Loading...



  • body iron
  • There are several methods available for diagnosing and monitoring hemosiderosis including: Serum ferritin Liver biopsy MRI Serum ferritin is a low cost, readily available, and minimally invasive method for assessing body iron stores. (wikipedia.org)
  • levels
  • However, the major problem with using it as an indicator of hemosiderosis is that it can be elevated in a range of other medical conditions unrelated to iron levels including infection, inflammation, fever, liver disease, renal disease and cancer. (wikipedia.org)
  • gene
  • In a patient with negative HFE gene testing, elevated iron status for no other obvious reason, and family history of liver disease, additional evaluation of liver iron concentration is indicated. (wikipedia.org)
  • This led investigators to the discovery of a gene polymorphism in the gene for ferroportin, which predisposes some people of African descent to iron overload. (wikipedia.org)
  • The HFE gene makes a protein that helps cells regulate the absorption of iron from the digestive tract and into the cells of the body. (wikipedia.org)
  • Individuals who are homozygotes for the C282Y allele of the HFE gene are at risk for developing lethal concentrations of iron, particularly in the liver. (wikipedia.org)
  • To determine whether the HFE gene of black rhinoceroses has undergone mutation as an adaptive mechanism to improve iron absorption from iron-poor diets, Beutler et al. (wikipedia.org)
  • deficiency
  • Low TS is indicative of iron deficiency. (neurologyadvisor.com)
  • Measuring the amount of iron in the body is important because either too much (iron overload) or too little iron (iron deficiency) can be harmful. (clinicaltrials.gov)
  • Chemical evidence of tissue vitamin C deficiency and mild to moderate liver dysfunction are likely to be seen in individuals with African iron overload. (wikipedia.org)
  • These accumulations may be caused by excessive red blood cell destruction (haemolysis), excessive iron uptake/hyperferraemia, or decreased iron utilization (e.g. anaemia of copper toxicity) /uptake hypoferraemia (which often leads to iron deficiency anaemia). (wikipedia.org)
  • hepcidin
  • We will also determine the levels of hepcidin (a hormone produced in the liver that appears to regulate iron homeostasis) from blood and urine. (clinicaltrials.gov)
  • Measurement of serum hepcidin levels may be useful in diagnostic for iron overload. (wikipedia.org)
  • Its primary mode of action is the regulation of the iron storage hormone hepcidin. (wikipedia.org)
  • In 2001, she became a member of the Department of Medicine at UCLA, where she worked on iron metabolism and the hormone hepcidin. (wikipedia.org)
  • absorption
  • Pancreatin reduces the absorption of iron from food in the duodenum during digestion Some contact lens cleaning solutions contain porcine pancreatin extractives to assist in the intended protein-removal process. (wikipedia.org)
  • diagnosis
  • Piperno A (1998) Classification and diagnosis of iron overload. (springer.com)
  • Positive HFE analysis confirms the clinical diagnosis of haemochromatosis in asymptomatic individuals with blood tests showing increased iron stores, or for predictive testing of individuals with a family history of haemochromatosis. (wikipedia.org)
  • oxidative
  • Too much iron in the tissues leads to increased oxidative stress - an imbalance in the production of chemically reactive molecules containing oxygen - and multiple organ failure. (newsmax.com)
  • anemia
  • Too little iron in the blood results in iron-deficient anemia. (newsmax.com)
  • Anemia is corrected by increasing iron intake in the diet (eating more red meat) as well as taking iron supplements or administering it intravenously. (newsmax.com)
  • Anemia is the most common disease in the world, and thus iron is a precious resource. (neurologyadvisor.com)
  • Iron overload associated with hemolytic anemia is mild and develops slowly and may never be significant in a patient's lifetime. (neurologyadvisor.com)
  • 400 ng/mL) in the presence of other factors such as family history of HH, hemolytic anemia, or other conditions associated with iron overload. (neurologyadvisor.com)
  • Low iron can cause anemia, or low red blood cell count. (blackdoctor.org)
  • In sideroblastic anemia, the body has iron available but cannot incorporate it into hemoglobin, which red blood cells need in order to transport oxygen efficiently. (wikipedia.org)
  • Her research has suggested treatments for anemia and iron overload. (wikipedia.org)
  • homeostasis
  • Pr Leduc's team in collaboration with GSK is validating the hypothesis that an inhibitor to an enzyme associated with iron homeostasis will efficiently lower iron-overload and act as a new drug. (mitacs.ca)
  • tissues
  • Iron in the blood binds with oxygen and carries it throughout the body to the tissues. (newsmax.com)
  • To count a cell as a ring sideroblast, the ring must encircle a third or more of the nucleus and contain five or more iron granules, according to the 2008 WHO classification of the tumors of the hematopoietic and lymphoid tissues. (wikipedia.org)
  • Also Siderosis Bulbi, deposition of iron into the eye causing injury as the material chemically reacts with tissues and cells. (wikipedia.org)
  • Alternative HFE splicing variants may serve as iron regulatory mechanisms in specific cells or tissues. (wikipedia.org)
  • It binds iron, decreasing the toxic reactions catalysed by the unbound metal, and it also decreases the uptake of iron by tissues. (wikipedia.org)
  • abnormalities
  • Endocrine abnormalities in thalassemic patients involve the overloaded iron interfering with the production of insulin-like growth factor (IGF-1), as well as stimulating hypogonadism, both of which cause poor pubertal growth. (wikipedia.org)
  • toxic
  • Iron is not a toxic heavy metal, but rather is a metal that is essential for human biology. (newsmax.com)
  • Iron is required by many of the chemical reactions (i.e. oxidation-reduction reactions) in the body but is toxic when not properly contained. (wikipedia.org)
