• genome
  • Virtual karyotype is the digital information reflecting a karyotype, resulting from the analysis of short sequences of DNA from specific loci all over the genome, which are isolated and enumerated. (wikipedia.org)
  • Conventional karyotypes can assess the entire genome for changes in chromosome structure and number, but the resolution is relatively coarse, with a detection limit of 5-10Mb. (wikipedia.org)
  • cells
  • Historically, karyotypes have been obtained by staining cells after they have been chemically arrested during cell division. (wikipedia.org)
  • Despite the diversity of platforms, ultimately they all use genomic DNA from disrupted cells to recreate a high resolution karyotype in silico. (wikipedia.org)
  • variations
  • It detects genomic copy number variations at a higher resolution level than conventional karyotyping or chromosome-based comparative genomic hybridization (CGH). (wikipedia.org)
  • comparative
  • Recently, platforms for generating high-resolution karyotypes in silico from disrupted DNA have emerged, such as array comparative genomic hybridization (arrayCGH) and SNP arrays. (wikipedia.org)
  • Thus a record of the history of karyotype changes that have occurred during evolution have been attained through comparative chromosome maps. (wikipedia.org)
  • samples
  • Virtual karyotypes can be performed on germline samples for constitutional disorders, and clinical testing is available from dozens of CLIA certified laboratories (genetests.org). (wikipedia.org)
  • Copy
  • Keep in mind also that a karyotype including '-7' doesn't mean there is only one copy of 7, it means there is only one NORMAL 7 present. (protocol-online.org)