• Reperfusion plays an important role in the pathophysiology of cerebral ischemia. (nih.gov)
  • Magnetic resonance imaging (MRI) and histological studies in rat focal ischemia models using transient middle cerebral artery (MCA) occlusion indicate that reperfusion after an ischemic episode of 2- to 3-hour duration does not result in reduction of the size of the infarct. (nih.gov)
  • When cerebral ischemia-reperfusion injury happened in patients, multiple pathological processes occur, such as leukocyte infiltration, platelet, and complement activation, which would result in cognitive dysfunction and inflammation. (hindawi.com)
  • The original phenolic hydroxyl in the puerarin molecules was substituted in order to change the blood-brain barrier permeability and thus enhance the efficacy for preventing cerebral ischemia/reperfusion injury. (hindawi.com)
  • The mouse model of cerebral artery ischemia/reperfusion injury was established to test the anticerebral ischemia-reperfusion injury activity of the puerarin derivatives. (hindawi.com)
  • The results showed that puerarin derivative P1-EA and P2-EA were resulting in an increased lipophilicity that enabled the derivatives to pass more efficiently through the blood-brain barrier, thus, improving the protective effects against cerebral ischemia/reperfusion injury. (hindawi.com)
  • Therefore, derivatives of puerarin may serve as promising approach to improve neuron function in ischemia-reperfusion brain injury-related disorders. (hindawi.com)
  • Studies have shown that VaD is frequently caused by ischemia-reperfusion injury. (hindawi.com)
  • Studies have shown that puerarin reduced cerebral edema in rats with cerebral ischemia-reperfusion injury, removed lipid peroxidation products, enhanced antioxidant capacity, improved antioxidant activity of the brain tissue, and reduced the degree of focal cerebral ischemic injury [ 2 - 4 ]. (hindawi.com)
  • In addition, we tested the anticerebral ischemia-reperfusion injury activity of these puerarin derivatives in order to determine their permeability through the blood-brain barrier and pharmacological activity. (hindawi.com)
  • Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
  • Alpha adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats. (jci.org)
  • Thus, enhanced alpha-adrenergic responsiveness occurs during myocardial ischemia and appears to be primary mediator of the electrophysiological derangements and resulting malignant dysrhythmias induced by catecholamines during myocardial ischemia and reperfusion. (jci.org)
  • Furthermore, Sesn2-knockout hearts demonstrate a cardiac phenotype and response to ischemic stress that is similar to wild-type aged hearts ( i.e., impaired ischemic AMPK activation and higher sensitivity to ischemia- and reperfusion- induced injury). (nih.gov)
  • To evaluate the effects of dexmedetomidine on myocardial ischemia-reperfusion injury in rats and its anti-apoptotic role, as well as the mechanism by which it regulates Janus kinase 2/signal transducers and activators of transcription 3 signal. (ijpsonline.com)
  • The left anterior descending coronary artery was ligated to construct the model of myocardial ischemia-reperfusion. (ijpsonline.com)
  • Dexmedetomidine pretreatment can obviously relieve myocardial ischemia-reperfusion injury and cardiomyocyte apoptosis in rats probably by activating the Janus kinase 2/signal transducers and activators of transcription 3 signaling pathway. (ijpsonline.com)
  • Global cerebral ischemia followed by reperfusion, which leads to extensive neuronal damage, particularly the neurons in the hippocampal CA1 region. (springer.com)
  • Apoptosis is one of the major mechanisms that lead to neuronal death after cerebral ischemia and reperfusion. (springer.com)
  • The neuroprotective effects of remifentanil preconditioning against cerebral ischemia/reperfusion injury have been recently reported. (springer.com)
  • Here we investigated whether remifentanil postconditioning exerts neuroprotective effects against global cerebral ischemia/reperfusion injury in rats and its potential mechanisms. (springer.com)
  • We found remifentanil postconditioning markedly improved the spatial learning and memory as well as attenuated neuronal apoptosis in hippocampus caused by cerebral ischemia/reperfusion injury. (springer.com)
