• coronary artery
  • This ischemia may be secondary to coronary artery disease, or a result of the previously described changes in microvasculature. (wikipedia.org)
  • Cardiac magnetic resonance imaging perfusion (cardiac MRI perfusion, CMRI perfusion), also known as stress CMR perfusion, is a clinical magnetic resonance imaging test performed on patients with known or suspected coronary artery disease to determine if there are perfusion defects in the myocardium of the left ventricle that are caused by narrowing of one or more of the coronary arteries. (wikipedia.org)
  • To screen patients who have chest pain and risk factors for coronary artery disease, to assess for ischaemia which may be caused by a narrowing in one of the coronary arteries. (wikipedia.org)
  • arterial
  • Reduced blood flow to the skin layers may result in mottling or uneven, patchy discoloration of the skin Ischemia is a vascular disease involving an interruption in the arterial blood supply to a tissue, organ, or extremity that, if untreated, can lead to tissue death. (wikipedia.org)
  • occurs
  • After total ischemia occurs, the myocardium switches immediately from aerobic glycolysis to anaerobic glycolysis resulting in the reduced ability to produce high energy phosphates such as ATP and Creatinine Phosphate. (wikipedia.org)
  • It occurs when the heart muscle, or myocardium, receives insufficient blood flow. (wikipedia.org)
  • persist
  • The positive effects observed in clinical trials today are a result of the work of donated stem cells that persist in the damaged myocardium for just days to weeks after delivery. (wikipedia.org)
  • slower
  • In an abnormal scan an area of the myocardium will turn grey slower than the surrounding tissue as the blood (and hence gadolinium) enters more slowly due to a narrowing of the coronary artery supplying it. (wikipedia.org)
  • experimental
  • The cellular electrophysiologic consequences of both regional and global experimental ischemia and reperfusion were studied in the isolated cat myocardium, using conventional microelectrode techniques. (docphin.com)
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • cellular
  • This dissertation serves to analyze the molecular and cellular signaling mechanisms by which aldose reductase (AR) contributes to ischemia/reperfusion (I/R) injury, specifically in the myocardium. (columbia.edu)
  • The cellular electrophysiologic changes induced by ischemia returned to baseline values within the next 5 minutes. (docphin.com)
  • Cellular cardiomyoplasty, or cell-based cardiac repair, is a new potential therapeutic modality in which progenitor cells are used to repair regions of damaged or necrotic myocardium. (wikipedia.org)
  • protective
  • In 1993, Karin Przyklenk and colleagues began using the term "remote" when they observed that cross-clamping on the right side of the heart (right circumflex artery) protected the left side of the heart (LAD territory) from ischemia: that is, the protective trigger was remote from the observed effect. (wikipedia.org)
  • results
  • These results suggest that externalization of beta-adrenergic receptors from a light vesicle fraction to the sarcolemma contributes to up-regulation of beta-receptors that occur in response to both propranolol treatment and ischemia. (ahajournals.org)
  • less
  • Due to the high contrast between the blood pool and the myocardium it is common to get what looks like a thin subendocardial area of ischaemia called the Gibbs artifact, this however, is less common with newer technology allowing higher resolution imaging. (wikipedia.org)
  • regional
  • A standard visual perfusion imaging assessment is based on defining regional uptake relative to the maximum uptake in the myocardium. (wikipedia.org)
  • Effects
  • Depletion of this pool of receptors along with receptor blockade may thus contribute to the mechanism by which the drug is efficacious in preventing some adverse effects of ischemia. (ahajournals.org)
  • prevent
  • Coronary perfusion with procainamide (20 mg/liter) aggravated the ischemic depressions of action potential amplitude and action potential duration and increased conduction delay during ischemia, but it did not prevent rapid ventricular activity induced by reperfusion. (docphin.com)
  • patients
  • It is a non-invasive test, is generally regarded as a safe (see below) procedure and is well tolerated by patients (apart from people who suffer from claustrophobia) The majority of scans are performed using a stress/rest protocol using adenosine as the stressor which acts to induce ischaemia in the myocardium by the coronary 'steal' phenomenon. (wikipedia.org)