• Vitiligo is an idiopathic skin disorder that causes depigmentation of sections of skin, most commonly on the extremities. (arkansasbluecross.com)
  • As a result, many healing properties have been attributed to Khellin that are actually due to other constituents in the extract. (wikipedia.org)
  • However, studies have shown that khellin is not the active ingredient in Ammi Visnaga extract. (wikipedia.org)
  • Upon studying calcium oxalate nucleation, ammi visnaga extract as a whole was shown to prolong nucleation time as well as change stone conformation, while khellin alone had no effect. (wikipedia.org)
  • When khellin is applied topically in combination with UVA light, it is able to stimulate melanocytes (cells that produce melanin) in hair follicles for successful treatment of vitiligo. (wikipedia.org)
  • Vitiligo is a progressive disorder in which some or all of the melanocytes in the affected skin are selectively destroyed. (medscape.com)
  • Generally agreed upon principles are an absence of functional melanocytes in vitiligo skin and a loss of histochemically recognized melanocytes, owing to their destruction. (medscape.com)
  • The autoimmune theory proposes alteration in humoral and cellular immunity in the destruction of melanocytes of vitiligo. (medscape.com)
  • Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. (wikipedia.org)
  • however, the amount of Khellin and other ingredients varies greatly between brands and even batches of the same brand. (wikipedia.org)
  • Vitiligo is an acquired pigmentary disorder of the skin that is characterized by circumscribed, depigmented macules and patches. (medscape.com)
  • While vitiligo may be more obvious in patients with darker skin, this disorder does not have a racial or ethnic predilection. (medscape.com)
  • Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis. (medscape.com)
  • Vitiligo (vit-ill-EYE-go) is a disorder in which white patches of skin appear on different parts of the body. (mynation.net)
  • However, you can improve your appearance and gain your confidence with lifestyle changes and natural home remedies for vitiligo disease. (allremedies.com)
  • In this article in AllRemedies , I would like to introduce to you the top natural home remedies for vitiligo disease that make the white patches in your skin less visible. (allremedies.com)
  • therefore, turmeric is also included in a list of home remedies for vitiligo. (allremedies.com)
  • Vitiligo and other skin infections can be treated with apple cider vinegar, one of amazing natural home remedies for vitiligo I would like to introduce in this article. (allremedies.com)
  • Therefore, looking for the excellent home remedies for vitiligo or white patches, you should not ignore honey. (allremedies.com)
  • Psoralens are commonly used for vitiligo treatment, but have higher phototoxic and DNA mutagenic effects. (wikipedia.org)
  • While Khellin treatment in conjunction with UV therapy is successful, accelerated photoaging and increased risk of skin cancer is another concern. (wikipedia.org)
  • Unique combination in VITILIGO treatment with Khellin Ext. Cucis Melo Ext. (yapbioceuticals.com)
  • Vitimed Plus Tablet : The only Tablet truly work for melanin genesis Unique combination in VITILIGO treatment with Khellin Ext, Cucus Mellow Ext. Picrohiza Kurroa, Gikgo Biloba. (yapbioceuticals.com)
  • It is used in the treatment of the vitiligo. (yapbioceuticals.com)
  • Topical corticosteroids, alone or in combination with topical vitamin D3 analogues, are common first-line treatment for vitiligo. (arkansasbluecross.com)
  • Treatment options for vitiligo recalcitrant to first-line therapy include, among others, light box therapy with narrowband B (NB-UVB) and psoralen plus ultraviolet A (PUVA). (arkansasbluecross.com)
  • In 2001, XTRACTM (PhotoMedex), a xenon chloride (XeCl) excimer laser was cleared for marketing by the U.S. Food and Drug Administration (FDA) through the 510(k) process for the treatment of skin conditions such as vitiligo. (arkansasbluecross.com)
  • PUVA for the treatment of vitiligo which is not responsive to other forms of conservative therapy (e.g., topical corticosteroids, coal/tar preparations, and ultraviolet light) meets member benefit certificate primary coverage criteria that there be scientific evidence of effectiveness in improving health outcomes. (arkansasbluecross.com)
  • Targeted phototherapy (i.e., broadband (BB)-ultraviolet B (UVB) devices, narrowband (NB)-UVB devices, xenon chloride (XeCl) lasers and lamps) for the treatment of vitiligo does not meet member benefit certificate primary coverage criteria that there be scientific evidence of effectiveness in improving health outcomes. (arkansasbluecross.com)
  • Vitiligo is a disease which causes loss of pigmentation in portions of skin. (wikipedia.org)
  • Vitiligo refers the color loss of skin in blotches. (allremedies.com)
  • Furthermore, the antibacterial properties of turmeric are effective in getting rid of bacteria that cause vitiligo as well as other skin infections. (allremedies.com)
  • Because of the antifungal and antibacterial properties, honey has been used to deal with various skin infections including vitiligo. (allremedies.com)
  • Moreover, honey is beneficial in getting rid of bacteria causing vitiligo and other skin infections. (allremedies.com)
  • It contains Khellin Ext, Cucus Mellow Ext. Picrohiza Kurroa, Gikgo Biloba which are popular herb, which has since long been used in traditional Ayurvedic and Chinese medicine for its magical effects to cure various skin diseases. (yapbioceuticals.com)