  • The results suggest that remifentanil postconditioning exhibits neuroprotective effects against global cerebral ischemia/reperfusion injury in rats, and its mechanisms might involve inhibition of neuronal apoptosis through the PI3K pathway. (springer.com)
  • Wang JY, Shen J, Gao Q et al (2008) Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. (springer.com)
  • Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (springer.com)
  • Retinal ischemia/reperfusion (I/R) injury can cause severe vision impairment. (mdpi.com)
  • Given the central role that mitochondria play during hypoxia, we hypothesized that Txnip deletion would enhance ischemia-reperfusion damage. (jci.org)
  • Surprisingly, Txnip-KO hearts had greater recovery of cardiac function after an ischemia-reperfusion insult. (jci.org)
  • Whereas mitochondrial ATP synthesis was minimally decreased by Txnip deletion, cellular ATP content and lactate formation were higher in Txnip-KO hearts after ischemia-reperfusion injury. (jci.org)
  • Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
  • Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. (hindawi.com)
  • The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
  • Kidney partial ischemia-reperfusion (IR) injury is defined as a reduction of the renal blood flow (RBF) followed by the recovery of RBF and reoxygenation [ 1 ]. (hindawi.com)
  • IPC is described as short, transient, and nonlethal ischemia periods and subsequent reperfusion which is performed before IR injury and can protect the kidney against long-term ischemia [ 6 - 8 ]. (hindawi.com)
  • Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
  • The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
  • A model of cerebral ischemia‑reperfusion was established using the MCAO method. (spandidos-publications.com)
  • These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
  • yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
  • An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
  • A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)
  • Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion. (aspetjournals.org)
  • The effects of acidified sodium nitrite (NaNO2) which releases nitric oxide, a substance which is thought to be indistinguishable from endothelium-derived relaxing factor, were investigated in a 6-h model of myocardial ischemia (MI) with reperfusion in open-chest, anesthetized cats. (aspetjournals.org)
  • Thus, acidified NaNO2 exerts a significant protective action during ischemia and reperfusion injury, which suggests that endothelium-derived relaxing factor has a cardioprotective effect in MI. (aspetjournals.org)
  • British Library EThOS: Aspects of ischaemia and reperfusion injury in the isolated rat heart. (bl.uk)
  • Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion injury remains incomplete. (elifesciences.org)
  • Study on the pharmacodynamic effect of Rhizoma Dioscoreae polysaccharides on cerebral ischemia-reperfusion injury in rats and the possible mechanism. (iasp-pain.org)
  • The primary ischemia/hypoxia injury and secondary reperfusion injury are mainly caused by oxidative stress, which caused by hypoxia, such as free radical generation, energy metabolism disorder, intracellular calcium overload, excitatory amino acid release and inflammatory reaction. (iasp-pain.org)
  • To elucidate the cardioprotective mechanisms of mild hypothermia, we analyzed cardiac performance in a porcine model of ischemia/reperfusion, with serial cardiovascular magnetic resonance (CMR) imaging throughout one week using non-invasive pressure-volume loops. (lu.se)
  • CONCLUSION: Using non-invasive pressure-volume loops by CMR, we observed that mild hypothermia at reperfusion alleviates the heart's work after ischemia/reperfusion injuries during the first week and preserves short-term cardiac performance. (lu.se)
  • This study tested the hypotheses that compared to drinking water, consumption of a caffeinated soft drink sweetened with high-fructose corn syrup (HFCS) attenuates the cutaneous vasodilatory response to local skin heating without (Protocol 1) and following ischemia-reperfusion injury (Protocol 2). (cdc.gov)
  • Thirty minutes following beverage consumption local skin heating commenced on the right forearm (Protocol 1), while on the left forearm ischemia-reperfusion commenced with 20 min of ischemia followed by 20 min of reperfusion and then local skin heating (Protocol 2). (cdc.gov)
