• This Human Sodium/hydrogen exchanger 1 (SLC9A1) ELISA Kit employs a two-site sandwich ELISA to quantitate SLC9A1 in samples. (abbkine.com)
  • Human Sodium/hydrogen exchanger 1 (SLC9A1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SLC9A1. (abbkine.com)
  • Sodium/hydrogen exchangers or sodium/proton antiports are a family of transporters that maintain cellular pH by utilising the sodium gradient across the plasma membrane to extrude protons produced by metabolism, in a stoichiometry of 1 Na + (in) : 1 H + (out). (guidetopharmacology.org)
  • The strict exchange of protons for sodium ions across cell membranes by Na +/ H + exchangers is a fundamental mechanism for cell homeostasis. (elsevierpure.com)
  • Na+/H+ exchangers-1-6 (Na+/H+ antiporters, NHE-1-6) are integral membrane proteins that are expressed in most mammalian tissues where they regulate intracellular pH and cell volume. (thermofisher.com)
  • Sodium-hydrogen exchangers (Na + /H + exchangers, NHE) are ATP-independent membrane glycoprotein transporters that are involved in the regulation of intracellular pH, cell volume and the cellular response to hormones and mitogens. (tocris.com)
  • One approach involves the generation of isoform- and phospho-specific polyclonal and monoclonal antibodies to identify the cellular and subcellular sites of expression of ion exchangers in the kidney and other tissues, and to study their regulation. (yale.edu)
  • A complementary approach uses mice with targeted gene disruption to elucidate the physiological roles of ion exchangers and associated proteins under in vivo conditions. (yale.edu)
  • The transporters mediate the simultaneous efflux of a hydrogen ion and the influx of a sodium ion across the plasma membrane, the driving force being the inwardly directed electrochemical Na + gradient. (tocris.com)
  • These results suggest that the enhanced salt tolerance conferred by codA in transgenic tomato plants might be due to the regulation of ion channel and transporters by GB, which would allow high potassium levels and low sodium levels to be maintained in transgenic plants under salt stress condition. (oregonstate.edu)
  • The members of the MFS are secondary active, ion-coupled transporters of sugars, amino acids, drugs, nucleosides as well as organic and inorganic cations and anions (13). (kentlandsinitiative.org)
  • Amiloride blocks the epithelial sodium channel (ENaC) in the late distal tubule, connecting tubule, and collecting duct of the nephron, which both reduces absorption of sodium ion from the lumen of the nephron and reduces excretion of potassium ion into the lumen. (worldsbest.rehab)
  • Because Liddle phenotype usually involves an upregulation of ENaC channels, leading to retention of sodium and water and to hypokalemia, amiloride is useful as an ENaC channel inhibitor due to its promotion of sodium excretion and its potassium-sparing effects, restoring potassium to normal levels. (worldsbest.rehab)
  • Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. (childrensmercy.org)
  • Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. (childrensmercy.org)
  • This graph shows the total number of publications written about "Sodium-Potassium-Exchanging ATPase" by people in this website by year, and whether "Sodium-Potassium-Exchanging ATPase" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Sodium-Potassium-Exchanging ATPase" by people in Profiles. (childrensmercy.org)
  • Membrane proteins that allow the exchange of hydrogen ions for potassium ions across the cellular membrane. (bvsalud.org)
  • The action of these antiporters influences intracellular pH and potassium ion homeostasis. (bvsalud.org)
  • The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. (assaygenie.com)
  • A family of plasma membrane exchange glycoprotein antiporters that transport sodium ions and protons across lipid bilayers. (nih.gov)
  • They are ANTIPORTERS that exchange vesicular PROTONS for cytoplasmic NEUROTRANSMITTER and play an essential role in regulating neurotransmission. (uams.edu)
  • Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. (assaygenie.com)
  • When there is a reduction in effective arterial blood volume, reabsorption of sodium predominates over the kidney's ability to maintain acid-base balance. (abdominalkey.com)
  • A qRT-PCR assay indicated that GB enhanced NaCl-induced expression of genes encoding the K transporter, Na/H antiporter, and H-ATPase. (oregonstate.edu)
  • The NhaB family (TC# 2.A.34) belongs to the ion transporter (IT) superfamily. (wikipedia.org)
  • The Gene Ontology (GO) terms were enriched in ion transmembrane transporter and oxidoreductase activity under NaCl and KCl stress. (researchsquare.com)
  • Nevertheless, extensive analysis on the model Na + /H + antiporter NhaA from Escherichia coli, has shown that residues on the cytoplasmic surface, termed the pH sensor, shifts the pH at which NhaA becomes active. (elsevierpure.com)
