• Comparative medicine is a distinct discipline of experimental medicine that uses animal models of human and animal disease in translational and biomedical research. (wikipedia.org)
  • But not all of the billions of taxpayer dollars the United States invests each year in biomedical research produce such rapid gains for human health. (issues.org)
  • One factor holding back the development of new treatments is a complex and long-standing problem: the widespread irreproducibility of biomedical research results. (issues.org)
  • Indeed, of the approximately 1.5 million papers published in biomedical journals each year, researchers have estimated that at least half are so poorly designed, conducted, analyzed, or reported that the results cannot be replicated and therefore cannot be trusted. (issues.org)
  • As a writer and health policy expert with a long-standing interest in research integrity and the ethics of clinical studies, I (Shannon Brownlee) first became interested in reproducibility while writing a review of Richard Harris's 2017 book, Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions , in which he describes the reproducibility crisis in biomedical research. (issues.org)
  • Difficulty in reproducing published biomedical research studies has become a matter of increasing concern that, if unaddressed, will waste limited research funding and may erode public support for research. (nature.com)
  • Another point often related to the lack of reproducibility in biomedical research is the biased use of statistical models. (bvsalud.org)
  • While Einstein (pictured above in an image from Wikipedia) may have had less trouble with irreproducibility in Physics, the biomedical sciences-particularly in pre-clinical and clinical studies-is highly variable and often data are not reproducible. (ipscell.com)
  • Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. (ox.ac.uk)
  • A project to assess the reproducibility of biomedical research in Brazil has been described today in the open-access journal eLife. (phys.org)
  • Unfortunately, basic biomedical research has a reproducibility problem . (footnote.co)
  • a problem it is in fields other than those where it is being actively examined, such as biomedical research and social psychology. (nationalacademies.org)
  • This funding opportunity announcement (FOA) encourages applications from small business concerns (SBCs) for Small Business Innovation Research (SBIR) projects to facilitate the design, creation, and implementation of novel tools and devices for the health and management of research animals, and to advance equipment that improves the operation and environmental conditions of animal facilities that support biomedical and bio-behavioral research. (nih.gov)
  • In 2020, we began collaborating, drawing on Bielekova's decades of research at the National Institutes of Health (NIH) and Brownlee's knowledge of health care policy. (issues.org)
  • Beyond Open Data: A Model for Linking Digital Artifacts to Enable Reproducibility of Scientific Claims ," V. Stodden, Third International Workshop on Practical Reproducible Evaluation of Computer Systems (P-RECS'20) , June 2020. (stodden.net)
  • At the beginning of 2020, STEMCELL Technologies conducted a survey asking scientists to help highlight the needs and challenges in the hPSC field and to gather ideas on how to achieve greater reproducibility. (stemcell.com)
  • New reporting standards for Nature journal authors are intended to improve transparency and reproducibility. (nature.com)
  • Ensuring systematic attention to reporting and transparency is only a small step toward solving the issues of reproducibility that have been highlighted across the life sciences. (nature.com)
  • This workshop Workshop II on "Improving experimental design in basic and clinical research for increased science reproducibility" is part of the Lemanic "Open Science & reproducibility" workshop series that aims at educating researchers from UNIL, CHUV, EPFL, UNIGE and HUG about Open Science in order to improve transparency and reproducibility of their research. (bium.ch)
  • Transparency and Reproducibility are critical in the process of transforming sophisticated speculation into knowledge. (genewhisperer.com)
  • Although the focus is primarily health issues, and the authors stated in a briefing that the US National Institutes of Health (NIH) are making some progress towards Transparency and Reproducibility, the Afterward was written by physicist William Happer. (genewhisperer.com)
  • While irreproducibility of research results in the field of genetics is encouraging greater transparency in methods and materials, along with the analytic codes that underlie the conclusions, this does not appear to be the case for clinical trials. (appliedclinicaltrialsonline.com)
  • In a paper published earlier in 2021 in the open peer review journal F1000 Research , we proposed a cost-effective, minimally intrusive solution for aligning the self-interest of researchers with the societal goal of maximizing research reproducibility and its value to human health. (issues.org)
  • We proposed a cost-effective, minimally intrusive solution for aligning the self-interest of researchers with the societal goal of maximizing research reproducibility and its value to human health. (issues.org)
  • Differences in how researchers prepare and image samples can lead to discrepancies in their results. (the-scientist.com)
  • However, reproducing the "analytical phase" seems less difficult, as it would essentially require access to the primary and/or derived data and to the analytical tools used by the researchers to derive some result. (dlib.org)