  • in which, blisters are formed on an unaffected area and are then grafted onto a vitiligo affected area. (wikipedia.org)
  • Koebner phenomenon: Development of vitiligo in sites of specific trauma, such as a cut, burn, or abrasion. (medscape.com)
  • The typical natural history of vitiligo involves stepwise progression with long periods in which the disease is static and relatively inactive, and relatively shorter periods in which areas of pigment loss increase. (arkansasbluecross.com)
  • Khellin is found in Egypt, the Middle East, and areas surrounding the Mediterranean. (wikipedia.org)
  • [ 12 ] Hence, making a diagnosis of nonsegmental vitiligo in a person with a family history of autoimmune disease may warrant a more thorough workup. (medscape.com)
  • The certain causes of vitiligo disease have been not known. (allremedies.com)
  • Vitiligo is not a life-threatening or contagious disease. (allremedies.com)
  • Vitiligo affects 0.5-2% of the world population, and the average age of onset is 20 years. (medscape.com)
  • It is estimated that approximately 1.5% of people in the world experience vitiligo each year. (allremedies.com)
  • When khellin is applied topically and treated with UV light, pigmentation returns to treated areas. (wikipedia.org)
  • This guideline for the treatment of segmental and nonsegmental vitiligo has been developed by the members of the Vitiligo European Task Force and other colleagues. (medscape.com)
  • A significant incidence of thyroid dysfunction has been found in pediatric patients with nonsegmental vitiligo, suggesting that it may be prudent to screen thyroid function and antibody levels in pediatric patients with vitiligo. (medscape.com)
  • [ 12 ] Hence, making a diagnosis of nonsegmental vitiligo in a person with a family history of autoimmune disease may warrant a more thorough workup. (medscape.com)
  • Excimer laser has been combined with both topical tacrolimus and short-term systemic corticosteroids in the setting of segmental vitiligo, which is a type known to be more resistant to repigmentation in some patients. (medscape.com)
  • [ 40 ] Studies suggest that segmental vitiligo has a better repigmentation response with excimer laser treatment used at earlier stages of the disease. (medscape.com)
  • Dermatosurgical techniques for repigmentation of vitiligo. (medscape.com)
  • In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy. (wikipedia.org)
  • Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. (wikipedia.org)
  • Additionally, the use of khellin 4% ointment in combination with monochromatic excimer light (MEL) at 308 nm has been investigated and may be a valid therapeutic option worthy of consideration in the treatment of vitiligo. (medscape.com)
  • Some types of vitiligo or lesions in certain locations may be more or less responsive to treatment. (medscape.com)
  • Localized lesions of vitiligo are treated twice weekly for an average of 24-48 sessions. (medscape.com)
  • In terms of therapy, the immune-mediated inflammatory phase of vitiligo needs to be better defined in order to develop specific approaches targeted to this important phase of the disease pathogenesis. (medscape.com)
  • The results of therapy have been reported as moderately successful, particularly in patients with localized vitiligo and/or an inflammatory component to their vitiligo. (medscape.com)
  • Khellin has also been used to treat renal colic, which is due mostly to schistosomiasis infections and stone formation. (wikipedia.org)
  • The excimer laser produces monochromatic rays at 308 nm to treat limited, stable patches of vitiligo. (medscape.com)
  • Vitiligo is frequently associated with disorders of autoimmune origin, with thyroid abnormalities being the most common. (medscape.com)
  • Vitiligo can be found in patients with autoimmune polyendocrinopathy candidiasis-ectodermal dystrophy. (medscape.com)
  • Moreover, studies suggest that an association exists between a positive family history of vitiligo, autoimmune/endocrine diseases, leukotrichia, and an increased incidence of vitiligo in children. (medscape.com)
  • Although the diagnosis of vitiligo generally is made on the basis of clinical findings, biopsy is occasionally needed for differentiating vitiligo from other hypopigmenting or depigmenting disorders. (medscape.com)
  • Vitiligo usually precedes the onset of thyroid dysfunction. (medscape.com)
  • Vitiligo affects 0.5-2% of the world population, and the average age of onset is 20 years. (medscape.com)
  • It is believed that active vitiligo in patients with melanoma may indicate a better prognosis, as melanoma patients with vitiligo have been shown to have longer survival than otherwise expected. (medscape.com)
  • Hypocholesterolemic effect of khellin and methoxsalen in male albino rats. (nih.gov)
  • Extracellular granular material and degeneration of keratinocytes in the normally pigmented epidermis of patients with vitiligo. (medscape.com)
  • Once purified, khellin exists as colorless, odorless, bitter-tasting needle-shaped crystals and is classified as a gamma-pyrone, a furanochromone derivative. (wikipedia.org)
  • Narrowband UV-B (NB-UVB) is widely used and has become the first choice of phototherapy for adults and children with generalized vitiligo. (medscape.com)
  • Other forms of vitiligo (such as mucosal or eyelid vitiligo) may necessitate specific approaches not detailed in depth in this guideline. (medscape.com)