  • Nevertheless, extensive analysis on the model Na+/H+ antiporter NhaA from Escherichia coli, has shown that residues on the cytoplasmic surface, termed the pH sensor, shifts the pH at which NhaA becomes active. (elsevierpure.com)
  • The involvement of NHE activity during organ ischemia is complex: H + efflux driven by the NHE corrects the drop in intracellular pH, yet the concurrent influx of Na + ions leads to Ca 2+ overload through the actions of the NCX. (tocris.com)
  • Some people with the Liddle phenotype have Liddle syndrome, which involves a genetic mutation resulting in upregulation of the epithelial sodium channel (ENaC), located in the apical membrane of polarized epithelial cells in the late distal tubule and collecting duct of the kidney. (worldsbest.rehab)
  • NHE3 is highly expressed in the intestine and kidneys and regulate sodium movements in those tissues. (guidetopharmacology.org)
  • A large input of NaHCO 3 cannot maintain metabolic alkalosis because the kidneys will readily excrete sodium (Na + ) and HCO 3 − or potential HCO 3 − (citrate) very quickly, unless reduced kidney function is present. (abdominalkey.com)
  • Loss of tubular function prevents the kidneys from excreting hydrogen cations (H+) and thereby causes metabolic acidosis. (medscape.com)
  • Our general goal is to characterize the mechanisms regulating sodium, acid-base, and anion excretion by the kidney. (yale.edu)
  • Our work is primarily focused on membrane transport proteins mediating ion exchange, namely NHE isoforms mediating Na + -H + exchange, and SLC26 isoforms mediating anion exchange. (yale.edu)
  • HDX-MS, on the other hand, provides an extremely sensitive method for interrogating the conformational dynamics of proteins and their complexes via monitoring the exchange of hydrogens to deuterium [ 17-19 ]. (silverchair.com)
  • Gemperli, A. C., Dimroth, P. & Steuber, J. Sodium ion cycling mediates energy coupling between complex I and ATP synthase. (uzh.ch)
  • It mediates the coupled exchange of alpha-ketoglutarate with organic ions such as P-AMINOHIPPURIC ACID . (nih.gov)
  • By the treatment with a solution of 3% sodium hydroxide and 1.9% monomethylamine, the isoelectric point of type I collagen was lowered from 9.3 to 4.8 because of the conversions of Asn and Gln to Asp and Glu. (lookformedical.com)
  • At active pH, Na + /H + exchange can be modelled as competition between H + and Na + to an ion-binding site, harbouring either one or two aspartic-acid residues. (elsevierpure.com)
  • The ion exchange occurs regardless of the substance's charge. (medscape.com)
  • The antiporter is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. (abbkine.com)
  • encodes the lysosomal polytopic CLN7 membrane protein of unknown function which contains sequence similarities with the drug: H+ antiporter family DHA1 of the major facilitator superfamily (MFS) (4,12). (kentlandsinitiative.org)
  • The first portion of each renal tubule is called the proximal tubule, and the proximal tubules are collectively responsible for reabsorbing the vast majority of the filtered NaCl, bicarbonate and water, and secreting acid in the form of ammonium ions. (yale.edu)
  • La acción de tales antiportadores influye en el pH intracelular y en la homeostasis de los iones potasio. (bvsalud.org)
  • Portal: Biology As of this edit, this article uses content from "2.A.34 The NhaB Na+:H+ Antiporter (NhaB) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. (wikipedia.org)
  • H + antiporters of the CPA2 family (TC #2.A.37) to establish homology (K. Studley and M.H. Saier, Jr., unpublished results). (tcdb.org)
  • One of the major generalities that has emerged during this progress is that the great functional diversity of active transport processes existing among living systems is based mainly on mechanisms in the fourth category: protein-mediated coupling between different species of transiting ions and molecules. (silverchair.com)
  • What we now refer to as a pH gate, triggers a conformational change that enables water and Na + to access the ion-binding site, as supported by molecular dynamics (MD) simulations. (elsevierpure.com)
  • A proposed structure of the holoenzyme positions the water-filled central channel of the Gcdα dimer coaxial with the ion channel in Gcdβ. (tcdb.org)
  • Prospective studies involving very low birth weight (VLBW) infants (BW ≤1500 g) and extremely low birth weight (ELBW) infants (BW ≤1000 g) demonstrated a consistent pattern of fluid and sodium balance despite varying intakes of sodium and water over the first five to seven days of life [ 3,4 ]. (medilib.ir)
  • An acid is a substance that can donate hydrogen ions (H + ). A base is a substance that can accept H + ions. (medscape.com)