  • The cutaneous microvascular vasodilator response to local heating with or without prior ischemia-reperfusion injury is not affected by acute consumption of a caffeinated soft drink sweetened with HFCS. (cdc.gov)
  • Ischemia of the small bowel is called mesenteric ischemia. (wikipedia.org)
  • Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three major arteries that supply the small and large intestines. (medlineplus.gov)
  • The outlook for chronic mesenteric ischemia is good after a successful surgery. (medlineplus.gov)
  • People with acute mesenteric ischemia often do poorly because parts of the intestine may die before surgery can be done. (medlineplus.gov)
  • However, with prompt diagnosis and treatment, acute mesenteric ischemia can be treated successfully. (medlineplus.gov)
  • Tissue death from lack of blood flow (infarction) in the intestines is the most serious complication of mesenteric artery ischemia. (medlineplus.gov)
  • Chronic mesenteric ischemia (CMI) usually results from long-standing atherosclerotic disease of two or more mesenteric vessels. (medscape.com)
  • In 1958, Shaw and Maynard described the first thromboendarterectomy of the superior mesenteric artery (SMA) for the treatment of both acute mesenteric ischemia (AMI) and CMI. (medscape.com)
  • Mastery of the anatomy of the mesenteric vessels is essential to management of chronic mesenteric ischemia (CMI), although the wide array of vascular variations can make such mastery difficult to achieve. (medscape.com)
  • This communication is an important connection that helps maintain bowel perfusion in the setting of mesenteric ischemia. (medscape.com)
  • Chronic mesenteric ischemia, also known as intestinal angina, is defined by reduced blood flow to major mesenteric arteries (celiac, superior mesenteric, inferior mesenteric) causing abdominal pain which is often postprandial. (logicalimages.com)
  • Chronic mesenteric ischemia is typically caused by atherosclerotic disease. (logicalimages.com)
  • The same risk factors for peripheral and coronary artery disease predispose to chronic mesenteric ischemia, namely smoking, hypertension, diabetes, and hyperlipidemia. (logicalimages.com)
  • In the first part of my talk, I discussed colon ischemia and now in the second part of my talk, I'm going to discuss a variety of topics including acute mesenteric ischemia, focal segmental ischemia, mesenteric arterial occlusive disease, mesenteric venous thrombosis, and chronic mesenteric ischemia or intestinal angina. (hstalks.com)
  • I'm now going to talk about acute mesenteric ischemia, which also is a spectrum of disease. (hstalks.com)
  • Next most common is non-exclusive mesenteric ischemia. (hstalks.com)
  • The blood vessels were relatively normal and it was, therefore, called non-inclusive mesenteric ischemia. (hstalks.com)
  • Superior mesenteric venous thrombosis accounts for 5 - 10 percent of patients with acute mesenteric ischemia and focal segmental ischemia, probably another 5 percent. (hstalks.com)
  • Acute mesenteric ischemia is sudden blockage of blood flow to part of the intestines, which may lead to gangrene and perforation (puncture). (msdmanuals.com)
  • Acute mesenteric ischemia has multiple causes. (msdmanuals.com)
  • If the person has typical symptoms of acute mesenteric ischemia or if the abdomen is very tender, doctors usually take the person right to surgery. (msdmanuals.com)
  • Cardiac ischemia may be asymptomatic or may cause chest pain, known as angina pectoris. (wikipedia.org)
  • These issues are "not very controversial" among cardiac electrophysiologists, Hussein said, but it remains "common practice" for other specialists to order angiography or ischemia testing for patients with monomorphic VT storm, typically in the cardiac care unit (CCU), before considering ablation. (medscape.com)
  • Myocardial ischemia, also called cardiac ischemia, reduces the heart muscle's ability to pump blood. (sparrow.org)
  • Immunoprecipitation with Sesn2 Ab revealed that cardiac Sesn2 forms a complex with AMPK and upstream liver kinase B1 (LKB1) during ischemia. (nih.gov)
  • The main objective of this work is to improve understanding of the regulation of energy metabolism during skeletal/cardiac muscle ischemia by combining in vivo experiments and quantitative models of metabolism. (nasa.gov)
  • Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
  • For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
  • For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
  • This study provides important findings on the distinct functions of resident and recruited macrophages during cardiac healing after myocardial ischemia. (elifesciences.org)
  • The extract with high phenolic content (T. terrestris L. ethyl acetate extract-TTME) was further characterized for its chemical constituents and taken forward for evaluation against cardiac ischemia. (amrita.edu)
  • The patient had severe cardiac dysfunction and atrial fibrillation and presented with acute ischemia in the right lower limb 24 h after receiving an inferior vena cava filter. (medscape.com)
  • Ren C, Yan Z, Wei D et al (2009) Limb remote ischemic postconditioning protects against focal ischemia in rats. (springer.com)
  • Ding ZM, Wu B, Zhang WQ et al (2012) Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the same effect on inhibition of apoptosis. (springer.com)
  • Jeong S, Kim SJ, Jeong C et al (2012) Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats. (springer.com)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • Liang HW, Qiu SF, Shen J et al (2008) Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus. (springer.com)
  • Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via MAPK pathway. (iasp-pain.org)
  • Patients with a severe form of ventricular arrhythmia who may be referred for catheter ablation are often first tested for coronary artery disease (CAD) or ischemia. (medscape.com)
  • The findings, they say, question such routine CAD/ischemia testing in patients like those studied, who had episodes of monomorphic ventricular tachycardia (VT) storm but not an acute coronary syndrome (ACS) and ultimately went to ablation. (medscape.com)
  • The findings "argue against performing routine evaluations to rule out coronary [disease] or myocardial ischemia as culprits in monomorphic VT storm" in patients without evidence of ACS, write Feras Alkhalaileh, MD, Heart and Vascular Institute, Cleveland Clinic, Ohio, and colleagues in their report published August 2 in JACC: Clinical Electrophysiology . (medscape.com)
  • Amsterdam, the Netherlands and New Orleans, U.S. - At the American College of Cardiology's (ACC) annual meeting in New Orleans, U.S., Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today announced the results of the DEFINE PCI [1] study, which assessed the level of residual ischemia found in patients after percutaneous coronary interventions (PCI). (philips.com)
  • PCI is an image-guided, minimally invasive treatment to open a coronary artery blockage (stenosis) that is causing a reduced blood flow (ischemia) to heart tissue. (philips.com)
  • Myocardial ischemia occurs when the blood flow through one or more of your coronary arteries is decreased. (sparrow.org)
  • Coronary artery spasm is an uncommon cause of myocardial ischemia. (sparrow.org)
  • To determine whether ischemic AMPK activation-modulated by the Sesn2-AMPK complex in the heart-is impaired in aging that sensitizes the heart to ischemic insults, young C57BL/6 mice (age 3-4 mo), middle-aged mice (age 10-12 mo), and aged mice (age 24-26 mo) were subjected to left anterior descending coronary artery occlusion for in vivo regional ischemia. (nih.gov)
  • A study published on July 9 in the Journal of the American College of Cardiology: Cardiovascular Imaging found that "in stable coronary artery disease (CAD), ischemia worsening is an independent predictor of death or myocardial infarction (MI), resulting in significantly improved risk reclassification when added to previously known predictors. (acc.org)
  • Looking at "1,425 consecutive patients with angiographically documented CAD who underwent two serial MPS scans," ischemia change was calculated for patients undergoing medical therapy (MT) alone, percutaneous coronary intervention (PCI), or coronary artery bypass grafting (CABG). (acc.org)
  • Diabetes is a pivotal cause of asymptomatic myocardial ischemia (MI) even in the absence of coronary artery disease [ 3 ]. (springer.com)
  • Brain ischemia is insufficient blood flow to the brain, and can be acute or chronic. (wikipedia.org)
  • Chronic ischemia of the brain may result in a form of dementia called vascular dementia. (wikipedia.org)