  • The main cause attributed to the observations described above is a publication and incentive system that rewards the impact and novelty of scientific findings, but does not systematically assess their reproducibility, which is rarely considered in the evaluation of researchers (14,15). (bvsalud.org)
  • Last year, Nature surveyed life sciences researchers who had published in Nature journals, and of the 480 who responded, 86 percent said poor reproducibility is a crisis in their field. (simplicis.com)
  • Researchers can achieve manufacturing-grade performance in their research without the typical cost, complexity and inflexibility associated with manufacturing systems. (sciad.com)
  • Unlike any previous replication project, this dataset includes the data from not only the replications but also from the original studies, creating a unique corpus that researchers can use to better understand reproducibility and irreproducibility in science. (edu.au)
  • Researchers, journal publishers and representatives from the pharmaceutical industry and medical communication agencies joined together in this virtual event, to share their perspectives on the importance of research integrity and how it can be achieved. (thepublicationplan.com)
  • Medical schools and teaching hospitals are helping early career researchers learn best practices and how to improve writing skills for research reproducibility. (aamc.org)
  • What is a scientific study worth if other researchers can't achieve the same results? (aamc.org)
  • In response, the NIH spearheaded an effort to better train young researchers in experimental methods and ethics, including a discussion of rigor and reproducibility in grant applications. (aamc.org)
  • In addition, some medical schools are developing research training on their own, including workshops, online training modules, and additions to curricula designed to help young researchers conduct stronger science. (aamc.org)
  • Perhaps, therefore, the problem is a general (ish) academic one: pressure to publish and win research grants lead researchers to, ahem, tweak their findings. (typepad.com)
  • Some academics have suggested linking studies that support or refute each other on databases such as PubMed to create a "metric of reproducibility," 2 which funders and academic institutions could use to evaluate researchers' reproducibility track records. (footnote.co)
  • All stakeholders in the scientific research enterprise - researchers, institutions, publishers, funders, scientific societies, and federal agencies - should improve their practices and policies to respond to threats to the integrity of research, the report says. (ens-newswire.com)
  • Detrimental research practices should be understood to include not only actions of individual researchers but also irresponsible or abusive actions by research institutions and journals. (ens-newswire.com)
  • The research process goes beyond the actions of individual researchers," said Nerem. (ens-newswire.com)
  • 1. "Researchers should avoid regarding the P-value as a dispositive measure of evidence for or against a particular research hypothesis. (genewhisperer.com)
  • 3. "In reporting their results, researchers should consider replacing 'either-or' tests of statistical significance with confidence intervals that provide the range in which a variable's true value most likely falls. (genewhisperer.com)
  • Researchers should make their data available for public inspection after publication of their results. (genewhisperer.com)
  • It will then provide an overview of existing tools that help researchers publish open reproducible research and which aspects users should consider when selecting the right tool for the own work. (sc-ctsi.org)
  • This webinar will highlight two initiatives designed to help scientists disseminate their research: (1) We Share Science, an online platform for science videos (video abstracts), and (2) Parsing Science podcast, the stories behind the science, as told by the researchers themselves. (sc-ctsi.org)
  • These costs are mainly considered from a U.S. perspective, even though it is important to remember that research misconduct and DRPs are global phenomena and that their costs are borne by researchers, institutions, funding agencies, and journals around the world. (nationalacademies.org)
  • A 2015 study estimated that researchers spent billions of dollars annually in the United States alone on irreproducible preclinical research into new drug treatments. (discoveryengineering.net)
  • By making research easy to access, and puts the academic needs of the researchers before the business interests of publishers. (intechopen.com)
  • In this chapter, we will use "reproducibility" and "replicability" interchangeably, indicating that a similar result is obtained when collecting new data under conditions similar to those in the original study. (bvsalud.org)
  • Theme Editor's Introduction to Reproducibility and Replicability in Science ," V. Stodden, Harvard Data Science Review, 2(4). (stodden.net)
  • Highlights of the US National Academies Report on "Reproducibility and Replicability in Science" ," H. Fineberg, V. Stodden, and X.L. Meng, Harvard Data Science Review, 2(4). (stodden.net)
  • We will all be using a checklist ( http://www.nature.com/authors/policies/checklist.pdf ) intended to prompt authors to disclose technical and statistical information in their submissions and to encourage referees to consider aspects important for research reproducibility. (nature.com)
  • As underscored in three Correspondences in this issue, statistical analysis of reproducibility itself is still immature. (nature.com)
  • But most research studies can be robustly assessed with existing statistical methods, when they are applied properly. (nature.com)
