophylline, noradrenaline, lactate) were shown to inhibit the transport of fluorescein (a weak organic acid) into the rat renal proximal tubules at 20 degrees C. Carbacholine decreasing intracellular cAMP concentration stimulated the transport. (semanticscholar.org)
  • metabolic
  • Further analysis will determine the kidney meprin targets and metabolic pathways which play a role in the progression of DN. (rti.org)
  • Many negatively charged metabolic waste products are eliminated from the body by the kidneys. (wikipedia.org)
  • blood
  • Contraindications include: Hyperchloremic acidosis Hypokalemia (low blood potassium) Hyponatremia (low blood sodium) Adrenal insufficiency Impaired kidney function Hypersensitivity to acetazolamide or other sulfonamides. (wikipedia.org)
  • injury
  • Kidney fibrosis following kidney injury is an unresolved health problem and causes significant morbidity and mortality worldwide. (jci.org)
  • Our preliminary data suggest that Kim-1-mediated phagocytosis induces autophagy and cytoprotection in PTCs following acute kidney injury. (grantome.com)
  • water
  • As a result, there is a change in the activity of the potassium ion (K+) channels that changes the transepithelial transport of solutes and water in the kidney. (wikipedia.org)
  • similar
  • Specifically, the fibroblasts become enlarged and show increased activity of 5'-nucleotidase, and the S1 segment of the proximal tubule shows similar alterations as in various models of hypoxia. (uni-regensburg.de)