• KRT7
  • Here we use luciferase reporter assays to analyze the tissue-specific regulatory elements of murine keratin 7 (Krt7) promoter in vitro and in vivo. (dundee.ac.uk)
  • genes
  • Keratin 6A and keratin 6B are encoded by the neighbouring genes, which are identical in intron-exon organization to KRT6C and are more than 99% identical in their DNA coding sequences. (wikipedia.org)
  • The human genome encodes 54 functional keratin genes which are located in two clusters on chromosomes 12 and 17. (wikipedia.org)
  • Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex and dermatopathia pigmentosa reticularis, both of which are autosomal dominant mutations. (wikipedia.org)
  • Duplication and divergence events then led to claw β-keratin genes, and further recombination resulted in new feather and feather-like avian β-keratin genes. (wikipedia.org)
  • A recent study using molecular dating methods to link the evolution of avian β-keratin genes in general to that of feathers specifically reveals that the avian β-keratin family began diverging from the crocodile family about 216 million years ago. (wikipedia.org)
  • epidermal
  • Keratin monomers assemble into bundles to form intermediate filaments, which are tough and form strong unmineralized epidermal appendages found in reptiles, birds, amphibians, and mammals. (wikipedia.org)
  • cytokeratins
  • Keratins (also described as cytokeratins) are polymers of type I and type II intermediate filaments, which have only been found in the genomes of chordates (vertebrates, Amphioxus, urochordates). (wikipedia.org)
  • Fibrous
  • Fibrous keratin molecules supercoil to form a very stable, left-handed superhelical motif to multimerise, forming filaments consisting of multiple copies of the keratin monomer. (wikipedia.org)
  • Fibrous keratin molecules can twist around each other to form helical intermediate filaments. (wikipedia.org)
  • helical
  • This model has been confirmed by the determination of the crystal structure of a helical domain of keratins. (wikipedia.org)
  • The major force that keeps the coiled-coil structure is hydrophobic interactions between apolar residues along the keratins helical segments. (wikipedia.org)
  • Analysis of the sequence of this keratin together with that of the first type I keratin led to the discovery of the four helical domains in the central rod of keratins. (wikipedia.org)
  • K5/K14 keratin pairs are able to undergo extensive bundling due to the non-helical tail of K15 acting as a weak cross-linker at the intermediate filament surface. (wikipedia.org)