  • Thus, it appears feasible to strive for a more reduced version of reproducibility that we will refer to as "analytical reproducibility" in order to ensure that a third party researcher could reproduce the computational/statistical analysis performed on derived data to yield a particular conclusion, thereby being able to independently verify the results and research hypothesis. (dlib.org)
  • A related problem is the lack of objective statistical validation in reporting modeling results, a very important topic that has been highlighted recently . (fieldofscience.com)
  • Even when protocols are supposedly accurately described, the absence of error bars or statistical variation means that one can get a different result even if the original recipe is meticulously followed. (fieldofscience.com)
  • With more statistical expertise on research teams, one expert argues, scientists could think with more nuance about whether a research finding is significant. (chronicle.com)
  • But the conversation over the study on aging points to another possibility: that too much research is hamstrung by a lack of pure statistical ability. (chronicle.com)
  • ICH has also provided guidelines for global research on protocols, terminologies, and statistical analyses. (appliedclinicaltrialsonline.com)
  • Reproducibility of scientific research is an essential principle within science. (dlib.org)
  • In fact, meta-studies in psychology, medicine and also computer science have documented the challenges involved therein and they have empirically shown that the success rate in reproduction of research results is low. (dlib.org)
  • The process of verification and correction of published science, however, occurs in a non systematic way, which means that reproducibility is not guaranteed by scientific publication in its current format. (bvsalud.org)
  • But in science, how sane is it to expect experiments to give precisely the same results? (ipscell.com)
  • How big a problem is irreproducibility in science? (ipscell.com)
  • Reproducibility is central to all science because our goal is to test hypotheses and try to come to solid conclusions based on data. (ipscell.com)
  • This series of events, supported by the FBM Publication & Data Management Unit at CHUV Library , Lemanic Neuroscience Doctoral School and RESAL will be a unique opportunity for scientists to discuss and discover Open Science best practices and standards at all stages of the research process. (bium.ch)
  • Sam Burridge, Managing Director, Open Research at Springer Nature said: "We believe we're the first of the longstanding science publishers to reach the landmark of over 60% open access content. (rug.nl)
  • They can t be reproduced and if you can t reproduce a result, it isn t science. (independent.org)
  • Science s failure is called the "Irreproducibility Crisis. (independent.org)
  • A recent issue of Science has an article discussing an issue that has been a constant headache for anyone involved with any kind of modeling in drug discovery - the lack of reproducibility in computational science. (fieldofscience.com)
  • The result is bad science. (vox.com)
  • To Smaldino, the selection pressures in science have favored less-than-ideal research: "As long as things like publication quantity, and publishing flashy results in fancy journals are incentivized, and people who can do that are rewarded … they'll be successful, and pass on their successful methods to others. (vox.com)
  • Trust but Verify: How to Leverage Policies, Workflows, and Infrastructure to Ensure Computational Reproducibility in Publication ," C. Willis and V. Stodden, Harvard Data Science Review, 2(4). (stodden.net)
  • Yes, science is self-correcting, but the time for that with this topic was *before* publication, during peer review - or at the very latest, independent reproduction shortly after with retractions…but not 16 years and countless research time and money later. (stormeyes.org)
  • As a (non-medical) scientist and photographer, who is also a journal editor, I care about experimental and data reproducibility, photographic & science ethics, as well as waste of taxpayers' research funding. (stormeyes.org)
  • A 6-month investigation by Science provided strong support for Schrag's suspicions and raised questions about Lesné's research. (stormeyes.org)
  • The report endorses the definition of scientific misconduct proposed in the 1992 Academies report Responsible Science: "fabrication, falsification, or plagiarism in proposing, performing, or reporting research. (ens-newswire.com)
  • Writing for the National Association of Scholars, David Randall and Christopher Welser produced a study titled "The Irreproducibility Crisis of Modern Science: Causes, Consequences, and the Road to Reform. (genewhisperer.com)
  • Presents reproducibility in science, the ability of experiments to be reproduced or replicated by others. (bvsalud.org)
  • Some NSF awards in its Science and Society grants program go toward efforts related to research integrity. (nationalacademies.org)
  • SLM-Lab has the same two purposes that science labs have: research and education. (gitbook.io)
  • NAS refers to this as, the Irreproducibility Crisis of Modern Science . (discoveryengineering.net)
  • The 'systems' nature of the research integrity issue means that responsibility does not sit with any one group and so the UKRN was launched in 2019 to bring together different stakeholders to fill that gap. (thepublicationplan.com)
  • Scientific Tests and Continuous Integration Strategies to Enhance Reproducibility in the Scientific Software Context ," Krafczyk, Shi, Bhaskar, Marinov, and Stodden, Second International Workshop on Practical Reproducible Evaluation of Computer Systems (P-RECS'19) , June 2019. (stodden.net)
