Kidney aminoglycosides. Medical search. Frequent questions

Other examples of aminoglycosides include the deoxystreptamine-containing agents kanamycin, tobramycin, gentamicin, and neomycin (see below). (wikipedia.org)
Kanamycin A Amikacin Tobramycin Dibekacin Gentamicin Sisomicin Netilmicin Neomycins B, C Neomycin E (paromomycin) Streptomycin Plazomicin Aminoglycosides display concentration-dependent bactericidal activity against "most gram-negative aerobic and facultative anaerobic bacilli" but not against gram-negative anaerobes and most gram-positive bacteria. (wikipedia.org)
As with other aminoglycosides, gentamicin injection is potentially nephrotoxic. (nih.gov)
Gentamicin sulfate, a water-soluble antibiotic of the aminoglycoside group, is derived by the growth of Micromonospora purpurea , an actinomycete. (nih.gov)
Use with caution in animals when given with probenecid or aminoglycosides such as neomycin and gentamicin. (medi-vet.com)
It is less nephrotoxic than gentamicin although all aminoglycosides have the potential for both renal and otic toxicity. (wedgewoodpharmacy.com)
Report the use of other drugs which might be potentially toxic to the kidney such as: aminoglycosides (e.g., gentamicin, amikacin), amphotericin B, cyclosporine, non-steroidal anti-inflammatory drugs (e.g., ibuprofen), tacrolimus, vancomycin. (patientassistance.com)
Combination therapy with a cell wall-active agent (eg, ampicillin, vancomycin) and an aminoglycoside (eg, gentamicin, streptomycin) has long been regarded as the standard of care for E faecalis native valve endocarditis. (medscape.com)
Gentamicin belongs to a class of drugs known as aminoglycoside antibiotics . (webmd.com)

Although the kidney functions as the major excretory system in mammals, monitoring and screening for mycotoxin induced nephrotoxicity is only now a developmental area in the field of livestock feed toxicology. (frontiersin.org)
Systemic use of amikacin and other aminoglycoside antibiotics are usually reserved for serious illnesses because of the risk of nephrotoxicity and ototoxicity. (wedgewoodpharmacy.com)
When using amikacin or other aminoglycoside antibiotics, monitoring of renal function and peak trough drug concentrations can be very useful to decrease the risks of nephrotoxicity. (wedgewoodpharmacy.com)
Aminoglycoside antibiotics such as paromomycin can cause oto- and nephrotoxicity. (hyperdrug.co.uk)
More recently, the third-generation cephalosporin cefotaxime has been demonstrated to be as effective as the ampicillin/aminoglycoside combination, and it does not carry the increased risk of nephrotoxicity in cirrhotic patients. (medscape.com)
The objective of this study was to describe the incidence of acute and chronic nephrotoxicity due to cumulative intravenous (IV) aminoglycoside exposure. (bvsalud.org)

Amikacin is an aminoglycoside antibiotic that is used to treat serious gram-negative bacterial infections. (wedgewoodpharmacy.com)
There are some gram-positive Staphyloccus that are sensitive to amikacin although generally the aminoglycosides are combined with other antibiotics when both gram-negative and gram-positive bacteria are present. (wedgewoodpharmacy.com)
Amikacin and other aminoglycosides are eliminated via the kidney and can be nephrotoxic. (wedgewoodpharmacy.com)
Amikacin and other aminoglycosides are commonly used in ophthalmic preparations to treat corneal ulcers. (wedgewoodpharmacy.com)
An increase of Cr (1.3 g/dL) was observed 9 days after the end of the treatment with amikacin, which was compatible with the presence of acute kidney injury. (aacc.org)
Amikacin, like other aminoglycosides, can be given in multiple daily doses (conventional) or once-daily dose (pulse). (medscape.com)

6, 7 Finally, as a cohort, these patients are exposed to industrial quantities of potentially nephrotoxic chemotherapeutic agents (in our CF centre some children have received a cumulative intravenous dose of over 300 g of the aminoglycoside tobramycin). (bmj.com)
Chemistry - An aminoglycoside derived from Streptomyces tenebrarius , tobramycin oc-curs as a white to off-white, hygroscopic powder that is freely soluble in water and very slightly soluble in alcohol. (elephantcare.org)
Pharmacology - Tobramycin, like the other aminoglycoside antibiotics, act on susceptible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibit-ing protein synthesis. (elephantcare.org)
Pharmacokinetics - Tobramycin, like the other aminoglycosides is not appreciably ab-sorbed after oral or intrauterine administration, but it is absorbed from topical administra-tion (not skin or urinary bladder) when used in irrigations during surgical procedures. (elephantcare.org)
The median cumulative weight-based aminoglycoside dose was 1183 mg/kg of tobramycin or tobramycin equivalent. (bvsalud.org)

