• pancreas
  • CYP2C9, CYP2JP, and possibly the more recently characterized CYP2S1 appear to be the main produces of the EETs in humans with CYPP2C9 being the main EET producer in vascular endothelial cells and CYP2JP being highly expressed (although less catalytically active than CYP2C) in heart muscle, kidneys, pancreas, lung, and brain. (wikipedia.org)
  • perfusion
  • As a compensatory mechanism, the unaffected nephrons (specifically, the preglomerular arterioles) vasodilate to increase blood flow to the kidney perfusion and increase glomerular filtration across undamaged glomeruli. (wikipedia.org)
  • include
  • Risk factors for HN include poorly controlled moderate to high blood pressure, older age, other kidney disorders. (wikipedia.org)
  • Indications for its use include: High blood pressure Congestive heart failure Following heart attack in patients with clinical evidence of heart failure Susceptible patients over 55 years: prevention of heart attack, stroke, cardiovascular death, or need of revascularization procedures kidney damage due to diabetes with protein in the urine (In low doses it is used as a prophylaxis for developing nephropathy and related secondary cardiovascular events. (wikipedia.org)
  • Additional small-molecule mediators that suppress baroreceptor activity and contribute to exaggerated sympathetic drive in hypertension include reactive oxygen species and endothelin. (wikipedia.org)
  • high
  • and Afro-Caribbean background - unclear whether this is due to them being more genetically susceptible to kidney damage by hypertension or whether it is because of poor management of high blood pressure amongst them. (wikipedia.org)
  • This narrowing of the renal artery can impede blood flow to the target kidney, resulting in renovascular hypertension - a secondary type of high blood pressure. (wikipedia.org)
  • Renal segmental hypoplasia (Ask-Upmark kidney) Neurogenic hypertension - excessive secretion of norepinephrine and epinephrine which promotes vasoconstriction resulting from chronic high activity of the sympathoadrenal system, the sympathetic nervous system and the adrenal gland. (wikipedia.org)
  • Congenital adrenal hyperplasia, a group of autosomal recessive disorders of the enzymes responsible for steroid hormone production, can lead to secondary hypertension by creating atypically high levels of mineralocorticoid steroid hormones. (wikipedia.org)
  • Renovascular hypertension (or "renal hypertension") is a condition in which high blood pressure is caused by the kidneys' hormonal response to narrowing of the arteries supplying the kidneys. (wikipedia.org)
  • Ramipril, sold under the brand name Altace among others, is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure. (wikipedia.org)
  • glomerular
  • with one theory identifying glomerular ischemia as the main contributor to HN and the other identifying glomerular hypertension and glomerular hyperfiltration at the centre of HN's pathogenesis. (wikipedia.org)
  • citation needed] An alternative mechanism of hypertensive nephropathy is prolonged glomerular hypertension and hence glomerular hyperfiltration. (wikipedia.org)
  • enzyme
  • This effect can also be produced by prolonged ingestion of liquorice (which can be of potent strength in liquorice candy), by causing inhibition of the 11β-hydroxysteroid dehydrogenase enzyme and likewise leading to secondary apparent mineralocorticoid excess syndrome. (wikipedia.org)
  • function
  • It does this by regulating the peripheral vasculature, and kidney function, which in turn affect cardiac output, vascular resistance, and fluid retention. (wikipedia.org)
  • progressive
  • It can be autosomal dominant or autosomal recessive, with the autosomal dominant form being more common and characterized by progressive cyst development and bilaterally enlarged kidneys with multiple cysts, with concurrent development of hypertension, renal insufficiency and renal pain. (wikipedia.org)
  • family
  • Persons with a family history of hypertension manifest augmented vasoconstrictor and sympathetic responses to laboratory stressors, such as cold pressor testing and mental stress, that may predispose them to hypertension. (wikipedia.org)