MyocardiumRatsInhibitionAnti-ischemicAcuteSusceptibilityFibrosisTachycardiaMiceCardioprotective effectsConductionInhibitorAdenosineSyndromesCardiacCardiomyocytesAbstractArrhythmiasHeartsReductionStrokeHeart diseaseDiseasesMetabolicTherapeuticExposureInjuryDamageBlood flowActivationBrainStudyGroupsFunction
Myocardium3
- Reoxygenation of ischemic myocardium may be harmful due to the formation of free radicals. (uni-giessen.de)
- The effects of ryanodine on calcium uptake by the sarcoplasmic reticulum of ischemic and reperfused rat myocardium. (wanfangdata.com.cn)
- Revascularization for Acute Coronary Syndromes Revascularization is the restoration of blood supply to ischemic myocardium in an effort to limit ongoing damage, reduce ventricular irritability, and improve short-term and long-term outcomes. (msdmanuals.com)
Rats7
- This study investigated the cardioprotective effects of PN formula on isoproterenol-induced myocardial infarction (IMI) in Sprague-Dawley rats. (hindawi.com)
- For instance, the administration of isoproterenol (ISO), a β ‐adrenergic receptor agonist, was used to mimic the characteristics of MI in rats to study the effectiveness of medicinal plants or active compounds in disease intervention [ 1 , 2 ]. (hindawi.com)
- Ma S, Ma J, Tu Q, Zheng C, Chen Q, Lv W ( 2020 ) Isoproterenol Increases Left Atrial Fibrosis and Susceptibility to Atrial Fibrillation by Inducing Atrial Ischemic Infarction in Rats. (multichannelsystems.com)
- A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)
- Isoproterenol was administered in rats to induce myocardial infarction. (scialert.net)
- The present study was designed to investigate the cardioprotective effects of Malaysian Tualang honey against isoproterenol- (ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and antioxidant defense system combined with histopathological examination. (blogspot.com)
- Pretreatment of ischemic rats with Tualang honey conferred significant protective effects on all of the investigated biochemical parameters. (blogspot.com)
Inhibition5
- Cyclooxygenase inhibition in ischemic brain injury. (southampton.ac.uk)
- We will discuss issues related to the biochemistry and selective pharmacological inhibition of COX enzymes, and further refer to their expression in the brain under normal conditions and following excitotoxicity and ischemic cerebral injury. (southampton.ac.uk)
- d) inhibition of isoproterenol-induced tachycardia. (nih.gov)
- In standard animal or human pharmacological tests, beta-adrenoreceptor blocking activity of atenolol tablets have been demonstrated by: (1) reduction in resting and exercise heart rate and cardiac output, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol induced tachycardia, and (4) reduction in reflex orthostatic tachycardia. (nih.gov)
- Beta 2 -receptor blockade was demonstrated by inhibition of the isoproterenol-induced fall in diastolic blood pressure. (guidelinecentral.com)
Anti-ischemic4
- The anti-ischemic drug trimetazidine (TMZ) is reportedly useful in ventricular remodeling and associated with NADPH oxidase (NOX) 2. (dovepress.com)
- The anti-ischemic effects of NS on ischemia-induced isolated rat heart were investigated through analyses of changes in blood pressure, aortic flow, coronary flow, and cardiac output. (suntenglobal.com)
- In addition, the mechanism of the anti-ischemic effects of NS was also examined through quantitation of intracellular calcium content in rat neonatal cardiomyocytes. (suntenglobal.com)
- These results suggest that NS has distinct anti-ischemic effects through calcium antagonism. (suntenglobal.com)
Acute1
- 12. Mitsios N, Gaffney J, Kumar P, Krupinski J, Kumar S, Slevin M. Pathophysiology of acute ischaemic stroke: an analysis of common signalling mechanisms and identification of new molecular targets. (southampton.ac.uk)
Susceptibility1
