• mitochondrial
  • Isoflurane depolarized the mitochondrial membrane (−28%, n = 5), decreased oxidative phosphorylation (−59%, n = 5), and blunted the caffeine-induced Ca2+ transfer from SR to mitochondria (−22%, n = 7) in the cardiomyocytes of wild-type mice. (ovid.com)
  • mice
  • In 2008, members of the same MGH research team showed that isoflurane induced Alzheimer's-like changes - increasing activation of enzymes involved with cell death and generation of the A-beta plaques characteristic of the disease - in the brains of mice. (medindia.net)
  • Dogs
  • 157 dogs (107 ASAI, 32 ASAII, 12 ASAIII and 5 ASAIV) were anaesthetized with sevoflurane, and 150 patients (87 ASAI, 40 ASAII, 17 ASAIII and 6 ASAIV) with isoflurane. (vin.com)
  • another
  • Therefore, the authors hypothesized that isoflurane, by inhibiting the respiratory chain complex I, another regulator of PTP, might reinforce the myocardial protection afforded by CypD inhibition. (ovid.com)