Neomycin is available only for topical and oral use (oral aminoglycosides can be used to decontaminate the digestive tract because they are not absorbed). (msdmanuals.com)

Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria. (wikipedia.org)
Aminoglycosides that are derived from bacteria of the Streptomyces genus are named with the suffix -mycin, whereas those that are derived from Micromonospora are named with the suffix -micin. (wikipedia.org)
Aminoglycosides first cross bacterial cell walls-lipopolysaccharide in gram-negative bacteria-and cell membranes, where they are actively transported. (wikipedia.org)
Plazomicin injection is used to treat serious urinary tract infections, including kidney infections, that are caused by bacteria. (epnet.com)
Aminoglycosides work by preventing bacteria from producing proteins they need to grow and multiply. (msdmanuals.com)
The incidence of kidney disease due to bacteria such as streptococci has been gradually decreasing with the increasing living standards in Australia. (healthengine.com.au)
Use of the product deviating from the given instructions may increase the prevalence of bacteria resistant to paromomycin and may decrease the effectiveness of treatment with aminoglycosides due to the potential for cross-resistance. (hyperdrug.co.uk)
The aminoglycoside antibiotics are inactive against fungi, viruses and most anaerobic bacteria. (elephantcare.org)

Streptomycin is the first-in-class aminoglycoside antibiotic. (wikipedia.org)
In addition, when administered intravenously, diuretics may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue. (nih.gov)
We suggest using topical or local applications of aminoglycosides (e.g., respiratory aerosols, instilled antibiotic beads), rather than i.v. application, when feasible and suitable. (qxmd.com)

Kidney damage and reduced kidney function. (healthline.com)

Infections - to the kidney itself, or within the bloodstream (eg sepsis). (healthengine.com.au)
We suggest not using aminoglycosides for the treatment of infections unless no suitable, less nephrotoxic, therapeutic alternatives are available. (qxmd.com)
For very serious bacterial infections, an injection of aminoglycosides may be used. (adam.com)
Aminoglycosides are bactericidal antibiotics used primarily to treat gram-negative infections. (medscape.com)
Ureido-penicillins, cephalosporins, aminoglycosides, imipenem, trimethoprim-sulfamethoxazole are the drugs of choice to treat P. vulgaris associate infections but it possess high level of resistance against penicillin and other antibiotics[4]. (slideserve.com)
In the United States, aminoglycosides are most often used for emergencytreatment of people with serious infections who have not responded to othertypes of antibiotics," said Jochen Schacht, a professor of biological chemistryand otolaryngology in the U-M Medical School. (sciencedaily.com)
In clinical practice, combination therapy with a cell wall-active agent and a synergistic aminoglycoside should be considered for treating serious enterococcal infections in critically ill patients and in those with evidence of sepsis , as well as in patients with endocarditis, meningitis, osteomyelitis, or joint infections. (medscape.com)
In a completed study of nosocomial lower respiratory tract infections, 222 patients were treated with ZOSYN in a dosing regimen of 4.5 g every 6 hours in combination with an aminoglycoside and 215 patients were treated with imipenem/cilastatin (500 mg/500 mg q6h) in combination with an aminoglycoside. (druglib.com)
Most kidney infections need prompt treatment with antibiotics to stop the infection from damaging the kidneys or spreading to the bloodstream. (antibioticstalk.com)

Toxicity from foscarnet may occur with kidney dysfunction. (rxwiki.com)
Patients treated with aminoglycosides should be under close clinical observation because of the potential toxicity associated with their use. (nih.gov)
Excessive peak and/or trough serum concentrations of aminoglycosides may increase the risk of renal and eighth cranial nerve toxicity. (nih.gov)
The inherent toxicity of the aminoglycosides limit their systemic use to serious infec-tions when there is either a documented lack of susceptibility to other less toxic antibiotics or when the clinical situation dictates immediate treatment of a presumed gram negative infection before culture and susceptibility results are reported. (elephantcare.org)

