Isoflurane. Medical search. Frequent questions

The kidney effects of halothane, enflurane and isoflurane were evaluated by using the ratio of urinary excretion of alanine aminopeptidase (AAP) to urine creatinine. (hacettepe.edu.tr)
Groups 1, 2 and 3 received halothane, enflurane and isoflurane respectively, Creatinine and AAP activities in urine spot tests, serum creatinine and BUN levels were determined preoperatively and on the first and second postoperative days. (hacettepe.edu.tr)
The present study did not reveal any significant difference in the kidney effects of halothane, enflurane and isoflurane through AAP/creatinine in spot urine values. (hacettepe.edu.tr)
We have examined the short-term effects of three volatile anaesthetics, halothane, isoflurane and desflurane, on mucociliary activity in the rabbit maxillary sinus in vivo. (lu.se)
Administration of 1.0 MAC of halothane, isoflurane or desflurane caused a temporary increase in mucociliary activity, with mean peak responses of 47.8 (SEM 13.0)%, 44.0 (9.6)% and 45.1 (23.7)% (n = 6), respectively. (lu.se)
The second peak at 3-5 min was less pronounced for halothane than for isoflurane or desflurane. (lu.se)
the inhalational anesthetic is most often halothane, but other anesthetics (eg, isoflurane , sevoflurane , desflurane ) may also be involved. (msdmanuals.com)

he GE Datex Ohmeda Tec 7 Isoflurane anesthesia vaporizer delivers isoflurane effectively and efficiently. (med-equip.ca)

Isoflurane, sold under the brand name Forane among others, is a general anesthetic. (wikipedia.org)
NIOSH announced a request for information with the intent to review and evaluate toxicity data for the halogenated anesthetic agents: of isoflurane, desflurane, and sevoflurane for establishing a REL. (cdc.gov)
A new study of brain cells from juvenile rats suggests the effects of a common anesthetic, isoflurane, on the connections between neurons are temporary. (neurosciencenews.com)
Researchers discover the anesthetic drug isoflurane could help treat drug resistant depression. (neurosciencenews.com)
2) isoflurane would have a greater negative impact on the olfactory acuity of the dogs, and 3) the established linear system would provide a way to evaluate the short term effect of the anesthetic agents on the scent-detection dogs. (purdue.edu)
The dog was then anesthetized with either propofol or isoflurane and a light plane of anesthesia was maintained on each respective anesthetic for 30 minutes. (purdue.edu)
Isoflurane is a volatile anesthetic widely used in pediatric patients to induce general anesthesia, analgesia, and perioperative sedation. (iasp-pain.org)
We studied the effects of the volatile general anesthetic isoflurane on single acetylcholine (ACh) receptor channels from clonal BC3H-1 cells. (aspetjournals.org)
Isoflurane is an inhalation anesthetic agent used for induction and maintenance of general anesthesia in horses and dogs. (californiapetpharmacy.com)
Recordings were obtained in pups anesthetized with the injectable mix of ketamine/xylazine (K/X mix), with the volatile anesthetic isoflurane (ISO), or in pups anesthetized with K/X mix that were also exposed to ISO. (frontiersin.org)
The volatile anesthetic isoflurane differentially inhibits glutamatergic and GABAergic synaptic vesicle (SV) exocytosis by reducing presynaptic Ca 2+ influx without affecting the Ca 2+ -exocytosis relationship, but its effects on dopaminergic exocytosis are unclear. (eneuro.org)
Isoflurane, a widely used volatile anesthetic, inhibits voltage-gated sodium channels and differentially inhibits synaptic vesicle exocytosis depending on neurotransmitter phenotype. (eneuro.org)
These findings provide a synaptic mechanism for the observed role of reduced dopamine release in anesthetic-induced unconsciousness and implicate presynaptic Ca 2+ channels of dopaminergic neurons as important targets of isoflurane. (eneuro.org)
Incorporation of 70% N2O allowed for significant reductions in isoflurane (to 0.8%) while maintaining an effective anesthetic depth for prolonged noninvasive physiological examination in guinea pigs. (cardiff.ac.uk)
Isoflurane, a widely used anesthetic in surgery, has been found to induce neurotoxicity. (smarttots.org)
Since effects on transmitter transport have been implicated in anesthetic actions, the authors examined the sensitivity of presynaptic glutamate and GABA transporters to the effects of a representative volatile (isoflurane) and a representative intravenous (propofol) anesthetic. (cornell.edu)

