• MRNA
  • In mouse kidney cortex, si LRP2 reduced mRNA expression to 74.8 ± 6.3% 3 h and 70.1 ± 6.3% 6 h after administration. (hindawi.com)
  • In the kidney, siRNA stabilized with 2′O-methylation is filtered and reabsorbed in the renal proximal tubule (PT) following IV administration, reducing relative mRNA expression temporarily in the PT [ 9 ]. (hindawi.com)
  • Four alternatively spliced transcripts encoding different isoforms have been described for this gene.DACH1 mRNA was detected in multiple human tissues, including kidney and heart. (wikipedia.org)
  • acute
  • siRNA directed to candidate genes, including p53, has prevented multiple forms of acute kidney injury (AKI) and renal fibrosis in animal models [ 10 - 14 ]. (hindawi.com)
  • Acute kidney injury (AKI) is a common clinical complication with uncertain outcome, ranging from complete restitution to high mortality. (hindawi.com)
  • rats
  • The larger one was observed in the kidneys of the adrenalectomized rats only when they had received chronic administration of excess amount of dexamethasone, and its kallikrein inhibitory activity was not lost with treatment with trypsin. (springer.com)
  • Analysis showed that the rats treated with EG/AC alone had higher amounts of calcium in the kidneys compared to negative control rats. (nih.gov)
  • Histology showed that rats treated with EG/AC alone had large deposits of calcium oxalate crystals in all parts of the kidney, and that such deposits were not present in rats also treated with either 100% or 75% lemon juice. (nih.gov)
  • Examination of kidney paraffin sections showed that Group 5 rats (EG/AC alone, positive control) had the greatest amount of CaOx deposition, and this was present in all parts of all three major areas of the kidney. (nih.gov)
  • We hypothesize that the expression of the major PGE2 synthesis enzymes cyclooxygenases 1 and 2 (COX-1, COX-2 ) and membrane -associated PGE2 synthase (mPGES) is altered in the kidneys of rats with NDI and CDI . (ndif.org)
  • Dehydration of NDI rats resulted in a marked increase in COX-2 immunolabeling in IM interstitial cells , and there was no significant change in COX-1 and mPGES expression in any kidney zone . (ndif.org)
  • The contralateral kidney received a RI infusion of vehicle in all rats. (ahajournals.org)
  • apical
  • Note=Colocalized with S100A10 and CC ANAX2 along the apical domain of kidney distal tubular cells (By CC similarity). (genome.jp)
  • Pendrin is also expressed in the kidney, and has been localized to the apical membrane of a population of intercalated cells in the cortical collecting duct where it is involved in bicarbonate secretion. (wikipedia.org)
  • left kidney
  • After 10 days, serum samples were collected for analysis, the left kidney was removed and assessed for calcium levels using flame spectroscopy, and the right kidney was sectioned for histopathological analysis using light microscopy. (nih.gov)
  • experimental
  • The finite element simulations correlate well in shape and amplitude with experimental results in the canine kidney. (asme.org)
  • Mean arterial pressure (MAP) was monitored, and urinary sodium excretion rate (U Na V) was calculated separately from experimental and control kidneys for each period. (ahajournals.org)
  • acid base
  • however, despite being expressed in the kidney, individuals with Pendred syndrome do not show any kidney-related acid-base, or volume abnormalities under basal conditions. (wikipedia.org)
  • calcium
  • Nevertheless the exact mechanism of the preventive effects of these products is still far to be clearly established, being its knowledge necessary to successfully apply these therapies to avoid stone formation.This EG/AC-induced increase in kidney calcium levels was inhibited by the administration of lemon juice.These data suggest that lemon juice has a protective activity against urolithiasis. (nih.gov)
  • This EG/AC-induced increase in kidney calcium levels was inhibited by the administration of lemon juice. (nih.gov)
  • RT "A rat kidney-specific calcium transporter in the distal nephron. (genome.jp)
  • organ
  • Dach1 deletion mice exhibit early postnatal death, although no developmental defects were detected in any organ system examined, including kidneys. (wikipedia.org)
  • regulation
  • Consistent with this, the density of COX-2 - expressing cells in macula densa was significantly increased, indicating differential regulation of COX-2 in IM and cortex . (ndif.org)
  • Thus, regucalcin plays a multifunctional role in the regulation of cell functions in liver, kidney cortex, heart and brain. (wikipedia.org)
  • widely
  • It is also more widely expressed in the earlier developing kidney, but again including definite podocyte expression. (wikipedia.org)
  • cell
  • 4. It was concluded that d -malate inhibited either the operation of the cytoplasmic l -malate dehydrogenase or malate outflow from the mitochondria in the intact kidney-cortex cell. (biochemj.org)
  • The cell line was derived from the kidney of an adult female North American opossum (Didelphis virginiana). (wikipedia.org)
  • expression
  • In ISOM and cortex , COX-1 expression was marginally reduced and mPGES expression was unaltered. (ndif.org)
  • COX-2 expression was undetected in ISOM and marginally increased in cortex . (ndif.org)
  • In the cortex , there were no changes in the expression of COX-1 and mPGES, whereas COX-2 expression was decreased. (ndif.org)
  • Administration
  • Ito K., Yamada K., Yoshida S., Hasunuma K., Tamura Y., Yoshida S. (1986) Endogenous Kallikrein Inhibitor in Rat Kidney Cortex-Effect of Glucocorticoid Administration. (springer.com)
  • function
  • This is probably the result of other bicarbonate or chloride transporters in the kidney compensating for any loss of pendrin function. (wikipedia.org)
  • model
  • This heat transfer model is developed based on actual physical measurements of the vasculature of the canine kidney cortex. (asme.org)
  • pure
  • That is, the way the kidney absorbs water involves osmosis - the flow of pure solvent through a permeable membrane in the direction of the less concentrated solution to the more concentrated solution . (ndif.org)
  • Group III (N = 6) kidneys were flushed with pure Nx HCl (2 mg/kg) during ischemia. (biomedsearch.com)
  • physical
  • Comparison of the size and physical properties of γ-glutamyltranspeptidase purified from rat kidney following solubilization with papain or with Triton X-100. (springer.com)