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CisaprideGastrointestinal AgentsGastric EmptyingGastrointestinal MotilityMetoclopramideGastroparesisDomperidoneMotilinReceptors, Serotonin, 5-HT4Gastrointestinal TransitPiperidinesDyspepsiaBenzyl CompoundsErythromycinSerotonin 5-HT4 Receptor AgonistsFumariaLaxativesViolaGastroesophageal RefluxSerotonin Receptor AgonistsAsclepiadaceaeGallbladder EmptyingConstipationPeristalsisBenzamidesSerotonin AntagonistsEsophagitis, PepticAntiemeticsSimethiconeStomachDefecationManometryMorpholinesDouble-Blind MethodCross-Over Studies
PropulsidErythromycinMetoclopramide and cisaprideGastric prokineticDrugsGastroprokinetic agentIntestinalEsophagusDomperidoneMosaprideReceptorsCardiac arrhythmiasConstipation2023ItoprideAgentsGERDTabletPlaceboVeterinaryDoseSymptomsStomachTabletsMegacolonEsophagealMedicationSide effectsDrugEffectsPregnancySevereConjunctionDisordersLongerDogsEffectivePrescription
Propulsid5
  • Propulsid (cisapride) is a "prokinetic" agent that increases muscle contractions of the lower esophagus and the lower esophagus sphincter used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn . (rxlist.com)
  • Our Propulsid (cisapride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Cisapride (Propulsid) causes less diarrhea and extra-pyramidal side effects than Metoclopropamide (Reglan). (web-gerd.com)
  • Generic name: cisapride [ SISS-a-pride ] Brand name: Propulsid Drug class: GI stimulants. (urlbacklinks.com)
  • Cisapride is available under the following different brand names: Propulsid What Are Dosages of Cisapride? (urlbacklinks.com)
Erythromycin6
  • Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. (nih.gov)
  • The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics. (nih.gov)
  • Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride. (nih.gov)
  • Other molecules, including macrolides such as mitemcinal and erythromycin, have affinity for the motilin receptor where they act as agonists resulting in prokinetic properties. (wikipedia.org)
  • Cisapride is the drug of choice for treating delayed gastric emptying followed by erythromycin and ranitidine or nizatidine. (oregonstate.edu)
  • However, Cisapride can cause life threatening cardiac arrhythmias, especially in patients with cardiac or renal diseases, those with prolonged QT interval on their EKG, patients who are on anti-fungal, anti-viral and Mycin types of antibiotics like erythromycin and clarithromycin. (web-gerd.com)
Metoclopramide and cisapride2
Gastric prokinetic1
  • Treatment consists of dietary management and gastric prokinetic agents. (oregonstate.edu)
Drugs10
  • However, its efficacy has not yet been compared with that of other prokinetic drugs. (nih.gov)
  • Many of these patients also took drugs expected to increase cisapride blood levels by inhibiting the cytochrome P450 3A4 enzymes that metabolize cisapride. (rxlist.com)
  • Cisapride is contraindicated in patients taking any of these drugs. (rxlist.com)
  • QT prolongation, torsades de pointes (cisapride removed from us market) (sometimes with syncope), cardiac arrest, and sudden death have been reported in patients taking cisapride without the above-mentioned contraindicated drugs. (rxlist.com)
  • Activation of a wide range of serotonin receptors by serotonin itself or by certain prokinetic drugs results in enhanced gastrointestinal motility. (wikipedia.org)
  • Other prokinetic drugs may increase acetylcholine concentrations by stimulating the M1 receptor which causes acetylcholine release, or by inhibiting the enzyme acetylcholinesterase which metabolizes acetylcholine. (wikipedia.org)
  • Researchers are examining ways to improve reflux control by developing better acid suppressors with more rapid onsets and longer durations, by testing prokinetic drugs, and by searching for ways to reduce esophageal sensitivity. (pharmacytimes.com)
  • We have previously published findings in the anaesthetised in vivo pig, that cisapride and mebeverine when infused IL into the sigmoid colon resulted in a pharmacological dose dependent responses, which was more efficacious and localised than systemic administration of these drugs. (annals.edu.sg)
  • While it was originally developed for use in humans, cisapride has since been withdrawn from the human market in many countries due to the risk of reactions with other drugs causing heart arrhythmias and death. (wagwalking.com)
  • AEPIO DSR CAPSULE is a combination of Domperidone and Esomeprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. (netmeds.com)
Gastroprokinetic agent1
  • A prokinetic agent (also gastroprokinetic agent, gastrokinetic agent or propulsive) is a type of drug which enhances gastrointestinal motility by increasing the frequency or strength of contractions, but without disrupting their rhythm. (wikipedia.org)
Intestinal4
  • if necessary, these can be followed by intestinal secretagogues and/or prokinetic agents. (medscape.com)
  • Isolated perfused segments of pig ileum and sigmoid colon were used as an extrinsically denervated model of intestinal fluid propulsion to compare the effects of intraluminal (IL) with intraarterial (IA) administration of cisapride and mebeverine. (annals.edu.sg)