the Ministry of Health and Medical isoflurane, sevoflurane and desflurane. (who.int)

Isoflurane is given via inhalation. (wikipedia.org)
Inhalation anesthesia was then begun using 50% N2O in O2 with end-tidal 1.3% isoflurane. (druglib.com)
Short-term inhalation of isoflurane improves the outcomes of intraportal hepatocyte transplantation. (bvsalud.org)

This study examined the effects of two commonly used anesthetics, isoflurane (an inhalant agent) and propofol (an injectable agent), on canine olfactory-cognitive circuitry in detecting brown root rot fungus (BRR). (purdue.edu)
Each dog received two treatments, isoflurane and propofol, in a randomized order with an 11-day washout period between treatments. (purdue.edu)
Furthermore, isoflurane did not have a greater impact on the olfactory acuity of dogs compared to propofol (p = 0.669) and no significant difference in the overall effect between the two anesthetics (p = 0.278). (purdue.edu)
We concluded that isoflurane and propofol do not cause negative effect on canine olfaction within 24 hours. (purdue.edu)
We evaluated a database that included recovery endpoints from controlled, randomized, prospective studies sponsored by Abbott Laboratories that compared sevoflurane to isoflurane or propofol when extubation was planned immediately after completion of elective surgery in adult patients. (wgtn.ac.nz)
Methods: Sevoflurane was compared to isoflurane in eight studies (N = 2,008) and to propofol in three studies (N = 436). (wgtn.ac.nz)
Effects of isoflurane and propofol on glutamate and GABA transporters in isolated cortical nerve terminals. (cornell.edu)
RESULTS: Isoflurane produced small but statistically significant inhibition of l-[3H]glutamate and [14C]GABA uptake, while propofol had no effect. (cornell.edu)
CONCLUSIONS: These findings suggest that isoflurane and propofol at clinical concentrations do not affect excitatory glutamatergic transmission or inhibitory GABAergic transmission directly effects on their presynaptic neuronal transporters. (cornell.edu)

To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy. (scielo.br)

This isoflurane vaporizer provides output consistency with the dial setting throughout the clinical flow range.Our All Units Are Refurbished , Ready to Use and all units are checked with our Biomedical Engineer team. (med-equip.ca)
Datex-Ohmeda Isotec 5 Isoflurane Vaporizer. (usedmedicaltools.com)

Animal studies have raised safety concerns of certain general anesthetics, in particular ketamine and isoflurane, in young children. (wikipedia.org)

Isoflurane also affects intracellular molecules. (wikipedia.org)
[18] Isoflurane also affects intracellular molecules. (mdwiki.org)

Isoflurane is a halogenated ether. (wikipedia.org)

The subject was intubated with an 8.5 mm endotracheal tube and anesthesia was maintained with isoflurane (1.5-2.5 vol % in O 2 ) and 3 boluses of alfaxalone (1.0 mg/kg) delivered intravenously every 10 minutes. (usamv.ro)

however, other medications are often used to start anesthesia, due to airway irritation with isoflurane. (wikipedia.org)
This double-blind study investigates whether isoflurane/N2O anesthesia adds to the bronchodilating effect of the beta 2-adrenergic agonist, fenoterol, after an endotracheal tube (ETT)-induced increase in airway resistance. (druglib.com)
[2] It can be used to start or maintain anesthesia , however other medications are often used to start anesthesia rather than isoflurane, due to airway irritation with isoflurane. (mdwiki.org)