  • This free iron is toxic to the body since it catalyzes reactions that generate free hydroxyl radicals. (wikipedia.org)
  • blood
  • Long-term iron overload can result in blood clots, liver cancer, heart attack, and even death. (newsmax.com)
  • Iron overload can be diagnosed using a simple, inexpensive blood test. (newsmax.com)
  • The treatment for iron overload is to avoid foods that contain refined flour (iron is often added to the flour) and to undergo periodic blood tests. (newsmax.com)
  • Sideroblasts (sidero- + -blast) are atypical, abnormal nucleated erythroblasts (precursors to mature red blood cells) with granules of iron accumulated in the mitochondria surrounding the nucleus. (wikipedia.org)
  • HFE is prominent in small intestinal absorptive cells, gastric epithelial cells, tissue macrophages, and blood monocytes and granulocytes, and the syncytiotrophoblast, an iron transport tissue in the placenta. (wikipedia.org)
  • measures
  • Ideally one measures SI and total iron binding capacity (TIBC) after a 12-hour period of fasting TS is calculated by the formula TS = SI/TIBC. (neurologyadvisor.com)
  • The proposed research project will continue the application and development of a new method (biomagnetic susceptometry) that measures magnetic fields to determine how much iron is in the liver. (clinicaltrials.gov)
  • levels
  • Magnetic resonance imaging (MRI) is emerging as a noninvasive alternative to accurately estimate iron deposition levels in the liver as well as heart, joints, and pituitary gland. (wikipedia.org)
  • body iron
  • There are several methods available for diagnosing and monitoring hemosiderosis including: Serum ferritin Liver biopsy MRI Serum ferritin is a low cost, readily available, and minimally invasive method for assessing body iron stores. (wikipedia.org)
  • levels
  • However, the major problem with using it as an indicator of hemosiderosis is that it can be elevated in a range of other medical conditions unrelated to iron levels including infection, inflammation, fever, liver disease, renal disease and cancer. (wikipedia.org)
  • metabolism
  • The disease is characterized by genetic heterogeneity, affecting different ribosomal gene loci: Exceptions to this paradigm have been demonstrated, such as with rare mutations of transcription factor GATA1 and advanced alternative splicing of a gene involved in iron metabolism, SLC49A1 (FLVCR1). (wikipedia.org)
  • Hepcidin is a regulator of iron metabolism. (wikipedia.org)
  • ship
  • The daughter's husband, the only support of both women, had been lost at sea shortly before in an overloaded ship. (dawlishchronicles.com)
  • Ship wrecked in Lake Michigan in 1929 The SS Andaste was a bulk Great Lakes cargo vessel built of steel in 1892 by the Cleveland Ship Building Company for the Lake Superior Iron Company. (wikipedia.org)
  • The ship was overloaded with cargo, and thus unseaworthy, and only 19 survivors were able to escape the foundering ship by lifeboat, leaving a death toll of 220. (wikipedia.org)
  • coal
  • In 1898 Andaste and Choctaw were transferred from Lake Superior Iron to the Cleveland Cliffs Co. The vessels carried coal, iron ore, and grain to and from Lake Superior to the lower Great Lakes. (wikipedia.org)
  • blood
  • Positive HFE analysis confirms the clinical diagnosis of haemochromatosis in asymptomatic individuals with blood tests showing increased iron stores, or for predictive testing of individuals with a family history of haemochromatosis. (wikipedia.org)
  • In the case of iron overload, which may occur in individuals with β-thalessemia who have received blood transfusions, the target metal ion is in the +3 oxidation state and so forms stronger complexes than the divalent ions. (wikipedia.org)
  • Ceruloplasmin helps move iron from the organs and tissues of the body and prepares it for incorporation into a molecule called transferrin, which transports it to red blood cells to help carry oxygen. (wikipedia.org)
  • lead
  • This option may be considered when patients become transfusion-dependent because frequent transfusions can lead to iron overloading and organ damage. (wikipedia.org)
  • Chelation therapy is the preferred medical treatment for metal poisoning, including acute mercury, iron (including in cases of thalassemia), arsenic, lead, uranium, plutonium and other forms of toxic metal poisoning. (wikipedia.org)
  • stress
  • Erythroferrone, produced in erythroblasts, has been identified as inhibiting hepcidin and so providing more iron for hemoglobin synthesis in situations such as stress erythropoiesis. (wikipedia.org)
  • body
  • After Taggert explodes from the overloaded dosage, the explosion kills many people and injures Hogan while Savin regenerates his damaged body and walks away. (wikipedia.org)
  • transport
  • Aceruloplasminemia is caused by a mutation (a five-base pair insertion in exon 7) in the CP gene, which provides instructions for making a protein called ceruloplasmin, a protein involved in iron transport and processing. (wikipedia.org)
  • When ceruloplasmin is unavailable, transport of iron out of the body's tissues is impaired. (wikipedia.org)
  • Hepcidin inhibits iron transport by binding to the iron export channel ferroportin which is located on the basolateral surface of gut enterocytes and the plasma membrane of reticuloendothelial cells (macrophages). (wikipedia.org)
  • available
  • These include cirrhosis (especially related to alcohol abuse), steatohepatitis of any cause, porphyria cutanea tarda, prolonged haemodialysis, and post-portacaval shunting There are several methods available for diagnosing and monitoring iron loading including: Serum ferritin: In males and postmenopausal females, a serum ferritin value of over 300 ng/mL (670 pmol/L) indicates iron overload. (wikipedia.org)
  • Built
  • She was originally built for the Lake Superior Iron Company in 1892, but the Cleveland-Cliffs Iron Company became her owner after the original owner went into bankruptcy in 1898. (wikipedia.org)