In patients with kidney injury, measuring changes in the SOFA score in the first 24 hours of renal replacement therapy (RRT) can identify patients at high risk for mortality. (medscape.com)
Note: nonsteroidal drugs such as ibuprofen should be avoided in patients with myeloma, given the increased risk of kidney failure. (lls.org)
Myeloma patients may have serious problems with their kidney function. (lls.org)
For example, it may be used for patients who have very recent or acute kidney failure due to high levels of antibody proteins in the blood. (lls.org)
The impairment is most likely to occur in patients who already have impaired function of the kidney or congestive heart failure , and use of NSAIDs in these patients should be cautious. (hdkino.org)
A large multinational study was recently published in 2005, which studied over 29000 ICU patients in multiple countries to try and determine the incidence of acute kidney failure. (healthengine.com.au)
We suggest that, in patients with normal kidney function in steady state, aminoglycosides are administered as a single dose daily rather than multiple-dose daily treatment regimens. (qxmd.com)
4, 5 The impact of CFTR dysfunction on pancreatic function and architecture results in significant hypoinsulinaemia (CF-related diabetes) in a significant proportion of older patients with CF, again posing a challenge to fluid balance and the long-term possibility of diabetic kidney disease. (bmj.com)
However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving kanamycin injection. (drugs.com)
The epidemiology of aminoglycoside-associated acute kidney injury (AG-AKI) has not been well described in pediatric patients with cystic fibrosis (CF). We aimed to assess the impact of daily serum creatinine (SCr) measurement on detection of AG-AKI at our institution. (blogspot.com)
We examined a cohort of hospitalized patients with CF who received an intravenous (IV) aminoglycoside for ≥ 3 days. (blogspot.com)
We suggest systematic evaluation for AKI during aminoglycoside administration in patients with CF. (blogspot.com)
Patients receiving oral aminoglycosides with hemorrhagic or necrotic enteritises may ab-sorb appreciable quantities of the drug. (elephantcare.org)
Cystic fibrosis (CF) patients, with Pseudomonas aeruginosa infection, often require repeated aminoglycoside courses for the management of acute pulmonary exacerbations (APEs). (bvsalud.org)
Patients were eligible for inclusion if they received at least five courses of an IV aminoglycoside for at least 7 days each. (bvsalud.org)
This study presents three cases of Ralstonia bacteraemia among chronic kidney disease patients in a haemodialysis unit in Baguio City, the Philippines. (who.int)
Cette étude a permis de déterminer la fréquence et l'étiologie de l'insuffisance rénale aiguë chez des patients hospitalisés en Arabie saoudite sur une période de 2 ans. (who.int)

In the following gallery, kanamycin A to netilmicin are examples of the 4,6-disubstituted deoxystreptamine sub-class of aminoglycosides, the neomycins are examples of the 4,5-disubstituted sub-class, and streptomycin is an example of a non-deoxystreptamine aminoglycoside. (wikipedia.org)
Kanamycin belongs to the class of medicines known as aminoglycoside antibiotics. (drugs.com)

and (4) use of nephrotoxic drugs such as nonsteroidal anti-inflammatory drugs (NSAIDS), aminoglycosides, and radiographic contrast agents [ 1 ]. (hindawi.com)
It is also very important to avoid nonsteroidal anti-inflammatory drugs (NSAIDs), iodinated IV contrast and aminoglycoside antibiotics. (lls.org)

NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. (hdkino.org)

Traditionally, a combination of an aminoglycoside and ampicillin was used to treat SBP. (medscape.com)
In sensitive E faecalis native valve endocarditis treated with ampicillin plus an aminoglycoside, consideration should be given to limiting the aminoglycoside component to 2 weeks in order to avoid nephrotoxic, vestibular, and ototoxic events. (medscape.com)

Acute kidney injury (AKI) is one of the most serious complications, especially in end-stage liver disease. (hindawi.com)
Aspergillus -derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. (frontiersin.org)
liver disease (cirrhosis) or kidney disease, including nephrotic syndrome . (canadapharmacyonline.com)
At necropsy, there is multifocal hemorrhage in all visceral organs including the lung, liver, and kidney. (vin.com)
Do not use in cases with impaired function of the kidneys or liver. (hyperdrug.co.uk)

Do not use in animals with known hypersensitivity to paromomycin, other aminoglycosides or any of the excipients. (hyperdrug.co.uk)
People with known hypersensitivity (allergy) to paromomycin or any other aminoglycosides should avoid contact with the product. (hyperdrug.co.uk)

Use with caution when given with other drugs that may affect the kidneys. (medi-vet.com)
This results in the release of myoglobin in the blood, which can affect the kidneys. (healthengine.com.au)

Aminoglycoside-induced ototoxicity is usually irreversible. (nih.gov)