Isoflurane likely binds to GABA, glutamate and glycine receptors, but has different effects on each receptor. (wikipedia.org)
Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood. (iasp-pain.org)
A single isoflurane (3%, 2 h) exposure at PND7 did not acutely alter cell viability in cortical and hippocampal slices of infant rats (PND8) per se and did not alter slice susceptibility to in vitro glutamate challenge. (iasp-pain.org)
Ex vivo analysis of brain slices showed isoflurane neonatal exposure selectively decreased cell viability and glutamate uptake in cortical slices, but it did not alter hippocampal slice viability or glutamate uptake (PND65). (iasp-pain.org)
Isoflurane exposure did not alter in vitro glutamate-induced neurotoxicity to slices, and isoflurane exposure caused no significant long-term damage to cell membranes in hippocampal or cortical slices. (iasp-pain.org)
Volatile anesthetics such as isoflurane modulate synaptic and extrasynaptic neurotransmission through multiple postsynaptic targets, primarily by potentiating inhibitory GABA A receptors and depressing excitatory glutamatergic transmission via ionotropic glutamate receptors ( Rudolph and Antkowiak, 2004 ). (eneuro.org)

Additionally, behavioral analysis showed neonatal isoflurane exposure induces short-term recognition memory impairment, consolidating that neonatal exposure to volatile anesthetics may lead to behavioral impairment in the adulthood, although it may damage brain regions differentially. (iasp-pain.org)

General anaesthesia with isoflurane reduces plasma endocannabinoid AEA concentrations, and this could be a consequence of stress reduction after loss of consciousness. (wikipedia.org)
Excised patches were exposed to concentrations of isoflurane ranging from 0.18% to 4.0%, in the presence of 200 nM ACh. (aspetjournals.org)
The duration of brief closures within bursts was 300-400 musec at concentrations above 0.3% isoflurane. (aspetjournals.org)
Mean maintenance isoflurane and sevoflurane concentrations were 2% and 4%, respectively. (vin.com)

In the present study, we investigated the effects of a single neonatal isoflurane (3% in oxygen, 2 h) exposure in rats at postnatal day (PND) 7, in short-term (24 h - PND8) and long-term (adulthood) protocols. (iasp-pain.org)
In this study, we studied the protective effects of genistein on isoflurane-induced neuroinflammation in rats and BV2 cells. (smarttots.org)
Syngeneic rat hepatocytes (1.0 × 107) were transplanted to analbuminemic rats with (ISO group) and without (AW group) isoflurane . (bvsalud.org)

Side effects of isoflurane include a decreased ability to breathe (respiratory depression), low blood pressure, and an irregular heartbeat. (wikipedia.org)
To quantitate dose- and time-related magnitudes of interactive effects of morphine (MOR) and isoflurane (ISO) in horses and to characterize pharmacokinetics of MOR in plasma and the ventilatory response to MOR during administration of ISO. (nih.gov)
Effects of isoflurane on acetylcholine receptor channels. (aspetjournals.org)
These results indicate that isoflurane has effects on closed as well as open ACh receptor channels. (aspetjournals.org)
Twenty-three, male captive-bred green iguanas ( Iguana iguana ) weighing 0.51-0.67 kg were anesthetized to determine the effectiveness and the cardiopulmonary effects of butorphanol- sevoflurane and butorphanol-isoflurane. (vin.com)
In conclusion, the cardiopulmonary effects of butorphanol-isoflurane and butorphanol-sevoflurane were similar, however quality and speed of induction and recovery was significantly shorter with sevoflurane when compared to isoflurane. (vin.com)
Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers. (ucdenver.edu)
Here, we show that in dopaminergic neurons of the ventral tegmental area isoflurane acts via a sodium channel-independent mechanism to inhibit synaptic vesicle exocytosis in proportion to reduced presynaptic Ca 2+ flux mediated by Ca V 2.1 and/or Ca V 2.2, in contrast to its effects in non-dopaminergic neurons. (eneuro.org)

