• enzyme
  • Moreover, regucalcin has been shown to have an inhibitory effect on aminoacyl t-RNA synthetase, a rate limiting enzyme at translational process of protein synthesis and an activatory effect on cystein protease and superoxide dismutase in liver and kidney cells. (wikipedia.org)
  • Acute
  • Acute kidney injury (AKI) is a common clinical complication with uncertain outcome, ranging from complete restitution to high mortality. (hindawi.com)
  • rats
  • The larger one was observed in the kidneys of the adrenalectomized rats only when they had received chronic administration of excess amount of dexamethasone, and its kallikrein inhibitory activity was not lost with treatment with trypsin. (springer.com)
  • We hypothesize that the expression of the major PGE2 synthesis enzymes cyclooxygenases 1 and 2 (COX-1, COX-2 ) and membrane -associated PGE2 synthase (mPGES) is altered in the kidneys of rats with NDI and CDI . (ndif.org)
  • Dehydration of NDI rats resulted in a marked increase in COX-2 immunolabeling in IM interstitial cells , and there was no significant change in COX-1 and mPGES expression in any kidney zone . (ndif.org)
  • The contralateral kidney received a RI infusion of vehicle in all rats. (ahajournals.org)
  • tissues
  • Four alternatively spliced transcripts encoding different isoforms have been described for this gene.DACH1 mRNA was detected in multiple human tissues, including kidney and heart. (wikipedia.org)
  • widely
  • It is also more widely expressed in the earlier developing kidney, but again including definite podocyte expression. (wikipedia.org)
  • regulation
  • Consistent with this, the density of COX-2 - expressing cells in macula densa was significantly increased, indicating differential regulation of COX-2 in IM and cortex . (ndif.org)
  • Thus, regucalcin plays a multifunctional role in the regulation of cell functions in liver, kidney cortex, heart and brain. (wikipedia.org)
  • cell
  • 4. It was concluded that d -malate inhibited either the operation of the cytoplasmic l -malate dehydrogenase or malate outflow from the mitochondria in the intact kidney-cortex cell. (biochemj.org)
  • The cell line was derived from the kidney of an adult female North American opossum (Didelphis virginiana). (wikipedia.org)
  • function
  • This is probably the result of other bicarbonate or chloride transporters in the kidney compensating for any loss of pendrin function. (wikipedia.org)
  • expression
  • In ISOM and cortex , COX-1 expression was marginally reduced and mPGES expression was unaltered. (ndif.org)
  • COX-2 expression was undetected in ISOM and marginally increased in cortex . (ndif.org)
  • In the cortex , there were no changes in the expression of COX-1 and mPGES, whereas COX-2 expression was decreased. (ndif.org)
  • model
  • This heat transfer model is developed based on actual physical measurements of the vasculature of the canine kidney cortex. (asme.org)
  • pure
  • That is, the way the kidney absorbs water involves osmosis - the flow of pure solvent through a permeable membrane in the direction of the less concentrated solution to the more concentrated solution . (ndif.org)
  • Group III (N = 6) kidneys were flushed with pure Nx HCl (2 mg/kg) during ischemia. (biomedsearch.com)
  • physical
  • Comparison of the size and physical properties of γ-glutamyltranspeptidase purified from rat kidney following solubilization with papain or with Triton X-100. (springer.com)