This research was divided into three parts which include, the isolation of eugenol from clove oil, followed by the synthesis of butyl eugenol and ethyl isoeugenol, and lastly the determination of antibacterial activity of butyl eugenol and ethyl isoeugenol using disk-diffusion method. (ugm.ac.id)
Eugenol is one of the key volatile constituents of cinnamon and clove oils. (sigmaaldrich.com)
Isoeugenol (2-methoxy-4-(prop-1-en-1-yl)phenol), a component of from clove (Eugenia caryophylata) oil, is a starting material for both the biotechnological and synthetic production of vanillin and vanillic acid. (researchgate.net)
Clove Bud Essential Oil generally contains up to 85% Eugenol, a phenol that dramatically contributes to the oil's aroma, therapeutic properties, and safety precautions. (aromaweb.com)
Dari minyak1
Tujuan dari penelitian ini adalah untuk mensintesis butil eugenol dan etil isoeugenol dan menganalisa aktivitas antibakterinya Penlitian ini dimulai dengan mengisolasi eugenol dari minyak cengkeh dan mensintesis butil eugenol dan etil isoeugenol serta menentukan aktivitas antibakteri butil eugenol dan etil isoeugenol dengan metode difusi cakram. (ugm.ac.id)
Isolasi eugenol2
Penelitian dibagi menjadi tiga tahap yang terdiri dari isolasi eugenol, sintesis butil eugenol dan etil isoeugenol, dan uji aktivitas antibakteri. (ugm.ac.id)
Isolasi eugenol dilakukan melalui serangkaian ekstraksi asam-basa dan metode pemurnian. (ugm.ac.id)
Phenol1
The substances addressed are phenol, 2-methoxy-4-(2-propenyl)- and rose, Rosa canina, ext., also referred to as eugenol and Rosa canina extract, respectively. (canada.ca)
Elemicin1
the first group contains c. baileyanum, c. oliveri and one chemotype of c. laubatii, and they produce oils rich in Me eugenol and bicyclo- germacrene (c. baileyanum), safrole, Me eugenol elemicin and bicyclogermacrene (c. laubatii), camphor, safrole and Me eugenol (c. oliveri). (erowid.org)
Butyl5
The purpose of this research is to synthesize butyl eugenol and ethyl isoeugenol and analyze their activity as antibacterial agents. (ugm.ac.id)
Further, the synthesis of butyl eugenol and ethyl isoeugenol were accomplished by alkylation of eugenol with 1-bromobutane for butyl eugenol and alkylation of eugenol with diethyl sulphate and isomerization with potassium tert-butoxide for ethyl isoeugenol. (ugm.ac.id)
Butyl eugenol and ethyl isoeugenol samples were tested for their antibacterial activity using disk- diffusion method. (ugm.ac.id)
The synthesis of butyl eugenol and ethyl isoeugenol were successfully synthesized producing yields of 86.59% and 87.80% respectively. (ugm.ac.id)
Furthermore, butyl eugenol and ethyl isoeugenol were not potential antibacterial agents with inhibition diameters in Escherichia coli of 8 mm and 10 mm respectively and in Staphylococcus aureus of 10 mm and 12 mm respectively. (ugm.ac.id)
Fragrance1
In Canada, eugenol is found in a range of products including cosmetics, natural health products, air fresheners and cleaning products (as a fragrance ingredient). (canada.ca)
Dengan3
Selanjutnya, sintesis butil eugenol dan etil isoeugenol dilakukan dengan alkilasi eugenol dan isomerisasi dengan kalium tert-butoksida dilakukan untuk etil isoeugenol. (ugm.ac.id)
Selain itu, butil eugenol dan etil isoeugenol tidak menunjukkan potensi sebagai agen antibakteri karena kedua senyawa tersebut menunjukkan aktivitas antibakteri yang rendah di E. coli dengan diameter masing- masing 8 mm and 10 mm dan di S. aureus dengan diameter masing- masing 10 mm dan 12 mm. (ugm.ac.id)
Dibandingkan dengan eugenol dan asam ferulat, butil eugenol and etil isoeugenol menunjukkan aktivitas anibakteri yang lemah terhadap bakteri E.coli dan S.aureus. (ugm.ac.id)
Naturally2
Eugenol is a naturally occurring substance that is found in various types of plants. (canada.ca)
Among them, methyl eugenol, an important chemical constituent belonging to the phenylpropanoid group, is found in different spices, vegetables, and herbs ( Linchtenstein and Casida 1963 Linchtenstein EP and Casida JE (1963) Myristicin, an insecticide and synergistic occurring naturally in the edible part of parsnips. (scielo.br)
Flower extract1
Since the composition of the Rosa canina extract is variable and complex, the health effects information for the main components of the Rosa canina flower extract, eugenol and 2-phenethyl alcohol (CAS RN 60-12-8), were considered in the assessment. (canada.ca)
Extract2
Both eugenol and Rosa canina extract were identified according to information considered under the Ecological Risk Classification of organic substances approach as having low ecological exposure potential. (canada.ca)
To identify effects of concern for human health, published literature and national and international reports of data on eugenol and Rosa canina extract were reviewed. (canada.ca)
Substances1
The screening assessment focused on 2 of 4 substances referred to collectively under the Chemicals Management Plan (CMP) as the Eugenol and Isoeugenol Derivatives Group . (canada.ca)
Antibacterial1
The two compounds exhibited low antibacterial activities in comparison to eugenol and ferulic acid against both E.coli and S.aureus bacterial strains. (ugm.ac.id)
Potassium1
Mixtures containing eugenol, sodium or potassium carbonate as solid support, with or without sodium or potassium hydroxide as base, with or without tetrabutylammonium bromide as phase transfer catalyst, with dimethyl sulfate as the methylating agent were irradiated in a domestic microwave oven for 20 - 50 seconds. (ugm.ac.id)