  • Standardization of clinical research data will be a topic explored in depth at the 2019 Bridging Clinical Research & Clinical Health Care Collaborative on March 4-5 in Washington, D.C. (appliedclinicaltrialsonline.com)
  • Since 2004, the problem of irreproducible findings has been documented in every area of preclinical and clinical research, on afflictions including Alzheimer's, depression, cancer, and stroke. (issues.org)
  • An analysis of this crisis published in PLOS Biology in 2015 determined that in the United States, about $28 billion per year is spent on irreproducible preclinical research. (simplicis.com)
  • In a 2011 internal survey, pharmaceutical firm Bayer HealthCare of Leverkusen, Germany, was unable to validate the relevant preclinical research for almost two-thirds of 67 in-house projects. (ipscell.com)
  • Basically, what happened is that a while back Vox saw a news report about an article in Nature condemning the quality of current preclinical research. (scienceblogs.com)
  • A systemic problem with preclinical research? (scienceblogs.com)
  • Some studies have suggested that roughly 50% of preclinical research may be irreproducible. (aamc.org)
  • The Office of Research on Women's Health (ORWH) announces the availability of administrative supplements to support research highlighting the impact of sex/gender differences (or similarities) and/or sex and gender factors in human health and illness, including basic, preclinical, clinical and behavioral studies. (nih.gov)
  • In 2005, epidemiologist John Ioannidis analyzed published replications of highly cited articles in clinical research that presented either a higher level of methodological rigor or a higher sample size than the original articles. (bvsalud.org)
  • The NIH is also awarding grants to institutions to provide training in rigor and reproducibility. (aamc.org)
  • The rigor and reproducibility training is really an effort to make everybody aware of what can happen when things aren't done by the book and how to avoid those kinds of problems. (aamc.org)
  • The Gulf Coast Consortia, seven research institutions in the Houston, Texas, area, won the AAMC's first prize for a rigor and reproducibility workshop that involved many institutions. (aamc.org)
  • address the reproducibility problem in DRL research by standardizing implementation, benchmarking, and adding rigor to evaluation. (gitbook.io)
  • It's not clear why grain-fed mice are better able to recover after infection, but a study's findings suggest food type may skew the results of animal studies. (the-scientist.com)
  • In recent years, data on the reproducibility of published findings in some areas of research has become available. (bvsalud.org)
  • In experimental psychology, several warning signs about the low reproducibility of published findings emerged in the early 2010s (7,8). (bvsalud.org)
  • Still, the available figures suggest that research findings, even if peer-reviewed and published in reputable journals, should not be necessarily assumed to be reproducible. (bvsalud.org)
  • Thus, the acceptance of an article, particularly in journals that are very selective for high-impact findings, ends up depending not only on the research's methods but also on its results. (bvsalud.org)
  • In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. (edu.au)
  • Results revealed a mix of reliable, unreliable, and culturally moderated findings. (edu.au)
  • There are concerns, however, that the scientific method has become distorted over time by changes in technology and pressures on academia to publish and obtain grants (a seminal moment being the publication of the essay titled ' Why Most Published Research Findings Are False ' by Ioannidis in 2005). (thepublicationplan.com)
  • More dangerously, skepticism is often put on hold if newly published findings support one's own line of research, and thus may give that scientist a competitive advantage to receive funding. (nautil.us)
  • How do we differentiate between research findings that point to some broader truth and those that are just a fluke? (footnote.co)
  • New studies show that a large proportion (75-90%) of the research findings in even top academic journals cannot be reliably replicated. (footnote.co)
  • Actions are needed to ensure the availability of data necessary for reproducing research, clarify authorship standards, protect whistleblowers, and make sure that negative as well as positive research findings are reported, among other steps. (ens-newswire.com)
  • In this workshop, you will learn how to use web-based approaches and social media to accelerate the dissemination and impact of your research findings. (sc-ctsi.org)
  • To maximize their utility, clinical research data should be traceable, accessible, interoperable, reproducible, and of good quality, allowing study findings to be imparted and shared in a clear and understandable way. (appliedclinicaltrialsonline.com)
  • A significant issue that arises when working with research data is the inability to validate and reproduce findings to demonstrate that the experimental result is in fact true. (appliedclinicaltrialsonline.com)
  • 4 The landmark article by Ioannidis in 2005 titled Why Most Published Research Findings Are Falsestates: "The greater the flexibility in designs, definitions, outcomes, and analytical modes in a scientific field, the less likely the research findings are to be true. (appliedclinicaltrialsonline.com)
  • The AAMC recognized three of these new training efforts as templates that other schools might follow with the 2017 Innovation in Research and Research Education Awards. (aamc.org)
  • The 2017 AAMC Innovation in Research and Research Education Awards highlighted institutions who implemented exemplary programs to address these problems. (aamc.org)