- In young female mice, BPA exposure led to greater susceptibility of stress-induced ischemic damage to their hearts, compared to unexposed female mice. (thealternativedaily.com)
Fibrosis1
- In the male mice who were exposed to BPA, there was an increase in fibrosis, but the addition of isoproterenol did not bring about any additional health problems the way it did in females. (thealternativedaily.com)
Tachycardia3
- In anesthetized dogs and cats, acebutolol is more potent in antagonizing isoproterenol-induced tachycardia (β1) than in antagonizing isoproterenol-induced vasodilatation (β2). (nih.gov)
- In guinea pigs and cats, it is more potent in antagonizing this tachycardia than in antagonizing isoproterenol-induced bronchodilatation (β2). (nih.gov)
- Labetalol HCl's beta 1 -receptor blockade in man was demonstrated by a small decrease in the resting heart rate, attenuation of tachycardia produced by isoproterenol or exercise, and by attenuation of the reflex tachycardia to the hypotension produced by amyl nitrite. (guidelinecentral.com)
Mice4
- Isoproterenol (ISO) (150 mg/kg/day, i.p for 2 consecutive days) was administered to mice to cause myocardial necrosis. (biomedcentral.com)
- Phlorizin (400 mg/kg/day i.p twice daily for 2 days) and Ritonavir (10 mg/kg/day i.p twice daily for 2 days) were administered in two different groups of mice before isoproterenol administration. (biomedcentral.com)
- Here, we investigated pathological phenotypic alterations in the systemic immune response, especially changes in T lymphocytes, from one day to six months after ischemic stroke in mice. (en-journal.org)
- To replicate stress-induced ischemic damage, researchers treated the mice with isoproterenol, which mimics a heart attack and leads to tissue enlargement. (thealternativedaily.com)
Cardioprotective effects1
- The present study aimed to investigate the biomolecular mechanisms underlying cardioprotective effects of diallyl trisulfide (DATS) as well as captopril (CAP) in isoproterenol (ISO) induced AMI focusing on autophagy & PI3K/Akt signaling. (springeropen.com)
Conduction1
- In symptomatic cases, intravenous atropine or isoproterenol may transiently improve conduction. (wikipedia.org)
Inhibitor1
- In the present study, we evaluated the role of Ritonavir in isoproterenol-induced myocardial necrosis in vivo and compared the effect with Phlorizin, a nonslective SGLTs inhibitor. (biomedcentral.com)
Adenosine1
- Enhanced Gi2 signalling HTRA3 defends the center from ischaemic damage Adenosine, opioids, bradykinin, and various other agonists that work at Gi-coupled receptors protect the center from ischaemic damage. (woofahs.com)
Syndromes1
- Should Women with Unstable Ischaemic Syndromes be Investigated Differently from Men? (portlandpress.com)
Cardiac1
- Wrote the paper: JAS AJS.Clinical point of view and limitationsSympathetic activity increases in a wide array of cardiac ailments, for example ischemic heart failure [42]. (axlinhibitor.com)
Cardiomyocytes1
- Here, we report that remodeled Cx43 protein forms Cx43 hemichannels in the lateral membrane of Dmd mdx cardiomyocytes and that the β-adrenergic agonist isoproterenol (Iso) aberrantly activates these hemichannels. (jci.org)
Abstract1
- ENGLISH ABSTRACT: The Mechanism of -adrenergic preconditioning ( -PC) Ischaemic preconditioning (IPC), a potent endogenous protective intervention against myocardial ischaemia, is induced by exposure of the heart to repetitive short episodes of ischaemia and reperfusion. (sun.ac.za)
Arrhythmias1
- These arrhythmias are often induced by exercise, isoproterenol (in the electrophysiology laboratory), the recovery phase of exercise, or hormonal changes in female patients (pregnancy, menses, menopause). (medscape.com)
Hearts3
- As a result, we utilized the Langendorff-isolated center model to determine whether GS/+ and GS/GS hearts are shielded from ischaemic damage. (woofahs.com)