We have previously shown that isoflurane induces activation of NLRP3, cleavage of caspase 1, and increase of IL-1β and TNF-α levels in the hippocampus of aging mice and supposed that inhibiting the NLRP3 inflammasome might have therapeutic merit for ameliorating general anesthesia-induced cognitive deficits [ 5 ] as cited in Wang's study. (biomedcentral.com)
Wang's study found that isoflurane activated NLRP3-caspase-1 pathway and increased the secretion of IL-18 and IL-1β in cells pretreated with lipopolysaccharide and suggested that isoflurane induces age-related hippocampal inflammation through NLRP3-caspase-1 pathway. (biomedcentral.com)

A comparison of extradural and intravenous methadone on intraoperative isoflurane and postoperative analgesia requirements in dogs. (scielo.br)

Isoflurane is the most widely used veterinary anaesthetic agent in animals, allowing both routine and emergency surgeries to be performed. (bsava.com)

Isoflurane reduces pain sensitivity (analgesia) and relaxes muscles. (wikipedia.org)
To support all veterinary professionals working with small animals during the isoflurane shortage, the BSAVA is providing free access to the chapter on 'Injectable anaesthetics' from the BSAVA Manual of Canine and Feline Anaesthesia and Analgesia, 3rd edition. (bsava.com)
Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs. (scielo.br)

Isoflurane is frequently used for veterinary anaesthesia. (wikipedia.org)
13 patients subjected to the operational treatment of intracranial aneurysm with isoflurane anaesthesia manifested haemodynamic changes in systemic and cerebral circulation. (medscimonit.com)
The results obtained in the present study allow for the conclusion that general complex anaesthesia with low isoflurane concentration does not ensure a full stabilisation of both systemic and cerebral circulation in the most important stages of the operation of intracranial aneurysm. (medscimonit.com)

Isoflurane acts as a positive allosteric modulator of the GABAA receptor in electrophysiology studies of neurons and recombinant receptors. (wikipedia.org)
Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia. (ucdenver.edu)
We tested the hypothesis that isoflurane inhibits exocytosis in dopaminergic neurons. (eneuro.org)
Thus, isoflurane inhibits exocytosis from dopaminergic neurons by a mechanism distinct from that in non-dopaminergic neurons involving reduced Ca 2+ entry through Ca V 2.1 and/or Ca V 2.2. (eneuro.org)

Recently, we read with great interest the article titled "Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment" by Dr. Wang Z et al. (biomedcentral.com)
Genistein Attenuates Isoflurane-Induced Neuroinflammation by Inhibiting TLR4-Mediated Microglial-Polarization in vivo and in vitro. (smarttots.org)

In parallel, genistein is thought to attenuate isoflurane-induced neurotoxicity, although underlying molecular mechanisms are still unclear. (smarttots.org)

Inhibition of uptake by isoflurane was noncompetitive, an outcome that was mimicked by indirectly affecting transporter function through synaptosomal depolarization. (cornell.edu)

The study revealed that the combination of dexmedetomidine (10 µg/kg body weight) and ketamine (10mg/kg body weight) intramuscularly could be used as chemical restraining and induction agents and isoflurane as a safe inhalant anaesthetic for maintenance. (thepharmajournal.com)

In rat's adulthood, behavioral analysis revealed that the neonatal isoflurane exposure did not alter anxiety-like behavior and locomotor activity (open field and rotarod tests). (iasp-pain.org)
However, isoflurane exposure impaired short-term memory evaluated in the novel object recognition task. (iasp-pain.org)
Your solution for minimal isoflurane exposure without a fume hood. (ezsystemsinc.com)

Isoflurane is always administered in conjunction with air or pure oxygen. (wikipedia.org)
Thirty minutes after premedication, the heart rate and respiratory rate of each iguana was recorded and 12 animals were induced with isoflurane (5% in 100% oxygen), and 11 were induced with sevoflurane (8% in 100% oxygen), via face mask. (vin.com)