  • WASHINGTON, DC , April 21, 2017 (ENS) - The United States should establish an independent, nonprofit Research Integrity Advisory Board to support ongoing efforts to strengthen research integrity, according to a new report from the National Academies of Sciences, Engineering, and Medicine. (ens-newswire.com)
  • Research Ethics Monthly Receive copies of the Research Ethics Monthly directly by email. (ahrecs.com)
  • In pharmaceutical research, success rates are even lower at around 18% for clinical trials [ 2 ] second phase. (dlib.org)
  • Problems caused in clinical research burst into the open in a very public way then. (phys.org)
  • sex based comparisons of pathophysiology, biomarkers, gene expression, clinical presentation and prevention and treatment of diseases The proposed research must address at least one objective from Goals 1 through 3 of the NIH Strategic Plan for Women's Health Research . (nih.gov)
  • Leaders from various clinical research offices talk about how they help advance clinical research at USC. (sc-ctsi.org)
  • Irreproducible results are a big problem, especially in clinical research. (promegaconnections.com)
  • Sponsors and investigators should share the various types of clinical trial data no later than the times specified in this report (e.g., the full analyzable dataset with metadata no later than 18 months after study completion-with specified exceptions for trials intended to support a regulatory application-and the analytic dataset supporting publication results no later than 6 months after publication). (nationalacademies.org)
  • Clinical research is only as effective as its ability to have an impact on health. (appliedclinicaltrialsonline.com)
  • 1 Unfortunately, today clinical research data are often collected in a variety of formats, leading to difficulties to effectively share and compare the data under the terms allowed by study participants' consent. (appliedclinicaltrialsonline.com)
  • This disconnect creates an evidence gap that slows scientific advances, which can result in ineffective and even harmful treatments and diagnostics that continue to be employed in clinical practice. (appliedclinicaltrialsonline.com)
  • Currently, an estimated 85% of research studies do not translate to a meaningful clinical discovery. (appliedclinicaltrialsonline.com)
  • Covered topics will include a general introduction to null hypothesis testing, sampling methodologies, independence of measurements, reduction of systematic error/bias, power/sample size calculation, danger of data dredging and the impact of null results in publication bias. (bium.ch)
  • All scientists want to see it, but nobody is able to actually do it, because they'll lose status, publication opportunities, and funding…What things could be done to make reproducing results actually an attractive activity to scientists? (nautil.us)
  • In my previous article , I outlined the incentives and constraints scholars face during the research and publication processes and discussed how these contribute to the reproducibility problem. (footnote.co)
  • Many newly launched journals like the Journal of Negative Results in Biomedicine , the All Results Journals (with subject-specific versions for chemistry, biology, nanotechnology and physics), and the Journal of Negative Results (specializing in ecology and evolutionary biology) seek to provide a publication platform for negative results. (footnote.co)
  • The 8th European Medical Writers Association (EMWA) symposium, entitled ' Research Integrity & The Medical Communicator: What We Do When No One Is Watching' took place on 6th November. (thepublicationplan.com)
  • The research enterprise is not broken, but it faces significant challenges in creating the conditions needed to foster and sustain the highest standards of integrity," said Robert Nerem , chair of the committee that wrote the report and professor emeritus at the Institute for Bioengineering and Bioscience, Georgia Institute of Technology. (ens-newswire.com)
  • It suggests that the Research Integrity Advisory Board should work with all stakeholders in the research enterprise to share expertise and approaches for minimizing and addressing research misconduct and detrimental practices. (ens-newswire.com)
  • Research institutions, journals, scientific societies, and other parts of the research enterprise all can act in ways that either support or undermine integrity in research. (ens-newswire.com)
  • Because research institutions play a central role in fostering research integrity, they should maintain the highest standards for research conduct, going beyond simple compliance with federal regulations and applying these standards to all research independent of the source of funding. (ens-newswire.com)
  • For example, the Office of Research Integrity's (ORI) budget for fiscal 2014 was $8.5 million, which includes its investigative oversight, educational activities, such as support for Research Integrity Officers (RIOs) training, and for research on research integrity ( HHS, 2014b ). (nationalacademies.org)
  • Scientists need to ask "uncomfortable questions" about the value of their own research and potentially give up their line of inquiry to work on larger, group-run projects to help address science's reproducibility crisis, an influential voice on research integrity has argued. (ahrecs.com)
  • However, some sources propose different uses of the two terms to distinguish the reproducibility of analyses based on the same data from those based on new experiments or observations (3). (bvsalud.org)
  • Experiments on that question have given variable results. (ipscell.com)