  • Inadequate blood supply to a limb may result in acute limb ischemia or chronic limb threatening ischemia. (wikipedia.org)
  • Exposure to air pollution, especially fine particulate matter, is a leading risk factor for noncommunicable diseases, in particular: ischaemia, myocardial infarction, stroke, chronic obstructive pulmonary disease and cancers. (who.int)
  • In the current study, induction of ischemia enhanced the levels of pro-inflammatory cytokines and increased phosphorylation of MAPK signaling factors in the hippocampus and basolateral amygdala. (iasp-pain.org)
  • H9c2 cells were pretreated with TTME (10, 25, 50 and 100 µg/ml) for 24 h before the induction of ischemia. (amrita.edu)
  • Prolonged ischemia may lead to INFARCTION of spinal cord tissue. (harvard.edu)
  • QT dispersion and components of the QT interval in ischaemia and infarction. (bmj.com)
  • metabolic acidosis, arrhythmias, myocardial ischemia or infarction, and noncardiogenic pulmonary edema, although any organ system might be involved. (cdc.gov)
  • and global ischemia, which encompasses wide areas of brain tissue. (wikipedia.org)
  • Charron C, Messier C, Plamondon H (2008) Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia. (springer.com)
  • Revascularization for silent ischemia was associated with better outcomes in the long run compared with medical therapy alone, a registry study suggested. (medpagetoday.com)
  • Practice varied substantially among hospitals: their ratios of revascularization vs medical therapy for silent ischemia ranged from under 0.80 to more than 1.60 (average 1.12). (medpagetoday.com)
  • He pointed to the ISCHEMIA trial that includes patients with silent ischemia and is to be presented in 2019. (medpagetoday.com)
  • Some people who have myocardial ischemia don't have any signs or symptoms (silent ischemia). (sparrow.org)
  • Transient forebrain ischemia leads to delayed death of the CA1 neurons in the hippocampus. (nih.gov)
  • Immunohistochemical and biochemical investigations of Ca2+/calmodulin-dependent protein kinase II(CaM kinase II) and protein phosphatase (calcineurin) after transient forebrain ischemia demonstrated that the activity of CaM kinase II was decreased in the CA1 region of the hippocampus early (6-12 hours) after ischemia. (nih.gov)
  • A sudden, brief episode (symptoms lasting only minutes) of ischemia affecting the brain is called a transient ischemic attack (TIA), often called a mini-stroke. (wikipedia.org)
  • Other effects that may result from brain ischemia are stroke, cardiorespiratory arrest, and irreversible brain damage. (wikipedia.org)
  • citation needed] Other pathological events that may result in brain ischemia include cardiorespiratory arrest, stroke, and severe irreversible brain damage. (wikipedia.org)
  • Cannabinoids may have therapeutic potential in disorders resulting from cerebral ischemia, including stroke, and may protect neurons from injury through a variety of mechanisms. (erowid.org)
  • When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
  • Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)
  • [ 1 ] A recent hypothesis to explain the migraine-stroke association, based on experimental data obtained in mice expressing familial hemiplegic migraine type 1 mutations, is that the cerebral hyperexcitability phenotype associated with migraine might sensitize brain tissue to ischemia. (medscape.com)
  • Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)
  • Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). (wikipedia.org)
  • Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue i.e. hypoxia and microvascular dysfunction. (wikipedia.org)
  • Without immediate intervention, ischemia may progress quickly to tissue necrosis and gangrene within a few hours. (wikipedia.org)
  • Ischemia is a vascular disease involving an interruption in the arterial blood supply to a tissue, organ, or extremity that, if untreated, can lead to tissue death. (wikipedia.org)
  • Cerebral ischemia causes tissue death owing to occlusion of the cerebral blood vessels, and cerebral ischemia activates mitogen-activated protein kinase (MAPK) and induces secretion of pro-inflammatory cytokines. (iasp-pain.org)
  • Cerebral hyperexcitability in migraine experiencers might sensitize brain tissue to ischemia. (medscape.com)