  • Do not give cisapride for dogs to pets who are allergic to the drug or have an intestinal obstruction or perforation. (wagwalking.com)
  • Cisapride for intestinal constipation. (dergipark.org.tr)
Esophagus2
  • Use of prokinetics along with Nexium sachets may provide better relief for GERD for children, as excess stomach acid is expelled more quickly and there's less chance of it burning or irritating the esophagus. (canadadrugsdirect.com)
  • Cisapride increases the rate at which your esophagus, stomach, and intestines move during digestion. (urlbacklinks.com)
Domperidone1
  • Domperidone is a prokinetic medicine with anti-emetic properties. (netmeds.com)
Mosapride1
Receptors1
  • As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] channels) contributes to its potential to cause cardiac arrhythmias. (wikipedia.org)
Cardiac arrhythmias1
  • Serious cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, torsades de pointes, and QT prolongation have been reported in patients taking cisapride. (rxlist.com)
Constipation9
20231
Itopride1
  • Itopride is a prokinetic that helps the intestines flow more freely, resulting in more bowel movements, softer stools, and less stomach pain and discomfort. (asterisklabs.in)
Agents2
  • Most prokinetic agents are grouped under the Anatomical Therapeutic Chemical Classification System (a World Health Organization drug classification system), as ATC code A03F. (wikipedia.org)
  • We propose that analogues of ghrelin may represent a new class of prokinetic agents. (bmj.com)
GERD1
Tablet3
  • The starting dose of cisapride is one 10 mg tablet or 10 ml of the suspension 4 times daily at least 15 minutes before meals and at bedtime. (rxlist.com)
  • Cisapride is available as a compounded tablet, capsule, or liquid . (wagwalking.com)
  • Cisapride comes as a tablet and liquid to take by mouth. (urlbacklinks.com)
Placebo2
  • Only 1 cross‐over trial with a duration of 12 months, including 17 patients, was selected in which participants were randomly allocated to either cisapride (a gastro‐prokinetic agent) or placebo for 6 months each. (cfdb.eu)
  • No significant differences were registered at 6 months between cisapride and placebo for abdominal distension, MD ‐0.90 (95% CI ‐2.39 to 0.59) or abdominal pain, MD ‐0.4 (95% CI ‐2.05 to 1.25). (cfdb.eu)
Veterinary1
  • However, according to the Merck Veterinary Manual , there haven't been reports of similar adverse reactions to the clinical use of cisapride in veterinary medicine. (wagwalking.com)
Dose1
  • IL cisapride produced a dose-dependent response in the dose range 1 × 10 -9 M to 3 × 10 -1 & l-3 × 10 -7 M in the ileum, and 3 × 10 -11 to 3 × 10 -9 M in the colonic segments, IL cisapride was significantly more effective than IA delivery of equivalent doses. (annals.edu.sg)
Symptoms1
  • To improve the effectiveness of relief of symptoms, it is possible to add prokinetic in the scheme of therapy, to reduce the frequency of relapses, the application of gastroprotectia of rebamipide. (omnidoctor.ru)
Stomach1
  • As a result, cisapride treats vomiting caused by megaesophagus, as well as a range of other conditions associated with the stomach emptying too slowly. (wagwalking.com)
Tablets2
Megacolon1
  • This page is a mishmash - hodgepodge of information on Megacolon and the En spotting breeds. (vgr1.com)
Esophageal1
Medication1
  • Cisapride is a prescription medication used for treating gastrointestinal dysmotility. (urlbacklinks.com)
Side effects3
  • metoclopramide has been associated with extrapyramidal side effects and movement disorders, and cisapride with serious cardiac events. (pharmacytimes.com)
  • If your dog has been prescribed cisapride, it's important to know how the drug works and what potential side effects it could have on your dog. (wagwalking.com)
  • Consult your veterinarian if you're concerned about any of the side effects of cisapride. (wagwalking.com)
Drug3
  • Cisapride for dogs is a prokinetic drug that supports the proper functioning of the digestive tract. (wagwalking.com)
  • Keep reading for more information on the dosage, efficacy, and drug interactions of cisapride for dogs. (wagwalking.com)
  • A prokinetic drug, cisapride speeds up the passage of food through the digestive tract. (wagwalking.com)
Effects1
  • Research into the prokinetic effects of probiotics on the gastrointestinal tract has also been conducted in humans. (wikipedia.org)
Pregnancy1
Severe1
  • In terms of dosage amount and cisapride toxicosis, severe clinical signs have been reported in acute exposures as low as 18 mg per kg . (wagwalking.com)
Conjunction1
  • Cisapride is one of the more common Prokinetics that a physician may recommend be used in conjunction with Nexium sachets. (canadadrugsdirect.com)
Disorders1
  • Most patients had disorders that may have predisposed them to arrhythmias with cisapride. (rxlist.com)
Longer2
  • Beacause of this side-effect, Cisapride is no longer availabe in the US. (web-gerd.com)
  • Furthermore, cisapride is no longer licensed for use in several countries due to the risk of serious cardiac events. (cfdb.eu)
Dogs2
Effective1
  • Cisapride and mebeverine were more effective per given concentration, when delivered IL than IA in both the ileum and sigmoid colon preparations. (annals.edu.sg)
Prescription2