Heterologous expression of an ATPase inhibitor completely eliminated bactericidal activity, while loss of the F-ATPase reduced the electrophysiological response to aminoglycosides. (elifesciences.org)
Bryan and Van den Elzen, 1976 ), is thought to be essential for the bactericidal activity of aminoglycosides, and requires respiration ( Bryan and Van den Elzen, 1976 ). (elifesciences.org)
Throughout these early studies, uptake of the aminoglycosides was often treated as synonymous with bactericidal activity. (elifesciences.org)

Given the apparent pivotal role of CFTR in other organs, the lack of impact of CFTR dysfunction on the kidney is remarkable. (bmj.com)

Tell your doctor if you have or have ever had kidney disease or if you have a dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration or recently have had diarrhea, vomiting, fever, infection, excessive sweating, or have been unable to drink enough fluids. (medlineplus.gov)
Burinex works to remove the excess water by making your kidneys produce more urine. (canadapharmacyonline.com)
Some of these include: the build up of waste products that the kidneys usually excrete, such as urea and creatinine, high or low concentrations of molecules such as sodium and potassium, low numbers of red blood cells, inability to concentrate the urine properly and build up of excess fluid. (healthengine.com.au)

Acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products (measured by blood urea nitrogen [BUN] and serum creatinine levels) over the course of hours to weeks. (medscape.com)
Chronic kidney disease (CKD) is also called chronic renal failure and chronic renal insufficiency. (ceufast.com)
RIFLE criteria include parameters present during the whole course of the condition, ranging from kidney injury to end-stage renal failure. (hindawi.com)
Acute renal failure (ARF) is a frequent tients who required kidney biopsy. (who.int)

The inhibition of protein synthesis is mediated through aminoglycosides' energy-dependent, sometimes irreversible binding, to the cytosolic, membrane-associated bacterial ribosome (image at right). (wikipedia.org)

The Acute Kidney Injury Network (AKIN) has developed specific criteria for the diagnosis of AKI. (medscape.com)
On the basis of the RIFLE criteria, the Acute Kidney Injury Network (AKIN) criteria were established in 2007. (hindawi.com)

Daily serum creatinine monitoring promotes earlier detection of acute kidney injury in children and adolescents with cystic fibrosis. (blogspot.com)

Plazomicin injection is in a class of medications called aminoglycoside antibiotics. (epnet.com)

Serum concentrations of aminoglycosides should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels. (nih.gov)
Adjustment of aminoglycoside dosage sought to maintain concentrations within the therapeutic intervals. (aacc.org)
It achieves high, sustained serum concentrations but, like other aminoglycosides, has a narrow therapeutic index. (medscape.com)

Your doctor will order laboratory tests before and during your treatment to see if your kidneys are affected by this medication. (medlineplus.gov)
This medication can cause serious kidney problems and nerve damage , resulting in permanent hearing loss (including deafness or decreased hearing) and balance problems. (webmd.com)

Spectinomycin, a related but distinct chemical structure class often discussed with aminoglycosides, does not induce mRNA misreading and is generally not bactericidal. (wikipedia.org)
Spectinomycin is chemically related to aminoglycosides and works in a similar way. (msdmanuals.com)

Because the new estimated glomerular filtration (GFR) rate equations, such as Modification of Diet in Renal Disease-isotope dilution mass spectrometry (MDRD-IDMS) or CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration), are not included in the software, estimations for dose adjustment were carried out using the creatinine clearance (CrCl) calculated by the Cockcroft-Gault (CG) formula. (aacc.org)
Cumulative weight-based aminoglycoside dose was reported in milligrams per kilogram. (bvsalud.org)
There was no correlation between cumulative aminoglycoside dose and change in eGFR. (bvsalud.org)

However, in many Indigenous communities, high incidences of streptococcal infection and kidney disease are still seen. (healthengine.com.au)
Aminoglycosides antibiotics are a class of anti-infection agents utilized primarily in the treatment of vigorous gram-negative bacilli diseases, in spite of the fact that they are likewise successful against different microbes including staphylococci and mycobacterium tuberculosis. (businessresearchinsights.com)
The types of antibiotics your vet will prescribe will depend on which type of kidney infection your pet may have. (antibioticstalk.com)
An acute kidney infection rarely results in kidney failure. (antibioticstalk.com)
Chronic kidney infection can escalate over a number of months or even years. (antibioticstalk.com)
The symptoms for chronic kidney infection are the similarto acute infection, but they do not present themselves as quickly. (antibioticstalk.com)
Chronic kidney infection does not cause vomitingone of the most alarming symptoms of the condition. (antibioticstalk.com)
Because chronic kidney infection is more advanced, several rounds of antibiotics may be required. (antibioticstalk.com)
In rare cases, a kidney infection can cause further problems. (antibioticstalk.com)
A kidney infection can develop quite quickly over a few hours or days, so dont wait to see the doctor. (antibioticstalk.com)
Any of the above symptoms of a UTI or kidney infection should trigger a visit to your doctor for a proper evaluation and diagnosis. (antibioticstalk.com)