  • Digital ischemia is associated with atherosclerotic, thromboembolic, or connective tissue diseases . (bvsalud.org)
  • Global cerebral ischemia was performed via 10 min of four-vessel occlusion. (springer.com)
  • As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in patients with type 2 diabetes mellitus and no history of cardiovascular events. (springer.com)
  • After 6 cycles, he remained asymptomatic and symptoms of digital ischemia were completely resolved. (bvsalud.org)
  • The signs and symptoms of ischemia vary, as they can occur anywhere in the body and depend on the degree to which blood flow is interrupted. (wikipedia.org)
  • The main symptoms of brain ischemia involve impairments in vision, body movement, and speaking. (wikipedia.org)
  • Symptoms of brain ischemia can include unconsciousness, blindness, problems with coordination, and weakness in the body. (wikipedia.org)
  • The symptoms of brain ischemia reflect the anatomical region undergoing blood and oxygen deprivation. (wikipedia.org)
  • Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, weakness in one arm or leg, or weakness in one entire side of the body. (wikipedia.org)
  • Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as dizziness, vertigo, double vision, or weakness on both sides of the body[citation needed]. (wikipedia.org)
  • The symptoms of brain ischemia range from mild to severe. (wikipedia.org)
  • Professor Bradbury led the HTA-funded Bypass Versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial, which was the first, and only, randomised controlled trial to investigate whether surgical bypass or keyhole treatment is best at relieving symptoms and preventing amputation or death in patients with Severe Limb Ischaemia (SLI). (birmingham.ac.uk)
  • 30%) with acute symptoms of right lower-extremity ischemia. (medscape.com)
  • Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
  • A 10-year experience of managing acute limb ischaemia in India. (who.int)
  • Acute limb ischaemia is threatening to both limb and life. (who.int)
  • We did a retrospective analysis of the clinical profile of patients presenting with non-traumatic acute limb ischaemia to our department (a tertiary care centre in India) from January 1998 to December 2007. (who.int)
  • Acute limb ischaemia is a catastrophic event. (who.int)
  • Ischemia can be partial (poor perfusion) or total blockage. (wikipedia.org)
  • citation needed] Blockage of arteries due to plaque buildup may also result in ischemia. (wikipedia.org)
  • We hypothesized that an imbalance of Ca2+/calmodulin dependent protein phosphorylation-dephosphorylation may be involved in delayed neuronal death after ischemia. (nih.gov)
  • These excitotoxic effects play important roles in neuronal and blood-brain barrier damage after cerebral ischemia ( 5 , 6 ). (spandidos-publications.com)
  • Myocardial ischemia occurs when blood flow to your heart is reduced, preventing the heart muscle from receiving enough oxygen. (sparrow.org)
  • Paralysis is a very late sign of acute arterial ischemia and signals the death of nerves supplying the extremity. (wikipedia.org)
  • Venous problems like venous outflow obstruction and low-flow states can cause acute arterial ischemia. (wikipedia.org)
  • An aneurysm is one of the most frequent causes of acute arterial ischemia. (wikipedia.org)
  • We also found that female mice sustained smaller infarcts than males three months post- ischemia . (nih.gov)
  • Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia. (harvard.edu)
  • The authors note that, "this is the largest reported series addressing changes in ischemia on serial myocardial perfusion single-photon emission computed tomography (MPS). (acc.org)
  • Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)
  • The clot might block an artery and lead to sudden, severe myocardial ischemia, resulting in a heart attack. (sparrow.org)
  • Currently, we are investigating the difference in the responses to sudden vs. gradual onset ischemia in swine by combining in vivo experimental studies with computational models of myocardial energy metabolism during normal and ischemic conditions. (nasa.gov)
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population. (wikipedia.org)
  • citation needed] Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
  • Myocardial ischemia can develop slowly as arteries become blocked over time. (sparrow.org)
