• The human rotamase or peptidyl-prolyl cis-trans isomerase Pin1 is a conserved mitotic regulator essential for the G2/M transition of the eukaryotic cell cycle. (rcsb.org)
  • Pin1 isomerase activity was motivated as. (bioskinrevive.com)
  • The observed catalytic tetrad is strikingly conserved in Pin1- and parvulin-type proteins and hence constitutes a common feature of small peptidyl prolyl isomerases. (birmingham.ac.uk)
  • This gene provides instructions for making an enzyme called triosephosphate isomerase 1. (medlineplus.gov)
  • The SlyD (sensitive to lysis D) protein of Escherichia coli is a folding enzyme with a chaperone domain and a prolyl isomerase domain of the FK506 binding protein type. (unboundmedicine.com)
  • Triosephosphate isomerase is a very well-known enzyme of glycolysis, an energy producing metabolic pathway, present in almost all known types of cells. (growkudos.com)
  • Triosephosphate isomerase is an enzyme with multiple functions. (growkudos.com)
  • Such cases exist: for example, a mutase such as phosphoglucomutase catalyses the transfer of a phospho group from one position to another, and isomerase is a more general term for an enzyme that catalyses any one-substrate one-product reaction, such as triosephosphate isomerase . (wikipedia.org)
  • Triosephosphate isomerase (TPI) is a glycolysis enzyme , which catalyzes the reversible isomerization between dihydroxyactetone-3- phosphate (DHAP) and glyceraldehyde -3- phosphate (GAP). (bvsalud.org)
  • Unfolded protein molecules initially form a highly dynamic complex with the chaperone domain of SlyD, and they are then transferred to the prolyl isomerase domain. (unboundmedicine.com)
  • The 0.8 Å crystal structure of the prolyl isomerase domain of parvulin Par14 shows the electron density of hydrogen atoms between the D74, H42, H123, and T118 side chains. (birmingham.ac.uk)
  • Triosephosphate isomerase deficiency is a disorder characterized by a shortage of red blood cells (anemia), movement problems, increased susceptibility to infection, and muscle weakness that can affect breathing and heart function. (medlineplus.gov)
  • individuals with triosephosphate isomerase deficiency have an excess of these substances circulating in the blood. (medlineplus.gov)
  • Movement problems typically become apparent by age 2 in people with triosephosphate isomerase deficiency. (medlineplus.gov)
  • This impairment leads to muscle weakness and wasting (atrophy) and causes the movement problems typical of triosephosphate isomerase deficiency, including involuntary muscle tensing (dystonia), tremors, and weak muscle tone (hypotonia). (medlineplus.gov)
  • can also occur in triosephosphate isomerase deficiency. (medlineplus.gov)
  • Individuals with triosephosphate isomerase deficiency are at increased risk of developing infections because they have poorly functioning white blood cells . (medlineplus.gov)
  • The most common infections in people with triosephosphate isomerase deficiency are bacterial infections of the respiratory tract. (medlineplus.gov)
  • People with triosephosphate isomerase deficiency often do not survive past childhood due to respiratory failure. (medlineplus.gov)
  • Mutations in the TPI1 gene cause triosephosphate isomerase deficiency. (medlineplus.gov)
  • are particularly affected in people with triosephosphate isomerase deficiency. (medlineplus.gov)
  • Death of red and white blood cells, nerve cells in the brain, and cardiac muscle cells leads to the signs and symptoms of triosephosphate isomerase deficiency. (medlineplus.gov)
  • In some extremely rare cases of human triosephosphate isomerase deficiency, it can produce neurodegenerative alterations. (growkudos.com)
  • Generally, "the names of isomerases are formed as "substrate isomerase" (for example, enoyl CoA isomerase), or as "substrate type of isomerase" (for example, phosphoglucomutase). (wikipedia.org)
  • The C alpha backbones of the glucose isomerase molecules of Streptomyces rubiginosus and Arthrobacter have been determined by X-ray crystallography and compared. (rcsb.org)
  • The Thermus thermophilus xylA gene encoding xylose (glucose) isomerase was cloned and expressed in Saccharomyces cerevisiae under the control of the yeast PGK1 promoter. (lu.se)
  • The hemozoin and other toxic factors such as glucose phosphate isomerase (GPI) stimulate macrophages and other cells to produce cytokines and other soluble factors which act to produce fever and rigors and probably influence other severe pathophysiology associated with malaria. (cdc.gov)
  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. (nih.gov)
  • The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis / trans isomerisation of a prolyl bond. (biomedcentral.com)
  • The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is traditionally comprised of three distinct protein families, the cyclophilins (cyclosporin A binding proteins), FKBPs (FK506 binding proteins) and parvulins, that are linked by their shared ability to catalyse the bond preceding a proline residue between its cis and trans forms. (biomedcentral.com)
  • Parvulins compose a family of small peptidyl-prolyl isomerases (PPIases) involved in protein folding and protein quality control. (birmingham.ac.uk)
  • Protein disulphide isomerase (PDI) has been known for many years to assist in the folding of proteins containing disulphide bonds, but the exact mechanism by which it achieves this is only now becoming clear. (kent.ac.uk)
  • The isomerization energy, for example, for converting from a stable cis isomer to the less stable trans isomer is greater than for the reverse reaction, explaining why in the absence of isomerases or an outside energy source such as ultraviolet radiation a given cis isomer tends to be present in greater amounts than the trans isomer. (wikipedia.org)
  • Isomerases can increase the reaction rate by lowering the isomerization energy. (wikipedia.org)