92% of participants will know how to stage and manage chronic kidney disease. (ceufast.com)
Define Chronic Kidney Disease. (ceufast.com)
Outline the staging of chronic kidney disease. (ceufast.com)
Identify the two main comorbidities associated with chronic kidney disease. (ceufast.com)
According to the U.S. Renal Data System, Medicare spent $81 billion in 2018 on beneficiaries with chronic kidney disease without end-stage renal disease. (ceufast.com)
Chronic kidney disease remains a significant public health concern both nationally and worldwide. (ceufast.com)
Currently, over 20 million people live with chronic kidney disease in the U.S. According to the National Center for Health Statistics, chronic kidney disease ranks the ninth leading cause of death in the United States (NCHS Health, 2016). (ceufast.com)
The financial costs associated with chronic kidney disease account for 20% of the total Medicare spending budget, with most of the costs being related to end-stage renal disease (Neyra, 2021). (ceufast.com)
Therefore, great importance should be placed on mitigating the incidence and diminishing the incidence and progression of chronic kidney disease. (ceufast.com)
The early identification and mitigation of modifiable risk factors for the development of chronic kidney disease are important for improved patient outcomes. (ceufast.com)
Chronic kidney disease remains a public health concern, given the strong association with morbidity and mortality and its socioeconomic impact (Neyra, 2021). (ceufast.com)
The definition of chronic kidney disease was initially proposed in 2002 by the National Kidney Foundation (NKF) Kidney Disease Outcomes Quality Initiative (KDOQI). (ceufast.com)
Acute failure of the kidneys is a condition in which there is a rapid loss of the normal function of your kidneys, due to a sudden, acute or chronic insult. (healthengine.com.au)
Ralstonia insidiosa is an opportunistic pathogen considered an emerging problem among clinically vulnerable populations such as those with chronic kidney disease. (who.int)

Acute Kidney Injury is defined as a sudden loss of kidney function. (randox.com)
The loss of kidney function is the result of a sudden reduction in glomerular filtration rate (GFR), the process through which waste is extracted from the blood and is often reversible 2 . (randox.com)
Under normal kidney function, these resistances are in equilibrium, facilitating the proper functioning of the GFR. (randox.com)
In the most severe instances of AKI, dialysis may be warranted to compensate for the diminished kidney function 5 . (randox.com)
Timely, adequate treatment of myeloma can improve kidney function and, potentially, even return it to normal in most cases. (lls.org)
As with the other aminoglycosides, on rare occasions changes in renal and eighth cranial nerve function may not become manifest until soon after completion of therapy. (nih.gov)
Animals with decreased kidney function may have a significantly increased half-life. (wedgewoodpharmacy.com)
If renal function or hydration status is questionable, other antibiotics outside the aminoglycoside family may be preferable. (wedgewoodpharmacy.com)
Poor blood supply to the kidney leads to abnormal kidney function. (healthengine.com.au)
Since the product is potentially ototoxic and nephrotoxic, it is recommended to assess kidney function. (hyperdrug.co.uk)
Laboratory and/or medical tests (e.g., kidney function tests) should be performed periodically to monitor your progress or check for side effects. (patientassistance.com)
It is even possible that absent CFTR function in the kidney may protect people with CF from renal insults, and certainly it has been recognised for many years that people with CF have increased renal clearance of many drugs including aminoglycoside antibiotics. (bmj.com)
At least one study found that those with low magnesium are at greater risk of diabetes complications, such as foot ulcers, vision problems, and a decrease in kidney function. (webmd.com)

The rapid advancement of UTIs can lead to dehydration, kidney failure, sepsis, and death. (antibioticstalk.com)

This makes openings in the cell wall that might kill the microorganisms before the aminoglycoside even arrives at the ribosome. (businessresearchinsights.com)

The aminoglycoside antimicrobials find use as wide range specialists for the treatment of contaminations brought about by high-impact Gram-negative and Gram-positive microscopic organisms including Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens, and Staphylococci. (businessresearchinsights.com)