  • Riffyn's cloud-based software unites visual design of experiments, real-time data integration, 24/7 analytics and peer-peer sharing to reduce error and accelerate discovery in research and development. (sciad.com)
  • Sound study design minimises the possibility of bias being introduced into experiments and leads to higher quality research with more reproducible results. (ox.ac.uk)
  • The Journal of Visualized Experiments , which publishes research in video format in order to make methods more accessible, is already addressing this issue. (footnote.co)
  • Though the experiments produced negative results, these results might nonetheless be extremely useful to other scientists studying the same cellular process. (footnote.co)
  • Shows examples of irreproducibility of data in experiments performed. (bvsalud.org)
  • There was a need for a framework that would allow us to compare algorithms and environments, quickly set up experiments to test hypotheses, reuse components, analyze and compare results, log results. (gitbook.io)
  • These examples should be viewed as a starting point for discussions about best practices for designing experiments and how to relate them to the research environment. (nih.gov)
  • A growing body of evidence indicates that substantial percentages of published results in some fields are not reproducible, the report says, noting that this is a complex phenomenon and much remains to be learned. (ens-newswire.com)
  • It is the result of improper use of statistics, arbitrary research techniques, lack of accountability, political groupthink, and a scientific culture biased toward producing positive results. (independent.org)
  • (a) This systemic lack of reproducibility undermines the scientific method and the ability to differentiate anecdote from evidence-based theories and models. (footnote.co)
  • Journals should also publish more negative results - those in which an experiment had no effect or clear outcome - because the lack of a finding can sometimes be as important as a finding itself. (footnote.co)
  • An electronic laboratory notebook (ELN) keeps data organized and secure, boosting productivity and reproducibility. (the-scientist.com)
  • Recently published scientific studies have found that irreproducibility is widely prevalent within the research community, even after releasing data openly. (dlib.org)
  • An important step in the generation of scientific results lies in the computational analysis of the primary data or derived secondary data. (dlib.org)
  • However, the mere availability of data is not enough to ensure analytical reproducibility. (dlib.org)
  • These tests, however, are usually applied flexibly after data collection and examination, and end up being reported selectively according to the results found (18,19). (bvsalud.org)
  • If a grant is provisionally accepted for funding it's handed over to a journal for a more thorough review of the protocol, which may lead to provisional acceptance of the results before any data have been collected, focusing on the importance of the question and the strength of the methodology. (thepublicationplan.com)
  • In his presentation, Barry Smith discusses the irreproducibility crisis in ontological terms of misuse of data analysis or p-hacking (selective reporting of data, data fishing, data dredging) and how to restore the scientific enterprise. (independent.org)
  • The scientific community has been struggling with the problem of data reproducibility-a key step in the process that guides how most scientists create knowledge in their field. (phys.org)
  • Same data, different conclusions: Radical dispersion in empirical results when independent analysts operationalize and test the same hypothesis. (stodden.net)
  • The obtained experimental results might not have been the desired results, and that data might have been changed to … better fit a hypothesis. (stormeyes.org)
  • Unfortunately, although negative results often constitute a large portion of scientists' data, journals consider them less interesting so they often go unpublished. (footnote.co)
  • While a certain level of irreproducibility due to unknown variables or errors is a normal part of research, data falsification and detrimental research practices - such as inappropriate use of statistics or after-the-fact fitting of hypotheses to previously collected data - apparently also play a role. (ens-newswire.com)
  • However, many practices that have until now been categorized as "questionable" research practices - for example, misleading use of statistics that falls short of falsification, and failure to retain research data - should be recognized as "detrimental" research practices, the new report says. (ens-newswire.com)
  • If the data and the procedures used (methodology) are not transparent, then reproducibility is impossible, and the results should be considered as speculative. (genewhisperer.com)
  • This webinar discusses leveraging racial data, in research, with equity-minded intentionality. (sc-ctsi.org)
  • Especially in the era of "Big Data," scientifically proven and accepted research methods are essential to gaining knowledge. (discoveryengineering.net)
  • There are also efforts to leverage 'big data', which may provide information on trends, signals, or hypotheses to be tested further, but generally do not provide results of sufficient adequacy to support regulatory submissions. (appliedclinicaltrialsonline.com)
  • One of the components which contribute most to Reproducibility is good experimental design. (nih.gov)
  • This leads to a literature that is full of positive and impacting results, but usually at the expense of selective or biased analyses and inflated effects, which distort our perception of the scientific problems under study (16). (bvsalud.org)
  • Workarounds" that necessitate workflow stoppages or interventions are not conducive to reproducible research. (simplicis.com)
