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  • mitochondrial
  • Isoflurane depolarized the mitochondrial membrane (−28%, n = 5), decreased oxidative phosphorylation (−59%, n = 5), and blunted the caffeine-induced Ca2+ transfer from SR to mitochondria (−22%, n = 7) in the cardiomyocytes of wild-type mice. (ovid.com)
  • researchers
  • In a pilot study with 20 patients who received ECT treatments compared to eight patients who received the isoflurane treatments, the researchers found that both therapies provided significant reduction in symptoms of depression. (scienceblog.com)
  • In the mid-1980s, researchers in Europe studied isoflurane as a potential depression therapy. (scienceblog.com)
  • Researchers don't know what produces the relief of depression symptoms from ECT or isoflurane. (scienceblog.com)
  • mice
  • In 2008, members of the same MGH research team showed that isoflurane induced Alzheimer's-like changes - increasing activation of enzymes involved with cell death and generation of the A-beta plaques characteristic of the disease - in the brains of mice. (medindia.net)
  • effect
  • One common effect of both ECT and isoflurane treatments is a brief state of low electrical activity in which the brain becomes unusually quiet. (scienceblog.com)
  • The results suggest that the partial inhibitory effect of isoflurane on respiratory complex I is insufficient to afford a synergy to CypD-induced protection. (ovid.com)
  • results
  • Later studies by other scientists, however, failed to confirm the results of the original work and isoflurane research fell out of favor. (scienceblog.com)
  • blood
  • Citrated whole blood was incubated for 60 min with either 0.5 or 1 MAC isoflurane. (ingentaconnect.com)
  • We also evaluated the relation between myocardial infarct size and coronary collateral blood flow in the presence and absence of isoflurane to determine if this relation is altered by the anesthetic agent. (asahq.org)
  • patients
  • In contrast, the patients treated with isoflurane showed no real impairment but instead had greater improvements in cognitive testing than ECT patients both immediately and four weeks after the treatments. (scienceblog.com)
  • another
  • Therefore, the authors hypothesized that isoflurane, by inhibiting the respiratory chain complex I, another regulator of PTP, might reinforce the myocardial protection afforded by CypD inhibition. (ovid.com)