  • Characterization of a Mannose-6-Phosphate Isomerase from Bacillus amyloliquefaciens and Its Application in Fructose-6-Phosphate Production PLoS One. (moleculardepot.com)
  • Triosephosphate isomerase (TPI) deficiency is a severe autosomal recessive inherited multisystem disorder of glycolytic metabolism characterized by hemolytic anemia and neurodegeneration. (raredisease.net)
  • Isomerases are a general class of enzymes that convert a molecule from one isomer to another. (wikipedia.org)
  • The sub-categories of isomerases containing racemases, epimerases and cis-trans isomers are examples of enzymes catalyzing the interconversion of stereoisomers. (wikipedia.org)
  • Calculating isomerase kinetics from experimental data can be more difficult than for other enzymes because the use of product inhibition experiments is impractical. (wikipedia.org)
  • OBJECTIVE: Thiol isomerases facilitate protein folding in the endoplasmic reticulum, and several of these enzymes, including protein disulfide isomerase and ERp57, are mobilized to the surface of activated platelets, where they influence platelet aggregation, blood coagulation, and thrombus formation. (reading.ac.uk)
  • The plastid-localized phosphoglucose isomerase isoform PGI1 is an important determinant of growth in Arabidopsis, probably due to its involvement in synthesis of plastidial isoprenoid derived hormones. (cas.cz)
  • Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds. (cdc.gov)
  • CONCLUSIONS: Platelet-borne thiol isomerases are trafficked independently of secretory granule contents in megakaryocytes and become concentrated in a subcellular compartment near the inner surface of the platelet outer membrane corresponding to the sarco/endoplasmic reticulum of these cells. (reading.ac.uk)
  • Isomerases catalyze reactions across many biological processes, such as in glycolysis and carbohydrate metabolism. (wikipedia.org)
  • Acetyl-CoA synthetase and isopentyl-diphosphate isomerase inhibition underscore columbin anti trypanosomiasis: Computational studies. (alliedacademies.org)
  • In conclusion, acetyl-CoA synthetase and isopentyl-diphosphate isomerase inhibition may underscore the anti-trypanosomal actions of columbin targeting isoprenoid metabolism. (alliedacademies.org)
  • Isomerases are further classified into six subclasses: This category (EC 5.1) includes (racemases) and epimerases). (wikipedia.org)
  • Protein molecules that left the prolyl isomerase site with an incorrect prolyl isomer can rapidly be re-bound by the chaperone domain because the association rate is very high as well. (unboundmedicine.com)
  • Genetic variation in the nucleotide sequences of Giardia microti parasites in the small subunit ribosomal RNA (SSU rRNA) (a) and triosephosphate isomerase (TPI) (b) genes. (cdc.gov)
  • The turnover number of the prolyl isomerase site is very high and guarantees that, after transfer, prolyl peptide bonds in substrate proteins are isomerized very rapidly. (unboundmedicine.com)
  • The Michaelis constant of catalyzed folding reflects the substrate affinity of the chaperone domain, and the turnover number is presumably determined by the rate of productive substrate transfer from the chaperone to the prolyl isomerase site and by the intrinsic propensity of the refolding protein chain to leave the active site with the native prolyl isomer. (unboundmedicine.com)
  • Two-dimensional Western blotting (2D-WB) and mass spectrometry analysis revealed a strong reactivity of this serum against protein disulfide isomerase A3 (PDIA3). (unito.it)
  • Qin R , Zhu H , Wang F , Song M , Lin P , Xing Y , Zhang W , Zhong M , Wang Z , . Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. (aging-us.com)
  • Thiol isomerases are mobilized to the surface of activated platelets via a process that requires actin polymerization but not soluble N-ethylmaleimide-sensitive fusion protein attachment receptor/Munc13-4-dependent vesicular-plasma membrane fusion. (reading.ac.uk)
  • Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
  • Isomerases facilitate intramolecular rearrangements in which bonds are broken and formed. (wikipedia.org)
  • Immunofluorescence microscopy and flow cytometry were used to monitor thiol isomerase mobilization in activated platelets in the presence and absence of actin polymerization (inhibited by latrunculin) and in the presence or absence of membrane fusion mediated by Munc13-4 (absent in platelets from Unc13dJinx mice). (reading.ac.uk)
  • Violin plots show distribution of expression levels for Protein disulfide-isomerase A5 (SMED30035571) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of Protein disulfide-isomerase A5 (SMED30035571) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for Protein disulfide-isomerase A5 (SMED30035571) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • the E-value for the Pro_isomerase domain shown below is 7.1e-13. (embl.de)
  • In addition, a third cell-surface protein called protein disulfide isomerase (PDI) is found to play a major role in HIV-1 entry. (biomedcentral.com)
  • You need info about Human Protein disulfide-isomerase A4 (PDIA4) ELISA Kit or any other Gentaur produtct? (gentaurshop.com)
  • APPROACH AND RESULTS: Immunofluorescence microscopy imaging was used to localize protein disulfide isomerase and ERp57 in murine and human megakaryocytes at various developmental stages. (reading.ac.uk)
  • Find the perfect raw materials and ingredients for your food production or product development on LEROMA's B2B platform and buy Pentose Phosphate Epimerase (Isomerase B) from high quality B2B wholesalers, suppliers and producers around the world. (leroma.com)
  • The purpose of this study was to investigate the release of Endothelial microparticle (EMP)-associated protein disulfide isomerase (PDI) after endothelial cell injury induced in diabetes and the changes in platelet activation. (aging-us.com)