  • 30. "Government agencies should institute review commissions to determine which existing regulations are based on reproducible research, and to rescind those which are not. (genewhisperer.com)
  • Analytical reproducibility in scientific research has become a keenly discussed topic within scientific research organizations and acknowledged as an important and fundamental goal to strive for. (dlib.org)
  • By some estimates, half of recent scientific research could be irreproducible. (independent.org)
  • Unless you've been living under a rock (no judgment, by the way), I'm sure you've heard about the reproducibility crisis in scientific research. (phys.org)
  • Open Access is an initiative that aims to make scientific research freely available to all. (intechopen.com)
  • We made progress on both lines of work by combining basic psychological research on information search and processing as well as arousal with incentive-compatible research paradigms. (mpg.de)
  • Progress in this direction can be facilitated by changing academic publishing policies, establishing projects directed at measuring reproducibility, and improving training for graduate students. (footnote.co)
  • Reproducibility applies not to results but to methodology - it means that another research team is able to reproduce a study. (simplicis.com)
  • Many factors contribute to irreproducible results and addressing the problem will require strong leadership at the highest levels. (issues.org)
  • How big is this irreproducibility problem? (ipscell.com)
  • Another part of the problem surely is that the emphasis amongst scientists themselves, editors, funding agencies, and others is on doing new stuff, not reproducing published results. (ipscell.com)
  • The problem is that a lot of research is being published that is not necessarily as definitive as it might seem, given the fact that it has been peer-reviewed and published in a journal, sometimes a high-impact journal," says Carrie Cameron, PhD, associate director of the MD Anderson Cancer Prevention Research Training Program. (aamc.org)
  • Nevertheless, it poses a problem for those of us who are consumers of economic research: how should we respond to this? (typepad.com)
  • The phenomenon is so widely recognized, it now has a name: the reproducibility crisis. (issues.org)
  • [16] A survey on higher education published by The Economist in 2005 commented ARWU as "the most widely used annual ranking of the world's research universities. (alquds.edu)
  • The entire theory (and research thereon) that Alzheimer's disease is caused by "amyloid beta" protein plaques, which has been around since a widely publicized and seminal 2006 paper, now teeters on the brink of implosion, or at least deep and major reworking. (stormeyes.org)
  • It will also compare r/SampleSize to Amazon Mechanical Turk (MTurk), a widely used crowdsourcing platform for recruiting research participants. (sc-ctsi.org)
  • I was not surprised that few produced replicable results. (issues.org)
  • It should be noted that the reproducibility of a scientific finding can be defined in many ways, and that there is no consensus on the use of the terms "reproducible" and "replicable" (1,2). (bvsalud.org)
  • Economics research is usually not replicable' say (pdf) Andrew Chang and Phillip Li ( via ). (typepad.com)
  • The checklist focuses on experimental and analytical design elements that are critical for the interpretation of research results but that are often reported incompletely. (nature.com)
  • We also continue to encourage authors to use resources for sharing detailed methods and reagent descriptions by providing direct online linking between primary research articles and Protocol Exchange ( http://www.nature.com/protocolexchange/ ), an open resource into which authors can deposit the detailed step-by-step experimental protocols used in their study. (nature.com)
  • At Bielefeld University, nine research project groups from varied disciplines have embarked on a "reproducibility" journey by collaborating on the Conquaire project as case study partners. (dlib.org)
  • One particularly interesting approach is to have studies pre-registered , which emphasizes study design over results. (nautil.us)
  • I recently proposed a publishing model that may increase the tendency to publish negative and confirmatory results by decreasing the minimum amount of information a new study needs to provide. (nautil.us)
  • A recent headline-grabbing study about the limits of the human life span has drawn rebuttals with implications for how universities and scientists might approach the reproducibility crisis in research. (chronicle.com)
  • As scientists across various fields move through a period of soul-searching over the disturbing number of studies that apparently cannot be reproduced, the leading suspects include industry bias, financial and career pressures, poor study design, and wide variations in research methodologies, equipment, and standards. (chronicle.com)
  • One hour of Supervisory Training will be awarded for completion of one hour of interaction with Lab Staff/trainees on Reproducibility and Study design. (nih.gov)
  • This chapter reviews the benefits and costs of improved approaches to addressing research misconduct and detrimental research practices and explores several new approaches considered by the committee. (nationalacademies.org)
  • In addition, new forms of detrimental research practices are appearing, such as predatory journals that do little or no editorial review or quality control of papers while charging authors substantial fees. (ens-newswire.com)