Chemical3
In enzymology, a (iso)eugenol O-methyltransferase (EC 2.1.1.146) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + isoeugenol ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + isomethyleugenol Thus, the two substrates of this enzyme are S-adenosyl methionine and isoeugenol, whereas its two products are S-adenosylhomocysteine and isomethyleugenol. (wikipedia.org)
To begin with, the isolation of eugenol was performed through a series of acid-base chemical extractions and purification methods. (ugm.ac.id)
Exposure to eugenol may also occur through food, from its possible use as a food flavouring agent and from its natural presence in some foods. (canada.ca)
Methyl dopa, an important hypertensive medication, can be synthesized from methyl eugenol ( Robinson and Barr 2006 Robinson SH and Barr DB (2006) Use of bio monitoring data to evaluate methyl eugenol exposure. (scielo.br)
Inhibition1
Evaluation of the effects of the isoeugenol on AChE, α-amylase, and α-glycosidase was an important aim of this article and inhibition findings are represented in Table 4. (researchgate.net)
Product1
Without combination of base and TBAB only one product, i.e. methyl eugenol, was formed. (ugm.ac.id)
Group1
The Government of Canada conducted a science-based evaluation, called a screening assessment , of the Eugenol and Isoeugenol Derivatives Group , to address the potential for harm to Canadians and to the environment. (canada.ca)
Rich1
A new strain of Cymbopogon khasianus rich in methyl eugenol was identified and named Jor Lab L-9. (scielo.br)
Research1
A research on conversion of eugenol to methyl isoeugenol via one-step reaction with microwave irradiation has been carried out. (ugm.ac.id)
Methyl eugenol is a naturally occurring material found in a variety of food sources, including spices, oils, and nutritionally important foods such as bananas and oranges. (nih.gov)
Methyl eugenol has been used as a biomarker of exposure. (nih.gov)
An analytical method to detect methyl eugenol in human blood samples is well characterized but not readily available. (nih.gov)
Human studies indicate that methyl eugenol is short-lived in the body, and despite the high potential for exposure through the diet and environment, human blood levels are relatively low. (nih.gov)
However, an understanding is lacking regarding how this effect relates to the exposures that result when food containing methyl eugenol is consumed. (nih.gov)
Overall, the level of methyl eugenol detected in biomonitoring studies indicates that human exposure is several orders of magnitude lower than the lowest dose used in the bioassay. (nih.gov)
Furthermore, there are no known health effects in humans that result from typical dietary exposure to methyl eugenol. (nih.gov)
Methyl eugenol [1,2-dimethoxy-4-(2-propenyl)benzene (CAS no. 93-15-2), structure shown in Figure 1 ] is a member of a family of chemicals known as allyl alkoxy-benzenes, which include other naturally occurring materials such as isoeugenol, eugenol, estragole, and safrole. (nih.gov)
Given the broad potential for exposure resulting from both dietary and consumer product use and its structural similarity to other carcinogenic allyl alkoxybenzenes, methyl eugenol was nominated for study by the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences. (nih.gov)
The NTP evaluated methyl eugenol in a rodent bioassay using oral gavage as the route of administration ( NTP 2000 ). (nih.gov)
Although toxicologic end points have been established in animals, searches of the literature have identified no clinical studies or epidemiology data to provide perspective on whether there are health effects associated with long-term consumption of methyl eugenol by humans. (nih.gov)
To provide human exposure data in support of NTP's assessment of methyl eugenol, the Centers for Disease Control and Prevention (CDC) measured methyl eugenol in a non-representative subset of adult serum samples collected as a part of the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) ( CDC 2004 ). (nih.gov)
Safrole1
We were interested in the cytotoxicity and genotoxicity caused by methyleugenol and other alkenylbenzene compounds: safrole (a known hepatocarcinogen), eugenol, and isoeugenol. (nih.gov)
1.1461
In enzymology, a (iso)eugenol O-methyltransferase (EC 2.1.1.146) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + isoeugenol ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + isomethyleugenol Thus, the two substrates of this enzyme are S-adenosyl methionine and isoeugenol, whereas its two products are S-adenosylhomocysteine and isomethyleugenol. (wikipedia.org)
Contiene2
El aceite de clavo contiene una sustancia química llamada eugenol que podría ayudar a disminuir el dolor y combatir las infecciones. (medlineplus.gov)
El aceite de clavo contiene una sustancia química llamada eugenol que parece retardar la coagulación de la sangre. (medlineplus.gov)
Compounds1
Coupling of eugenol ( I ) and isoeugenol ( II ) by means of horseradish peroxidase and hydrogen peroxide resulted in ~20% yield of dimeric compounds: 5,5'-diallyl-2,2'-dihydroxy-3,3'-dimethoxy-biphenyl ( III ) and 2-(4'-hydroxy-3'-methoxy)phenyl-7-methoxy-3-methyl-5-propenyl-2,3-dihydrobenzofurane ( IV ), respectively. (cas.cz)
Approximately1
In contrast, isoeugenol and eugenol produced cytotoxicity in hepatocytes with LC50s of approximately 200-300 microM, but did not cause UDS. (nih.gov)