  • For the induction of cerebral ischemia, the common carotid arteries were exposed, and then aneurysm clips were used to occlude the common carotid arteries bilaterally for 7 minutes. (iasp-pain.org)
  • Of 97 such patients, about 44% underwent CAD/ischemia testing by invasive angiography, myocardial functional imaging, or both. (medscape.com)
  • All subjects underwent Technetium-99 m sestamibi single-photon emission computed tomographic imaging for the estimation of myocardial ischemia, expressed as Summed Stress Score (SSS). (springer.com)
  • He subsequently underwent a Roux-en-Y reconstruction and gastrostomy tube placement via the distal gastric remnant. (sages.org)
  • This article describes the pathophysiology of, and treatment strategy for, cerebral ischemia. (nih.gov)
  • Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. (wikipedia.org)
  • Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and energy crisis. (wikipedia.org)
  • The causes of brain ischemia vary from sickle cell anemia to congenital heart defects. (wikipedia.org)
  • Accordingly, this discovery raised the possibility of intervening after brain ischemia before the damage becomes irreversible. (wikipedia.org)
  • Brain ischemia has been linked to a variety of diseases or abnormalities. (wikipedia.org)
  • Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. (wikipedia.org)
  • citation needed] A heart attack can also cause brain ischemia due to the correlation that exists between heart attack and low blood pressure. (wikipedia.org)
  • Therefore, brain ischemia can result from events other than heart attacks. (wikipedia.org)
  • citation needed] Congenital heart defects may also cause brain ischemia due to the lack of appropriate artery formation and connection. (wikipedia.org)
  • In this study, we examined the histological presence of insulin-like growth factor-I (IGF-1) and insulin receptor substrate (IRS-1) in anatomically distinct brain circuits compared with morphological brain damage in a co-morbid rat model of striatal ischemia (ET1) and A beta toxicity. (bepress.com)
  • In this research, a simple ratiometric electrochemical biosensor for NO monitoring in rat brain following cerebral ischemia was developed using a carbon nanotube fiber (CNF) modified with hemin, in which the CNF not only served as a platform to assemble the hemin molecule, but greatly facilitated the electron transfer of hemin on to the electrode surface. (rsc.org)
  • We investigated whether a personal history of migraine is associated with vulnerability to brain ischemia in humans. (medscape.com)
  • Details for: Treatment of reversible myocardial ischemia-angina pectoris. (who.int)
  • The development of effective neuroprotection methods and the establishment of reliable imaging modalities for an early and accurate diagnosis of the extent and degree of the ischemia are imperative. (nih.gov)
  • Ischemia is the most common cause of cardiovascular disease and myocardial damage in the developed world. (southcarolinablues.com)
  • Of the patients with residual ischemia, the study showed that 81.6% of those patients had an untreated focal stenosis (narrowing of an artery). (philips.com)
  • We recently reported that neonatal ischemia induces microglia/macrophage activation three days post- ischemia . (nih.gov)
  • This indicates that if the precise locations causing ischemia are better detected prior to stenting, patient outcomes may be improved. (philips.com)
  • The fact that nearly one-quarter of patients had residual ischemia despite an angiographically successful result, mostly due to focal lesions that can easily be treated, has important implications for improving outcomes of patients undergoing stent implantation globally," said Gregg W. Stone, MD, Professor of Medicine at Columbia University Medical Center. (philips.com)
  • Ischemia causes not only insufficiency of oxygen, but also reduced availability of nutrients and inadequate removal of metabolic wastes. (wikipedia.org)
  • Bowel ischemia represents a process of insufficient blood supply of the small or large bowel with the consequences ranging from a transient, totally reversible attack to a lethally catastrophic event. (ajronline.org)
  • Pathology revealed gastric ischemia at the base of the wrap making it impossible to visualize through endoscopy. (sages.org)