  • TRACKMAN® Connected is a tablet with accessories and apps that makes pipetting faster and more verifiable, which improves reliability, traceability, and reproducibility at the bench. (the-scientist.com)
  • Understanding Reproducibility and Characteristics of Flaky Tests Through Test Reruns in Java Projects ," W. Lam, S. Winter, A. Astorga, V. Stodden, D. Marinov, International Symposium on Software Reliability Engineering (ISSRE20) . (stodden.net)
  • In an era where the volume of scholarly articles is constantly increasing, and the rapid pace of scientific discovery necessitates ongoing updates, it is essential to ensure the accuracy and reliability of published research. (igminresearch.com)
  • Marcus Munafò (University of Bristol) gave a fascinating account of the UKRN (United Kingdom Reproducibility Network), including why it was established, its structure, its activities, and the ways in which it is facilitating conversations across different levels of the academic and research ecosystem. (thepublicationplan.com)
  • Building a Vision for Reproducibility in the Cyberinfrastructure Ecosystem: Leveraging Community Efforts ," D. Chapp, V. Stodden, M. Taufer. (stodden.net)
  • My lab has developed a protocol to easily assess the specificity of antibodies-and hopefully stem some of the reproducibility crisis. (the-scientist.com)
  • The checklist was developed on the basis of community discussion, including workshops held last year by the US National Institute of Neurological Disorders and Stroke and the National Cancer Institute, to address the problems underlying irreproducibility. (nature.com)
  • The survey report shares some of the most interesting insights, on topics such as irreproducibility and quality control, and how to address them in your research. (stemcell.com)
  • The budgets of federal agencies that address research misconduct should also be included in this accounting. (nationalacademies.org)
  • Developed by CrossRef, a nonprofit organization dedicated to advancing research communication, CrossMark was introduced in 2012 to address the challenges posed by the increasing volume of academic literature and the dynamic nature of scientific discoveries. (igminresearch.com)
  • As a young scientist, it was deeply discouraging to realize that research on MS biomarkers was of such poor quality that I could not determine if any of them might be useful for finding new treatments. (issues.org)
  • Reproducibility is the idea that an experiment can be repeated by another scientist and they will get the same result. (phys.org)
  • An essential element of the scientific process is reproducibility - the idea that any scientist in any lab should be able to conduct the same experiment under the same conditions and obtain the same results. (footnote.co)
  • I knew there were many sources of waste in our health care system, but the failure on the part of the research enterprise to ensure the validity of publicly funded studies, especially those involving patients, seemed particularly egregious. (issues.org)
  • In 2015, the results of a large systematic replication of studies in cognitive and social psychology were released, which indicated success rates between 36% and 47% (9). (bvsalud.org)
  • Since then, similar projects have found reproducibility rates between 30% and 85% in different samples of studies from the social and behavioral sciences (10-13). (bvsalud.org)
  • This creates a problematic conflict of interest for the authors, as career advancement depends on obtaining particular results, biasing the conduct and the analysis of studies (17). (bvsalud.org)
  • This obsession with perceived novelty results in many published studies standing alone without ever having been recapitulated. (ipscell.com)
  • Results: Among 4 studies specifying the progression-free survival (PFS) for comparing the groups treated either using targeted therapy or other modality/placebo, 50% of studies show a slight increase in PFS in the group treated with TT and other 50% show PFS increase in the non-TT group. (bvsalud.org)
  • The RIPOSTE (Reducing IrreProducibility in labOratory STudiEs) framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies and, therefore, to reduce irreproducibility. (ox.ac.uk)
  • That's fitting, since our inability to independently replicate our results, I argue, threatens to undermine trust in the scientific enterprise-something every citizen has a stake in. (nautil.us)
  • Scientific results should stand the scrutiny of the research community and should be verifiable by peers. (dlib.org)
  • The substantial investments in human genetics and genomics made over the past three decades were anticipated to result in many innovative therapies. (bvsalud.org)
  • This presentation will summarize the Getting to Outcomes approach and its research. (sc-ctsi.org)
  • Learn strategies for promoting your research, publications, conference talks and other efforts. (sc-ctsi.org)
  • During this 60-minute webinar, we feature a panel of six productive scholars, ranging from graduate students to professors, who offer tips and strategies for effective research writing. (sc-ctsi.org)
  • This presentation introduces basic concepts and issues around reproducibility. (sc-ctsi.org)
  • A thorough understanding of mechanisms leading to irreproducibility through false positives or negatives, confounding variables or uncontrolled bias in both research context will be presented, as well as the solution to prevent them. (bium.ch)
  • To meet these challenges, all parties in the research enterprise need to take deliberate steps to strengthen the self-correcting mechanisms that are part of research and to better align the realities of research with its values and ideals," he said. (ens-newswire.com)
  • At the time, I well understood that reproducibility is truth. (issues.org)