• epidermal
  • Here we report the generation of a mouse model that allows focal activation of a mutant keratin 14 allele in epidermal stem cells upon topical administration of an inducer, resulting in EBS phenotypes in treated areas. (rupress.org)
  • protein
  • In EB simplex, there is a weakness in one of these proteins (usually type 5 or type 14 keratin, but very occasionally another protein called plectin), which causes affected cells to be less resilient to friction and to rupture when subjected to even minor physical stress. (skinsupport.org.uk)
  • cell
  • In this study, the effects of two chemical chaperones (trimethylamine-N oxide (TMAO) and 4-phenylbutyrate (4-PBA)) on heat stress-induced keratin aggregation responses were examined in newly and previously established immortalized control and EBS patient-derived keratinocyte cell lines. (diva-portal.org)
  • Each cell has an internal support system formed from proteins (keratins), giving it strength and shape. (skinsupport.org.uk)