Tell your doctor if you have or have ever had kidney disease. (epnet.com)
Partly based on the AKIN and RIFLE criteria, Kidney Disease: Improving Global Outcomes (KDIGO) published the KDIGO standard for the evaluation and management of AKI in 2012. (hindawi.com)
Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease. (frontiersin.org)
Acute disease of the kidneys (acute glomerulonephritis ) due to: immune causes, development of antibodies and sometimes from unknown causes. (healthengine.com.au)
Tell your doctor if you have: kidney disease, allergies (especially drug allergies). (patientassistance.com)
9 Interestingly, CFTR does appear to have a role in the pathophysiology of autosomal recessive polycystic kidney disease, where fluid secretion into the cysts appears to be mediated through CFTR. (bmj.com)
The risk is increased if you are older, already have kidney disease , or if you have a severe loss of body water ( dehydration ). (webmd.com)

This pressure contrast is influenced by the combined resistances of the afferent (leading to the glomerulus) and efferent (leading away from the glomerulus) vascular pathways in the kidney. (randox.com)
Toxic medications or contrast - eg aminoglycoside antibiotics, non-steroidal anti-inflammatory drugs, tetracyclines, iodine contrast. (healthengine.com.au)

It is widely accepted that membrane voltage potentiates aminoglycoside activity, which is ascribed to voltage-dependent drug uptake. (elifesciences.org)
In this paper, we measured the response of Escherichia coli treated with aminoglycosides and discovered that the bactericidal action arises not from the downstream effects of voltage-dependent drug uptake, but rather directly from dysregulated membrane potential. (elifesciences.org)
As the kidneys are one of the primary means that the body excretes drugs and drug by-products, they are susceptible to damage induced by medications such as those listed above. (healthengine.com.au)
We recommend monitoring aminoglycoside drug levels when treatment with multiple daily dosing is used for more than 24 hours. (qxmd.com)
Ninety-nine percent is excreted unchanged in the kidneys, where the drug undergoes glomerular filtration. (medscape.com)

Antimicrobial activity of the aminoglycosides are enhanced in an alkaline environment. (elephantcare.org)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar). (wikipedia.org)
Aminoglycosides additionally seem to uproot cations in the bacterial cell biofilm that are answerable for connecting the lipopolysaccharide particles normal for gram-negative bacterial cell walls. (businessresearchinsights.com)

For the past thirty years I have dedicated my laboratory toward the study of acute kidney injury (AKI) from both ischemic and nephrotoxic compounds, primarily secondary to aminoglycosides. (proquest.com)
After absorption, aminoglycosides are distributed primarily in the extracellular fluid. (elephantcare.org)

Identifying new markers of kidney injury with clinical value has also become an increasing focus of research. (hindawi.com)
If clinical trials show that iron chelators work as well in humans as they do inguinea pigs, the U-M research could lead to a safe and inexpensive way toeliminate the threat of deafness to individuals treated with a common class ofbroad-spectrum antibiotics called aminoglycosides. (sciencedaily.com)

Taking certain antibiotics with tenofovir can increase your risk of kidney damage. (healthline.com)
The risk of kidney damage is greater in people that are dehydrated. (medlineplus.gov)

Foscarnet may cause serious kidney problems. (medlineplus.gov)

While tubular and glomerular functions generally remain intact, pre-renal AKI may be caused by systemic hypoperfusion (decreased blood flow) or selective hypoperfusion to the kidney, caused by renal artery stenosis or aortic dissection 3 . (randox.com)

Anatomy12

Organisms23

Diseases23

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes22

Information Science2

Gentamicin9

Nephrotoxicity6

Amikacin6

Tobramycin5

Neomycin1

Bacteria8

Antibiotic3

Reduced kidney function1

Infections9

Toxicity4

Patients17

Kanamycin2

Nonsteroidal anti-2

NSAIDS1

Ampicillin2

Liver5

Paromomycin2

Affect the kidneys2

Ototoxicity1

Bactericidal activity3

Dysfunction1

Urine3

Renal Failure4

Irreversible1

Acute Kidney Injury2

Cystic1

Injection1

Concentrations3

Medication2

Spectinomycin2

Dose3

Infection11

Chronic14

Function13

Sepsis1

Ribosome1

Pseudomonas1

Disease7

Contrast2

Drug5

Alkaline1

Gram-negative2

Primarily2

Clinical2

Risk of kidney damage2

Cause serious kidney problems1

Systemic1