- Hearts were preconditioned with 5 min isoproterenol 0.1 μM ( 1/ 2-AR agonist), or formoterol 1 nM ( 2-AR agonist) or BRL 37344 1 μM ( 3-AR agonist) followed by 5 min reperfusion. (sun.ac.za)
- Results: Infarct sizes of hearts preconditioned with isoproterenol of formoterol were significantly smaller compared to those of non-preconditioned hearts. (sun.ac.za)
Reduction1
- The 1- and 2-AR blockers CGP-20712A and ICI-118551 completely abolished the isoproterenol-induced reduction in infarct size and improvement in mechanical recovery, while the 3-AR blocker was without effect. (sun.ac.za)
Stroke2
- Pathobiology of ischaemic stroke: an integrated view. (southampton.ac.uk)
- Ischemic stroke occurs when blood flow to the brain is blocked. (en-journal.org)
Heart disease1
- It can be seen in myocardial ischemia, propranolol use, digitalis use, rheumatic fever, and chronically in ischemic heart disease and other structural diseases (amyloidosis, mitral valve prolapse, aortic valve disease, and atrial septal defect). (wikipedia.org)
Diseases2
- http://www.who.int/cardiovascular_diseases/resources/atlas/en/index.html. (southampton.ac.uk)
- The plant Tribulus terrestris Linn, a deciduous tree of the Zygophyllaceae family, is an important herb from Indian and Chinese traditional medicine literature for the treatment of various diseases especially ischemic heart diseases (Warrier, 1994). (scialert.net)
Metabolic1
- During an AMI, the first ischemic insult initiates a cascade of unanticipated biochemical and metabolic changes inside the heart tissue. (springeropen.com)
Therapeutic1
- Clofarabine manufacture These data claim that RGS Clofarabine manufacture protein may provide book therapeutic targets to safeguard the center from ischaemic damage. (woofahs.com)
Exposure1
- Regrettably, inside the existing design and style, it can't be determined whether the advantages of physical exercise training will continue to counteract isoproterenol more than longer term exposure, which could be more relevant to chronic human sympathetic hyperactivity.Author ContributionsConceived and made the experiments: JAS AJS. (axlinhibitor.com)
Injury1
- D. odorifera may be a potential candidate drug for treating myocardial ischemic injury. (wjtcm.net)
Damage1
- We used an isoproterenol model that in some ways mimics damage that can occur during a heart attack. (thealternativedaily.com)
Blood flow1
- The re-establishing of blood flow to an ischemic zone is called reperfusion [ 1 ]. (biomedcentral.com)
Activation1
- Release of endogenous catecholamines and activation of the beta-adrenergic receptors (b-AR) have also been shown to be involved in ischaemic preconditioning. (sun.ac.za)
Brain1
- We will review present knowledge of the relative contribution of each COX isoform to the brain ischemic pathology, based on data from investigations utilizing selective COX-1/COX-2 inhibitors and genetic knockout mouse models. (southampton.ac.uk)
Study2
- In vitro study with heart homogenate confirmed no antioxidant effect of ritonavir and phlorizin in the absence and presence of isoproterenol. (biomedcentral.com)
- In the present study, we inhibited SGLTs and GLUTs transporters in heart by using pharmacological inhibitors, phlorizin (nonselective SGLT blocker) and ritonavir (nonselective GLUTs blocker) respectively, and evaluated the relative importance of these transporters during myocardial necrosis induced by isoproterenol. (biomedcentral.com)
Groups1
- sham (saline treated only), isoproterenol (ISP) control (saline and ISP) and Tribulus terrestris treatment groups ( T. terrestris and ISP). (scialert.net)
Function1
- Graphpad Prism software program (NORTH PARK, CA, USA) was useful for statistical evaluation, and 0.001) increased the contractile amplitude of myocytes from both genotypes ( 0.05) ( 0.001) weighed against basal contractile function in the lack of isoproterenol. (woofahs.com)