Sprague-Dawley rat pups were exposed to 0.75% isoflurane for 6 hours at postnatal day 7 (P7), and genistein (20, 40, or 80 mg/kg/day) or saline administered from P3 to P15. (smarttots.org)

In this regard, we present a hypothesis that pyroptosis plays a critical role in the mechanism of isoflurane-induced cognitive impairment and MCC950 inhibits the NLRP3 inflammasome-dependent pyroptosis in isoflurane anesthesia to improve the cognition. (biomedcentral.com)

Isoflurane inhibits conduction in activated potassium channels. (wikipedia.org)

The study was conducted to evaluate the efficacy of a combination of dexmedetomidine (10 µg/kg body weight) and ketamine (10mg/kg body weight) as induction agent and isoflurane as an maintenance agent in 12 Bonnet Macaques ( Macaca radiata radiata ) which were referred for vasectomy. (thepharmajournal.com)

This user manual is for the cagemount isoflurane vaporizers used in the Harvard Apparatus Complete Anesthesia systems (e.g. 72-6467, 72-6468, 75-0232, 75-0233, 72-6469 and 72-6470). (harvardapparatus.com)

Isoflurane transformed channel behavior from isolated openings into bursts of brief openings. (aspetjournals.org)

The British Equine Veterinary Association (BEVA), The British Small Animal Veterinary Association (BSAVA) and The Association of Veterinary Anaesthetists (AVA) have successfully engaged with the Veterinary Medicines Directorate (VMD) to facilitate a practical solution to the isoflurane supply problems. (bsava.com)

For mice receiving isoflurane anesthesia, ECS was administered before mice fully recovered consciousness (2 mins, 30s). (mendeley.com)
Arc immunofluorescence: One hour after administration of ECS, mice were sacrificed via isoflurane overdose and perfused with 1x phosphate buffered saline (PBS) followed by 4% paraformaldehyde (PFA). (mendeley.com)

Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation. (biomedcentral.com)

The duration of bursts also decreased in the presence of isoflurane. (aspetjournals.org)
Times to recovery endpoints increased with increasing case duration with isoflurane but not with sevoflurane (patients receiving isoflurane took 4-5 min more to emerge and respond to commands and 8.6 min more to achieve orientation during cases longer than 3 hr in duration than those receiving sevoflurane). (wgtn.ac.nz)

Please visit https://www.ismp.org/alerts/isoflurane-labeled-animal-use-only-cartons-i... to review a Special Alert regarding isoflurane labeled "for animal use only" that has been inadvertently packaged in cartons of isoflurane intended for human use and distributed to healthcare organizations. (medsafetyofficer.org)

To achieve this, 12 age and sex-matched juvenile Dunkin Hartley guinea pigs underwent extended anesthesia (≤150 min) with either (a) isoflurane (ISO: 1.5%), or (b) isoflurane + N2O (ISO+ N2O: 0.8% +70%), in this randomized cross-over designed study. (cardiff.ac.uk)

Isoflurane was approved for medical use in the United States in 1979. (wikipedia.org)
Isoflurane" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)

Anatomy1

Organisms2

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes4

Health Care1

Halothane7

Datex Ohmeda Tec1

Anesthetic16

Desflurane1

Inhalation3

Propofol9

Minimum alveolar concentration of i1

VAPORIZER2

Ketamine and isoflurane1

Affects intracellular molecules2

Halogenated ether1

Anesthesia was maintained1

Airway3

Glutamate6

Anesthetics1

Concentrations4

Rats3

Effects8

Induces2

Intravenous1

Widely1

Analgesia3

Anaesthesia3

Neurons4

Microglial2

Neurotoxicity1

Inhibition1

Inhalant1

Exposure3

Oxygen2

Pups1

Cognition1

Inhibits1

Induction1

Vaporizers1

Behavior1

Veterinary1

Mice2

Mechanism1

Duration2

Https1

Juvenile1

Medical2